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SYNCHRONIZING NUMEROUS SAMPLING TASKS BY GEOMETRIC SERIES IN SENSOR FIELD
Rajasekar Rangasamy,Prakasam Periasamy 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10
wireless sensor network employed mobile sinks to collect a set of samples from sensor field. Low-cost and small sensor devices contain various resource restrictions that introduce new challenges for data collection and aggregation in sensor networks. Among these limitations, energy is usually the primary concern when designing an in-network algorithm. The main task of sampling the sensor field is to manage the energy efficiency of the sensor source nodes when sharing out the data to the target node. The path of sending the sensor data is effectively recognized however uses more cost to forward sensor data packet. To improve the mobile sampling in sensor field, a novel method is designed to plan synchronize numerous sampling tasks. It is feasible by the sensor nodes to hold numerous sampling tasks, started by means of the same or different mobile objects in which the sampling regions gets overlapped. So, it is attractive to include an effective synchronization mechanism so that overlapped regions required only one reply for the sampling tasks. Here, a geometric series method is presented as a synchronization mechanism to synchronize the numerous sampling tasks to help the rebroadcast system by utilizing only the minimum amount of energy. Experimental simulations are carried out to calculate the performance of the proposed synchronizing numerous sampling tasks in sensor field using geometric series [SNSTGS] system against Band-based Directional Broadcast by means of average number of messages, overlap percentage, data deliverability.
Rajasekar Seetharaman,박순영,윤무경,곽정호,손병구,박영훈,강점순,이용재,최영현,배외식,최영환 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.2
This study investigated the effects of (10Z)-1-[(5Z,8Z)-tetradeca-5,8-dienoyloxy]-3-[(Z)-tetradec-8-enoyloxy]propan-2-yl hexadec-10-enoate (TTPH) from garlic on the inducible nitric oxide synthase (iNOS) and cycloxygenase-2 (COX-2)systems in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The TTPH dose-dependently reduced nitriteaccumulation and production of prostaglandin E2 in the supernatants of LPS-stimulated macrophages. Markedly reducediNOS and COX-2 enzyme activities were observed in Western blots. In addition, a dose-dependent change in mRNAexpression was recorded using reverse transcription-polymerase chain reaction analyses. Moreover, TTPH exerted antiinflammatoryactivity by inducing heme oxygenase-1 (HO-1) expression; this was supported by the use of the HO-1inhibitor protoporphyrin IX, which abolished the inhibitory effect of TTPH on the production of nitric oxide, tumornecrosis factor-alpha, interleukin (IL)-1β, and IL-6 in LPS-stimulated macrophages. These observations indicate thatTTPH inhibits the expression of iNOS and COX-2, and up-regulates HO-1 in activated macrophages. The possiblelink of this effect to the beneficial features attributed to garlic is discussed.
Rajasekar Seetharaman(라자세카 시타르만),Seong Mi Choi(최성미),Lu Guo(궈루),Zheng Wei Cui(추이정웨이),Duuriimaa Otgonbayar(두리마 오타곤바야르),Ju Ha Park(박주하),Young-Seok Kwon(권영석),Jung Ho Kwak(곽정호),Young Hee Kwon(권영희),Ji Hyun 한국생명과학회 2019 생명과학회지 Vol.29 No.10
마늘(Allium sativum)의 주요 생리활성 성분들은 다양한 종류의 암에 대해 항암효과가 보고되고 있다. 본 연구에서는 활성추적분리방법(activity-guided purification)을 이용하여 마늘의 항암성분을 발굴하고자 하였다. 마늘 에탄올 추출물을 칼럼크로마토그래피로 얻은 각각의 분획물에 대해서 AGS세포의 증식 억제율을 검증하여 가장 효과가 좋은 분획물로부터 물질을 순수분리하여 구조를 동정한 결과 N-benzyl-N-methyldecan-1-amine (NBNMA)로 밝혀졌다. NBNMA의 암생장 억제효능을 검증하기 위해서 CT-26, AGS, HepG2, HCT-116, MCF7, B16F10 및 Sarcoma-180 세포에 대한 in vitro 효과와 CT-26 결장암 세포를 마우스에 이식한 다음 in vivo 효과를 조사하였다. NBNMA는 Bcl-2의 down-regulation과 Bad의 up-regulation을 유도하여 CT-26 세포의 세포사멸 촉진시켰다. 또한, NBNMA는 세포사멸의 외적 및 내적 경로에서 caspases 억제자인 caspase 3과 caspase 9의 활성을 약간 증가시켰다. CT-26세포를 이식한 쥐에 19.13μM/kg의 NBNMA를 21일 동안 경구투여한 결과 암종의 크기가 43% 감소하였다. NBNMA는 in vitro 및 in vivo에서 항암 효과를 나타내었는데, 이러한 결과는 마늘로부터 순수분리한 NBNMA가 대장암치료를 위한 항암제 후보물질로서 활용 가능성이 있을 것으로 기대된다. A components of garlic (Allium sativum) have anti-proliferative effects against various types of cancer. We aimed to investigate the capacity of garlic compounds to anti-tumor on a various cancer cell lines. Fractionation of garlic extract, guided by antiproliferative activity against human gastric cancer (AGS) cells, has resulted in the isolation of N-benzyl-N-methyldecan-1-amine (NBNMA). We investigated the effect of newly isolated NBNMA from garlic cloves on the inhibition of the growth of CT-26, AGS, HepG2, HCT-116, MCF7, B16F10, and Sarcoma-180 cells for in vitro and CT-26 colon carcinoma cells in vivo. NBNMA exhibited an antiproliferative effect in CT-26 cells by apoptotic cell death. NBNMA exhibited down-regulation of anti-apoptotic Bcl-2 proteins and up-regulation of apoptotic Bad protein expression in western blot analyses. In addition, NBNMA meagre activated caspase 3 and caspase 9, initiator caspases of the extrinsic and intrinsic pathways of apoptosis. NBNMA treatment at a dose of 10 mg/kg for 21 days in experimental mice implanted with tumors resulted in significant reduction of the tumor weight (43%). NBNMA exhibited both in vitro and in vivo anticancer activity. These results indicate that NBNMA has promising potential to become a novel anticancer agent from garlic cloves for the treatment of colon carcinoma cancer.
Jayabal Rajasekar,김태호,김희동 한국가시화정보학회 2022 한국가시화정보학회지 Vol.20 No.3
The interaction of planar shock wave with rectangular water column is investigated numerically. The flow phenomenon like reflection, transmission, cavitation, recirculation of shock wave, and large negative pressure due to expansion waves was discussed qualitatively and quantitatively. The numerical simulation was performed in a shock tube with a water column, and planar shock was initiated with a pressure ratio of 10. Three cases of the water column with different thicknesses, namely 0.5D, 1D, and 2D, were installed and studied. Water naturally has a higher acoustic impedance than air and mitigates the shock wave considerably. The numerical simulations were modelled using Eulerian and Volume of fluids multiphase models. The Eulerian model assumes the water as a finite structure and can visualize the shockwave propagation inside the water column. Through the volume of fluids model, the stages of breakup of the water column and mitigation effects of water were addressed. The numerical model was validated against the experimental results. The computational results show that the installation of a water column significantly impacts the mitigation of shock wave.