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Rakib, Md. Abdur,Lee, Won Sup,Kim, Gon Sup,Han, Jae Hee,Kim, Jeong Ok,Ha, Yeong Lae Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>The major conjugated linoleic acid (CLA) isomers, <I>c</I>9,<I>t</I>11-CLA and <I>t</I>10,<I>c</I>12-CLA, have anticancer effects; however, the exact mechanisms underlying these effects are unknown. Evidence suggests that reversal of reduced gap junctional intercellular communication (GJIC) in cancer cells inhibits cell growth and induces cell death. Hence, we determined that CLA isomers enhance GJIC in human MCF-7 breast cancer cells and investigated the underlying molecular mechanisms. The CLA isomers significantly enhanced GJIC of MCF-7 cells at 40 <I><I>μ</I></I>M concentration, whereas CLA inhibited cell growth and induced caspase-dependent apoptosis. CLA increased connexin43 (Cx43) expression both at the transcriptional and translational levels. CLA inhibited nuclear factor-<I><I>κ</I></I>B (NF-<I><I>κ</I></I>B) activity and enhanced reactive oxygen species (ROS) generation. No significant difference was observed in the efficacy of <I>c</I>9,<I>t</I>11-CLA and <I>t</I>10,<I>c</I>12-CLA. These results suggest that the anticancer effect of CLA is associated with upregulation of GJIC mediated by enhanced Cx43 expression through inactivation of NF-<I><I>κ</I></I>B and generation of ROS in MCF-7 cells.</P>
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Md. Rakib Hasan,Nizam Uddin,Tanmoy Sana,Md. Monir Hossain,Milon Mondal,Ismat Jarin Kanta,M. S. K. Choudhuri 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
The aim of our current study is to investigate the analgesic and anti-inflammatory potentials of methanolic extract of Mallotus repandus stem (MSM) using different in vivo assay models. Analgesic and anti-inflammatory activities were evaluated using acetic acid induced writhing test, tail immersion method, hot-plate test, formalin induced hind paw licking, xylene induced ear edema, carrageenan-induced paw edema and cotton pellet induced granuloma in animal model at doses of 500, 1000 and 2000 mg/kg body weight. MSM showed significant (p < 0.05) analgesic activities in the acetic acid-induced writhing tests in mice. In the tail immersion and hot-plate test, MSM significantly prolonged the latency period (p < 0.05). Significant (p < 0.05) formalin induced paw licking inhibition was observed at different doses and the highest 74.47% inhibition was observed at 2000 mg/kg. Besides, MSM showed significant (p < 0.05) anti-inflammatory responses in carrageenan induced paw edema, xylene induced ear edema and cotton pellet induced granuloma methods. These findings suggest that the plant may be a potential source for the development of new analgesic and anti-inflammatory agent.
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Diagnostic analysis of US fashion brand’s Bangladeshi outsourcing
H. M. Rakib Ul Hasan,Mijeong Noh,Adah Ward Randolph 한국마케팅과학회 2022 마케팅과학연구 Vol.32 No.2
The purpose of this paper is to examine Bangladesh’s performance as an outsourcing destination from the perspectives of buyers and suppliers involved in a representative US apparel company which has outsourced from Bangladesh. This study employed a sequential mixed method research design which consisted of quantitative evaluation and qualitative interviews. The sample was comprised of three buyers and three suppliers in the Phillip’s Van-Heusen (PVH). From the results of quantitative evaluation, it was found that Bangladesh has a greater advantage in the cost and quality clusters than Vietnam. The interviews revealed that the US buyers have some concerns in geographic location, trade restrictions, country’s political situation, warranty policies, and currency exchange situations. To strengthen Bangladeshi capability, Bangladeshi government’s investment to improve facilities, nomination of supplier’s backward linkage, improvement of manufacturing capacity, running improvement programs, negotiation to reduce tariff, and building mutual trust between buyers and suppliers were suggested. These diagnosis results provide the US buyers and the Bangladeshi suppliers with not only valuable information on the current status of Bangladesh’s performance but guidance to successful strategies for improvement of outsourcing performance.
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H M Rakib ul Hasan,Mijeong Noh 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
The concept of retail therapy which refers to “the phenomenon in which consumers buy things to make themselves feel better” (Kacen, 1998) has been used by the U.S. retail firms in marketing (Kang & Johnson, 2010). Previous studies found that retail therapy concept was associated to consumption behaviors including compulsive buying (Faber & O’Guinn, 1992; O’Guinn & Faber, 1989). Frost et al. (1998) found that compulsive hoarders show compulsive buying tendencies. O’Guinn and Faber (1989) found that compulsive buyers are more likely to confirm compulsivity as a personality trait with a low self-esteem. Lack of research into association of retail therapy to compulsive consumer behaviors motivated us to pursue this study which investigate relationships among retail therapy, compulsive buying and compulsive hoarding, and to examine the moderating effect of consumers’ personality traits on the relationship between retail therapy and compulsive hoarding. Our research questions are: (1) How retail therapy is related to compulsive buying and compulsive hoarding? and (2) Which personality traits moderate the relationship between retail therapy and compulsive hoarding? Based on the literature review, the following hypotheses were proposed. H1: Retail therapy is positively related to compulsive buying; H2: Compulsive buying is positively related to compulsive hoarding; H3: Retail therapy is positively related to compulsive hoarding & H4: Personality trait moderates the relationship between retail therapy and compulsive hoarding. The researchers used 12 items to measure retail therapy (Kang, 2009), 6 items to measure compulsive buying (Faber & O’Guinn, 1992), 9 items to measure compulsive hoarding (Frost, Sketekee, & Grisham, 2004) 8 items of Big Five Inventory (Rammstedt & John, 2007) and 15 item Narcissistic Personality Inventory (NPI) (Ames, Rose & Anderson, 2006) to measure personality trait based on 7‑point Likert scales (1 = strongly disagree, 7 = strongly agree). The online survey was conducted with college students enrolled at a major Midwestern University. A total of 354 undergraduate and graduate students’ responses were used to analyze data. A principal component factor analysis with varimax rotation was conducted to evaluate the measurement of each construct. The factor loadings were above of 0.60, indicating acceptable convergent validity. Reliabilities with Cronbach’s alphas for retail therapy,compulsive buying, compulsive hoarding and personality trait construct were 0.96, 0.81, 0.90 and 0.81 respectively, exceeding the suggested level of 0.70. Simple linear regression was performed to test hypotheses. The results revealed that F statistic (F(1, 352)=126.53, p =.000) was significant and regression coefficient was statistically significant. Therefore, H1 was supported and consistent with previous findings (Faber & O’Guinn, 1992). The regression coefficient for the path from compulsive buying to compulsive hoarding was statistically significant (F(1, 352)=77.15, p=.000). Therefore, H2 was supported and consistent with Frost et al. (1998)’s study. The retail therapy contributed significantly to the prediction of compulsive hoarding with the statistically significant regression results (F(1, 352)=20.28, p=.000), supporting H3. From the principle component analysis with varimax rotation, four factors were extracted from 23 personality trait measurement items which are labeled as “authority-leadership narcissism”, “self-esteem narcissism”, “positive disposition”, and “negative disposition”. All factor loadings were above 0.60 for their respective factors. Then, the researchers divided one single group into four personality trait groups, using these four factors. 4%, 27.1%, 53.7% & 15.3% participants represented “authority-leadership narcissism”, “self-esteem narcissism”, “positive disposition” & “negative disposition” group respectively. Simple regression analysis was performed to test H4. The regression coefficients for positive disposition group (F(1, 188)=13.19, p=.000) and negative disposition group (F(1, 52)=5.01, p≤.05) were statistically significant. H4 was partially supported. The results indicated that people from two groups characterized by positive/negative personality tend to engage in compulsive hoarding to alleviate their negative feelings or mood. Anyone with narcissistic personality with a high self-efficacy may not be engaged in compulsive hoarding even when a therapeutic treatment is made through shopping. They tend to purchase products for changing their moods, but their therapeutic behavior doesn’t lead to compulsive hoarding, which causes sufferings in the end. The low self-esteem has been presented with people being engaged in compulsive behaviors (Marlatt et al., 1988). These findings can help apparel marketers develop the strategies to upgrade their sellingenvironment entertaining so that their customers’ moods are repaired and customers feel satisfied through therapeutic shopping behavior. This study has a limitation that prevents us from generalizing the results to the young consumer population due to sample size to college students.
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Demonstration of All-Optical nand Gate Using Single-Mode Fabry–Pérot Laser Diode
Nakarmi, B,Rakib-Uddin, M,Hoai, T Q,Yong Hyub Won IEEE 2011 IEEE photonics technology letters Vol.23 No.4
<P>A novel, simple, and universal all-optical NAND gate using single-mode Fabry-Pérot laser diode (SMFP-LD) is demonstrated. The basic operating principle of the proposed NAND gate is the modulation of the dominant lasing mode of SMFP-LD by the injection of external beams. The dominant lasing mode gain is suppressed only when both input beams are high. As SMFP-LD is used to demonstrate the logic function, no additional beam is required as needed in the multimode Fabry-Pérot laser diode (MMFP-LD) schemes. The operating principle is explained and the experimental results are presented at 10 Gb/s input data. The logic function is realized with a clear eye opening and an extinction ratio of 14.6 dB with a rising and falling time of 38.3 and 67.1 ps, respectively.</P>
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Nakarmi, Bikash,Rakib-Uddin, M,Won, Yong Hyub Optical Society of America 2011 Optics express Vol.19 No.15
<P>We propose a novel idea for the suppression of the dominant mode of the single-mode Fabry-Pérot laser diode (SMFP-LD) to realize all-optical multi-logic functions and a digital adder. The basic principle of the proposed scheme is the power management of input beams to suppress the dominant mode of the SMFP-LD for multi-input injection locking. The proposed principle is explained and implemented to realize all-optical multi-logic functions and a digital adder at an input data rate of 10 Gbps. A clear eye opening with an extinction ratio of about 12 dB and a rising-falling time of less than 40 ps are observed at the outputs. The bit error rate (BER) performance is measured for all logic gates and half adder operation. We found there is no BER floor up to BER of 10(-12) and the maximum power penalty of about 1.2 dB at a BER of 10(-9).</P>
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