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Roberta Gomes Coelho,Neli Kika Honda,Maria do Carmo Vieira,Rosenei Louzada Brum,Fernando Roge´rio Pavan,Clarice Queico Fujimura Leite,Claudia Andre´a Lima Cardoso 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5
Bromelia balansae (Family Bromeliaceae) is a medicinal plant commonly used in the central region of Brazil as a cough syrup and also eaten roasted. The methanolic extract of ripe fruits was analyzed by chromatographic methods and spectrometrically. Four glycoside flavonols were isolated: kaempferol-3-O-α-l-rhamnopyranoside (1), kaempferol-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (2), quercetin-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (3), and kaempferol 3,7-di-O-α-l-rhamnopyranoside (4). The resazurin microtiter assay was used to measure the biological activity in vitro against Mycobacterium tuberculosis. The results showed a moderate activity of the methanolic extract with a minimal inhibitory concentration of 128μg/mL. Antioxidant activity was evaluated as free radical scavenging capacity and inhibition of peroxidation. Free radical scavenging capacity was assessed by measuring the scavenging activity of methanolic extract and methanolic fraction on 2,2-diphenyl-1-picrylhydrazyl radical. The methanolic extract showed low values of antioxidant activities, whereas the methanolic fraction exhibited free radical scavenging activity ranging from 20.2% to 91.1%, and the inhibition of peroxidation values ranging from 5.6% to 27.5%. This is the first chemical study reported in the literature about this species.
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review
Daiene Santos Buglio,Ledyane Taynara Marton,Lucas Fornari Laurindo,Elen Landgraf Guiguer,Adriano Cressoni Arau´jo,Roge´rio Leone Buchaim,Ricardo de Alvares Goulart,Cla´udio Jose´ Rubira,Sandra M. Barb 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.8
Advancing age is one of the risk factors for developing many diseases, including cancer, cardiovascular disorders, and neurodegenerative alterations, such as mild cognitive impairment (MCI), and Alzheimer's Disease (AD). Studies have indicated that supplementation with resveratrol (RSV) might improve cerebrovascular function and reduce the risk of developing dementia. Thus, the aim of this systematic review was to assess the effects of RSV on MCI and AD. MEDLINE-PubMed, Cochrane, and EMBASE were used to perform the search, and PRISMA guidelines were followed. Five studies met the eligible criteria; three with AD and two with MCI. In AD patients, the use of RSV reduces Aβ levels, improves brain volume, reduces the Mini-mental status score, and improves AD scores. In patients with MCI, this polyphenol prevents decline in Standard Volumes of Interest and increases the Resting-state Functional Connectivity score. RSV can activate the human silent information regulator 2/sirtuin 1 (Sirt-1) and can inhibit the cyclooxygenase-2 (COX-2), 5-lipoxygenase, and nuclear factor-κB, resulting in the reduction of the proinflammation pathways. It is also associated with the increase in the levels of interleukin (IL)-10 and reduction of interferon-γ and IL-17. Both anti-inflammatory and antioxidant effects can be related to preventing neurodegenerative diseases, doing maintenance, and enabling the recovery of these conditions directly related to inflammation and oxidative stress. We suggest that the use of RSV can bring beneficial effects to patients with MCI or AD.
Renata M. Martinez,Daniela T. Longhi-Balbinot,Ana C. Zarpelon,Larissa Staurengo-Ferrari,Marcela M. Baracat,Sandra R. Georgetti,Roge´rio C. Sassonia,Waldiceu A. Verri Jr.,Rubia Casagrande 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
We have recently developed betalain-richbeetroot (Beta vulgaris) dye (betalain) to be used in foodproducts. Betalain (30–300 mg/kg) intraperitoneal (i.p.)treatment diminished carrageenan (100 lg/paw)-inducedpaw edema and neutrophil migration to the paw skin tissue. Betalain (100 mg/kg) treatment by subcutaneous or peroral routes also inhibited the carrageenan-induced pawedema. Importantly, the post-treatment with betalain(100 mg/kg, i.p.) significantly inhibited carrageenan- andcomplete Freund’s adjuvant (10 ll/paw)-induced pawedema. Betalain (100 mg/kg) also reduced carrageenan(500 lg/cavity)-induced recruitment of total leukocytes,including mononuclear cells and neutrophils, as well asincreasing vascular permeability in the peritoneal cavity. Furthermore, betalain significantly reduced carrageenaninducedsuperoxide anion, tumor necrosis factor-alpha(TNF-a) and interleukin (IL)-1b levels in the peritonealfluid, as well as augmenting IL-10 levels. Therefore, thiscompound presents prominent anti-inflammatory effect oncarrageenan-induced paw edema and peritonitis by reducingthe production of superoxide anion and the cytokinesTNF-a and IL-1b, in addition to increasing IL-10 levels. These results suggest that betalain shows therapeuticpotential that could be utilized in the treatment of inflammation-associated diseases.
Mycotoxins’ evaluation in wheat flours used in Brazilian bakeries
Andressa Lanza,Rosselei Caie´l da Silva,Ingrid Duarte dos Santos,Ionara Regina Pizzutti,Karine Cence,Roge´rio Luis Cansian,Jamile Zeni,Eunice Valduga 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.3
The aim of this study was to evaluate themycotoxicological quality of wheat flours used by bakeriesfrom the North Region in Rio Grande do Sul state, Brazil,regarding the presence of mycotoxins. On collecting type-1refined wheat flour, a conglomerate sampling from 13 citiesand 3 bakeries per city (n = 39), selected from the definedregion was performed. The mycotoxins analysis was usingQuEChERS method and UPLC–MS/MS analysis. As aresult, 100% of samples presented contamination by DON,with concentrations ranging from 76.7 to 3630.2 lg kg-1and ZON was found in one sample (26.7 lg kg-1), whichrepresented 2.6% of the analyzed wheat flours. Othermycotoxins (AFB1, AFB2, AFG1, AFG2, DAS, HT-2toxin, OTA, FB1 and FB2) were not detected in the analyzedsamples.