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Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study
Kim, S.,Kim, N.,Presson, Angela P.,Metzger, Mark E.,Bonifacino, Aylin C.,Sehl, M.,Chow, Samson A.,Crooks, Gay M.,Dunbar, Cynthia E.,An, D.,Donahue, Robert E.,Chen, Irvin S.Y. Cell Press 2014 Cell stem cell Vol.14 No.4
In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in repopulation characteristics. However, it is unclear whether similar properties apply in primates. Here, we examined this issue through tracking of thousands of hematopoietic stem and progenitor cells (HSPCs) in rhesus macaques for up to 12 years. Approximately half of the clones analyzed contributed to long-term repopulation (over 3-10 years), arising in sequential groups and likely representing self-renewing HSCs. The remainder contributed primarily for the first year. The long-lived clones could be further subdivided into functional groups contributing primarily to myeloid, lymphoid, or both myeloid and lymphoid lineages. Over time, the 4%-10% of clones with robust dual lineage contribution predominated in repopulation. HSPCs expressing a CCR5 shRNA transgene behaved similarly to controls. Our study therefore documents HSPC behavior in a clinically relevant model over a long time frame and provides a substantial system-level data set that is a reference point for future work.
CEP-stable, sub-6 fs, 300-kHz OPCPA system with more than 15 W of average power.
Prinz, Stephan,Haefner, Matthias,Teisset, Catherine Yuriko,Bessing, Robert,Michel, Knut,Lee, Yeon,Geng, Xiao Tao,Kim, Seungchul,Kim, Dong Eon,Metzger, Thomas,Schultze, Marcel Optical Society of America 2015 Optics express Vol.23 No.2
<P>We report on a CEP-stable OPCPA system reaching multi-GW peak powers at 300 kHz repetition rate. It delivers 15 W of average power, over 50 ?J of compressed pulse energy and a pulse duration below 6 fs. By implementing an additional pump-seed-synchronization, the output parameters are stabilized over hours with power fluctuations of less than 1.5%.</P>