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- 저자 : Reza, A. M. (검색결과 2,837 건)
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Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Ali Reza Fallahzadeh,Zohreh Rezaei,Hamid Reza Rahimi,Mehrazd Jafari Barmak,Hossein Sadeghi,Sadrollah Mehrabi,Seyed Mohammadreza Rabani,Iraj Ragerdi Kashani,Vahid Barati,Reza Mahmoudi 한국독성학회 2017 Toxicological Research Vol.33 No.3
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDP. Therefore, this study investigated the potentially protective effects of PTX on CDDP-induced testicular toxicity in adult male rats. For this purpose, 42 male rats were randomly divided into 7 groups. The rats were orally pretreated with PTX at the 3 doses of 75, 150, and 300 mg/kg once a day for 14 successive days. On the 14<SUP>th</SUP> day of the study, they were intraperitoneally (IP) administered with a single dose of CDDP (7 mg/kg). Finally, the sperm/testis parameters, serum levels of reproductive hormones, including testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) as the pivotal endocrine factors controlling testicular functions, and histopathological changes of testis tissue were examined. Pretreatment with the two doses of 75 and 150 mg/kg PTX indicated significant increases in the sperm count and motility induced by CDDP administration. The right and significantly left testis weights were decreased following the treatment with 300 mg/kg of PTX plus CDDP. However, 75 mg/kg of PTX plus CDDP showed the best near-to-normal histopathological features. The results demonstrated that PTX alone enhanced some parameters, such as the sperm count, while reducing other parameters, including sperm fast motility and germ layer thickness. Furthermore, despite testosterone or LH levels, the mean serum FSH level was significantly augmented by the doses of 75 and 150 mg/kg. It was concluded that PTX administration cannot reduce CDDP-induced testicular toxicity even at high doses (e.g., 300 mg/kg), while it seemed to partially intensify CDDP toxicity effects at a dose of 75 mg/kg. Thus, further research is required in this regard.
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Hamid Reza Rouhi Ghorabaie,Reza Fotouhi Ghazvini,Behrouz Golein,Ali Reza Nabipour 한국원예학회 2010 Horticulture, Environment, and Biotechnology Vol.51 No.4
Understanding phylogenetic relationships and genetic diversity in Citrus are important in clarifying genetic relationships, characterizing germplasm and the registration of new cultivars. There are some Citrus accessions in Iranian citrus collections which have been classified merely based on their morphological traits. Molecular markers would help to infer their relations with known cultivars. In this study 30 Citrus accessions and eight known cultivars from Kotra collection were investigated using 11 pairs of SSR markers, which in total produced 63 alleles with an average of 5.72 alleles per locus. The lowest number of alleles was observed in cAGG9 locus with only 2 alleles and the highest number of alleles was observed in TAA41 locus with 10 alleles. All loci had pretty high PIC with an average of 0.571. The highest PIC was related to TAA41 locus with 0.745. A similarity dendrogram was constructed using Complete Linkage clustering method which put the 38 samples into 5 major groups.
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RNAi and miRNA in Viral Infections and Cancers
Mollaie, Hamid Reza,Monavari, Seyed Hamid Reza,Arabzadeh, Seyed Ali Mohammad,Shamsi-Shahrabadi, Mahmoud,Fazlalipour, Mehdi,Afshar, Reza Malekpour Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Since the first report of RNA interference (RNAi) less than a decade ago, this type of molecular intervention has been introduced to repress gene expression in vitro and also for in vivo studies in mammals. Understanding the mechanisms of action of synthetic small interfering RNAs (siRNAs) underlies use as therapeutic agents in the areas of cancer and viral infection. Recent studies have also promoted different theories about cell-specific targeting of siRNAs. Design and delivery strategies for successful treatment of human diseases are becomingmore established and relationships between miRNA and RNAi pathways have been revealed as virus-host cell interactions. Although both are well conserved in plants, invertebrates and mammals, there is also variabilityand a more complete understanding of differences will be needed for optimal application. RNA interference (RNAi) is rapid, cheap and selective in complex biological systems and has created new insight sin fields of cancer research, genetic disorders, virology and drug design. Our knowledge about the role of miRNAs and siRNAs pathways in virus-host cell interactions in virus infected cells is incomplete. There are different viral diseases but few antiviral drugs are available. For example, acyclovir for herpes viruses, alpha-interferon for hepatitis C and B viruses and anti-retroviral for HIV are accessible. Also cancer is obviously an important target for siRNA-based therapies, but the main problem in cancer therapy is targeting metastatic cells which spread from the original tumor. There are also other possible reservations and problems that might delay or even hinder siRNA-based therapies for the treatment of certain conditions; however, this remains the most promising approach for a wide range of diseases. Clearly, more studies must be done to allow efficient delivery and better understanding of unwanted side effects of siRNA-based therapies. In this review miRNA and RNAi biology, experimental design, anti-viral and anti-cancer effects are discussed.
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Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
Fallahzadeh, Ali Reza,Rezaei, Zohreh,Rahimi, Hamid Reza,Barmak, Mehrazd Jafari,Sadeghi, Hossein,Mehrabi, Sadrollah,Rabani, Seyed Mohammadreza,Kashani, Iraj Ragerdi,Barati, Vahid,Mahmoudi, Reza Korean Society of ToxicologyKorea Environmental Mu 2017 Toxicological Research Vol.33 No.3
Chemotherapy is associated with male infertility. Cisplatin (cis-diamminedichloro-platinum (II) (CDDP) as a chemotherapy medication used to treat a number of cancers has been reported to most likely induce testicular toxicity. Administration of antioxidants, such as pentoxifylline (PTX) may reduce some Adverse Drug Reactions (ADRs) of CDDP. Therefore, this study investigated the potentially protective effects of PTX on CDDP-induced testicular toxicity in adult male rats. For this purpose, 42 male rats were randomly divided into 7 groups. The rats were orally pretreated with PTX at the 3 doses of 75, 150, and 300 mg/kg once a day for 14 successive days. On the $14^{th}$ day of the study, they were intraperitoneally (IP) administered with a single dose of CDDP (7 mg/kg). Finally, the sperm/testis parameters, serum levels of reproductive hormones, including testosterone, Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) as the pivotal endocrine factors controlling testicular functions, and histopathological changes of testis tissue were examined. Pretreatment with the two doses of 75 and 150 mg/kg PTX indicated significant increases in the sperm count and motility induced by CDDP administration. The right and significantly left testis weights were decreased following the treatment with 300 mg/kg of PTX plus CDDP. However, 75 mg/kg of PTX plus CDDP showed the best near-to-normal histopathological features. The results demonstrated that PTX alone enhanced some parameters, such as the sperm count, while reducing other parameters, including sperm fast motility and germ layer thickness. Furthermore, despite testosterone or LH levels, the mean serum FSH level was significantly augmented by the doses of 75 and 150 mg/kg. It was concluded that PTX administration cannot reduce CDDP-induced testicular toxicity even at high doses (e.g., 300 mg/kg), while it seemed to partially intensify CDDP toxicity effects at a dose of 75 mg/kg. Thus, further research is required in this regard.
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Fateh, Abolfazl,Aghasadeghi, Mohammad Reza,Keyvani, Hossein,Mollaie, Hamid Reza,Yari, Shamsi,Tasbiti, Ali Reza Hadizade,Ghazanfari, Morteza,Monavari, Seyed Hamid Reza Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: A recent genome-wide association study (GWAS) on patients with chronic hepatitis C (CHC) treated with peginterferon and ribavirin (pegIFN-${\alpha}$/RBV) identified a single nucleotide polymorphism (SNP) on chromosome 19 (rs12979860) which was strongly associated with a sustained virological response (SVR). The aim of this study was twofold: to study the relationship between IL28B rs12979860 and sustained virological response (SVR) to pegIFN-${\alpha}$/RVB therapy among CHC patients and to detect the rs12979860 polymorphism by high resolution melting curve (HRM) assay as a simple, fast, sensitive, and inexpensive method. Materials and Methods: The study examined outcomes in 100 patients with chronic hepatitis C in 2 provinces of Iran from December 2011 to June 2013. Two methods were applied to detect IL28B polymorphisms: PCR-sequencing as a gold standard method and HRM as a simple, fast, sensitive, and inexpensive method. Results: The frequencies of IL28B rs12979860 CC, CT, and TT alleles in chronic hepatitis C genotype 1a patients were 10% (10/100), 35% (35/100), and 6% (6/100) and in genotype 3a were 13% (13/100), 31% (31/100), and 5% (5/100), respectively. In genotype 3a infected patients, rs12979860 (CC and CT alleles) and in genotype 1a infected patients (CC allele) were significantly associated with a sustained virological response (SVR). The SVR rates for CC, CT and TT (IL28B rs12979860) were 18%, 34% and 4%, respectively. Multiple logistic regression analysis identified two independent factors that were significantly associated with SVR: IL-28B genotype (rs 12979860 CC vs TT and CT; odds ratio [ORs], 7.86 and 4.084, respectively), and HCV subtype 1a (OR, 7.46). In the present study, an association between SVR rates and IL28B polymorphisms was observed. Conclusions: The HRM assay described herein is rapid, inexpensive, sensitive and accurate for detecting rs12979860 alleles in CHC patients. This method can be readily adopted by any molecular diagnostic laboratory with HRM capability and will be clinically beneficial in predicting treatment response in HCV genotype 1 and 3 infected patients. In addition, it was demonstrated that CC and CT alleles in HCV-3a and the CC allele in HCV-1a were significantly associated with response to pegIFN-${\alpha}$/RBV treatment. The present results may help identify subjects for whom the therapy might be successful.
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Reza S. Razmara,Ali Daneshfar,Reza Sahrai 한국공업화학회 2011 Journal of Industrial and Engineering Chemistry Vol.17 No.3
In this research work a simple and very fast salting-out assisted liquid–liquid extraction (SALLE)followed by UV–vis spectrphotometric method was developed and applied for determination of methylene blue and sunset yellow in wastewater and food samples. Water-miscible extraction solvent (4.5 mL acetonitrile) was added to aqueous solution (5.5 mL) for formation of a homogeneous solution. To the mixture solution, suitable amount of (NH4)2SO4 was added, themixture solution was shaken until the salt was dissolved, and then it was separated into two clear phases easily and rapidly. The target analytes in the sample was extracted into the water-miscible extraction solvent. After extraction, the analytes in the organic phase was determined by spectrphotometric method using the analytical wavelengths of 417 nm, 656 nm for sunset yellow and methylene blue, respectively. The influences of effective parameters such as salt (type and amount), water-miscible organic solvent, phase volume ratio,and pH of sample solution were studied and optimized. Under optimized experimental conditions,calibration plots were found to be linear in the range of 0.2–7.0 mg/L, and 0.4–15.0 mg/L for methylene blue and sunset yellow, respectively, with coefficient of determinations more than 0.996. The limits of detection were 0.06 and 0.07 mg/L for methylene blue and sunset yellow, respectively. The limits of quantification were 0.20 mg/L and 0.25 mg/L for methylene blue and sunset yellow, respectively The proposed procedure was successfully applied to the determination of analytes in spiked samples with satisfactory results. The relative recoveries ranged over 90.2–106.0%, with relative standard deviations varying from 1.1% to 3.8%.
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Robust Model Predictive Control of Biped Robots with Adaptive On-line Gait Generation
Reza Heydari,Reza Heydari 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1
In this paper, an on-line gait control scheme is proposed for the biped robots for walking up and down thestairs. In the proposed strategy, the nonlinear model predictive control approach is used for the trajectory planningand as well as for the control of the robot. The motion of the robot is expressed in the form of a cost functionand some constraints that are related to the stable walking of the robot. The main feature of this method is that itdoes not need any off-line trajectory planning and the walking gait is formulated such that the environmental andstability constraints of the robot are satisfied. This on-line trajectory planning gives the important ability to therobot to adjust its gait lengths. In this way, the robot is able to ascend and descend the stairs without knowing theheight and depth of the stairs in advance. In the control algorithm, the Radial-Basis Function (RBF) neural networkwith on-line training method is used to model the behavior of the robot over the prediction horizon. The stabilityanalysis of the closed-loop system is performed using the Lyapunov method as well as the Poincaré map. Theproposed method is applied to a 5-DOF biped robot in the sagittal plane. The simulation results show effectivenessof the proposed method.
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Reza Rezaei,Arsalan Golfam,Ferdows Aghagolzadeh,Hamid Reza Shairi 고려대학교 응용문화연구소 2016 에피스테메 Vol.0 No.15
Nostalgia, originally a psychological term, is a recurrent concept in the literary works. The meaning of the term encompasses homesickness, regret for past, and a desire for an earlier time. The immigrant authors have also dealt with the theme of nostalgia to a great extent. In this article, the authors by choosing the Shemiran house, the novel written by Goli taraghi Persian contemporary immigrant writer, aims to respond to the following question by adopting post ─ Greimassian approaches to semiotics. How and under what circumstances nostalgia would be considered as semiotic and discursive mediation? How it would be possible to establish a relationship between this notion and the question of identity in the host culture? In the light of theoretical frame work of tensive semiotics, cultural mediation and semiosphere theory of Lotman, the hypothesizes of this article in one hand prove that nostalgia creates a tensive zone which is temporally and spatially bounded and on the other hand it causes the transmission of values to the present time of enunciator which results in the scission of being and the challenge between Self and I. The interaction of guest and host semiosphers leads to the formation of a hybrid identity as well.
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Reza Jalali,Mojtaba Parhizkar,Hasan Bidadi,Hamid Naghshara,Seyd Reza Hosseini,Majid Jafari 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.6
TiAlN thin films were deposited by using the reactive magnetron co-sputtering method whitindividual Ti and Al targets, where the Ti and the Al targets were simultaneously powered by usingDC and RF sources, respectively. the electrical resistivity and the structural and microstructuralproperties of the deposited TiAlN thin films and the effects of Al content, substrate temperatureand nitrogen gas flow rate on those properties were investigated. At a low flow rate of nitrogen gas(0.51 sccm), the electrical resistivity of the films was found to increase with increasing AC power,but at a high flow rate of nitrogen gas, it was found to decrease. The structural and microstructuralanalyses performed by using X-ray diffraction and scanning electron microscopy (SEM) showed thatwith increasing substrate temperature from room temperature to 400◦C, the films prepared at 400◦C have a crystalline structure while those prepared at room temperature had an amorphous nature. Also, the SEM analysis revealed that with decreasing AC power and increasing nitrogen flow rate,the size of the grains in the prepared films become larger.
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