A systematic method of synthesizing composite superabsorbent hydrogels from crosslink copolymer for removal of textile dyes from water

Ruma Bhattacharyya,Samit Kumar Ray,Bidyadhar Mandal 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.4

A systematic method was employed to synthesize several hydrogels by crosslink copolymerization of acrylamide (AM), hydroxyl ethylmethacrylate (HEMA) and N,N’-methylenebisacrylamide (NMBA) at varied operating conditions. Composite hydrogels were also prepared by in situ incorporation of varied amounts of sodium aluminosilicate filler to the monomer mixtures at optimum operating conditions. These hydrogels were used for removal of rhodamine B and methyl violet dye from water at low (0.5–3 mg/L) and high concentration (50–500 mg/L) ranges. The composite hydrogels showed much higher dye adsorption than the unfilled hydrogels. Kinetic, adsorption and thermodynamic parameters for dye adsorption were also evaluated.

Adsorption of industrial dyes by semi-IPN hydrogels of Acrylic copolymers and sodium alginate

Ruma Bhattacharyya,Samit Kumar Ray 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.22 No.-

Several hydrogels were synthesized from sodium alginate and copolymer of acrylic acid and acrylamide. These hydrogels were characterized by FTIR, XRD, DTA-TGA, swelling and diffusion characteristics. Thehydrogel showing the best result for swelling was used for adsorption of Basic fuschin (BF) and Methylviolet (MV) dyes. The hydrogel showed high adsorption and removal% for these dyes for both low (2.5–25 mg/L) and high range (100–600 mg/L) of feed concentration. The dye adsorption data were fitted todifferent kinetics and adsorption isotherm models. The external mass transfer coefficient, diffusioncoefficient and thermodynamic parameters of dye adsorption were also determined.

Enhanced adsorption of synthetic dyes from aqueous solution by a semi-interpenetrating network hydrogel based on starch

Ruma Bhattacharyya,Samit Kumar Ray 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5

Several semi-interpenetrating network (Semi-IPN) hydrogels were synthesized by free radical copolymerization of acrylamide, hydroxyethyl methacrylate and N0N0-methylene bis acrylamide crosslinker (MBA) in presence of starch. These hydrogels were characterized by FTIR, DTA-TGA, XRD and SEM. The hydrogel showing the highest swelling% in water was used for removal of low (2.5–40 mg/L) and high (200–500 mg/L) concentration range of malachite green and methyl violet dyes from water. The hydrogel showed high adsorption for both of these dyes. Isotherms, kinetics, mass transfer coefficients and thermodynamics of dye adsorption were also studied.

Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats

Rani, Ruma,Dahiya, Shakti,Dhingra, Dinesh,Dilbaghi, Neeraj,Kim, Ki-Hyun,Kumar, Sandeep Elsevier 2017 European journal of pharmaceutical sciences Vol.106 No.-

<P><B>Abstract</B></P> <P>Glycyrrhizin is an active constituent of the roots and rhizomes of <I>Glycyrrhiza glabra</I> and has anti-hyperglycemic effects. In this study, nanoparticles (NPs) loaded with glycyrrhizin or metformin were evaluated <I>in vivo</I> for their anti-hyperglycemic potency towards type-II diabetes in rats. The NPs were produced <I>via</I> the ionotropic gelation method using the biocompatible polymers chitosan and gum arabic. The polymer concentration was optimized using the 3<SUP>2</SUP> factorial method to acquire both minimum particle size and maximum encapsulation efficiency. The NPs were then characterized with respect to particle size, encapsulation efficiency, stability, chemical interactions, and <I>in vitro</I> drug dissolution profiles using spectroscopic and microscopic analysis. Furthermore, glycyrrhizin and metformin and their nanoformulations were administered for 21 successive days to diabetic rats. Glycyrrhizin-loaded NPs had significant anti-diabetic effects even though they contained approximately one quarter of the dosage relative to the pure form.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

An efficient solid base catalyst from coal combustion fly ash for green synthesis of dibenzylideneacetone

Nurul A. Mazumder,Ruma Rano 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.29 No.-

The objective of the investigation was to evaluate the catalytic efficiency of a solid base catalyst (SBC)derived from coal combustion fly ash to synthesize dibenzylideneacetone (DBA, 94% yield). The catalystwas produced using potassium hydroxide (30 wt.%) on thermally activated F-type fly ash. The physico-chemical, mineralogical and morphological characterization of the fly ash and catalyst were performedusing XRF, FT-IR, BET surface area analyser, XRD and SEM-EDS. The results of such analysis revealed thatthe catalyst obtained was associated with strong basic hydroxyl (–OH) sites that were highly suited toproduce DBA by crossed aldol condensation reaction.

Carbon nanotubes: a novel material for multifaceted applications in human healthcare

Kumar, Sandeep,Rani, Ruma,Dilbaghi, Neeraj,Tankeshwar, K.,Kim, Ki-Hyun The Royal Society of Chemistry 2017 Chemical Society reviews Vol.46 No.1

<P>Remarkable advances have been achieved in modern material technology, especially in device fabrication, and these have facilitated the use of diverse materials in various applications. Carbon nanotubes (CNTs) are being successfully implemented in drug delivery, sensing, water purification, composite materials, and bone scaffolds. Thus, CNTs must meet a wide range of criteria such as surface modification, high aspect ratio, desired conductivity, high porosity and loading, non-toxicity, specificity, and selectivity, and compatibility for device fabrication. The main focus of this review is to explore the maximum applications of CNTs for human health, and we particularly focus on nanocarrier and biomedical applications. The scope of this review initially covers the basic aspects of CNTs and is also extended further to describe their synthesis strategies as well as various challenges encountered in their functionalization, dispersion, and toxicity. Our discussion also emphasizes future directions for these emerging fields of research.</P>

A green and efficient solid acid catalyst from coal fly ash for Fischer esterification reaction

Nurul A. Mazumder,Ruma Rano,Gitarthi Sarmah 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.32 No.-

A green and efficient solid acid catalyst (SAC) has been synthesized upon modification of F-type fly ashusing ortho-phosphoric acid (35 wt. %). Catalyst characterization has been accomplished using differentanalytical techniques, such as FT-IR, XRD, SEM–EDS, and BET surface area analysis. SAC possessedexcellent catalytic activity for Fischer esterification reaction between 4-aminobenzoic acid andmethanol at 95 8C to produce methyl 4-aminobenzoate (MAB), an important precursor for the synthesisof pharmaceutical drugs, ( ) martinelline, and ( ) martinellic acid. This investigation suggests theutilization of fly ash to develop novel solid acid catalyst system for catalyzing industrially importantesterification reaction.

Synthesis and characterization of copper doped zinc oxide nanoparticles and its application in energy conversion

Poonam Bandyopadhyay,Anindita Dey,Ruma Basu,Sukhen Das,Papiya Nandy 한국물리학회 2014 Current Applied Physics Vol.14 No.8

Solar cells, in general, perform under light source of solar influx, while the heat energy of solar radiation remains unutilized. Using an aqueous suspension of copper doped zinc oxide nanoparticles in speciallydesigned electrochemical cells we have observed significant voltage (maximum 632.0 mV) and storage duration (~47 h) upon thermal excitation. The cells exhibit reasonable energy conversion efficiency (maximum 1.36%). These cells generate voltage even at room temperature (~30 C) and the voltage increases gradually with increasing temperature. When the platinum foil separating the two compartments of the electrochemical cell is replaced by a planar lipid membrane, all the parameters e.g., thermovoltage, storage capacity and the energy conversion efficiency increase significantly.

Analysis of H3K4me3-ChIP-Seq and RNA-Seq data to understand the putative role of miRNAs and their target genes in breast cancer cell lines

Kotipalli, Aneesh,Banerjee, Ruma,Kasibhatla, Sunitha Manjari,Joshi, Rajendra Korea Genome Organization 2021 Genomics & informatics Vol.19 No.2

Breast cancer is one of the leading causes of cancer in women all over the world and accounts for ~25% of newly observed cancers in women. Epigenetic modifications influence differential expression of genes through non-coding RNA and play a crucial role in cancer regulation. In the present study, epigenetic regulation of gene expression by in-silico analysis of histone modifications using chromatin immunoprecipitation sequencing (ChIP-Seq) has been carried out. Histone modification data of H3K4me3 from one normal-like and four breast cancer cell lines were used to predict miRNA expression at the promoter level. Predicted miRNA promoters (based on ChIP-Seq) were used as a probe to identify gene targets. Five triple-negative breast cancer (TNBC)-specific miRNAs (miR153-1, miR4767, miR4487, miR6720, and miR-LET7I) were identified and corresponding 13 gene targets were predicted. Eight miRNA promoter peaks were predicted to be differentially expressed in at least three breast cancer cell lines (miR4512, miR6791, miR330, miR3180-3, miR6080, miR5787, miR6733, and miR3613). A total of 44 gene targets were identified based on the 3'-untranslated regions of downregulated mRNA genes that contain putative binding targets to these eight miRNAs. These include 17 and 15 genes in luminal-A type and TNBC respectively, that have been reported to be associated with breast cancer regulation. Of the remaining 12 genes, seven (A4GALT, C2ORF74, HRCT1, ZC4H2, ZNF512, ZNF655, and ZNF608) show similar relative expression profiles in large patient samples and other breast cancer cell lines thereby giving insight into predicted role of H3K4me3 mediated gene regulation via the miRNA-mRNA axis.

An Alternative High-throughput Staining Method for Detection of Neutral Lipids in Green Microalgae for Biodiesel Applications

Gour Gopal Satpati,Sanjaya Kumar Mallick,Ruma Pal 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.6

A simple and high-throughput method for determining in situ intracellular neutral lipid accumulation in Chlorella ellipsoidea and Chlorococcum infusionum with flow cytometry and confocal microscopy was established by employing different solvents and a lipophilic dye, Nile red. Seven different organic solvents, acetic acid, dimethyl sulfoxide (DMSO), acetone, methanol, ethanol, n-hexane, and chloroform at different concentrations ranging from 0 to 80% (v/v) were tested. The fluorescence signal for neutral lipids was collected with a 586/42 emission filter (PE-A) and the maximum fluorescence intensity (% grandparent) was measured as 74.01 ± 4.82% for Chlorella and 70.1 ± 5.52% for Chlorococcum at 30% acetic acid (v/v). The statistical analysis of Nile red-stained cells showed a high coefficient of variation (CV), standard deviation (SD), mean, and median values in the acetic acid-based staining method, followed by DMSO, n-hexane and chloroform. Confocal microscopy revealed a high rate of accumulation of cytosolic neutral lipids when stained with Nile red and other organic solvents. Higher lipid accumulation in Fesupplemented conditions was also detected and a maximum lipid content of 57.36 ± 0.41% (4-fold) in Chlorella and 48.20 ± 0.43% (4-fold) in Chlorococcum were measured at 0.001 g/L of ferrous sulfate (FeSO4). High fluorescence intensity (75.16 ± 0.24% in Chlorella and 72.24 ± 1.07% in Chlorococcum) in Fe-treated cells confirmed the efficiency of the staining procedure.