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Ryohei Shigefuji,Masamitsu Serikawa,Akinobu Usami 대한해부학회 2022 Anatomy & Cell Biology Vol.55 No.2
The mandibular second molars show various morphological features in the roots and root canal, and a gutter-shaped root (GSR) caused by fusion of the mesial and distal roots is frequently encountered. In this study the number of the roots associated with mandibular second molars were observed using dental cone-beam computed tomography (CBCT). For those with a GSR, determination of root morphology and root canal classification were performed. CBCT image data from 173 Japanese mandibular second molars were obtained. Using sliced images, the number of the roots and root morphology were determined. In cases with a GSR, the ratio for the fused roots was determined and root canal morphology features were classified. A GSR was found in 61 (35.3%), with greater prevalence in females. In addition, the overall ratio of the fused part to root thickness in those with a GSR was 48.7%, with no significant difference related to sex. Furthermore, a C-shaped root canal morphology was commonly observed in both males and females with a GSR. In the present cohort examined in Japanese, most of the mandibular second molar were found to have two roots, with a GSR noted in 35.5%. While a GSR was more often observed in females, a C-shaped root canal was the most common root canal morphology in both sexs. It is considered that assessment using CBCT findings is helpful for precise determination of root canal morphology and presence of a GSR in mandibular second molars.
Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
( Ryohei Hayashi ),( Yoshitaka Ueno ),( Shinji Tanaka ),( Kana Onishi ),( Takeshi Takasago ),( Masaki Wakai ),( Toshikatsu Naito ),( Kensuke Sasaki ),( Shigehiro Doi ),( Takao Masaki ),( Kazuaki Chaya 대한장연구학회 2021 Intestinal Research Vol.19 No.4
Background/Aims: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. Some patients with this condition have been reported to present with immunoglobulin A nephropathy (IgAN), a renal complication that can cause end-stage renal failure, but the frequency of this comorbidity has not been described. Thus, the aim of this study was to investigate the frequency of IgAN in patients with IBD. Methods: This study included 620 patients with IBD (338 with ulcer-ative colitis [UC] and 282 with Crohn’s disease [CD]) from the Hiroshima University Hospital outpatient department. IgAN cases were identified from medical interviews, blood examinations (serum immunoglobulin A), and urinalyses (occult blood, proteinuria). Definitive IgAN cases were diagnosed by renal biopsies, while those detected through the clinical course and test results, but not clinically recommended for renal biopsy, were defined as suspected IgAN. Results: We analyzed 427 cases meeting the inclusion criteria (220 with UC and 207 with CD). The incidence of IgAN across all patients with IBD was 3.0%. The frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) (P< 0.01). Moreover, a significant correlation was found between CD patients with ileostomy or colostomy and a diagnosis of IgAN. Con-clusions: Patients with IBD present a high incidence of IgAN, especially those with CD who have undergone ileostomy or co-lostomy. (Intest Res 2021;19:430-437)
Measurement of Roll-over Shape of Prosthetic Feet by Using an Ambulatory Gait Monitoring System
Ryohei Fujita,Shoji Morimoto 한국재활복지공학회 2012 한국재활복지공학회 학술대회논문집 Vol.2012 No.11
The purpose of this study is to test feature of prosthetic foot with Roll-over shape. This paper describes how to calculate model of roll-over shape. Calculating the model has developed system of using installed 6-compnet force to prosthetic lower leg. The system is used to measure analytically Roll-over shape with walking. The experimental results show that the proposed model can analysis feature of prosthetic foot with Roll-over shape.
Proposal of Dynamic Modeling of Distribution System with System Identification
Ryohei, Kawagishi,Yamanaka, Daisuke,Shirai, Yasuyuki The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.3
In this study, a new method of building a dynamic load model for dynamic stability analysis was proposed. This method is as follows: First, inject some small electric power disturbance of known pattern to power system and measure the response in distribution system. Next, analyze the measured response using system identification and create the load model. Simulation was performed with PSCAD, and a dynamic load model was build and evaluated. In the simulation, the availability of the proposed method was confirmed. The model could reproduce the response of the stable system precisely. In addition to it, the stability of the system could evaluate with proposed method.
Thiamylal sodium increased inflammation and the proliferation of vascular smooth muscle cells
Ryohei Miyazaki,Sumio Hoka 대한마취통증의학회 2016 Korean Journal of Anesthesiology Vol.69 No.3
Background: Thiamylal sodium is a common anesthetic barbiturate prepared in alkaline solution for clinical use. There is no previously reported study on the effects of barbiturates on the inflammation and proliferation of vascular smooth muscle cells (VSMCs). Here, we examined the effects of clinical-grade thiamylal sodium solution (TSS) on the inflammation and proliferation of rat VSMCs. Methods: Expression levels of interleukin (IL)-1α, IL-1β, IL-6, and toll-like receptors in rat VSMCs were detected by quantitative reverse transcription-polymerase chain reaction and microarray analyses. The production of IL-6 by cultured VSMCs or ex vivo-cultured rat aortic segments was detected in supernatants by enzyme-linked immunosorbent assay. VSMC proliferation and viability were determined by the water-soluble tetrazolium-1 assay and trypan blue staining, respectively. Results: TSS increased expression of IL-1α, IL-6, and TLR4 in VSMCs in a dose-dependent manner, and reduced IL-1β expression. Ex vivo TSS stimulation of rat aorta also increased IL-6. Low concentrations of TSS enhanced VSMC proliferation, while high concentrations reduced both cell proliferation and viability. Expression of IL-1 receptor antagonist, which regulates cell proliferation, was not increased by TSS stimulation. Exposure of cells to the TSS additive, sodium carbonate, resulted in significant upregulation of IL-1α and IL-6 mRNA levels, to a greater extent than TSS. Conclusions: TSS-induced proinflammatory cytokine production by VSMCs is caused by sodium carbonate. However, pure thiamylal sodium has an anti-inflammatory effect in VSMCs. TSS exposure to VSMCs may promote vascular inflammation, leading to the progression of atherosclerosis or in-stent restenosis, resulting in vessel bypass graft failure.