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Roque Calvo,Emilio Gómez,Rosario Domingo 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
Flatness and planar straightness are fundamental form tolerances in engineering design and its materialization through manufacturing processes. Minimum zone tolerance is a preferred approach of flatness and straightness for widely accepted ISO and ANSI standards. In this paper, we propose a novel accurate method of minimum zone tolerance based on vectorial calculus of point coordinates. The non-linear minimax formulation of the original flatness or straightness problem is transformed into a set of linear problems. Next, the optimal solution of the envelop planes or lines is reached through vectorial calculus for both flatness and planar straightness. Then, the developed algorithms are compared to a selection of methods with published tests in recent and classic literature on the topic, reaching the best attained accuracies or outperforming them in the trials. Finally, we propose a new decomposition of the uncertainty contributions for analysis and the improvement of sampling strategy. We conclude remarking the practical contributions of the proposals.
Jason Roque,Shiaw-Hooi Ho,Khean-Lee Goh 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.1
Palliation of jaundice improves the general health of the patient and, therefore, surgical outcomes. Because of the complexity and location of strictures, especially proximally, drainage has been accompanied by increased morbidity due to sepsis. Another concern is the provocation of an inflammatory and fibrotic reaction around the area of stent placement. Preoperative biliary drainage with self-expanding metallic stent (SEMS) insertion can be achieved via a percutaneous method or through endoscopic retrograde cholangiopancreatography. A recently published multicenter randomized Dutch study has shown increased morbidity with preoperative biliary drainage. A Cochrane meta-analysis has also shown a significantly increased complication rate with preoperative drainage. However, few of these studies have used a SEMS, which allows better biliary drainage. No randomized controlled trials have compared preoperative deployment of SEMS versus conventional plastic stents. The outcomes of biliary drainage also depend on the location of the obstruction, namely the difficulty with proximal compared to distal strictures. Pathophysiologically, palliation of jaundice will benefit all patients awaiting surgery. However, preoperative drainage often results in increased morbidity because of procedure-related sepsis. The use of SEMS may change the outcome of preoperative biliary drainage dramatically.
Synthesis, characterization and thermodynamic study of carbon dioxide adsorption on akaganéite
R. Roque-Malherbe,F. Lugo,C. Rivera-Maldonado,R. Polanco-Estrella,O. Uwakweh 한국물리학회 2015 Current Applied Physics Vol.15 No.4
A mixture of akaganéite nanoparticles and sodium salts was synthesized and modified, first by washing, and then by Li exchange. The structural characterization of the produced materials was performed with: powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, thermogravimetric analysis, diffuse reflectance infrared Fourier transform spectrometry, Mössbauer spectroscopy and magnetization measurements. Additionally low pressure nitrogen and high pressure carbon dioxide adsorption experiments were performed. The sum of the characterization information made possible to conclude that the produced akaganéite phases crystallized in a structure exhibiting the symmetry of the I2/m space group, where the measured equivalent spherical diameter of the akaganéite crystallites yielded 9 nm, as well, the tested phases exhibited a standard behaviour under heating and displayed a superparamagnetic behaviour. Finally the high pressure carbon dioxide adsorption experiments demonstrated a pressure-responsive framework opening event due to a structural transformation of the adsorbent framework induced by the guest molecules. This fact opens new applications for akaganéite as a high pressure adsorbent.
Endoscopic Ablation Therapy for Biliopancreatic Malignancies
Jason Roque,Shiaw-Hooi Ho,Nageshwar Reddy,Khean-Lee Goh 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.1
Biliopancreatic malignancies such as cholangiocarcinoma (CCA) has notoriously been diagnosed late. As such most therapy have been palliative in nature. Cholangioscopy allows for an earlier diagnosis to be made. Brachytherapy with the insertion of catheter with iridium-132 seeds, percutaneously or through endoscopic retrograde cholangiopancreatography (ERCP) was the earliest ablative techniques used. It has been shown to have a beneficial effect only in prolonging survival. Photodynamic therapy (PDT) has also been used for several years. stenting with PDT versus stenting alone for unresectable CCA showed a marked survival benefit with the addition of PDT. However the most exciting endoscopic ablative modality appears to be intraductal radiofrequency ablation using the Habib catheter and device. Several case series have shown the effectiveness of this technique in ablating tumors. This technique is evolving and coupled with early diagnosis of CCA through cholangioscopy will allow for a curative therapy. The crux to the effective treatment of early cancerous lesions in the bile or pancreatic duct is the early diagnosis of such lesions. Effective endoscopic ablative therapy is now available with the advent of radiofrequency ablation probes that can be passed through the duodenoscope via ERCP.
Katharine Roque,임경동,송은섭,Ravi Gautam,이재희,김연경,조아랑,신소정,김창열,김형아,허용 계명대학교 자연과학연구소 2016 Quantitative Bio-Science Vol.35 No.2
Hazardous biochemical agents in indoor animal husbandry environments promote the occurrence of various illnesses among husbandry workers and industrial animals. The relationship between endotoxin levels in dust collected from Korean beef cattle farms and markers of bovine cellular immunity was investigated. Peripheral blood was obtained from 25 cattle from five cattle farms in Korea. Endotoxin levels present in total or respirable dust were determined by the Limulus Amebocyte Lysate Kinetic method. Cytokine production was evaluated following the stimulation of peripheral mononuclear cells with concanavalin A for 72 h in a 5% CO2 incubator. Production of both interleukin (IL)-4 and interferon (IFN)γ was significantly higher in the high endotoxin exposure group (100.9±70.6 EU/m3) compared with the low endotoxin exposure group (17.7±18.6 EU/m3), with a lower IFNγ/IL-4 ratio in animals from the high endotoxin farms, indicating immunity skewed toward a type-2 response. The proportion of γδ T lymphocyte, important bovine immune cells involved in protection against microbial infection, was lower in cattle from the high endotoxin farms than in those from the low endotoxin farms. The numbers of white blood cells, red blood cells, lymphocytes, eosinophils, and basophils were significantly downregulated in cattle from the high endotoxin farms. Overall, these results suggest a probable negative association between dust endotoxin levels and cell-mediated immunity in Korean beef cattle.