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Qin, Yi,Chen, Jing,Li, Li,Liao, Chun-Jie,Liang, Yu-Bing,Guan, En-Jian,Xie, Yu-Bo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Morphine is not only an analgesic treating pain for patients with cancer but also a potential anticancer drug inhibiting tumor growth and proliferation. To gain better insight into the involvement of morphine in the biological characteristics of gastric cancer, we investigated effects on progression of gastric carcinoma cells and the expression of some apoptosis-related genes including caspase-9, caspase-3, survivin and NF-${\kappa}B$ using the MGC-803 human gastric cancer cell line. The viability of cells was assessed by MTT assay, proliferation by colony formation assay, cell cycle progression and apoptosis by flow cytometry and ultrastructural alteration by transmission electron microscopy. The influences of morphine on caspase-9, caspase-3, survivin and NF-${\kappa}B$ were evaluated by semi-quantitative RT-PCR and Western blot. Our data showed that morphine could significantly inhibit cell growth and proliferation and cause cell cycle arrest in the G2/M phase. MGC-803 cells which were incubated with morphine also had a higher apoptotic rate than control cells. Morphine also led to morphological changes of gastric cancer cells. The mechanism of morphine inhibiting gastric cancer progression in vitro might be associated with activation of caspase-9 and caspase-3 and inhibition of survivin and NF-${\kappa}B$.
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Ontology-Based Exchange of Product Data Semantics between CAD and CAE
Qinyi Ma,Yajun Wang,Yan Lv,Xin Jin,Maojun Zhou 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12
The interoperation of various applications will need a representation that goes beyond the traditional geometry-based one, which is inadequate for capturing semantic information. This paper proposes an approach to annotate the CAD models based on ontology with the aim of making the design intent understood by computer and applied in engineering analysis, such as FEA. The paper presents the design domain ontology and FEA domain ontology, and applies feature technologies and the semantic Web to complete annotation. Semantic markup can embed the engineering semantic information such as product function, and design principle into the CAD geometry data through annotating, it makes the analyzers reuse design ideas quickly and conveniently to increase efficiency. The semantic file is proposed to support an exchange of product data semantics between CAD and CAE. The main idea of the approach is presented and key technologies are elaborated, including the creation of the FEA solution template, and the matching algorithm between semantic markup file and FEA template file. Finally, the feasibility and effectiveness of the approach is empirically validated by a case study.
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Framework for automated finite element analysis with an ontology-based approach
Wei Sun,Qinyi Ma,Shuang Chen 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.12
To obtain accurate and reliable results of finite element analysis (FEA) requires a high level of expertise and the fullscale physical context information, which are bottlenecks restricting the application of achievements of FEA in industry. This paper proposes an ontology-based framework including a hierarchy transfer approach and a three-stage automated finite element analysis method to solve these problems. The hierarchy transfer approach is proposed to create different transfer formats according to the data, information, and knowledge, to carry out the integration at different levels. The knowledge found in design and FEA theories is presented by ontology in order to uniformly describe the physical phenomenon with the same semantic meanings. This involves the development of a shared design and FEA ontology, as well as, specific application ontologies in the Ontology Web Language (OWL). The three-stage automated finite element analysis method is applied to mark up artifact in problem definition, to reuse domain knowledge in problem formulation, and to enable the automation of the FEM analysis process in the solution routine with the application of AI techniques. The feasibility and effectiveness of the framework and concepts are empirically validated by a case study.
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Research on flexible job-shop scheduling problem based on a modified genetic algorithm
Wei Sun,Ying Pan,Xiaohong Lu,Qinyi Ma 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.10
Aiming at the existing problems with GA (genetic algorithm) for solving a flexible job-shop scheduling problem (FJSP), such as description model disunity, complicated coding and decoding methods, a FJSP solution method based on GA is proposed in this paper, and job-shop scheduling problem (JSP) with partial flexibility and JIT (just-in-time) request is transformed into a general FJSP. Moreover, a unified mathematical model is given. Through the improvement of coding rules, decoding algorithm, crossover and mutation operators,the modified GA’s convergence and search efficiency have been enhanced. The example analysis proves the proposed methods can make FJSP converge to the optimal solution steadily, exactly, and efficiently.
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Zhiyun Zhang,Jian Wang,Weiping Wan,Zhengchao Shen,Aixue Zuo,Rong Chen,Qinyi Wu,Enli Cai,Feng Huang,Rongping Zhang,Xinan Shi 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1
Hepatocellular carcinoma (HCC) is a frequently occurring malignant gastrointestinal cancer. The 5-year survival rate of HCC is still below 8%, and thus, identifying more effective therapeutic methodsis needed. Here, we evaluated the effects of Stigmast-4-en-6β-ol-3-one (S463) on the viability andcolony formation of liver cancer cells. S463 treatment decreased the viability and inducedapoptosis and ferroptosis in liver cancer cells, and also increased cellular malondialdehyde(MDA) and lipid peroxidation levels. In S463 treated cells, the expression level of Bax wasincreased, and the expression level of GPX4 was reduced, and the cleavage of PARP wasimproved. We also found that S463 treatment downregulated E2F1 and upregulated p53 atboth the mRNA and protein levels. Importantly, rescue experiments revealed thatoverexpression of E2F1 partially restored S463-induced Bax and p53 upregulation and GPX4downregulation and counteracted the S463-induced decrease in cell viability and colonyformation and the S463-induced increase in MDA and lipid peroxidation levels. Our findingssuggest that S463 significantly inhibits viability and colony formation and induces apoptosisand ferroptosis in liver cancer cells via E2F1.
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