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      • KCI등재

        Performance-Based Seismic Design of Corrugated Steel Plate Shear Walls

        Qiuhong Zhao,Jing Qiu,Yu Zhao,Cheng Yu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8

        Corrugated steel plate shear walls (CoSPSWs) consist of corrugated steel wall plates and a steel boundary frame, which could be adopted as seismic-resistant systems for high-rise buildings. In this study, a performance-based seismic design (PBSD) method was proposed for CoSPSWs, in which an ideal yield mechanism and target drifts were selected as performance objectives to evaluate and control the inelastic behavior of the system. Two 10-story CoSPSW structures were then designed with the PBSD method and the traditional method respectively, and static pushover analyses as well as nonlinear dynamic time-history analyses were conducted on both structures. It turned out that the CoSPSW structure designed with the PBSD method presented the ideal yield mechanism, all inter-story drifts were well below the target drift of 2.5%, and the drifts distributed more smoothly under rare earthquakes. Structural and nonstructural fragility curves of both CoSPSW structures were obtained through probabilistic seismic demand analysis using Incremental Dynamic Analyses. The results showed that for the structural repair states of RS1 to RS5, the 25th percentile PGA values of the fragility curves of the CoSPSW structure designed with the PBSD method were 220%, 98%, 84%, 51% and 13% higher than the CoSPSW structure designed with the traditional method, respectively. For the nonstructural damage states of Slight to Complete, the 25th percentile PGA values of the fragility curves of the CoSPSW structure designed with the PBSD method were 145%, 98%, 36%, and 7% higher than the CoSPSW structure designed with the traditional method, respectively. Therefore, CoSPSW structure designed with the PBSD method had lower seismic vulnerability as well as probability of nonstructural damage.

      • KCI등재후보

        Seismic Behavior of Composite Shear Wall Systems and Application of Smart Structures Technology

        Qiuhong Zhao,Abolhassan Astaneh-Asl 한국강구조학회 2007 International Journal of Steel Structures Vol.7 No.1

        Shear wall systems are one of the most comonly used lateral load resisting systems in high-rise buildings. This paperconcentrates on the experimental and analytical studies of two composite shear wal systems and presents a sumary anddiscussion of research results. In addition, the paper discusses application of smart structures technology into the design of thesesystems. The composite shear wal system studied herein consists of a steel boundary frame and a steel plate shear wall withe reinforced concrete wal by bolts. In the system caled “traditional” the reinforced concrete wall is in direct contact withthe boundary stel frame, while in the system caled “innovative” there is a gap in betwen.

      • KCI등재후보

        Seismic Behavior of Steel Shear Wall Systems and Application of Smart Structures Technology

        Qiuhong Zhao,Abolhassan Astaneh-Asl 한국강구조학회 2007 International Journal of Steel Structures Vol.7 No.1

        Stel shear walls have been used more frequently in recent years as the lateral load resisting system in the design and retrofitof high-rise buildings. This paper concentrates on the experimental studies of an innovative steel shear wal system used intechnology into the design of steel shear wall system. The steel shear wall system studied herein consists of steel plate shearwalls welded inside a multi-bay steel moment frame. The steel moment frame consists of large concrete filed steel tubes (CFT)at the edges, internal wide flange (WF) columns, and horizontal WF beams. Most of the gravity load is resisted by the CFTcolumns, and lateral loads are resisted by the dual system consisting of the moment frame and the steel plate shear wall.

      • KCI등재

        Analysis of treatment modalities and prognosis on microinvasive cervical cancer: a 10-year cohort study in China

        Qiuhong Qian,Jiaxin Yang,Dongyan Cao,Yan You,Jie Chen,Keng Shen 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4

        Objective: To explore appropriate treatment modality of microinvasive cervical cancer (MIC) and to analyze prognosis and risk factors of recurrence. Methods: A cohort of 324 Chinese patients with MIC diagnosed and treated at Peking Union Medical College Hospital was retrospectively reviewed. Demographic features, treatment modalities, pathologic parameters, risk factors of residual disease, survival and risk factors of recurrence were analyzed. Results: Of all patients, 280 cases were staged IA1 and 44 cases staged IA2 MIC. Twenty-five cases (7.7%) were found to have lympho-vascular space involvement (LVSI), but no parametrial involvement or ovarian metastasis was detected. Only one staged IA2 patient with LVSI was found to have lymph node metastasis. 32.4% patients (82/253) had residual diseases after conization. No significant difference of LVSI, lymph node metastasis and residual disease after coniztion was found between stage IA1 and IA2 MIC patients. Multivariate logistic analysis showed positive margin was the only independent risk factor of residual disease after conization (odds ratio [OR], 4.18; p<0.001). Recurrence occurred in five cases, but no mortality was found. Progression-free survival for stage IA1 patients treated by conization or hysterectomy was similar (92.3% and 98.8%, p=0.07). Cox regression analysis revealed LVSI as an independent risk factor for recurrence in stage IA1 patients (OR, 12.14; p=0.01). Conclusion: For stage IA1 patients with negative resection margin and no LVSI, conization can be an ideal treatment modality. For stage IA2 patients, more conservative surgery such as simple hysterectomy may be considered. LVSI is an independent risk factor for recurrence in patients with stage IA1 cervical cancer.

      • KCI등재

        Estimating Fundamental Period of Corrugated Steel Plate Shear Walls

        Qiuhong Zhao,Jing Qiu,Yu Zhao,Cheng Yu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.10

        Corrugated steel plate shear walls (CoSPSWs), which consist of corrugated infill steel wall panels and steel boundary frames, could be used as lateral force-resisting systems for mid- to high-rise buildings. In seismic design, the fundamental vibration period is generally estimated by empirical formulae corresponding to different types of lateral force-resisting systems. However, both the formulae in various design specifications and improved formulae proposed recently for steel shear walls with flat wall panels were not suitable and accurate for CoSPSWs since the difference in the load-carrying mechanism of steel shear walls with flat and corrugated wall panels respectively. Eigenvalue frequency analyses were conducted on a total of 60 validated CoSPSW finite element models with varying geometries, and results showed that fundamental periods estimated by current formulae were shorter than periods from the analyses, which might lead to the over-conservative and uneconomic design. Improved empirical formula was proposed for the fundamental period of CoSPSWs based on regression analyses. Simplified calculation method for calculating the fundamental period of CoSPSWs after the first trial design was proposed using the shear-flexure cantilever formulation, and validated through finite element analyses. Furthermore, influences of major geometric properties of CoSPSWs on the fundamental period was investigated.

      • KCI등재

        Fabrication of Aligned PI/GO Nanofibers for Battery Separators

        Qiong Tian,Qiuhong Liu,Kedong Song,Yufan Mei,Jinfeng Peng,Jinfeng Peng,Ji Zhou,Yanhuai Ding 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1

        Highly aligned polyimide/graphene oxide (PI/GO) nanofibers were fabricated by using the electrospinning method. As a separator for Li-ion batteries, the PI/GO nanofibers show excellent thermal stability, good wettability toward organicliquid electrolytes and superior electrochemical performance compared to raw PI and commercial battery separators. TheGO nanosheets not only greatly enhance the mechanical strength of the PI matrix, but also increase the resistance to Lidendrites.

      • KCI등재

        Optimization on Anthocyanins Extraction from Wine Grape Skins Using Orthogonal Test Design

        Zheng Li,Qiuhong Pan,Xiangyun Cui,Changqing Duan 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.4

        To optimize the extraction of anthocyanins from grape skins, orthogonal test with 4 factors and 3 levels was designed and the analysis of extracts was conducted using high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The results showed that the optimal extraction for obtaining the highest amounts of anthocyanins was carried out by formic acid/methanol solvent (5/95, v/v), with ultrasonication for 10 min, extraction temperature at 25℃, and extraction time for 1.5 hr. The precision and accuracy of this method were established. This work will provide a basis for further study involving in anthocyanins of grape berries.

      • KCI등재

        Advances in plant-derived natural products for antitumor immunotherapy

        Yi Yang,Qinying Liu,Xianai Shi,Qiuhong Zheng,Li Chen,Yang Sun 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11

        In recent years, immunotherapy has emergedas a novel antitumor strategy in addition to traditional surgery,radiotherapy and chemotherapy. It uniquely focuses onimmune cells and immunomodulators in the tumor microenvironmentand helps eliminate tumors at the root by rebuildingthe immune system. Despite remarkable breakthroughs,cancer immunotherapy still faces many challenges: lack ofpredictable and prognostic biomarkers, adverse side eff ects,acquired treatment resistance, high costs, etc. Therefore,more effi cacious and effi cient, safer and cheaper antitumorimmunomodulatory drugs have become an urgent requirement. For decades, plant-derived natural products obtainedfrom land and sea have provided the most important sourcefor the development of antitumor drugs. Currently, moreattention is being paid to the discovery of potential cancerimmunotherapy modulators from plant-derived naturalproducts, such as polysaccharides, phenols, terpenoids, quinonesand alkaloids. Some of these agents have outstandingadvantages of multitargeting and low side eff ects and lowcost compared to conventional immunotherapeutic agents.

      • SCIESCOPUSKCI등재

        Effect of Glucagon-like Peptide 2 on Tight Junction in Jejunal Epithelium of Weaned Pigs though MAPK Signaling Pathway

        Yu, Changsong,Jia, Gang,Jiang, Yi,Deng, Qiuhong,Chen, Zhengli,Xu, Zhiwen,Chen, Xiaolin,Wang, Kangning Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.5

        The glucagon-like peptide 2 (GLP-2) that is expressed in intestine epithelial cells of mammals, is important for intestinal barrier function and regulation of tight junction (TJ) proteins. However, there is little known about the intracellular mechanisms of GLP-2 in the regulation of TJ proteins in piglets' intestinal epithelial cells. The purpose of this study is to test the hypothesis that GLP-2 regulates the expressions of TJ proteins in the mitogen-activated protein kinase (MAPK) signaling pathway in piglets' intestinal epithelial cells. The jejunal tissues were cultured in a Dulbecco's modified Eagle's medium/high glucose medium containing supplemental 0 to 100 nmol/L GLP-2. At 72 h after the treatment with the appropriate concentrations of GLP-2, the mRNA and protein expressions of zonula occludens-1 (ZO-1), occludin and claudin-1 were increased (p<0.05). U0126, an MAPK kinase inhibitor, prevented the mRNA and protein expressions of ZO-1, occludin, claudin-1 increase induced by GLP-2 (p<0.05). In conclusion, these results indicated that GLP-2 could improve the expression of TJ proteins in weaned pigs' jejunal epithelium, and the underlying mechanism may due to the MAPK signaling pathway.

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