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Informatics center for mouse genomics: the dissection of complex traits of the nervous system.
Rosen, Glenn D,La Porte, Nathan T,Diechtiareff, Boris,Pung, Christopher J,Nissanov, Jonathan,Gustafson, Carl,Bertrand, Louise,Gefen, Smadar,Fan, Yingli,Tretiak, Oleh J,Manly, Kenneth F,Park, Melburn R Humana Press, Inc 2003 Neuroinformatics Vol.1 No.4
<P>In recent years, there has been an explosion in the number of tools and techniques available to researchers interested in exploring the genetic basis of all aspects of central nervous system (CNS) development and function. Here, we exploit a powerful new reductionist approach to explore the genetic basis of the very significant structural and molecular differences between the brains of different strains of mice, called either complex trait or quantitative trait loci (QTL) analysis. Our specific focus has been to provide universal access over the web to tools for the genetic dissection of complex traits of the CNS--tools that allow researchers to map genes that modulate phenotypes at a variety of levels ranging from the molecular all the way to the anatomy of the entire brain. Our website, The Mouse Brain Library (MBL; http://mbl.org) is comprised of four interrelated components that are designed to support this goal: The Brain Library, iScope, Neurocartographer, and WebQTL. The centerpiece of the MBL is an image database of histologically prepared museum-quality slides representing nearly 2000 mice from over 120 strains--a library suitable for stereologic analysis of regional volume. The iScope provides fast access to the entire slide collection using streaming video technology, enabling neuroscientists to acquire high-magnification images of any CNS region for any of the mice in the MBL. Neurocartographer provides automatic segmentation of images from the MBL by warping precisely delineated boundaries from a 3D atlas of the mouse brain. Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes.</P>
Rosen Iliev 장전수학회 2022 Advanced Studies in Contemporary Mathematics Vol.32 No.2
The paper presents a Generalized net model (GN-model) of the decision-making process in building a collaborative information environment using a six-transitions aggregate net. When evaluating the parameters of the individual tokens, the possibility of using fuzzy and intuitionistic fuzzy values is envisaged.
Generalized net model of the decision making process in the crisis management
Rosen Iliev,Angel Genchev 장전수학회 2021 Advanced Studies in Contemporary Mathematics Vol.31 No.4
The paper presents a common Generalized Net model (GN-model) of the decision-making process in crisis management using a five-transitions aggregate net. By verifying the feasibility of the solution in the last transition, the fact is taken into account that all crisis management solutions generated cannot be successfully implemented. When evaluating the parameters of the individual tokens, the possibility of using fuzzy and intuitionistic fuzzy values is envisaged.
Lawrence Rosen 한국정보법학회 2006 정보법학 Vol.10 No.1
자유 소프트웨어 및 오픈소스 소프트웨어는 개방된 표준의 기초에 따라 결정된다. 그러나 이같은 용어들은 무엇을 의미하는가? 표준제정기관들이 자신들의 절차나 사양(스펙)이 개방된 것이라고 약속하지만, 이것은 스펙이 이용료 등 여러 장애를 받지 않고 오픈소스 소프트웨어나 사유 소프트웨어에서 자유로이 이행될 수 있다는 것을 의미하는가? 소프트웨어 커뮤니티는 이미 오픈소스를 정의하고 이를 수용하고 있다. 우리의 개방된 표준이라는 기초를 굳건히 해야 할 시간이 되었다. 이 논문은 누구든지 사유 소프트웨어나 오픈소스 소프트웨어에 있어서 개방된 표준을 자유로이 이행할 수 있어야 하고, 개방된 표준이 사용권자로 하여금 표준에 대한 특허청구범위 해석에 대하여 동일한 조건으로 부담할 것을 요구하는 합리적인 상호적 이용허락에 따라 제공되어야 하며, 개방된 표준이 누구에게든지 이용료를 지급하지 않는 조건에 따라 이용될 수 있어야 하며, 개방된 표준이 공동의, 균형잡힌, 총의에 바탕을 둔 승인절차에 따라 개발되어야 한다고 주장하였다. Free and open source software rests on a foundation of open standards. But what does that term really mean? When standards organizations promise that their processes and specifications are open, do they mean that the specification can be freely implemented in both open source and proprietary software without royalties or other encumbrances? The software community has already defined and embraced open source. It is time to firm up our open standards foundation. This Paper argues that Everyone should be free to implement open standards in both proprietary and open source software, that open standards should be made available under reasonable reciprocal licenses that require licensees to share under the same terms their own patent claims reading on the standard, that open standards should be available to everyone on royalty-free terms, and that open standards should be developed using a collaborative, balanced and consensus-based approval process.
New Insights into Calorie Restriction Induced Bone Loss
Clifford J. Rosen,Linyi Liu 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.2
Caloric restriction (CR) is now a popular lifestyle choice due to its ability in experimental animals to improve lifespan, reduce bodyweight, and lessen oxidative stress. However, more and more emerging evidence suggests this treatment requires careful consideration because of its detrimental effects on the skeletal system. Experimental and clinical studies show that CR can suppress bonegrowth and raise the risk of fracture, but the specific mechanisms are poorly understood. Reduced mechanical loading has long beenthought to be the primary cause of weight loss-induced bone loss from calorie restriction. Despite fat loss in peripheral depots withcalorie restriction, bone marrow adipose tissue (BMAT) increases, and this may play a significant role in this pathological process. Here, we update recent advances in our understanding of the effects of CR on the skeleton, the possible pathogenic role of BMAT inCR-induced bone loss, and some strategies to mitigate any potential side effects on the skeletal system.