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Pei Xu,Haibo Xiao,Qi Yang,Rui Hu,Lianyong Jiang,Rui Bi,Xueyan Jiang,Lei Wang,Ju Mei,Fangbao Ding,Jianbing Huang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Deubiquitinases (DUBs) and noncoding RNAs have been the subjects of recent extensive studies regarding their roles in lung cancer, but the mechanisms involved are largely unknown. In our study, we used The Cancer Genome Atlas data set and bioinformatics analyses and identified USP21, a DUB, as a potential contributor to oncogenesis in nonsmall-cell lung cancer (NSCLC). We further demonstrated that USP21 was highly expressed in NSCLCs. We then conducted a series of in vitro and in vivo assays to explore the effect of USP21 on NSCLC progression and the underlying mechanism involved. USP21 promoted NSCLC cell proliferation, migration, and invasion and in vivo tumor growth by stabilizing a well-known oncogene, Yin Yang-1 (YY1), via mediating its deubiquitination. Furthermore, YY1 transcriptionally regulates the expression of SNHG16. Moreover, StarBase bioinformatics analyses predicted that miR4500 targets SNHG16 and USP21. A series of in vitro experiments indicated that SNHG16 increased the expression of USP21 through miR-4500. In summary, the USP21/YY1/SNHG16 axis plays a role in promoting the progression of NSCLC. Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment.
Optimal impulse and regular control strategies for proportionalreinsurance problem
Yang Rui-cheng,Liu Kun-hui,Xia Bing 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1-2
We formulate a stochastic control problem on proportional reinsurance that includes impulse and regular control strategies. For the first time we combine impulse control with regular control, and derive the expected total discount pay-out (return function) from present to bankruptcy. By relying on both stochastic calculus and the classical theory of impulse and regular controls, we state a set of sufficient conditions for its solution in terms of optimal return function. Moreover, we also derive its explicit form and corresponding impulse and regular control strategies.
A Design of Adaptive Virtual Camera View Modes Based on Optimized Virtual Assembly Relation Model
Rui Yang,WenJie Fan 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10
This paper proposes an optimized virtual assembly relation model on the basis of deep analyses of traditional ones. Some typical adaptive virtual camera view modes are designed based on constraint conditions and dynamic data structure of optimized model mentioned above for a reversible virtual process of assembly and disassembly. These newly designed viewing modes are able to auto-adjust focus and field of view to follow and aid user operations by ensuring that camera view continuously focuses on virtual operating space currently in need, which lower the difficulty of user operations and heighten the efficiency of virtual operations.
Simple Synthesis of Multi-Halogen Pyrazino[1,2-a]indole-1,8(2H,5aH)-diones
Rui-Xia Yang,Yu-Cheng Zhao,Ling-Bin Kong,Sheng-jiao Yan,Jun Lin 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
A concise and efficient one-pot synthesis of multi-halogen pyrazino[1,2-a]indole-1,8(2H,5aH)-dione (MHPID) derivatives by the reaction of an enamino ester with multi-halogen benzoquinone derivatives is described. MHPIDs 3a–3d were obtained with good yields (78–83%) by refluxing enamino esters 1a and 1b and tetrahalogen-1,4-benzoquinones 2a and 2b for 24 h without the use of catalysts. Compounds 3e–3p were also obtained with excellent yields (69–92%) via the reaction of the phenyl-substituted enamino esters 1c–1h with tetrahalogen-1,4-benzoquinones 2a and 2b in CH3CN catalyzed by Cs2CO3. These two protocols are efficient and effective for the synthesis of MHPIDs.
ANALYSIS OF L<sup>1</sup>-WEIGHTS IN ONE-DIMENSIONAL MINKOWSKI-CURVATURE PROBLEMS
Yang, Rui,Lee, Yong-Hoon The Youngnam Mathematical Society 2019 East Asian mathematical journal Vol.35 No.1
$L^1$-weight functions are investigated to give necessary conditions on the existence of nontrivial solutions for various types of scalar equations and systems of one-dimensional Minkowski-curvature problems.
OPTIMAL IMPULSE AND REGULAR CONTROL STRATEGIES FOR PROPORTIONAL REINSURANCE PROBLEM
RUI-CHENG, YANG,KUN-HUI, LIU,BING, XIA 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1
We formulate a stochastic control problem on proportional reinsurance that includes impulse and regular control strategies. For the first time we combine impulse control with regular control, and derive the expected total discount pay-out (return function) from present to bankruptcy. By relying on both stochastic calculus and the classical theory of impulse and regular controls, we state a set of sufficient conditions for its solution in terms of optimal return function. Moreover, we also derive its explicit form and corresponding impulse and regular control strategies.
Research and Improvement on Active Compliance Control of Hydraulic Quadruped Robot
Rui Zhu,Qingjun Yang,Jiaxing Song,Shangru Yang,Yudong Liu,Qi Mao 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.5
This paper focuses on active compliance control of hydraulic quadruped robot, especially the analysis of the inner-loop of the coupled system. Current researches on active compliance control regard the bandwidth of the inner loop of the system as infinite, while ignoring that the extra-load will cause the inner-loop response characteristics to deteriorate when the leg is in the stance phase. In this work, we first briefly introduced the structure of the robot, and its kinematics and dynamics are analyzed. Next, the robot’s active compliance control framework is established, and the inner-loop two-cylinder coupling system is analyzed in depth. It can be concluded that the existence of low frequency poles in the system is the main reason for the poor response characteristics. Then through the analysis of the state equation and transfer function matrix of the multi-input multi-output system, we show that the equivalent hydraulic spring stiffness (EHSS) is the main factor affecting the zero-pole distribution. Furthermore, we optimize the structure to increase the EHSS to improve the response characteristics of the system. Finally, the co-simulation platform and single-leg experiment bench are introduced. The simulation and experimental results show that the response speed of the inner-loop control is significantly improved after optimization, and the robot with active compliance control strategies can significantly reduce the impact of the foot.
Rui Yang 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.9
With the development of network and big data technology, how to dig out the effective information from massive data is the problem that we are facing. Traditional data mining algorithms in the face of big data, it is powerless. With the ability of parallel computing, data is processed on several machines, so the efficiency of data processing will be greatly improved. In this paper, the author analyzes the parallel data mining algorithm application in the evaluation of college counselors' psychological guidance ability, and puts forward the strategies of improving the ability of college counselors' psychological guidance. Based on the statistical analysis, the result shows that there were no significant differences in gender, but in the context of communication, female were better than male. The male instructors are superior to female instructors in the understanding ability of the observation and diagnosis and the plan of action. Obviously, training is a very effective way to improve the ability of College Counselors' psychological counseling, and it should be promoted and applied.