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RISS 인기검색어
- 검색키워드
- 저자 : Repetto, (검색결과 8 건)
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Dynamic crosswind fatigue of slender vertical structures
Repetto, Maria Pia,Solari, Giovanni Techno-Press 2002 Wind and Structures, An International Journal (WAS Vol.5 No.6
Wind-excited vibrations of slender structures can induce fatigue damage and cause structural failure without exceeding ultimate limit state. Unfortunately, the growing importance of this problem is coupled with an evident lack of simple calculation criteria. This paper proposes a mathematical method for evaluating the crosswind fatigue of slender vertical structures, which represents the dual formulation of a parallel method that the authors recently developed with regard to alongwind vibrations. It takes into account the probability distribution of the mean wind velocity at the structural site. The aerodynamic crosswind actions on the stationary structure are caused by the vortex shedding and by the lateral turbulence, both schematised by spectral models. The structural response in the small displacement regime is expressed in closed form by considering only the contribution of the first vibration mode. The stress cycle counting is based on a probabilistic method for narrow-band processes and leads to analytical formulae of the stress cycles histogram, of the accumulated damage and of the fatigue life. The extension of this procedure to take into account aeroelastic vibrations due to lock-in is carried out by means of ESDU method. The examples point out the great importance of vortex shedding and especially of lock-in concerning fatigue.
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Characteristics of thunderstorms relevant to the wind loading of structures
Solari, Giovanni,Burlando, Massimiliano,De Gaetano, Patrizia,Repetto, Maria Pia Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.20 No.6
"Wind and Ports" is a European project that has been carried out since 2009 to handle wind forecast in port areas through an integrated system made up of an extensive in-situ wind monitoring network, the numerical simulation of wind fields, the statistical analysis of wind climate, and algorithms for medium-term (1-3 days) and short term (0.5-2 hours) wind forecasting. The in-situ wind monitoring network, currently made up of 22 ultrasonic anemometers, provides a unique opportunity for detecting high resolution thunderstorm records and studying their dominant characteristics relevant to wind engineering with special concern for wind actions on structures. In such a framework, the wind velocity of thunderstorms is firstly decomposed into the sum of a slowly-varying mean part plus a residual fluctuation dealt with as a non-stationary random process. The fluctuation, in turn, is expressed as the product of its slowly-varying standard deviation by a reduced turbulence component dealt with as a rapidly-varying stationary Gaussian random process with zero mean and unit standard deviation. The extraction of the mean part of the wind velocity is carried out through a moving average filter, and the effect of the moving average period on the statistical properties of the decomposed signals is evaluated. Among other aspects, special attention is given to the thunderstorm duration, the turbulence intensity, the power spectral density and the integral length scale. Some noteworthy wind velocity ratios that play a crucial role in the thunderstorm loading and response of structures are also analyzed.
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Massimo Giusti,Lucia Conte,Anna Maria Repetto,Stefano Gay,Paola Marroni,Miranda Mittica,Michele Mussap 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.4
Background: Owing to its large molecular size, polyethylene glycol (PEG)-precipitable thyrotropin (TSH) can accumulate in the circulation, elevating TSH levels. PEG-precipitable TSH can be used to detect macro-TSH (mTSH) in serum. Our aim was to evaluate the prevalence of mTSH in patients who had undergone thyroidectomy for thyroid cancer. Methods: Seventy-three thyroid cancer patients and 24 control subjects on levothyroxine (LT4) TSH-suppressive or replacement therapy were evaluated. Screening for mTSH was performed by adding PEG to serum in order to precipitate γ-globulin. A percentage of PEG-precipitable TSH ≥80% was considered suggestive of mTSH. Results: No correlation between free-T4 (fT4) and TSH levels was found. PEG-precipitable TSH was 39.3%±1.9% in thyroid cancer patients and 44.1%±3.9% in controls. Macro-TSH was deemed to be present in one thyroid cancer patient and in two control subjects. Only in the thyroid cancer group was PEG-precipitable TSH found to be negatively correlated with fT4 concentration. No correlation was found between PEG-precipitable TSH and other clinical conditions in any patients. Conclusion: The presence of mTSH seems to be a rare phenomenon in thyroid cancer. In some patients with low PEG-precipitable TSH, a reduction in LT4 dosage could be suggested. LT4 dosage adjusted to body weight is the main factor in maintaining TSH in a semi-suppressed or normal range. Evaluation of mTSH could be necessary in patients in whom a balance is required between adequate TSH suppression and the avoidance of unnecessary exogenous hyperthyroxinemia.
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Characteristics of thunderstorms relevant to the wind loading of structures
Giovanni Solari,Massimiliano Burlando,Patrizia De Gaetano,Maria Pia Repetto 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.20 No.6
“Wind and Ports” is a European project that has been carried out since 2009 to handle wind forecast in port areas through an integrated system made up of an extensive in-situ wind monitoring network, the numerical simulation of wind fields, the statistical analysis of wind climate, and algorithms for medium-term (1-3 days) and short term (0.5-2 hours) wind forecasting. The in-situ wind monitoring network, currently made up of 22 ultrasonic anemometers, provides a unique opportunity for detecting high resolution thunderstorm records and studying their dominant characteristics relevant to wind engineering with special concern for wind actions on structures. In such a framework, the wind velocity of thunderstorms is firstly decomposed into the sum of a slowly-varying mean part plus a residual fluctuation dealt with as a non-stationary random process. The fluctuation, in turn, is expressed as the product of its slowly-varying standard deviation by a reduced turbulence component dealt with as a rapidly-varying stationary Gaussian random process with zero mean and unit standard deviation. The extraction of the mean part of the wind velocity is carried out through a moving average filter, and the effect of the moving average period on the statistical properties of the decomposed signals is evaluated. Among other aspects, special attention is given to the thunderstorm duration, the turbulence intensity, the power spectral density and the integral length scale. Some noteworthy wind velocity ratios that play a crucial role in the thunderstorm loading and response of structures are also analyzed.
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Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction
Fabre, Bibiana,Grosman, Halina,Gonzalez, Diego,Machulsky, Nahuel Fernandez,Repetto, Esteban M,Mesch, Viviana,Lopez, Miguel Angel,Mazza, Osvaldo,Berg, Gabriela Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Prostate cancer (PCa) is one of the most common diseases in men. It is important to assess prognostic factors and whether high cortisol levels and complex hormonal interactions could be responsible for PCa development. We evaluated the relationship between cortisol, leptin and estrogens in 141 men, 71 with PCa and the remaining 70 constituting a low risk group (LRG). They were recruited for this study from a total of 2906 middle-aged men (ages 45-70 years) who completed an evaluation for prostatic diseases at the Urology Division, Hospital de Clínicas "$Jos{\acute{e}}$ de San $Mart{\acute{i}}n$", University of Buenos Aires, in May 2009. In this cross sectional study, cortisol, PSA, total-testosterone, free-testosterone, bioavailable testosterone, LH and estradiol were measured in serum. We observed increased cortisol levels in PCa patients as compared to LRG cases (p=0.004,). Leptin and estradiol levels were also higher in PCa patients (p=0.048; p<0.0001, respectively). Logistic regression analysis indicated that serum cortisol (OR: 1.110 (95% CI 1.016-1.213), p=0.022), estradiol (OR: 1.044 (95% CI 1.008-1.081), p=0.016) and leptin (OR: 1.248 (95% CI 1.048-1.487), p=0.013) explained 27% of the variance of dependent variables, even after adjusting for age, smoking, BMI and waist circumference. We found increased cortisol levels in PCa patients as compared to LRG, as well as an altered circulating hormonal profile.
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Santiago Tofé,Iñaki Argüelles,Cristina Álvarez,Álvaro Tofé,Alessandra Repetto,Antonia Barceló,Vicente Pereg 대한이비인후과학회 2023 Clinical and Experimental Otorhinolaryngology Vol.16 No.4
Objectives. Neck recurrence of papillary thyroid cancer (PTC) is frequently detected after initial surgery. The managementof these lesions may include rescue surgery (RS) or minimally invasive techniques in selected patients, but compara-tive studies evaluating the effectiveness and safety of these techniques are lacking. In this paper, we compared ultra-sound-guided ethanol ablation (EA) in selected patients to RS in a matched cohort. Methods. We retrospectively compared 41 patients and 41 matched PTC patients without known distant metastases, whounderwent ultrasound-guided EA or RS (matched reference group), who had 63 and 75 thyroid bed and/or lymphnode confirmed PTC recurrences during a median follow-up of 72.8 and 89.6 months, respectively. The primary out-come was time until structural recurrence, compared using Kaplan-Meier survival curves. The secondary outcomesincluded time until biochemical recurrence, plasma thyroglobulin (Tg) levels, American Thyroid Association (ATA) re-sponse-to-therapy categories by the last available observation, and treatment-derived complications in each group. Results. No significant differences were found between the EA and RS groups for time until structural recurrence (log-ranktest, P =0.94). The time until biochemical recurrence was also similar (P =0.51); and the plasma Tg concentration re-duction and proportions of patients in the ATA reclassification categories were also similar. A significantly higher pro-portion of patients in the RS group presented treatment-derived complications (29.27% vs. 9.75%, P <0.05). Conclusion. In this retrospective analysis, the treatment of PTC neck recurrence with EA in selected patients was compara-ble to RS in a matched reference group for the long-term risk of structural or biochemical relapse, but with a lowerrisk of treatment-derived complications. These results support the effectiveness and safety of this minimally invasivetechnique in the management of selected patients with recurrent PTC.
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Jorge A. Gonzalez-y-Merchand,Ruben Zaragoza-Contreras,Rosalina Guadarrama-Medina,Addy C. Helguera-Repetto,Sandra Rivera-Gutierrez,Jorge F. Cerna-Cortes,Leopoldo Santos-Argumedo,Robert A. Cox 한국미생물학회 2012 The journal of microbiology Vol.50 No.3
The study of the in vitro cell growth of mycobacteria still remains a fastidious, difficult, and time-consuming procedure. In addition, assessing mycobacterial growth in the laboratory is often complicated by cell aggregation and slow growth-rate. We now report that the use of a stainless steel spring in the culture led to an absence of large cell clumps, to a decrease of dead cells in the exponential phase and to growth of a more homogeneous population of large cells. We also report that flow cytometry is a rapid, simple and reliable approach to monitor mycobacterial cell growth and viability. Here, we monitored Mycobacterium smegmatis cellular growth by optical density, dry cell mass, and colony forming units; in addition, viability, cell size and granularity profiles were analyzed by flow cytometry, and cell morphology by electron microscopy. Cultures monitored by flow cytometry may lead to a better understanding of the physiology of mycobacteria. Moreover, this methodology may aid in characterizing the cell growth of other fastidious species of microorganisms.
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