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Atypical Presentation of Orbital Pseudotumor with Visual Loss as an Initial Manifestation
Recai Turkoglu,Naci Balak 대한신경과학회 2011 Journal of Clinical Neurology Vol.7 No.1
Background:An orbital pseudotumor typically presents with periorbital pain, cranial nerve palsies and proptosis. Although visual deterioration is not unexpected in this pathology, its presentation solely with visual loss is unusual. Case Report:In this short report, we summarize a case of orbital pseudotumor which presented solely with a decrease in visual acuity, and discuss the clinical and radiological findings. This part can be moved to the conclusion part. However, It is also good in this location. Conclusions:In the early clinical period, an orbital pseudotumor may manifest itself solely by visual loss. It should therefore be included in the differential diagnosis of visual pathologies-even in the absence of orbital pain and symptoms related to ocular movements.
Balak, Naci,Isiksacan, Nilgun,Turkoglu, Recai The Korean Neurosurgical Society 2009 Journal of Korean neurosurgical society Vol.45 No.3
Objective : It is well known that changes in cerebral hemodynamics occur after traumatic brain injury (TBI). Osmo-regulation in the brain is important for maintaining a constant milieu in the central nervous system. Nevertheless, to our knowledge, early osmolarity changes after minor head injury have not been studied until now. Methods : In this study, serum osmolarity was measured in 99 patients with minor head trauma. As a control group, blood samples were drawn from 99 patients who had a minor trauma in an extremity. Serum osmolarity was estimated using a fully automatic biochemical autoanalyzer within the first 3 hours after the trauma. Results : The mean serum osmolarity levels were $286.08{\pm}10.1\;mOsm/L$ in the study group and $290.94{\pm}5.65\;mOsm/L$ in the control group (p<0.001). However, after age adjustment between the study and control groups, this statistical significance was found to be valid only for patients over 30 years of age. Conclusion : It was noted that serum osmolarity levels decrease in the first 3 hours following minor head trauma in patients over 30 years of age. Further studies into this area could provide guidance for the management/treatment of elderly patients.
Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
Mahmut Sozmen,Alparslan Kadir Devrim,Recai Tunca,Murat Bayezit,Serpil Dag,Dinc Essiz 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
The present study was conducted to investigate the effect ofsilymarin on experimental liver toxication induced byFumonisin B1 (FB1) in BALB/c mice. The mice were dividedinto six groups (n = 15). Group 1 served as the control. Group2 was the silymarin control (100 mg/kg by gavage). Groups 3and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1,intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), andGroup 6 was given a higher dose of FB1 (4.5 mg/kg FB1) withsilymarin (100 mg/kg). Silymarin treatment significantlydecreased (p < 0.0001) the apoptotic rate. FB1 administrationsignificantly increased (p < 0.0001) proliferating cell nuclearantigen and Ki-67 expression. Furthermore, FB1 elevated thelevels of caspase-8 and tumor necrosis factor-alpha mediatorswhile silymarin significantly reduced (p < 0.0001) theexpression of these factors. Vascular endothelial growthfactor (VEGF) and fibroblast growth factor-2 (FGF-2)expressions were significantly elevated in Group 4 (p <0.0001). Silymarin administration alleviated increased VEGFand FGF-2 expression levels (p < 0.0001). In conclusion,silymarin ameliorated toxic liver damage caused by FB1 inBALB/c mice.
Sur Aslihan,Iflazoglu Mutlu Seda,Tatli Seven Pinar,Seven Ismail,Aslan Abdullah,Kizil Meltem,Kulaksiz Recai,Yaranoglu Mustafa Hilmi,Esen Selim 한국독성학회 2023 Toxicological Research Vol.39 No.4
In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of highdose administration of methylprednisolone (MP) in male rats. A total of 32 adult Wistar male albino rats were divided into four groups: (1) control (CON), received standard food only; (2) MP, received standard food + intraperitoneal injection of 60 mg/kg MP on day 7; (3) GSPE, received standard food + 200 mg/kg/day GSPE; and (4) MP + GSPE, received standard food + 200 mg/kg/day of GSPE + intraperitoneal injection of 60 mg/kg MP on day 7. All animals in the GSPE and GSPE + MP groups were treated once a day by oral gavage for 14 consecutive days. The feed intake of rats in the MP and MP + GSPE groups decreased significantly by 24.14% and 13.52%, respectively (p < 0.05). Administration of MP resulted in significant increases in serum concentrations of blood urea nitrogen (p < 0.001), glucose (p < 0.01), alkaline phosphatase, and adrenocorticotropic hormone (p < 0.05). High-dose MP administration significantly reduced catalase (p < 0.001) and glutathione peroxidase (p < 0.05) concentrations in the liver and kidney tissues of rats, while glutathione concentrations were only reduced in liver tissue (p < 0.05). The expression levels of Bcl-2 and TNF-α in liver, kidney, and testicular tissue were significantly increased, while the expression levels of caspase-3 were reduced (p < 0.001). Furthermore, sperm concentration was significantly affected by GSPE in rats induced by high-dose MP, and sperm loss was significantly reduced in MP + GSPE (p < 0.05). These findings suggest that GSPE could be useful as a supplement to alleviate MP-induced toxicity in rats.