Physiolosical Effects of Physical Exercise in Rats

Rhew, Tae Hyong,Chun, Jang Soo 부산대학교 1986 자연과학논문집 Vol.42 No.-

Plasma 및 중요 organ들에 있어서의 각 종류의 지질과 단백질 대사에 대한 근육운동의 영향에 대해서 고찰하였다. 흰쥐를 25℃의 수조에서 35분간 수영시켜서 10주 후에 plasma와 중요 조직들을 채취하였다. 정량분석한 결과, test group을 reference group에 비교할 때에 단백질에는 차이가 없었으나 lipid profile (total lipid, triglyceride, and free fatty acid)의 양은 주로 plasma와 근육조직, 간, 지방조직에서 현저히 줄어들었다. cholesterol, esterified cholesterol과 total cholesterol은 모든 조직에서 운동에 의하여 감소되었고 이와 반대로 오직 phospholipid 만은 근육과 신장을 제외한 모든 조직에서 운동에 의하여 증가하였다. 이러한 각 조직에서의 lipids의 감소는 근육운동시에 지질이 β-산화를 통하여 에너지원천으로 사용되고 있음을 시사하는 것이다. The effect of physical exercise on the contents of various lipid classes and protein were examined in female sprague-Dawley rats fed nutritionaly adequate solid diets for a duration of 10 weeks. The exercising group animals were forced to swim at a water bath at 25℃ for 35 minute daily. Physical activities produced significant reduction in the levels of TG and FFA in plasma and various organs. Physical esercise significntly reduced the levels of chloesterol esters, and total chloesterol in plasma and the orgasn. However, phospholipid values were elevated in plasma and all the organs except skeletal muscle and heart in exercise group animals. Physical execise did not affect protein values in the ortans but significantly reduced those in plasma. Thus, it is concluded that in rats, physical exercise significantly lowered the lipid contents especially TG, FFA, and cholesterols in plasma and various organs due to oxidation of fats to meet energy demand in muscle activity. Evidently, moderate physical exercise is valuable for health, especially, with respect to cholisterol significance.

Prioritization of diseases for the development of a pharmaceutical care service model in South Korea using the analytic hierarchy process

Rhew, Kiyon,Han, Nayoung,Cho, Keun-Tae,Yoon, Jeong-Hyun,Oh, Jung Mi Dustri-Verlag Dr. Karl Feistle 2017 International Journal of Clinical Pharmacology and Vol.55 No.11

Thermal Conductivity of Liquids : Water & Methanol

Rhew, Jong-Ha 영남이공대학 1980 論文集 Vol.9 No.-

극성 液體의 熱傳達量은 分子間 水素結合 또는 Van der Waals 結合等에 依해 만들어지는 Cluster의 크기에 의해 결정되고 液體의 熱傳達은 Cluster 間의 傳熱과 Cluster 內 분자 진동에 의한 傳熱로 구분되고, Cluster間에는 分子이동이 일어나 열이동이 일어나고 傳熱速度는 진동에 의한 경우보다 아주 느려 열전달의 율속단계로 해석될 수 있고 다음의 방정식으로 표시될 수 있다 λ=-A(1/V)(dq/dT)exp(-ΔE/RT)(1/d) 여기서 λ,V,ΔE,q 等은 각각 열전도로, Cluster의 體積, 두 인접한 Cluster間 포텔에너지의 차, Cluster內 分子數이고 A는 상수이다.

An Economic Impact Analysis of the 2014 Farm Bill on the U.S. Crop Sector

( Rhew Chan Hee ) 한국농촌경제연구원 2015 농촌경제 Vol.38 No.1

This study establishes a U.S. crop model containing 14 commodities to analyze economic impacts of changes in the 2014 Farm Bill. The forecasting results under the alternative scenario are in line with theoretical expectations. The 2014 Farm Bill is forecasted to decrease expected net returns (ENRs) for producers. The expected changes are in favor of consumers at the cost of producer surplus. Without substantially affecting producers’ planting decision, the 2014 Farm Bill is forecasted to contribute to the Federal budget deficit reduction.

Effects of Myo-inositol and Riboflavin on Ethanol-Induced Fatty Liver and Hyperlipidemia in Rats

Rhew, Tae Hyong,Chun, Jang Soo 부산대학교 1987 자연과학논문집 Vol.44 No.-

sz12/ Ethanol이 지방대사에 미치는 영향중에서 가장 특징적인 것이 과유지방혈증과 지방간에서부터 간경변에 이르는 간의 증상들인바, 본 실험에서는 diet 총 열량의 36%에 해당되는 ethanol을 실험용 흰쥐에 45일간 투여해서 ethanol유발성 지방간과 과유지방혈증을 일으키고 myo-inositol과 riboflavin의 처리에 따른 그 치료효과를 고찰하였다. Ethanol diet에 2.5mg/100g body wt.의 myo-inositol을 처리한 흰쥐에서는 간과 plasma에서 모든 종류의 지질들이 현저히 감소하였고, riboflavin(6.6mg/200g body wt.)을 처리한 쥐에서는 단지 간에서 Total lipid, 중성지질, 인지질 그리고 콜레스테롤의 양만이 현저히 감소되었다. The lipid-lowering effect of Myo-inositol and Riboflavin was examined in male Sprague-Dawley rats fed ethanol as 36% of the total calories for a duration of 45day, Ethanol produced typical hepatic steatiosis and hyperlipidemia characterized by significantly elevated levels of total lipid, triglycerides, phospholipid, and free fatty acids. Supplementation of ethanol diet with riboflabin(6.6mg/100g body weight) significantly lowered ethanol-induced increases of the various lipid classes such as total lipid, triglycerides, anf total cholesterol in liver, but reduction in plasma lipid classes was minimal. The effect of Myo-inositol appeared to be superior to that of riboflabin. Myo-inositol significantly reduced ethanol-induced elevation of all classes of lipids in livers and plasma.

Induction of fibronectin gene expression by inhibitors of protein phosphatase yype 2B in normal and transformed fibroblasts

Rhew, Jung-Hwa,Shin, Young-Ah,Lee, Byung-Heon,Park, Rang-Woon,Kim, In-San 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Two intracellular signal pathways mediated by CAMP and protein kinase C (PKC) were involved in the regulation of FN gene expression (Lee et al., Exp. Mol. Med. 30: 240, 1998). In this study, a possible involvement of protein phosphatase-dependent pathways in the regulation of FN gene expression was investigated by using protein phosphatase type 2B (PP2B) inhibitors, cyclosporin A and ascomycin. Both cyclosporin A and ascomycin increased the levels of FH mRNA in Wl-38 human lung fibroblasts and the SV40-trans formed Wl-38 cells but not in MC3T3-E1 osteoblasts. The expression of FN appears to increase from six hours up to 48 hours after treatment suggesting that it is not an immediate effect. In addition, this effect required a new protein synthesis. Neither cyclosporin A nor ascomycin affects the phorbol myristate acetate (PMA)-induced stimulation of FN gene expression and the same result occurred in vice versa suggesting the mechanism of PMA and cyclosporin A/ascomycin in the regulation of FN gene expression may share a common downstream pathway. Taken together, thins study suggests that PP2B is involved in the regulation of FN gene expression in normal and transformed fibroblasts but not in osteoblasts.

Progress and recent trends in photodynamic therapy with nanoparticles

Rhew Kiyon,Chae Yoon-Jee,Chang Ji-Eun 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.5

Background Photodynamic therapy (PDT) is an emerging treatment option for various therapeutic areas owing to its outstanding advantages compared with conventional therapies. PDT consists of three main components; a photosensitizer, a proper wavelength of light and oxygen. This alternative treatment is based on the selective accumulation of photosensitizers which generate reactive oxygen species to induce cell apoptosis and necrosis under the light irradiation. PDT provides less invasive way with high therapeutic efficacy and reduced side effects. When PDT is combined with nanoplatform, drug loading efficacy, tissue targeting efficiency and accumulation rate were enhanced leading to increase the therapeutic effect of PDT. Area covered In this review, we described progress and recent trends in nanoplatform-based PDT in various cancers and infectious diseases. We have selected lung cancer, liver cancer, and breast cancer for representative cancer types furthermore, bacteria-infected wound and acne vulgaris for typical infectious diseases. The above therapeutic areas were chosen since the researches on PDT with nanoparticles are actively ongoing with these indications. PDT as well as PDT with chemotherapy, and PDT with immunotherapy strategies were covered in this review. Expert opinion Nanotechnology combined with PDT greatly improved the therapeutic efficacy compared with PDT alone. In addition, novel combination strategies effectively enhanced the therapeutic outcomes with reduced side effects. However, more safety data will be needed to lead these innovative strategies to the clinical trials.

Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed?

Rhew, Shi Hyun,Ahn, Youngkeun,Kim, Min Chul,Jang, Su Young,Cho, Kyung Hoon,Hwang, Seung Hwan,Lee, Min Goo,Ko, Jum Suk,Park, Keun Ho,Sim, Doo Sun,Yoon, Nam Sik,Yoon, Hyun Ju,Kim, Kye Hun,Hong, Young Jo Chonnam National University Medical School 2012 CMJ Vol.48 No.1

<P>The present study aimed to investigate the clinical characteristics and 1-year outcomes of acute myocardial infarction (AMI) patients without significant stenosis on a coronary angiogram comparison with the clinical characteristics and outcomes of patients with significant coronary artery stenosis. A total of 1,220 patients with AMI were retrospectively classified into Group I (≥50% diameter stenosis, n=1,120) and Group II (<50%, n=100). Group II was further divided into two subgroups according to the underlying etiology: cryptogenic (Group II-a, n=54) and those with possible causative factors (Group II-b, n=46). Patients in Group II were younger, were more likely to be women, and were less likely to smoke and to have diabetes mellitus than were patients in Group I. The levels of cardiac enzymes, LDL-cholesterol levels, and the apo-B/A1 ratio were lower in Group II. However, 1-month and 12-month rates of major adverse cardiac events (MACE) were not significantly different between the two groups. The Group II-b subgroup comprised 29 patients with vasospasm, 11 with myocardial bridge, and 6 with spontaneous thrombolysis. Left ventricular ejection fraction and creatinine clearance were lower and levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) were higher in Group II-a than in Group II-b. However, outcomes including MACE and mortality at 12 months were not significantly different between the two subgroups. The 1-year outcomes of patients in Group II were similar to those of patients in Group I. The clinical outcomes in Group II-a were also similar to those of Group II-b, although the former group showed higher levels of NT-proBNP and hs-CRP.</P>

Monpe Workpants and Their Memetic Derivations

Rhew, Soohyeon,Ro, Juhyun,Yi, Jaeyoon The Korean Society of Costume 2017 International journal of costume and fashion Vol.17 No.1

Monpe, Korean women's wartime attire during the Japanese colonization period, has survived for 70 years as typical baggy workpants for rural women and emerged as retro-fashion. This paper applied a theory of "meme" to explain the monpe fashion trend in Korea. Based on literature review, empirical analyses were conducted by analyzing market and media including newspaper articles and blogs. We found that the monpe meme has evolved over time through variation, penetration, and diffusion. In terms of variation, the impression of monpe transitioned from a negative image to a positive one as a result of changes in design, functionality, and popular image. In terms of penetration, the monpe meme has spread into popular culture, again through mass media, with images of active, sexy, and attractive monpe-wearers on television and at popular occasions. Finally, the monpe meme has diffused throughout a broad range of consumers of various ages and both genders as an item of clothing for various occasions through diversified distribution channels. In this way, the development of monpe as fashionable clothing in Korea during the 2000s is itself a meme reflecting its evolution from a disgraceful colonial legacy to an item of contemporary fashion.

Aster yomena has anti-arthritic activity against septic arthritis induced by Candida albicans: its terpenoid constituent is the most effective and has synergy with indomethacin

Rhew Zheong-Imm,Lee Jong Hyun,Han Yongmoon 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2

In recent, various pharmacological activities of Aster yomena have been determined, but its anti-arthritic activity remains unknown until now. The aim of the present study was to investigate whether A. yomena has anti-arthritic activity against septic arthritis caused by Candida albicans, a major etiological agent causing septic arthritis. In experiments, three types of A. yomena extracts such as 70% ethanol extract (EEAY) and its n-buthanol fraction (BuF) and ethyl acetate fraction (EAF) were tested. The color tests and the GC–MS analysis revealed that BuF and EAF contained terpenoid and polyphenolic, respectively. Results from the anti-inflammatory tests showed that BuF-activity at 50 μg/ml was closely equivalent to EEAYor EAF-activity at 500 μg/ml, indicating that BuF was 10 times more potent than EAF and EEAY. In the mouse model of the arthritis, the footpad swelling of BuF (100 μg/mouse/time)-, and EEAY(1000 μg/mouse/time)-, and indomethacin (IMC; 30 μg/mouse/time)-treated mice groups decreased at a similar rate until the end of the observation. At Day 9, the highest peak of arthritic induction, there were app. 15.4%, 27.8%, and 48.2%—reductions of footpad swelling, corresponding to IMC-, BuF-, or EEAY-treatment, respectively. In terms of dosage comparison, the BuF effectiveness was assessed to be 10 folds more efficient than EEAY effectiveness. When compared to IMC potency, the BuF potency was almost twice more effective than the IMC. EAF’s anti-arthritic activity was alternatively determined because of its killing of test mice. The determination was done if EAF contains chlorogenic acid (CRA), which is known to have such anti-arthritic activity (Lee et al. in Int Immunopharmacol 8:1681–1685, 2008). The HPLC analysis revealed EAF contained CRA, a polyphenolic. This indicates CRA in EAF could be involved in the activity. BuF, the most effective extract, had synergy with IMC, a clinically available anti-inflammatory agent. The BuF synergism was exhibited at 12.5 time lower dose of EEAY in a similar pattern as EEAY was. In conclusion, for the first time, we provide insights into the potential of A. yomena against the septic arthritis. The terpenoid constituent is the most effective for the anti-arthritic activity and for synergy with IMC.