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Chun Yan Gao,Qi Lu,Hyoung Jin Choi,Nam Hui Kim,Chun Yeol You 한국자기학회 2019 Journal of Magnetics Vol.24 No.1
Magnetic Fe₃O₄@polystyrene (PS) nanoscale composite particles were fabricated using a unique Shirasu porous-glass membrane technique and used as additives to a magnetorheological (MR) suspension with magnetic carbonyl-iron (CI) particles. The morphology of the fabricated Fe₃O₄@PS composites was characterized by transmission electron microscopy. The effects of the Fe₃O₄@PS composite particle additive on its MR behavior was examined using a rotation rheometer under an applied magnetic field. The results revealed improved MR behavior, such as higher storage and loss moduli, and elastic yield stress compared to those of the pure CIbased MR suspension under an external magnetic field.
In vitro Chemosensitivity in Breast Cancer Using ATP-tumor Chemosensitivity Assay
Chun-Jian Qi,Yong-Ling Ning,Yu-Lan Zhu,Hai-Yan Min,Heng Ye,Ke-Qing Qian 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
Chemotherapy for breast cancer is given on the basis of empirical information from clinical trials, an approach which falls to take into account the known heterogeneity of chemosensitivity between patients. This study aimed to demonstrate the degree of heterogeneity of chemosensitivity in breast cancers. In this study, we examined the heterogeneity of chemosensitivity in breast cancer specimens (n = 50) using an ex vivo ATP-tumor chemosensitivity assay (ATP-TCA). Assay evaluability was 92% in surgical biopsies or pleural aspirates. A variety of chemosensitivity agents were tested. We found that the most active single agent tested was paclitaxel, to which 65.9% of samples were sensitive. Combinations of agents also showed more strong sensitivity cases. The Adriamycin+5-FU demonstrated a strong sensitivity in 23 of 43 (52.3%) of samples. Adriamycin+paclitaxel was more effective, with strong sensitivity in 37 of 43 cases tested (86.0%). There was a marked heterogeneity of chemosensitivity in breast cancer. Chemosensitivity testing may provide a practical method of testing new regimens before clinical trials in breast cancer patients.
Wan, Chun,Shen, Yong-Chun,Liu, Meng-Qi,Yang, Ting,Wang, Tao,Chen, Lei,Yi, Qun,Wen, Fu-Qiang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
The diagnosis of malignant mesothelioma (MM) remains a clinical challenge and the fluorescence in situ hybridization (FISH) assay has been reported to be one promising tool. The present meta-analysis aimed to establish the overall diagnostic accuracy of FISH for diagnosing MM. After a systematic review of English language studies, the sensitivity, specificity and other measures of accuracy of FISH in the diagnosis of MM were pooled using random-effects models. Summary receiver operating characteristic curves were applied to summarize overall test performance. Nine studies met our inclusion criteria, the pooled sensitivity and specificity for FISH for diagnosing MM being 0.72 (95% CI 0.67-0.76) and 1.00 (95% CI 0.98-1.00), respectively. The positive likelihood ratio was 34.5 (95% CI 14.5-82.10), the negative likelihood ratio was 0.24 (95% CI 0.16-0.36), and the diagnostic odds ratio was 204.9 (95% CI 76.8-546.6), the area under the curve being 0.99. Our data suggest that the FISH assay is likely to be a useful diagnostic tool for confirming MM. However, considering the limited studies and patients included, further large scale studies are needed to confirm these findings.
( Hua Qi Pan ),( Su Ya Yu ),( Chun Feng Song ),( Nan Wang ),( Hui Ming Hua ),( Jiang Chun Hu ),( Shu Jin Wang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.3
A new actinomycete strain NA4 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antifungal activities against soilborne fungal pathogens. It was identified as Streptomyces cavourensis by morphological, physiological, and phylogenetic analyses based on its 16S rRNA gene sequence. The main antifungal components were isolated and identified from the fermentation culture as bafilomycins B1 and C1. These compounds exhibited significant antifungal activities and a broad antifungal spectrum. The results suggest that the Streptomyces cavourensis NA4 and bafilomycins B1 and C1 could be used as potential biocontrol agents for soilborne fungal diseases of plants.
Mechanical Performance of 3D-Printing Plastic Honeycomb Sandwich Structure
Chun Lu,Mingxue Qi,Shafiul Islam,Ping Chen,Shuangsheng Gao,Yanrong Xu,Xiangdong Yang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.1
In this study, Bi-Grid, Tri-Grid, Quadri-Grid and Kagome-Grid honeycombs were designed and fabricated using 3D printing technology Sandwich composites were prepared by gluing the cores and composite face sheets together. Mechanical performance of the sandwich structures were characterized using finite element analysis and three-point bending test. Results indicate that when suffering from bending loads, the stress concentrations are located at the loading zone on upper face sheets (distributed in both sides of the indenter) and supporting zone on bottom face sheets, and the stress concentration zones of the honeycomb cores are located in the area that between indenter and supports. The failure mechanism of the Bi-Grid sandwich structure is interfacial de-bonding between composite face sheet and Bi-Grid core, and the failure modes of the Tri-Grid, Quadri-Grid and Kagome-Grid are core shear. The mechanical performance of Quadri-Grid sandwich structure is better than that of the other three structures.
Chun-Lin Ye,Xuan-Gan Liu,Qi Huang,Xian-Liang Zhao 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5
The molecular mechanism to induce apoptosis in human hepatoma SMMC-7721 cells was investigated using 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) isolated from the buds of Cleistocalyx operculatus. Typical morphological changes in apoptotic body formation after DMC treatment were observed using acridine orange (AO)/ethidium bromide (EB) staining. After 48 h of incubation with 0, 6.25, 12.5, and 25 μM of DMC, the percentages of annexin V-FITC-positive/PI negative cells were 1.51, 9.33, 33.84, and 61.32%, respectively. Apoptosis induced by DMC was blocked by z-VAD-fmk, a caspase inhibitor. Analysis of fluorescence intensities of rhodamine 123 in cells showed that DMC induced a loss of mitochondrial membrane potential (ΔΨm). Western blot results showed that DMC decreased the Bcl-2/Bax ratio,suggesting that the Bcl-2 family is involved in control of apoptosis. All of these signal transduction pathways are involved in initiating apoptosis. DMC is a potential anticancer agent that deserves further exploration.
Chun Wu,Zhe Chen,Rong Qi,Ralph Kennel 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4
To decouple the secondary saliencies in sensorless permanent magnet synchronous machine (PMSM) drives, a repetitive control (RC) in the angle domain is proposed. In this paper, the inductance model of a concentrated windings surface-mounted PMSM (cwSPMSM) with strong secondary saliencies is developed. Due to the secondary saliencies, the estimated position contains harmonic disturbances that are periodic relative to the angular position. Through a transformation from the time domain to the angle domain, these varying frequency disturbances can be treated as constant periodic disturbances. The proposed angle-domain RC is plugged into an existing phase-locked loop (PLL) and utilizes the error of the PLL to generate signals to suppress these periodic disturbances. A stability analysis and parameter design guidelines of the RC are addressed in detail. Finally, the proposed method is carried out on a cwSPMSM drive test-bench. The effectiveness and accuracy are verified by experimental results.