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Homocysteine as a Diagnostic and Etiopathogenic Factor in Children with Autism Spectrum Disorder
Jan Jozefczuk,Wiktoria Kasprzycka,Rafa1 Czarnecki,Alfreda Graczyk,Pawel Jozefczuk,Krzysztof Magda,Urszula Lampart 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.8
Substantial characteristics of autism are cognitive and psychophysical disorders. Etiopathogenetic factors are thought to be responsible for development of autism in children with genetic predisposition as well as have their effect on the severity of the disorders. The main problem of early identification of patients affected by autism spectrum disorder is that there are no clear diagnostic criteria. The aim of our study was assessment of hair magnesium and serum homocysteine concentrations in children with autism. The presented work is a continuation of previous study in which we investigated the influence of disturbances in magnesium and homocysteine levels in children with autism, performed on a new, larger group of patients. One hundred and forty children had hair magnesium levels analyzed, as well as blood serum levels of homocysteine and magnesium. Hair magnesium analysis was performed using a flame atomic absorption spectrometer, blood serum homocysteine determination was performed using a radioimmunological method, and blood serum magnesium level was determined using a biochemical method. Our research showed normal magnesium blood levels and significantly high homocysteine levels and very low hair magnesium levels, low concentration of hair magnesium progresses with age. Our hypothesis is that magnesium deficiency, as a relevant epigenetic factor, might be decreasing methylation of homocysteine, therefore decreasing genome transcription and lowering the synaptic plasticity. We suggest that analysis of hair magnesium and serum homocysteine levels might be useful in identification of children with autism spectrum disorder, as well as control of its treatment. Obtained results and performed analysis might therefore justify supplementation of magnesium among children with autism.
Jan Jozefczuk,Ewa Konopka,Joanna Beata Bier1a,Ilona Trojanowska,Agnieszka Sowin´ska,Rafa1 Czarnecki,Lucjan Sobol,Pawe1 Jo´zefczuk,Weronika Surd,Bo_zena Cukrowska 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.2
There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which is supposed to be the effect of intestinal barrier abnormalities. The aim of study was to evaluate the relation of antibody induced by gluten to zonulin and intestinal fatty acid binding proteins (I-FABP), that is, serological markers of an impaired gut barrier. The study included 77 patients with ASDs. Zonulin, I-FABP, celiac-specific antibodies, anti-gliadin antibodies (AGA), and antibodies against neural transglutaminase 6 (TG6) of immunoglobulin (Ig) A and IgG classes were detected in sera. Celiac-specific antibodies were negative in all ASD children, four children (5.2%) had positive anti-TG6 antibodies, and increased AGA-IgG production was found in 21 patients (27.3%). Mean levels of zonulin and I-FABP in ASD patients were similar to those found in healthy controls and revealed a negative correlation with age, whereas regression analysis revealed a significant positive relationship between antibody production and the age. Serum concentrations of zonulin and I-FABP showed no statistically significant association with antibody positivity. An increased production of antibodies related to gliadin and neural TG6 in ASD children is not related to serological markers of an impaired intestinal barrier.
Rafa, Ramisha Tabassum(라파 라미샤 타바섬),Park, Jihyun(박지현) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.2
The biophilic concept is a sustainable design approach with a broad focus on integrating natural systems with Humans and Architecture by creating and exploring green spaces within built areas in a city fabric frame. Modular built environments have the potential to blend form and spaces by creating accessibility through the pedestrian connection of each form. The ability to physically transform can still be possible by rebuilding a few specific blocks or breaking the existing forms on a grid on the ground floor. Recently the Seoul Metropolitan Government [1] plans to increase urban green spaces by creating more public parks and gardens, allowing citizens to enjoy leisure on weekends without the need to travel to the suburbs. This study aims to explore the patterns of biophilic design and analyze the maximum possibilities using a few elements to improve a selected city block area in Seodaemun-gu, Seoul as a development model. These changes will show what happens to urban functions when we are allowed to make changes to forms in a built area and what can be created from these changes from a biophilic design concept perspective.
Crop Residues Management for Rice-Wheat Cropping System in Saline-Sodic Soil
Ahmed, Khalil,Qadir, Ghulam,Jami, Abdul-Rehman,Rafa, Hafeezullah,Mehmood, Muhammad Aamer,Han, Kyung-Hwa,Ibrahim, Muhammad Korean Society of Soil Science and Fertilizer 2014 한국토양비료학회지 Vol.47 No.4
Series of field experiments were conducted to evaluate the long term effect of gypsum and crop residue on crop yield and soil health in rice-wheat crop rotation system in salt affected soil. A saline-sodic field having $EC_e$ (electrical conductivity of the saturation extract) 4.77 ($dSm^{-1}$); pH ($H_2O$) 8.96; SAR 43.78 ($mmol\;L^{-1}$) and gypsum requirement (G.R.) 2.86 (Mg $acre^{-1}$) was selected on Soil Salinity Research Institute Farm. Five treatments consisting of ($T_1$) control, ($T_2$) gypsum at 100% G.R., ($T_3$) gypsum at 25% G.R. + wheat straw at $3Mg\;ha^{-1}$, ($T_4$) gypsum at 25% G.R. + rice straw at $3Mg\;ha^{-1}$, ($T_5$) gypsum at 25% G.R.+ rice and wheat straw at $3Mg\;ha^{-1}$ were replicated four times under completely randomized block design. The data indicated that grain and straw yield of rice and wheat was significantly (P<0.05) increased by all the amendments used either single or in combination. $T_2$ (gypsum at 100% G.R.) significantly (P<0.05) increased grain and straw yield of rice and wheat crops followed by $T_3$ (gypsum at 25% G.R. + wheat straw at $3Mg\;ha^{-1}$) when compared with control. Soil properties were also improved by used amendments, pronounced decreased in $EC_e$, $pH_s$ and SAR were recorded in $T_2$ followed by $T_3$. The efficiency of the treatments could be arranged in following order gypsum at 100% G.R.> gypsum at 25% G.R. + wheat straw at $3Mg\;ha^{-1}$ > gypsum at 25% G.R. + rice and wheat straw at $3Mg\;ha^{-1}$ > gypsum at 25% G.R. + rice straw at $3Mg\;ha^{-1}$ > control.
Crop Residues Management for Rice-Wheat Cropping System in Saline-Sodic Soil
Khalil Ahmed,Ghulam Qadir,Abdul-Rehman Jami,Hafeezullah Rafa,Muhammad Aamer Mehmood,Kyung-Hwa Han,Muhammad Ibrahim 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.4
Series of field experiments were conducted to evaluate the long term effect of gypsum and crop residue on crop yield and soil health in rice-wheat crop rotation system in salt affected soil. A saline-sodic field having ECe (electrical conductivity of the saturation extract) 4.77 (dS m<SUP>-1</SUP>); pH (H₂O) 8.96; SAR 43.78 (mmol L<SUP>-1</SUP>) and gypsum requirement (G.R.) 2.86 (Mg acre<SUP>-1</SUP>) was selected on Soil Salinity Research Institute Farm. Five treatments consisting of (T₁) control, (T₂) gypsum at 100% G.R., (T₃) gypsum at 25% G.R. + wheat straw at 3 Mg ha<SUP>-1</SUP>, (T₄) gypsum at 25% G.R. + rice straw at 3 Mg ha<SUP>-1</SUP>, (T?) gypsum at 25% G.R.+ rice and wheat straw at 3 Mg ha<SUP>-1</SUP> were replicated four times under completely randomized block design. The data indicated that grain and straw yield of rice and wheat was significantly (P<0.05) increased by all the amendments used either single or in combination. T₂ (gypsum at 100% G.R.) significantly (P<0.05) increased grain and straw yield of rice and wheat crops followed by T₃ (gypsum at 25% G.R. + wheat straw at 3 Mg ha<SUP>-1</SUP>) when compared with control. Soil properties were also improved by used amendments, pronounced decreased in ECe, pHs and SAR were recorded in T₂ followed by T₃. The efficiency of the treatments could be arranged in following order gypsum at 100% G.R.> gypsum at 25% G.R. + wheat straw at 3 Mg ha<SUP>-1</SUP>> gypsum at 25% G.R. + rice and wheat straw at 3 Mg ha<SUP>-1</SUP>> gypsum at 25% G.R. + rice straw at 3 Mg ha<SUP>-1</SUP>> control.
Karol Fija kowski,Pawe Nawrotek,Magdalena Struk,Marian Kordas,Rafa Rakoczy 한국자기학회 2013 Journal of Magnetics Vol.18 No.3
This work presents results of the study which concerns the influence of the rotating magnetic field (RMF) on the growth rate, cell metabolic activity and ability to form biofilms by E. coli and S. aureus. Liquid cultures of the bacteria were exposed to the RMF (RMF frequency f = 1-50 Hz, RMF magnetic induction B = 22-34 mT, time of exposure t = 60 min, temperature of incubation 37℃). The present study indicate the exposition to the RMF, as compared to the unexposed controls causing an increase in the growth dynamics, cell metabolic activities and percentage of biofilm-forming bacteria, in both S. aureus and E. coli cultures. It was also found that the stimulating effects of the RMF exposition enhanced with its increasing frequencies and magnetic inductions.