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      • KCI등재

        The Effect of Strategic Orientation on Market Performance: Study of the Mediators

        Hamed Rahimpour Langroudi,Moslem Sharifi,Hossein Rahimpour Langroudi 한국유통과학회 2019 The Journal of Industrial Distribution & Business( Vol.10 No.4

        Purpose - This study investigates the effect of strategic orientation on market performance with emphasis on the mediative role of innovation capability, economic value and relational value in food producer companies. Research design, data, and methodology – In this descriptive study, a population of 244 managers and employees of Food industry companies in Tehran were investigated. The respondents filled a questionnaire on strategic orientation, innovation capability, economic value, relational value and market performance, during January to August 2018. Reliability and validity were evaluated by Cronbach’s alpha coefficient and confirmatory factor analysis. To analyze the data, Spearman's correlation coefficient and structural equation modeling were used by SmartPLS software. Results - Effects of competitor’s orientation and technology orientation on all three intermediary variables were positive and significant. The effect of customer orientation on innovation and economic value was positive and significant, but the effect of customer orientation on the value of the relationship was insignificant. Furthermore, entrepreneurial orientation has a positive and significant effect on innovation capability. The effects of three mediator variables on market performance are positive and significant. Conclusions - As the relationship between the mediator variables and market performance were positive and significant, companies should have a comprehensive plan of focus on strengthening these variables.

      • SCOPUSKCI등재
      • KCI등재

        The Supplementary Motor Complex in Parkinson’s Disease

        Shervin Rahimpour,Shashank Rajkumar,Mark Hallett 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.1

        Parkinson’s disease (PD) is a neurodegenerative disorder characterized by both motor and nonmotor symptoms. Although the basal ganglia is traditionally the primary brain region implicated in this disease process, this limited view ignores the roles of the cortex and cerebellum that are networked with the basal ganglia to support motor and cognitive functions. In particular, recent research has highlighted dysfunction in the supplementary motor complex (SMC) in patients with PD. Using the PubMed and Google Scholar search engines, we identified research articles using keywords pertaining to the involvement of the SMC in action sequencing impairments, temporal processing disturbances, and gait impairment in patients with PD. A review of abstracts and full-text articles was used to identify relevant articles. In this review of 63 articles, we focus on the role of the SMC in PD, highlighting anatomical and functional data to create new perspectives in understanding clinical symptoms and, potentially, new therapeutic targets. The SMC has a nuanced role in the pathophysiology of PD, with both hypo- and hyperactivation associated with various symptoms. Further studies using more standardized patient populations and functional tasks are needed to more clearly elucidate the role of this region in the pathophysiology and treatment of PD.

      • KCI등재

        Engineering the Cellular Protein Secretory Pathway for Enhancement of Recombinant Tissue Plasminogen Activator Expression in Chinese Hamster Ovary Cells: Effects of CERT and XBP1s Genes

        ( Azam Rahimpour ),( Behrouz Vaziri ),( Reza Moazzami ),( Leila Nematollahi ),( Farzaneh Barkhordari ),( Leila Kokabee ),( Ahmad Adeli ),( Fereidoun Mahboudi ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8

        Cell line development is the most critical and also the most time-consuming step in the production of recombinant therapeutic proteins. In this regard, a variety of vector and cell engineering strategies have been developed for generating high-producing mammalian cells; however, the cell line engineering approach seems to show various results on different recombinant protein producer cells. In order to improve the secretory capacity of a recombinant tissue plasminogen activator (t-PA)-producing Chinese hamster ovary (CHO) cell line, we developed cell line engineering approaches based on the ceramide transfer protein (CERT) and X-box binding protein 1 (XBP1) genes. For this purpose, CERT S132A, a mutant form of CERT that is resistant to phosphorylation, and XBP1s were overexpressed in a recombinant t-PA-producing CHO cell line. Overexpression of CERT S132A increased the specific productivity of t-PA-producing CHO cells up to 35%. In contrast, the heterologous expression of XBP1s did not affect the t-PA expression rate. Our results suggest that CERTS132A- based secretion engineering could be an effective strategy for enhancing recombinant t- PA production in CHO cells.

      • SCOPUSKCI등재
      • KCI등재

        Preparation and modification of nano-porous polyimide (PI) membranes by UV photo-grafting process: Ultrafiltration and nanofiltration performance

        Ahmad Rahimpour 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.1

        Polyimide (PI) membranes were prepared via non-solvent induced phase separation. The prepared PI membranes were modified by ultraviolet light (UV) and graft polymerization of hydrophilic acrylic and amino monomers in the absence and presence of benzophenone (BP) onto the membrane surface to introduce more hydrophilic and lower fouling membranes. Acrylic acid (AA) and 2-hydroxyethylmethacrylate (HEMA) as acrylic monomers, 1,3-phenylenediamine (mPDA) as amino monomer and BP as photo-initiator were used. The unmodified and modified PI membranes were characterized by degree of grafting (DG) and contact angle measurements. They were also characterized by their ultrafiltration performance with pure water and non-skim milk and nanofiltration performance with 500 ppm NaCl and MgSO_4 single solutions. The DG was increased with increasing monomer concentration, especially at presence of BP. The contact angle measurements indicated that hydrophilicity of PI membrane was improved after UV photografting of hydrophilic monomers onto the membrane surface in all cases. The ultrafiltration results showed that the pure water fluxes and milk water permeation of PI membrane declined after monomer photo-grafting while the protein rejection was extremely increased. The decrease in permeability was remarkable in the presence of BP. The mean pore size of base and modified PI membranes ranged from 8.3 to 0.55 nm when calculated from the solute transport data. Moreover, the irreversible flux loss and flux recovery of PI membrane were modified by UV photo-grafting of hydrophilic monomers. All modified membranes showed considerable NaCl and MgSO_4 rejections. In addition, the membrane modified with mPDA at presence of BP showed highest NaCl and MgSO_4 rejections.

      • KCI등재

        Relationship between Hospital Case Mix and Costs and Incomes of Tehran Heart Center

        Hamed Rahimpour Langroudi,Mohammad Jamil Kakhani,Roozbeh Hojabri 한국유통과학회 2017 Asian Journal of Business Environment (AJBE) Vol.7 No.3

        Purpose - Clarifying one of the biggest public Hospital Costs and incomes according to patients’ case mix. It leads to prepare financial information about pubic medical tariffs and hospital operational costs. Research design, data, and methodology - This study calculates the costs both, with and without taking into account capital costs. This holds for comparison of hoteling based on case mix in all medical procedures. The checklists were reviewed and filled by reviewing accounting documents of the hospital, warehouse exclusion list, and daily books of laundry and CSR. Data was analyzed descriptively by using Excel. Results - In both cases, the hospital is losing in terms of hoteling. Because the buildings and equipment are new, this loss is not tangible. However, this will be revealed when costs of reconstruction and replacement of equipment. The loss rate per day of hospitalization was 569318 Rials for Coronary Care Unit (CCU), 528171 Rials for Post Intensive Care Unit (Post ICU), 474570 Rials for ICU, 233183 Rials for Post CCU and 204803 for Surgical ward. Conclusions - Income of hoteling was lower than its costs. ANOVA showed a strong relationship between case mix and hospital costs as well as case mix and its income. This suggests that optimal case mix can minimize the costs and maximize income.

      • KCI등재

        Reduction in CO emissions along a two-stage hydrogen-permselective membrane reactor in methanol synthesis process

        M.R. Rahimpour,M.S. Baktash,B. Vaferi,S. Mazinani 한국공업화학회 2011 Journal of Industrial and Engineering Chemistry Vol.17 No.2

        Carbon monoxide (CO) is a scentless and invisible gas that is quite poisonous. It is also known to be a major environmental pollutant. Industrial chemical processes contribute to CO pollution levels in the atmosphere. One of the most important processes for controlling the carbon monoxide content is conversion of CO to methanol by catalytic hydrogenation. The present work investigates enhancement of CO conversion in a conventional two-stage methanol synthesis reactor using a hydrogen-permselective membrane. For this membrane system, a one-dimensional dynamic plug flow model was proposed in the presence of long-term catalyst deactivation. Thismodel compares CO removal in amembrane two-stage methanol synthesis reactor with a conventional two-stage methanol synthesis reactor. A conventional two-stage reactor is a vertical shell and tube in which the first reactor coolant is saturated water and the second one is cooled with synthesis gas. In a membrane two-stage reactor, the wall of the tubes in the gas-cooled reactor is coated with a Pd–Ag membrane, which only permits the diffusion of hydrogen. For validation of the recommended dynamic model, the measured daily process data of a methanol plant recorded for a period of 4 years were used and a good agreement was obtained.

      • KCI등재

        A novel configuration of decalin and hydrogen loop in optimized thermally coupled reactors in GTL technology via differential evolution method

        M.R. Rahimpour,A. Mirvakili 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2

        In this study, decalin and hydrogen looping approach is proposed in optimized thermally coupled membrane ternary reactors in gas-to-liquid technology (GTL). This novel configuration is named thermally coupled membrane ternary reactor (TCMTR), in which decalin dehydrogenation reaction is coupled with Fischer–Tropsch synthesis (FTS) reactions. Three different reactors are fabricated and integrated with membrane reactor where decalin and hydrogen are produced and utilized simultaneously. Under the optimized operating conditions of TCMTR via differential evolution method,decalin can be properly utilized in this novel configuration as a hydrogen carrier and the required decalin can be produced within the continuous loop and a slight amount of decalin is required for supplementation. 4.77% of the produced hydrogen in the first reactor is utilized in FTS reactions in the second reactor and the remaining 95.23% is utilized in hydrogenation reaction of naphthalene in the third reactor which leads to decalin production as a reactant of the first reactor. A comparison is made between the performances of optimized TCMTR (OTCMTR), conventional tubular reactor (CR) and thermally coupled membrane dual-type reactor (TCMDR). Significant decrease in decalin consumption rate can be achieved in this new scheme, and the hydrogen storage problem and no requirement for injection of fresh feed in each process. The results demonstrate the superiority of OTCMTR to all previously proposed configurations. Furthermore, the hydrogen storage problem is properly addressed by OTCMTR and significant decrease in decalin consumption rate can be achieved in this new scheme.

      • KCI등재

        Modeling of synthesis gas and hydrogen production in a thermally coupling of steam and tri-reforming of methane with membranes

        Hamid Rahnama,Mohammad Reza Rahimpour,Mahdi Farniaei,Mohsen Abbasi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

        In this novel study, tri-reforming process was used as a heat source to proceed steam reforming of methane in a two membrane hydrogen perm-selective Pd/Ag thermally coupled reactor. Results illustrated that H2/CO ratio at the output of steam and tri-reforming sides reached to 6.1 and 0.9, respectively. Additionally the results showed that methane conversion at the output of steam and trireforming sides reached to 31% and 96%, respectively. By increasing the feed flow rate of tri-reforming side from 28,120 to 140,600 kmol h 1, methane conversion and H2 molar flow rate enhanced 40% and 28.64%, respectively.

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