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Suzuki, Nobutaka,Takimoto, Yuko,Suzuki, Riho,Arai, Takanari,Uebaba, Kazuo,Nakai, Masuo,Strong, Jeffry Michael,Tokuda, Harukuni Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy. Twenty patients were studied in total. They received only hormone therapy in the first 4 weeks followed by hormone therapy and LEM during the next 8 weeks. Laboratory tests, QOL score and peripheral blood cytokine production levels were evaluated during the study period. No changes in QOL or cytokines were noted after the first 4 weeks. In contrast, during the following combined therapy period, improvements were noted in QOL and cytokine levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant use of LEM with postoperative adjuvant hormone therapy improves the QOL and immune function of patients.
Antioxidant and anti-adipogenic activities of acorn shells
Un-Young Youn,손명수,김교남,Riho Katagiri,Kaori Harata,Masayuki Kamegai,Yasuyuki Ishida,이승철 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4
Antioxidant and anti-adipogenic activities of water extract (WE) and methanol extract (ME)of acorn shells (AS), from Quercus acutissima Carruth. grown in Korea, were investigated. At aconcentration of 50 μg/mL, the WE had a scavenging activity of 53.84% for the DPPH and 76.09% forthe ABTS radical, while the ME had corresponding scavenging activities of 29.09 and 48.43%. Totalphenolic contents of WE and ME were 375.96 and 288.01 mg gallic acid equivalents/g of extracts,respectively. Both extracts significantly inhibited 3T3-L1 adipogenesis in a dose-dependent manner,and concomitantly decreased the size and number of intracellular lipid droplets. Furthermore, the antiadipogenicactivities of WE and ME are largely limited in the pre- and early stages of adipogenesis. Theresults suggest that AS may be a promising source of antioxidants and anti-obesity compounds.
Antioxidant effects of citrus pomace extracts processed by super-heated steam
Wang, Lei,Jo, Min-Ji,Katagiri, Riho,Harata, Kaori,Ohta, Moemi,Ogawa, Ayane,Kamegai, Masayuki,Ishida, Yasuyuki,Tanoue, Shota,Kimura, Sojiro,Lee, Seung-Cheol,Jeon, You-Jin Elsevier 2018 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.90 No.-
<P>This study was performed to investigate the enhanced antioxidant effects of citrus pomace (CP) extracts processed by super-heated steam (SHS). CP extracts were obtained using a closed SHS system at three different temperatures (100, 200, and 300 degrees C) with an extraction time of 10 or 20 min. These extracts were evaluated for their antioxidant activities by measuring their DPPH, alkyl, and hydroxyl radical scavenging activity using Electron Spin Resonance (ESR) spectroscopy and for their protective effects against H2O2-induced oxidative stress in Vero cells. All extracts exhibited strong radical scavenging activities and protective effects against H2O2-induced Vero cell damage. Especially, the SHS-CP extracts obtained at 300 degrees C with extraction times of both 10 min and 20 min exhibited antioxidant activities that were significantly higher than those of ethanol extracts and SHS-CP extracts obtained at other temperatures. The total phenolic and flavonoid contents of SHS-CP extracts and their antioxidant activities were found to be increased with elevated processing temperatures. Moreover, gas chromatography/mass spectrometry (GC/MS) in the presence of a methylating reagent revealed that some characteristic polyphenols and polyhydroxycyclohexanes were present in the SHS-CP extracts. Thus, this study demonstrated that SHS extraction is an efficient and environmentally friendly method for extracting antioxidants from CP.</P>
Antioxidant and anti-adipogenic activities of acorn shells
Youn, Un-Young,Shon, Myung-Soo,Kim, Gyo-Nam,Katagiri, Riho,Harata, Kaori,Kamegai, Masayuki,Ishida, Yasuyuki,Lee, Seung-Cheol 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4
Antioxidant and anti-adipogenic activities of water extract (WE) and methanol extract (ME) of acorn shells (AS), from Quercus acutissima Carruth. grown in Korea, were investigated. At a concentration of $50{\mu}g/mL$, the WE had a scavenging activity of 53.84% for the DPPH and 76.09% for the ABTS radical, while the ME had corresponding scavenging activities of 29.09 and 48.43%. Total phenolic contents of WE and ME were 375.96 and 288.01 mg gallic acid equivalents/g of extracts, respectively. Both extracts significantly inhibited 3T3-L1 adipogenesis in a dose-dependent manner, and concomitantly decreased the size and number of intracellular lipid droplets. Furthermore, the antiadipogenic activities of WE and ME are largely limited in the pre- and early stages of adipogenesis. The results suggest that AS may be a promising source of antioxidants and anti-obesity compounds.
Yohei Okada,Chiharu Shibamoto,Yukari Osumi,Chihiro Asano,Riho Takeuchi,Sachio Nabeshima,Shu Morioka,Koji Shomoto 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
We present a 47-year-old right-handed woman with a 15-year history of writer's cramp provided with six sessions of cathodal transcranial direct current stimulation (tDCS) combined with her observation of the writing actions performed by a healthy subject plus electromyographic (EMG) biofeedback training to decrease EMG activities of her right forehand muscles during writing for 30 min, 1 or 2/week for 4 weeks. She showed the improvement of dystonic posture and writing speed while writing after the intervention. The writing movement and writing speed scores on a writer's cramp rating scale and writing time decreased. Our findings demonstrated that cathodal tDCS combined with action observation and EMG biofeedback training might improve dystonic writing movements in a writer's cramp patient.