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韓国人日本語学習者における日本語のザ行音とジャ行音の習得について
藤田蘭子(Fujita, Ranko) 한국일본문화학회 2018 日本文化學報 Vol.0 No.79
This paper empirically investigates and analyzes the acquisition of the Japanese “Za-gyō-sounds” (za, zu, and zo) and “Ja-gyō-sounds” (ja, ju, and jo) by Korean learners. There are four research questions addressed here: (1) Do Za-gyō-sounds and Ja-gyō-sounds differ in how they are heard by Korean learners depending on their Japanese proficiency level?, (2) is there is a significant difference among the Za-gyō-sounds (za, zu, and zo) as heard by Korean speakers?, (3) is there is a significant difference among the Ja-gyō-sounds ( ja, ju, and jo) as heard by Korean speakers?, and (4) is there is a difference between the Za-gyō-sounds and Ja-gyō-sounds as heard by Korean speakers? The following results were obtained: (1) There was no difference in the hearing ability between Korean learners of Japanese at the beginner and intermediate levels, (2) there was a significant difference among the Za-gyō-sounds (za, zu, and zo), (3) there was also a significant difference among the Ja-gyō-sounds (ja, ju, and jo), and (4) there was no statistically significant difference between the Za-gyō-sounds and Ja-gyōsounds but there were significant differences between zu and ju and between zo and jo. From these results, I have empirically demonstrated that the acquisition of Japanese Za-gyō-sounds and Ja-gyō-sounds is different to those predicted in the contrastive linguistic analysis of Korean and Japanese.
High-Grade Prostatic Intraepithelial Neoplasia
Joseph C Klink,Ranko Miocinovic,Cristina Magi Galluzzi,Eric A Klein 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.5
High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.
Geraldes, Vanessa,de Medeiros, Livia Soman,Lima, Stella T.,Alvarenga, Danillo Oliveira,Gacesa, Ranko,Long, Paul F.,Fiore, Marli Fatima,Pinto, Ernani The Korean Society of Phycology 2020 ALGAE Vol.35 No.2
Cyanobacteria have been widely reported to produce a variety of UV-absorbing mycosporine-like amino acids (MAAs). Herein, we reported production of the unusual MAA, mycosporine-glycine-alanine (MGA) in the cyanobacterium Sphaerospermopsis torques-reginae ITEP-024 using a newly developed UHPLC-DAD-MS/HRMS (ultra-high performance liquid chromatography-diode array detection-high resolution tandem mass spectrometry) method. MGA had previously been first identified in a red-algae, but S. torques-reginae strain ITEP-024 is the first cyanobacteria to be reported as an MGA producer. Herein, the chemical structure of MGA is fully elucidated from one-dimensional / two-dimensional nuclear magnetic resonance and HRMS data analyses. MAAs are unusually produced constitutively in S. torques-reginae ITEP-024, and this production was further enhanced following UV-irradiance. It has been proposed that MAA biosynthesis proceeds in cyanobacteria from the pentose phosphate pathway intermediate sedoheptulose 7-phosphate. Annotation of a gene cluster encoded in the genome sequence of S. torques-reginae ITEP-024 supports these gene products could catalyse the biosynthesis of MAAs. However, addition of glyphosate to cultures of S. torques-reginae ITEP-024 abolished constitutive and ultra-violet radiation induced production of MGA, shinorine and porphyra-334. This finding supports involvement of the shikimic acid pathway in the biosynthesis of MAAs by this species.