중국의 固體廢物汚染放置法

노청석,최동일 한국환경법학회 2004 環境法 硏究 Vol.26 No.3

This is a study on the Act on the Control of Solid Wastes of China. An outlines of this study is as follows : China is called as ‘factory of the world’ lately due to economy development which is caused by reform and opening policy, practical economy policy. In economy development process, China government is getting into trouble about the control of solid wastes. Developing Cities yield refuses of life, industrial wastes, dangerous wastes. Its disposal is connected directly with cities' survival. In order to solve this problem, Government have established 'Act on the Control of Solid Wastes' which is fundamental Act on solid wastes disposal in 1995, and 'Interim regulation on the Environment Protection Control of Waste Import', 'Regulation on the Control of Medical Waste', 'Measures on the Control of City's Radiation', 'Act on the Control of Radiation Pollution', 'Measures on the Control of Medical Instrument and Waste' and so on. These statutory laws adopted 'reclamation' as a main disposal means, but will adopt 'incineration' in future. And special provisions have been established for dangerous wastes and radiation wastes. Government will expand investment in this part. But most important policy is prior protection. We must make an effort to reduce a waste and recycle for sound and sustainable development.

Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex

Dong Qing Zha,Cheng Chen,Cheng Chen,Xing Hua Chen,Tean Ma,Hong Xia Yang,Harry Van Goor,Guo Hua Ding 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.4

SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells

Qing-Qing Dong,Qiu-Tong Wang,Lei Wang,Ya-Xin Jiang,Mei-Ling Liu,Hai-Jie Hu,Yong Liu,Hao Zhou,Hong-Peng He,Tong-Cun Zhang,Xuegang Luo 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4

Sulforaphane (SFN), a natural compound derived from cruciferous vegetables, has been proved to possess potent anti-cancer activity. SMYD3 is a histone methyltransferase which is closely related to the proliferation and migration of cancer cells. This study showed that SFN could dose-dependently induce cell cycle arrest, stimulate apoptosis, and inhibit proliferation and migration of gastric carcinoma cells. Accompanied with these anticancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN. Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN. To the best of our knowledge, this is the first report describing the role of SMYD3 in the anti-cancer of SFN. These findings might throw light on the development of novel anti-cancer drugs and functional food using SFN-rich cruciferous vegetables.

Biomechanical Role of Nucleotomy in Vibration Characteristics of Human Spine

Qing-Dong Wang,Li-Xin Guo 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.7

Nucleotomy is a common surgical procedure for the treatment of lumbar diseases. It may accelerate degeneration in the operated disc and decreased segmental stability, and this has been widely concerned by scholars for many years. However, under whole-body vibration, nucleotomy how to affect the vibration characteristics of the lumbar spine and complications is urgent to know. A three-dimensional nonlinear osteoligamentous finite element model of the intact L1-sacrum lumbar spine with muscles was established, and the nucleus of the L4–L5 disc was removed in the nucleotomy model. The lower surface of the sacrum was fully constrained for all models. A 5 Hz, 40 N sinusoidal vertical load supplemented with a 400 N preload was applied at L1 to simulate the vertical vibration of the human body. The results showed that nucleotomy increased the dynamic responses of the discs such as stress in the annulus ground substance and intradiscal pressure both in the maximum value and vibration amplitude. The maximum endplate stresses and corresponding vibration amplitudes of the denucleated L4–L5 level increased because of nucleotomy. Nucleotomy decreased the maximum response values of disc height and segmental lordosis but increased the corresponding amplitudes. Therefore, these findings imply that nucleotomy may increase the risk of developing complications such as disc degeneration, adjacent segment disease, endplate degeneration, lumbar instability, nerve root compress, isthmic spondylolisthesis, and lumbar disc herniation under whole-body vibration. This study reveals insights into the effect of the nucleotomy on the vibration characteristics of the lumbar spine and provides new information toward the relationship between nucleotomy and complications.

Combination of TEM and 3D Atom Probe Study of Microstructure and Alloy Carbide in a Nb-V Micro-Alloyed Steel Tempered at 650℃

Qing-dong Liu,Wen-qing Liu,Shi-jin Zhao 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.4

3D atom probe (3DAP) combined with TEM is applied to characterize the nanostructure and composition of coarsening carbides that precipitate in a Nb-V micro-alloyed steel tempered at 650 °C for 4 h. The results indicate that high temperature tempering of the as-quenched lath-like martensitic structures leads to the coarsening of alloyed carbide in the recovered ferritic matrix. TEM characterization and EDS analysis show that the alloy carbides are typically spherical or ellipsoidal and are enriched with V, Nb and Mo. Crystallographic lattice overlap and distortion create a distinct optical Moiré pattern at the carbide/matrix boundary, as observed by HRTEM. 3DAP gives the compositional distribution at atomic scale in the coarsening carbide and the surrounding matrix. Non-carbide-forming elements such as Si and Al are depleted in the carbide and are enriched at the carbide/matrix heterophase interface. Carbide-forming elements such as Mn, V, Mo and Nb distribute heterogeneously in the whole carbide, leading to the formation of a Mn-, V- and Mo-enriched core and Mo-enriched external shell.

Maximum likelihood estimation method for dual-rate Hammerstein systems

Dong-Qing Wang,Zhen Zhang,Jin-Yun Yuan 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.2

For a dual-rate sampled Hammerstein controlled autoregressive moving average (CARMA) system, thispaper uses the polynomial transformation technology to obtain its dual-rate bilinear identification model whichis suitable for the available dual-rate sampled-data, uses the maximum likelihood principle to construct a unifiedparameter vector of all parameters and an information vector formed by the derivative of the noise variable tothe unified parameter vector, and directly identifies the parameters of the linear block and the nonlinear blockfor the dual-rate Hammerstein CARMA system. The unified parameter vector contains the minimum number ofthe unknown parameters, and the proposed maximum likelihood estimation algorithm has higher computationalefficiency than the over-parameterization model based least squares algorithm.

Risk assessment of remanufacturing arm structure for crane based on potential failure mode

Qing Dong,Gening Xu,Huili Ren 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.12

For the risk of remanufacturing arm structure with multi-coupling defects and the correlation and influence between risks factors, thejib structure risk evaluation theory based on improved DEMATEL method (JSRET-IDM) is presented to build a risk assessment modelfor jib structure in accordance with potential failure modes and to develop a risk assessment system of remanufacturing jib structures formobile crane. Failure performance datum of jib structure in service being collected, researched, and analyzed, the mechanical property,notch-crack and welding performance are backdated under characteristic parameters and typical service conditions to set up the failuremodes database. Testing positions and points can be determined according to the database. The direct and indirect influence fuzzy relationmatrixes between testing points or evaluation indexes are established by IDM to deduce influence matrixes and affected matrixes ofevery evaluation index, aiming at obtaining the centrality and reason degree being used to determine weighting factor of each index basedupon making an analysis of the correlation and influence of the indexes. Accordingly, combined with FSET, the failure risk can be easilyquantified. Using it as a base, the risk system is developed to realize the real-time, accurate and rapid assessment of the failure risk for jibstructure. Taking QY130 remanufacturing arm structure as an example, the effectiveness and scientificity of the proposed method andsystem are verified.

Isomeric Folate-Conjugated Polymeric Micelles Bind to Folate Receptors and Display Anticancer Effects

Dong, Qing,Xie, Zuo-Xu,Xie, Cao,Lu, Wei-Yue,Zhang, Qian,Li, Xue,Liu, Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

The present study aimed to prepare and evaluate polymeric micelles conjugated with folic acid through ${\alpha}$- or ${\gamma}$-carboxyl groups for antitumor efficacy. The isomeric block copolymers, ${\alpha}$- and ${\gamma}$-folate-polyethyleneglycol-distearoyl phosphatidylethanolamine (${\alpha}$- and ${\gamma}$-Fol-PEG-DSPE), were produced by solid phase peptide synthesis. Three types of doxorubicin (DOX)-loaded polymeric micelles (MPEG-DSPE-DOX and ${\alpha}$- / ${\gamma}$-Fol-PEG-DSPEDOX micelles) were prepared via the film formation method. Compared with MPEG-DSPE-DOX micelles, the ${\alpha}$- / ${\gamma}$-Fol-PEG-DSPE-DOX micelles presented a higher cellular uptake behavior in the live cell study. Cell viability percentages were 81.8%, 57.3%, 56.6% at 2 hours for MPEG-DSPE-DOX, ${\alpha}$- and ${\gamma}$-Fol-PEG-DSPE-DOX micelles, respectively (p<0.05). Using the KB xenograft tumor model, both ${\alpha}$- and ${\gamma}$-folate-conjugated micelles were found to have better antitumor effects with lower toxicity in comparison with MPEG-DSPE-DOX micelles. No difference in in vivo antitumor efficacy was found between ${\alpha}$- and ${\gamma}$-Fol-PEG-DSPE-DOX micelles. The folate-conjugated micelles might be a potentially useful strategy for tumor targeting of therapeutic agents, whether grafting with folic acid through ${\alpha}$- or ${\gamma}$-carboxyl groups.

Data Filtering based Least Squares Algorithms for Multivariable CARAR-like Systems

Dong-Qing Wang,Feng Ding,Da-Qi Zhu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.4

This paper focuses on the identification problem of multivariable controlled autoregressive autoregressive (CARAR-like) systems. The corresponding identification model contains a parameter vector and a parameter matrix, and thus the conventional least squares methods cannot be applied to directly estimate the parameters of the systems. By using the hierarchical identification principle, this paper presents a hierarchical generalized least squares algorithm and a filtering based hierarchical least squares algorithm for the multivariable CARAR-like systems. The simulation results show that the two hierarchical least squares algorithms are effective.

Analysis on Response Prediction of a Single Pile and Pile Groups Based on the Runge-Kutta Method

Dong-dong Pan,Qian-qing Zhang,Shan-wei Liu,Shi-min Zhang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.1

The conventional load-transfer approach can not consider the interaction of piles, and can not be directly used in the analysis of the response of pile groups. The interactive effects among piles can be taken into account in the shear displacement method based on the principle of superposition. In the present analysis, the shaft displacement of a single pile at a given depth is assumed to be composed of the pile-soil relative displacement developed at the disturbed soil around pile and the elastic vertical soil displacement developed in the soil mass. A new load-transfer function which is very similar to a hyperbolic model is then established to describe the relationship between unit skin friction and shaft displacement at a given depth. Furthermore, a hyperbolic model is used to simulate the relationship between unit end resistance and pile end displacement. As to the analysis of the response of pile groups, the interactive effects among piles are considered by using the shear displacement method. For an individual pile in pile groups, new load-transfer functions are established to capture the relationship between unit skin friction and shaft displacement and the relationship between end resistance and pile end displacement. Based on the fourth order Runge-Kutta method, a modified loadtransfer method is proposed to analyze the response of pile groups considering the interactive effects among piles. The reliability of the present method is checked by using comparisons of the present calculated results, the measured results and the computed values derived from other methods.