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Rituparna Maiti,Biswa Ranjan Mishra,Monalisa Jena,Archana Mishra,Santanu Nath 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.1
Objective: Serum melatonin, a biomarker of circadian rhythm, can upregulate Growth-associated protein 43 (GAP-43) which is involved in neural regeneration and plasticity. The present study was conducted to investigate the adequacy of the first-line antipsychotic drugs to improve sleep and circadian rhythm disruptions by assessing the effect of haloperidol and risperidone on serum melatonin and GAP-43 in schizophrenia. Methods: In this cohort study, 100 schizophrenic patients were recruited, and clinical evaluations were done using the Positive and Negative Syndrome Scale (PANSS) and the Pittsburgh sleep quality index (PSQI). The patients with predominantly positive symptoms taking haloperidol (Group I) and patients with predominantly negative symptoms taking risperidone (Group II) were admitted and serum melatonin, arylalkylamine N-acetyltransferase, GAP-43 and urinary melatonin were estimated. After 8 weeks, all clinical and biochemical parameters were repeated. Results: Serum melatonin (2:00 hours) was significantly decreased in both haloperidol (2.42; 95% confidence interval [95% CI]: 0.67−4.17; p = 0.008) and risperidone group (3.40; 95% CI: 0.54−6.25; p = 0.021). Urinary melatonin was significantly decreased in both haloperidol (p = 0.005) and risperidone group (p = 0.014). PSQI score was significantly increased in both haloperidol (p = 0.001) and risperidone group (p = 0.003). Serum GAP-43 was significantly decreased in both haloperidol and risperidone group (p < 0.001). PANSS decreased significantly in both the groups and there was a significant negative correlation between serum melatonin at 2:00 hours and PANSS (r = −0.5) at baseline. Conclusion: Monotherapy with haloperidol and risperidone can achieve symptomatic improvement but cannot improve sleep and circadian rhythm disturbances in schizophrenia.
Sociologies of India’s missing children
Rituparna Bhattacharyya 한국사회복지학회 2017 Asian Social Work and Policy Review Vol.11 No.1
The sociologies of India’s missing children merit spatial and contextual examination. The sociological space into which a child goes missing is highly under-researched in India. Building on overarching narratives emerging from secondary sources and existing literature on Indian children’s vulnerability and precarity, the article aims to evaluate the landscape of missing children. The analyses suggest that a number of interconnected sociologies contribute to the phenomenon of missing children – these children are mainly from the poorer backgrounds, who are kidnapped, trafficked, or lured largely for social, commercial, and sexual exploitation. This research was conducted to gain a deeper understanding into the problem of missing children in order to address the gaps that require intervention.
Street Violence against Women in India: Mapping Prevention Strategies
Rituparna Bhattacharyya 한국사회복지학회 2016 Asian Social Work and Policy Review Vol.10 No.3
Street violence against women (SVAW) in India is highly under researched. This article aims to understand the contextual factors responsible for the occurrence of SVAW in five cities of North-east India: Agartala, Kohima, Imphal, Shillong, and Guwahati. The aftermath of an horrific gang rape and the subsequent death of a 23-year-old woman in a moving bus in New Delhi in December 2012 served as a wake-up call for the Government of India (GOI), augmenting the need to understand the issues of SVAW. On December 23, 2012, the GOI constituted the Justice Verma Committee (JVC) who prepared a 630-page report, submitted to the Prime Minister of India, which identified “failure of governance” as the central cause of SVAW. Based on some of the recommendations of the JVC report, the GOI passed the Criminal Law Amendment Bill, 2013. Drawing upon semi-structured interviews from qualitative research in combination with a questionnaire survey, this research aims to understand the factors that allow SVAW to persist. Using recommendations of the JVC report and the Justice Usha Mehra Commission, the Criminal Law Amendment Act, 2013, as well as research findings, this article is an attempt to inform prevention strategies aimed at escalating the safety of women in public spaces of the study region.
Sensitivity Analysis of Atmospheric Dispersion Model-RIMPUFF Using the Hartley-like Measure
Rituparna Chutia,Supahi Mahanta,D. Datta 한국전산응용수학회 2013 Journal of applied mathematics & informatics Vol.31 No.1
In this article, sensitivity analysis of atmospheric dispersion model RIMPUFF is considered. Uncertain parameters are taken to be triangular fuzzy numbers,and sensitivity analysis is carried out by using the Hartley-like measure. Codes for evaluating membership function using the Vertex method and the Hartley-like measure are prepared using Matlab.
Rituparna Maiti,Biswa Ranjan Mishra,Jaseem Jowhar,Debadatta Mohapatra,Sansita Parida,Debasis Bisoi 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.2
Objective: In bipolar disorder, serum brain-derived neurotrophic factor (BDNF) level decreases leading to dysfunctions of critical neurotrophic, cellular plasticity and neuroprotective processes. The present study was conducted to evaluate the change in serum BDNF level with oxcarbazepine monotherapy in bipolar mania. Methods: The present study is a prospective, interventional, open label clinical study conducted on 25 patients of bipolar mania and 25 healthy controls. Detailed history, clinical evaluation including Young Mania Rating Scale (YMRS) scoring and serum BDNF were assessed at baseline for all 50 subjects. The bipolar patients were prescribed tablet oxcarbazepine and followed up after 4 weeks for clinical evaluation and re-estimation of serum BDNF and YMRS scoring. Results: The serum BDNF level in bipolar manic patients were compared with healthy controls at baseline and results revealed that there is a significant reduction (p=0.002) in serum BDNF level in bipolar patients. At follow-up after 4 weeks, the mean change in serum BDNF in bipolar group who were on oxcarbazepine monotherapy was found statistically significant (p=0.02) in comparison to healthy controls. In bipolar group, the YMRS score and serum BDNF at baseline have an inverse relation(r=−0.59) whereas change of the YMRS score had a positive correlation (r=0.67) with the change of serum BDNF over 4 weeks. Conclusion: In bipolar mania serum BDNF level is low and it is found to be increased with short term monotherapy with oxcarbazepine.
SENSITIVITY ANALYSIS OF ATMOSPHERIC DISPERSION MODEL-RIMPUFF USING THE HARTLEY-LIKE MEASURE
Chutia, Rituparna,Mahanta, Supahi,Datta, D. The Korean Society for Computational and Applied M 2013 Journal of applied mathematics & informatics Vol.31 No.1
In this article, sensitivity analysis of atmospheric dispersion model RIMPUFF is considered. Uncertain parameters are taken to be triangular fuzzy numbers, and sensitivity analysis is carried out by using the Hartley-like measure. Codes for evaluating membership function using the Vertex method and the Hartley-like measure are prepared using Matlab.
On the Fine Spectrum of the Lower Triangular Matrix B(r, s) over the Hahn Sequence Space
Das, Rituparna Department of Mathematics 2017 Kyungpook mathematical journal Vol.57 No.3
In this article we have determined the spectrum and fine spectrum of the lower triangular matrix B(r, s) on the Hahn sequence space h. We have also determined the approximate point spectrum, the defect spectrum and the compression spectrum of the operator B(r, s) on the sequence space h.
Archana Mishra,Rituparna Maiti,Biswa Ranjan Mishra,Monalisa Jena,Anand Srinivasan 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.1
Background and Purpose The role of low-frequency repetitive transcranial stimulation (rTMS) in drug-resistant epilepsy (DRE) has been conflicting and inconclusive in previous clinical trials. This meta-analysis evaluated the efficacy of rTMS on seizure frequency and epileptiform discharges in DRE. Methods A standard meta-analysis protocol was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO: CRD42018088544). After performing a comprehensive literature search using specific keywords in MEDLINE, the Cochrane database, and the International Clinical Trial Registry Platform (ICTRP), reviewers assessed the eligibility and extracted data from seven relevant clinical trials. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed in the selection, analysis, and reporting of findings. A random-effects model was used to estimate the effect size as the mean difference in seizure frequency and interictal epileptiform discharges between the groups. Quality assessment was performed using a risk-of-bias assessment tool, and a meta- regression was used to identify the variables that probably influenced the effect size. Results The random-effects model analysis revealed a pooled effect size of -5.96 (95% CI= -8.98 to -2.94), significantly favoring rTMS stimulation (p=0.0001) over the control group with regard to seizure frequency. The overall effect size for interictal epileptiform discharges also significantly favored rTMS stimulation (p<0.0001), with an overall effect size of -9.36 (95% CI=-13.24 to -5.47). In the meta-regression, the seizure frequency worsened by 2.00±0.98 (mean±SD, p=0.042) for each week-long lengthening of the posttreatment follow-up period, suggesting that rTMS exerts only a short-term effect. Conclusions This meta-analysis shows that rTMS exerts a significant beneficial effect on DRE by reducing both the seizure frequency and interictal epileptiform discharges. However, the meta-regression revealed only an ephemeral effect of rTMS.