산재지정병원 이용 후 산재요양환자에 대한 만족도 조사

이화평,임형준,주영수,권영준,강희태,김정민,조성식,이태경,윤종완 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.3

Henry James의 小說硏究 : The Wings of the Dove, The Ambassadors, The Golden Bowl을 중심으로 With specail reference to The Wings of the Dove, The Ambassadors, The Golden Bowl

朴炳和 동아대학교 문과대학 영어영문학과 1985 동아영어영문학 Vol.1 No.-

「질트리코모나스」(Trichomonas vaginalis)의 주별(株別) 병원성에 따른 Isozyme 양상에 관한 실험적 연구

劉能和,明春玉,鄭坪林,李根泰 연세대학교 의과대학 1984 연세의대논문집 Vol.17 No.1

社會批評家로서의 Mark Twain

朴炳和 東亞大學校 1985 東亞論叢 Vol.22 No.1

A Connecticut Yankee is the work on which opinions differ among the critics. But though it has a weakness to the construction of a novel, everyone is obliged to place high value on daring social criticism included in it. As DeVoto refers to it, it can't find consistency as a literary work, mixed with satire, humor, tall tale, democracy, religion, progress, and damned humor race, but we can't be innocent of the greatness of thought in it and it must be Twain's finest possibility as it is recognized by everyone. Though it is true for this work to criticize the society of those days with Arthur's England as its setting, these problems are such as America was confronted with late in the 19th century, and so we can say that Twain's thought shows actuality more and more. It shows Twains pessimism that the conclusion of this work ends in tragedy, but at any rate we all are compelled to sympathize with Twain's spirit which places high value on man's nobility and possibility.

마늘의 가열처리가 마늘추출액의 기능성에 미치는 영향

변평화,윤석권 동덕여자대학교 2002 생활과학연구 Vol.7 No.-

Effects of heat treatments of garlic on electron donating ability (EDA), nitrite-scavenging effects (NSE) and total thiosulfinates contents of garlic extracts were investigated. Garlic was heated at 40, 60, 80, 100 and 120℃ for 10~30 minutes and extracted with 50% ethanol. Electron donating ability (EDA) was rapidly decreased as heating temperature and time increased. Heating at higher temperature above 80℃ and over 20 minutes resulted approximately 65% reduction of EDA. The total thiosulfinates contents were affected more than EDA by heating. The garlic heated at 100℃ or higher temperature for longer than 10 minutes caused a 100% destruction of thiosulfinates. Nitrogen scavenging effects (NSE) was found to be relatively stable by heating. Even after heating at 100℃, more than 90% NSE was remained.

직업성 만성폐쇄성폐질환의 업무관련성 심의 사례들과 산업의학적 평가에 대한 고찰

이화평,고동희,이의철 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 많은 연구들을 통하여 만성폐쇄성폐질환의 직업성 원인에 대한 역학적 근거들이 제시되고 있지만 산재로 인정받는 경우는 아직 적은 편이다 본 연구에서는 산업안전보건연구원에서 근로복지공단의 의뢰를 받아 시행한 업무관련성 여부에 대한 심의 사례들을 조사하였으며 만성폐쇄성폐질환의 직업성 원인에 대한 근거들을 함께 고찰하여 직업성 만성폐쇄성폐질환에 대한 산업의학적 평가의 시행에 도움을 주고자 하였다 방법 1998년부터 2007년까지 10년간 산업안전보건연구원에서 이루어진 업무상 질병 여부에 대한 심의 기록들을 담고 있는 전산자료에서 만성폐쇄성폐질환을 진단명으로 하는 13건의 사례들을 수집하였다 이들 13건의 기록들로부터 질병명 병력 직업력 흡연력 해당 유해인자 사업장의 작업환경측정 기록 업무관련성 평가에 대한 심의 결과를 파악하였다 결과 총 13건의 사례들 중에서 업무관련성이 높다고 평가된 4건의 사례들은 다음과 같다 1) 도로상 미세 분진과 일반쓰레기 분진에 노출된 비흡연자인 환경미화원 2) 카드뮴 흄에 의해 폐손상을 입은 용접공 3) 방적공장의 면 분진에 의해 발생한 천식이 장기노출에 의해서 만성화되면서 비가역적으로 폐기능이 저하된 공조기 공기필터 관리작업자 4) 개인보호장구와 국소배기장치 없이 작업한 흡연력이 있는 주물공장 사상공 다음의 9건의 사례는 업무관련성이 낮은 것으로 평가되었다 1) 직업성 요인보다는 흡연에 의한 만성폐쇄성폐질환으로 판단된 경우 4례 2) 기존 질환(심한 결핵)의 악화에 의한 질병 발생의 가능성이 큰 경우 1례 3) 잘못 진단된 경우 1례 4) 작업 환경상 유해인자에 대한 노출의 정도가 너무 낮은 경우 2례 5) 유해인자에 노출되기 이전에 이미 발병한 경우 1례 흡연력이 있고 진폐가 없는 사상공의 경우 2006년에는 업무관련성이 낮은 것으로 평가되었으나 2007년에는 높은 것으로 평가되었다 결론 만성폐쇄성폐질환의 산업의학적 평가에 필요한 요소들은 다음과 같다 1) 폐기능 검사와 방사선학적 검사를 통한 만성폐쇄성폐질환의 정확한 진단과 다른 질환들의 배제 2) 해당 유해인자와 질병 발병 사이의 인과관계에 대한 충분한 근거 확보 3) 노출의 정도에 대한 평 가 4) 흡연으로 인한 발병가능성의 평가 산업의는 이러한 요소들을 충분히 고려하여 직업성 여부를 평가하여야한다 또한 환자가 흡연자라고 할지라도 직업성 유해인자에 의한 폐기능의 감소가 평균수명 혹은 건강수명의 실질적인 단축을 가져왔는가라는 문제를 충분히 고려하여 만성폐쇄성폐질환의 직업성 여부를 평가하여야 할 것이다 Objectives To analyse the characteristics of occupational COPD (Chronic obstructive pulmonary disease) cases that were evaluated by the Occupational Safety and Health Research Institute (OSHRI) of the Korea Occupational Safety & Health Agency (KOSHA) Methods Using the OSHRI database from KOSHA we collected 13 cases of occupational COPD that had been evaluated from 1998 to 2007 Results Four cases had been evaluated as occupational COPD 1) a nonsmoking road sweeper exposed to automobile exhaust gases and trash dust 2) an oxygen welding worker exposed to cadmium fumes 3) a cotton mill air conditioner cleaning worker exposed to cotton dust and 4) a foundry grinding worker exposed to dust gases vapors and fumes Nine cases had been evaluated as non-occupational COPD 1) 4 cases in which smoking was determined to be the main cause rather than occupational expo sure, 2) 1 case that was evaluated as another respiratory disease (severe tuberculosis sequelae) 3) 1 case that had been misdiagnosed as COPD 4) 2 cases in which the exposure levels in the workplace environments were too low and 5) 1 case that had developed before the employment Among these 13 cases a shipyard grinding worker had been evaluated in 2006 as having had a low occupational hazard but a similar case (a foundry grinding worker) was evaluated as having had a high hazard in 2007 Conclusions Proper evaluation of occupational COPD demands an accurate diagnosis of COPD itself and also the exclusion of other respiratory diseases that have similar symptoms an investigation of the relevant occupatioonal hazards and the amount of the exposure and a consideration of smoking history The evaluation should also take into account any substantial loss of life due to occupational hazards as well as any disease-free periods

저산소증이 신생아 혈중갑상선 홀몬치에 미치는 영향에 관한 연구

김명자,최평화 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.3

Alteration in the thyroid metabolism of hypoxic, fasted, and chronically ill adults and older children have been described. Present study was carried out to evaluate the effects of hypoxia on thyroidal indices of term newborns and compared them to those of a control population. Blood was drown from the cord and then serially at 3, 24, and 48 hours after delivery in all patients. Twenty healthy term newborns (group I) increased their free thyroxine (FT₄) concentrations significantly after delivery from a mean ±SD baseline of 0.94±0.13 ng/dl in cord blood to a mean ± SD of 2.6±0.5 ng/dl, 48 h after delivery (p < 0.001), while their free triiodothyronine (FT₃) levels increased from a mean ± SD baseline level of 2.3±0.5 pg/ml in cord blood to a mean ± SD peak of 3.7±0.5 pg/ml 48 hours after delivery (p<0.001). Twentyone term newborns with transient low Apgar scores at birth (group Ⅱ) and sixteen term neonates born to mothers with toxemia or hypertension (groupⅢ) failed to increase their FT₄ and FT₃ concentrations above baseline during the first 48 hour of life. FT₄ and FT₄ values at 3, 24, and 48 hours were significantly higher in control group than in groupⅡ and group Ⅲ. Cord blood thyroid-stimulating hormone, FT₄ and FT₃ levels were not statistically different in the three groups. A rapid increase in thyroid-stimulating hormone values by 3 hour after delivery (to a mean ± SD of 16.6±3, 18.0 ± 1.2 and 17.0 ± 3.0 ul/ml in group, Ⅰ,Ⅱ, and Ⅲ, respectively), followed by a progressive thyroid-stimulating hormone decline to levels similar to baseline over the following 48 hours, was noted in all three groups of subjects.

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

산모 및 신생아 제대혈내의 B형간염 항원 및 항체분포에 관한 연구

金高昌,金舜謙,崔平和 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

The prevalence of hepatititis B surface antigen in Asia and West Pacific areas shows a high range from 0.1% to 15%, also in Korea around 10% in order to determine the prevalence of HBs Ag, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe especially in the vertical transmission, above antigens and antibodies were detected by Radioimmunoassay in asymptomatic 361 pregnant women and their 361 newborn infants who were at Korea University Hospital during the period of 14 months from Jan. 1983 to Feb. 1984. The following results were obtained: 1. The majority was in birth weight of 3,001-3,5000㎎ and both sexes showed almost same ratio (51.2%:48.8%). 2. HBsAg was positive in 5.3% of pregnant women and 4.4% of newborn infants. 3. 16 newborn infants with HBsAg positive were born all to the HBsAg positive mothers. It shows very high percent (84.2%) of the vertical transmission. 4. There was no positive case of Anti-HBc, HBeAg and Anti-HBe in newborn infants, but only I case had Anti-HBs in infant which has been belived to be vertically transmitted in the end of the 2nd trimester. 5. 11 HBsAg positive infants were born to the both HBsAg and HBeAg positive mothers. The rest, 5 HBsAg positive infants, were born to HBsAg and Anti-HBeAg positive mothers which were thought of high percent of the vertical transmission (62.5%) in compared with other reports.

토끼의 Aflatoxin B₁중독증에 대한 인삼엑기스의 효과 : 임상, 생리적 및 병리학적 변화 Clinical, Physiological and Pathological Changes

김차용,변유성,문평일,정덕화,김종수 慶尙大學校 1987 論文集 Vol.26 No.1

Chinchilla 계통 1~1.5㎏ 되는 토끼 30마리를 5군 으로 나누어 체중㎏당 제 1군은 대조군으로서 Cornoil 0.3ml 씩 제 2군은 aflatoxin B? 0.03mg과 인삼 엑기스 8mg을 제 5군은 aflatoxin B? 0.06mg과 인삼엑기스 8mg을 3주동안 카테타로 경구 투여하여 임상, 혈액학적 및 병리학적 변화를 관찰하였다. 1.사료소비량 감소, 침울, 쇠약, 혼수, 체중증가율감소등과 같은 임상증상은 대조군을 제외한 전 처리군에서 독을 투여후 3일째 부터 전처리기간을 통하여 나타났으나 aflatoxin B? 단독처리군에서 인삼엑기스 혼합처리군보다 더 현저하게 나타났다. 2. 혈청 효소와 AST, ALT는 독물투여후 7일부터 인삼엑기스 혼합투여군 보다 aflatoxin B? 단독 투여군에서 높게 증가하였다. 3.전처리군에서 적혈수용적, 헤모글로빈농도는 영향을 받지 않았고, 혈장단백질은ㅇ 독물투여후 14일이후 aflatoxin B?단독 처리군에서 현저하게 감소하였다. 4. Aflatoxin B?과 인삼엑기스 혼합 투여군 보다 aflatoxin B? 단독투여군에서 간장의 공포변성,담관증생, 핵농축, 붕괴, hepatic fibrosis와 임파절 및 비장에서 현저한 임파양 세포의 소실을 나타내었다. The present study has been carried out to investigate the effectsof ginseng extract on induced chronic aflatoxicosis in rabits. Groups of rabbits were treated orally with aflatoxin B? and mixture of ginseng extract for 21 days with a dosage of 0.03mg, 0.06mg of the toxin and 0.03mg or o.o6mg of the toxin mixture of 8mg of ginseng extract or 0.3ml corn oil s place to per kg body weight. The results obtained were is follows. 1. Sings o toxicosis included reduction of feed consumption emaciation, decrese of body weight and coma revealed in both groups treated with 0.03mg pr 0.06,mg of aflatoxin B?/Kg/B.W than groups 4.5 after days 3. 2. In groups 2, 3(aflatoxin B? 0.03, 0.06mg), Activity of asparate aminotransferase(AST) and alanine aminotransferase (ALT)were increased sigificantly in dats7, 14 and 21. 3. In all groups, Mean values for packed cell volume(PCV)and hemogobin were unremarkasble, but plasma total protein were decreased in groups 2,3than 4,5 groups on days 14 and 21. 4. The rabits treated with aflatoxin B?(2,3 groups)showed markedly degenerative chasnges ranging from swelling and decreaseed granularity to marked vacuolation, hepatic necrosis, fibrosis and bile duct, Proliferation and depletion of lymphocytes in lymphocytes in lymphonde, spleen than groups 4,5.