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黃全?(Huang Quanyan),鄭劍平(Zheng Jianping) 동아인문학회 2013 동아인문학 Vol.26 No.-
Li Tiaoyuan,a SiChuan’s gifted scholar in Qing dynasty, he very loved BaShu Culture. On early Qing dynasty, BaShu’s Culture faced destitution, Li Tiaoyuan t printed many books to revived Shu Xue. He gathered Shu people’s works widespread. He preserved BaShu’s documents, he also writed many poets to extol BaShu. At the same time, he supported BaShu’s drama, On modern time, his supportion had his own meaning. Li Tiaoyuan’s contribution to BaShu culture had more consultion and inspiration to us, it was worth to study hard.
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Resilient Control in the Presence of DoS Attack: Switched System Approach
Yuan Yuan,Fuchun Sun,Quanyan Zhu 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.6
This paper studies the switched resilient control of the Cyber-Physical Systems (CPSs) under Denial-of-Service (DoS) attack. We interpret the term ‘resilience’ as the ability to be both robust to the external disturbances in the physical layer, and defending against DoS attacks in the cyber layer. A hybrid-theoretical framework is proposed which is comprised of a physical control subsystem, a cyber security subsystem, and an interface which integrates the control design with the security configuration. Within this framework, the controller will switch in accordance with the competing result of the cyber attacker and defender. Our approach highlights the interaction between the physical control layer and cyber security layer and achieves the goal of coupled design. Some algorithms are provided to obtain the so-called joint defense strategies. Finally, the proposed method is applied to the voltage regulation of the Uninterrupted Power System (UPS).
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Chen Aimei,Liu Zhiqiang,Wu Quanyan,Li Hailin 한국유전학회 2021 Genes & Genomics Vol.43 No.8
Background Disheveled-associated activator of morphogenesis (DAAM) family, including DAAM1 and DAAM2, is key regulators in Wnt signaling pathway. Although the oncogenic role of Wnt signaling pathway in colorectal cancer (CRC) was investigated in several lines, the expression and function of DAAM in CRC are still obscure. Objective To investigate the expression and function of DAAM in CRC. Methods DAAM1 and DAAM2 expression in high grade dysplasia (HGD), CRCs and corresponding adjacent tissues were detected with qRT-PCR and immunohistochemistry (IHC). The prognostic signifcance of DAAM1/2 were estimated with univariate and multivariate analyses. Moreover, the correlations between clinicopathological factors and DAAM were evaluated with the χ2 test. With experiments in vitro, we investigated the function of DAAM2 in CRC cell proliferation and invasion, and investigated the underlying mechanism of how DAAM2 facilitated CRC invasion. Results DAAM2, instead of DAAM1, was substantially up-regulated in CRCs compared with paired adjacent normal tissues and HGDs. The ratio of high DAAM1 and DAAM2 expression accounted for 44.83% and 46.31%, respectively. High DAAM2, instead of DAAM1, was a risk factor indicating an unfavorable prognosis of CRC. In multivariate analysis, high DAAM2 was identifed as an independent prognostic biomarker of CRC predicting poor prognosis. With experiments in vitro, DAAM2 promoted invasion of CRC cells via activating PAK1 and promoting the expression of MMP7, suggesting an essential role of DAAM2 in CRC invasion. Conclusions High expression of DAAM2, instead of DAAM1, indicated an unfavorable prognosis of CRC independently, which suggested that detecting DAAM2 can help defne the high-risk patients. DAAM2 activated PAK1 and promoted MMP7 expression and facilitated the invasion of CRC cells, indicating that DAAM2 may be a potential drug target of CRC.
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