http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Microflora Modulation of Motility
( Eamonn M M Quigley ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.2
That gastrointestinal motility can influence the gut microbiota has been known for decades and the clinical consequences of impaired motility, in terms of the bacterial population of the small intestine, amply illustrated by the syndrome of small intestinal bacterial overgrowth which so commonly accompanies diffuse intestinal motility disorders. As the importance of the microbiota to homeostasis in health and to a variety of disease states is increasingly appreciated and as the full diversity and biology of this "hidden organ" have been revealed by molecular methodologies, the true nature of the interaction between the microbiota and motility is being re-examined and the complexity of this relationship exposed. In health, as well as in disease states, this is a truly bi-directional relationship: not only can gut motor patterns influence the microbiota but changes in the microbiota can exert profound influences on gut sensori-motor function. (J Neurogastroenterol Motil 2011;17:140-147)
Review : Prokinetics in the Management of Functional Gastrointestinal Disorders
( Eamonn M M Quigley ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.3
A variety of common and some not common gastrointestinal syndromes are thought to be based on impaired gut motility. For some, the role of motility is well defined, for others and the functional gastrointestinal disorders, in particular, the role of hy-po- or dysmotility remains unclear. Over the years pharmacological and physiological laboratories have developed drugs which stimulate gut motility; many have been evaluated in motility and functional disorders with what can best be described as mixed results. Lack of receptor specificity and resultant expected and unexpected adverse events have led to the demise of some of these agents. Newer, more selective agents offer promise but the heterogeneity of the clinical disorders they target continues to pose a formidable challenge to drug development in this area. (J Neurogastroenterol Motil 2015;21:330-336)
Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider
Eamonn M M Quigley 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2
Probiotic products in various formulations are widely used world-wide for a seemingly limitless range of indications––from health maintenance to the alleviation of common intestinal ailments and on to the prevention and treatment of a variety of gastrointestinal diseases and disorders. The profusion of probiotic preparations, together with a very different regulatory climate compared to that which surrounds drugs and devices, leaves the consumer and the health care professional alike bewildered. How can they tell which products truly are what they claim to be? Which probiotics should be chosen for a particular clinical situation? These questions are thrown into stark relief when one evaluates the literature on probiotics in irritable bowel syndrome. To provide some guidance the current probiotic landscape is reviewed and some achievable steps to help bring light to a murky environment are proposed. The goal is to promote verifiable quality control and generate actionable evidence from well-conducted clinical trials of probiotic products in irritable bowel syndrome.
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective
( Fanny Giron ),( Eamonn M M Quigley ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.3
The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract--the gut microbiota. As our understanding of the role of the microbiota in health and human disease increases, so also do efforts to prevent and treat disease through the modulation of the microbiota. Several strategies are available to us and range from time honored approaches, such as antibiotics and probiotics, to changes in diet, the administration of prebiotics as food supplements, and fecal microbiota transplantation. Of these, diet is perhaps the most pervasive but often ignored modulator of the microbiota, and a failure to recognize its impact complicates the interpretation of many microbiota studies. The impacts of antibiotics on the microbiota are more complex than originally thought and, though antibiotics can be life-saving, their effects on commensal bacterial populations can be clinically significant. Though there have been many studies of, and even more claims made for, probiotics, the majority of available studies suffer from significant deficits in study design and execution and many claims remain to be substantiated. Though holding much promise, the study of prebiotics in human disease is still in its infancy. Possibilities other than the administration of live organisms have been identified through efforts to mine the microbiota for novel therapeutics and include: dead organisms, bacterial components, small molecules elaborated by bacteria, and even bacterial DNA. Accordingly, the term pharmabiotic has been introduced to encompass the full range of therapeutic possibilities that the microbiota offers. (J Neurogastroenterol Motil 2018;24:355-366)
Social Rhythms and Nocturnal Routines in Community Dwelling Older Adults
Julie Behan,David Prendergast,Lorcan Wals,Brenda Quigley 한국과학기술원 인간친화 복지 로봇 시스템 연구센터 2008 International Journal of Assistive Robotics and Me Vol.9 No.4
This paper describes a pilot carried out by The Digital Health Group in Intel, in which daily social rhythms of community dwelling older adults were examined and related to objectively and subjectively recorded sleep measurements. Ten relatively healthy independently living older adults were interviewed using ethnographic processes to determine a baseline of social activities, behaviours and nocturnal sleeping routines. Each home was fitted with six sensing elements to establish and monitor daily and nocturnal activities. Social behaviours were explored through social contact through phone conversation and human interaction, through mobility, inside and outside the home, and through a person's self reported internal state (how they feel each day). Nocturnal rhythms were examined through actigraph watches and bed pressure sensing devices. A preliminary sub-set of the results are presented in this paper in the form of case studies showing subjective and objective data sets and their comparison to social routines.
Social Rhythms and Nocturnal Routines in Community Dwelling Older Adults
Julie Behan,David Prendergast,Lorcan Walsh,Brenda Quigley 동국대학교 정보융합기술원 2008 International Journal of Assistive Robotics and Sy Vol.9 No.4
This paper describes a pilot carried out by The Digital Health Group in Intel, in which daily social rhythms of community dwelling older adults were examined and related to objectively and subjectively recorded sleep measurements. Ten relatively healthy independently living older adults were interviewed using ethnographic processes to determine a baseline of social activities, behaviours and nocturnal sleeping routines. Each home was fitted with six sensing elements to establish and monitor daily and nocturnal activities. Social behaviours were explored through social contact through phone conversation and human interaction, through mobility, inside and outside the home, and through a person’s self reported internal state (how they feel each day). Nocturnal rhythms were examined through actigraph watches and bed pressure sensing devices. A preliminary sub-set of the results are presented in this paper in the form of case studies showing subjective and objective data sets and their comparison to social routines.