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      • KCI등재

        Barrier Function Based Adaptive Global Sliding Mode Fault-tolerant Control of Quad-rotor UAV

        Pu Yang,Peng Liu,HuiLin Geng,ChenWan Wen,Bin Jiang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.3

        In this paper, Barrier function based adaptive global sliding mode fault-tolerant control and its application in quad-rotor UAV system are studied. Firstly, the global sliding mode surface is combined with Barrier function based adaptive sliding mode control, which omits the approach process of phase I of traditional Barrier adaptive sliding mode motion, thus improving the rapidity and accuracy of the algorithm. Secondly, the Barrier function adaptive law is used to adjust the gain of the switching term, so that the controller gain can change with the amplitude of the total disturbance in a timely and accurate manner, avoiding the overestimation problem and thus reducing the chattering of the control signal. Finally, the experimental results on the fault-tolerant control platform for multi-rotor UAVs prove the effectiveness and superiority of the proposed algorithm.

      • SCIESCOPUSKCI등재

        Novel strategy based on improved Kalman filter algorithm for state of health evaluation of hybrid electric vehicles Li-ion batteries during short- and longer term operating conditions

        Ren, Pu,Wang, Shunli,He, Mingfang,Cao, Wen The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.8

        To solve the problems in estimating the state of health (SOH) of Li-ion batteries due to real-time estimation difficulty and low precision under various operating conditions, the variations of the SOH caused by increases of the internal resistance have been analyzed. Based on the second-order RC equivalent circuit model, the short-term effect of the state of charge (SOC) on the internal resistance was considered, which was set under the discharge condition. In addition, the variation of the internal resistance was analyzed in two intervals of 0-1 s and 1-10 s. The extended Kalman filter (EKF) algorithm was improved to present a novel improved Kalman filter (IKF) algorithm to accurately predict the long-term internal resistance under different operating conditions. A computational formula based on the internal-resistance increasing was established and the SOH was estimated. The error of the calculated result when compared with the forgetting factor least square method based on the internal-resistance increasing was controlled to within 4.0% under the HPPC condition, 3.0% under the BBDST condition, and 6.0% under the DST condition. The proposed algorithm has good convergence, helps improve the SOH estimation, and encourages the application of Li-ion batteries.

      • KCI등재

        Risk Assessment and Mitigation Evaluation for Rockfall Hazards at the Diversion Tunnel Inlet Slope of Jinchuan Hydropower Station by Using Three-dimensional Terrestrial Scanning Technology

        Mao-pu Xia,Hai-bo Li,Nan Jiang,Jun-lin Chen,Jia-wen Zhou 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1

        Rockfall is a major geological disaster that frequently occurs on rock slopes in alpine and gorge regions and poses a significant threat to life and property in areas exposed to rockfall hazards. In this study, a methodology is presented for comprehensive rockfall hazard analysis, including data acquisition, source identification, numerical simulation, quantitative assessment and mitigation evaluation. A high-precision and high-resolution digital terrain model (DTM) is generated based on the point cloud data obtained by terrestrial laser scanning (TLS) and is utilized for rockfall simulation and automatic identification of structural planes. The model parameters are calibrated by three-dimensional (3D) back analysis, and the rockfall motion is simulated based on a probabilistic model and an energy dissipation model. Rockfall mitigation under passive protection is evaluated according to the rockfall interception ratio (RIR), hazard reduction rate (HRR) and statistics of the rockfall characteristics and hazards within the rockfall threat area. Under the influence of construction excavation, the diversion tunnel inlet slope of Jinchuan Hydropower Station has suffered from a series of rockfall events and potential overall instability, which has become a great threat to the construction personnel, equipment and vehicles below the slope. Thus, the presented methodology is applied to thoroughly study the example case of the rockfall events at the inlet slope of the diversion tunnel of Jinchuan Hydropower Station. The advantages, limitations and notes of each link of the presented methodology are discussed, and the suggestion of strengthening the cracked area with integral active support is proposed.

      • KCI등재

        QTLs of Cold Tolerance-Related Traits at the Booting Stage for NIL-RILs in Rice Revealed by SSR

        Ya Wen Zeng,Shu Ming Yang,Hong Cui,Xiao Juan Yang,Li Ming Xu,Juan Du,Xiao Ying Pu,Zi Chao Li,Zai Quan Cheng,Xing Qi Huang 한국유전학회 2009 Genes & Genomics Vol.31 No.2

        QTLs for cold tolerance-related traits at the booting stage using balanced population for 1525 recombinant inbred lines of near-isogenic lines (viz. NIL-RILs for BC5F3 and BC5F4 and BC5F5) over 3 years and two locations by backcrossing the strongly cold-tolerant landrace (Kunmingxiaobaigu) and a cold-sensitive cultivar (Towada) was analyzed. In this study, 676 microsatellite markers were employed to identify QTLs conferring cold tolerance at booting stage. Single marker analysis revealed that 12 markers associated with cold tolerance on chromosome 1, 4 and 5. Using a LOD significance threshold of 3.0, compositive interval mapping based on a mixed linear model revealed eight QTLs for 10 cold tolerance-related traits on chromosomes 1, 4, and 5. They were tentatively designated qCTB-1-1, qCTB-4-1, qCTB-4-2, qCTB-4-3, qCTB-4-4, qCTB-4-5, qCTB-4-6, and qCTB-5-1. The marker intervals of them were narrowed to 0.3-6.8 cM. Genetic distances between the peaks of the QTL and nearest markers varied from 0 to 0.04 cM. We were noticed in some traits associated cold tolerance, such as qCTB-1-1 for 5 traits (plant height, panicle exsertion, spike length, blighted grains per spike and spikelet fertility), qCTB-4-1 for 8 traits (plant height, node length under spike, leaf length, leaf width, spike length, full grains per spike, total grains per spike and spikelet fertility), qCTB-4-2 for 3 traits (spike length, full grains per spike and spikelet fertility), qCTB-5-1 for 5 traits (plant height, panicle exsertion, blighted grains per spike, full grains per spike and spikelet fertility). The variance explained by a single QTL ranged from 0.80 to 16.80%. Three QTLs (qCTB-1-1, qCTB-4-1, qCTB-4-2) were detected in two or more trials. Our study sets a foundation for cloning cold-tolerance genes and provides opportunities to understand the mechanism of cold tolerance at the booting stage.

      • Clinical Application of the Adenosine Triphosphate-based Response Assay in Intravesical Chemotherapy for Superficial Bladder Cancer

        Ge, Wen-Qing,Pu, Jin-Xian,Zheng, Shi-Ying Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

        Objective: To investigate correlations between adenosine triphosphate chemotherapy response assay (ATP-CRA) and clinical outcomes after ATP-CRA-based chemotherapy for drug selection in patients receiving intravesical chemotherapy to prevent recurrence of superficial bladder cancer after surgery. Methods: The chemosensitivities of 12 anticancer drugs were evaluated, including 5-Fu ADM, and EPI, using ATP-CRA and primary tumor cell culture in 54 patients. In addition, a further 58 patients were treated according to clinical experience. Differences in post-chemotherapeutical effects between drug sensitivity assay and experience groups were compared. Results: The evaluable rate of the test was 96.3%, the clinical effective rate was 80.8%, the sensitivity rate was 97.6% (41/42), the specificity was 20%, the total predicting accuracy was 74.3%, the positive predictive value was 83.7% (41/49), the negative predictive value was 66.7% (2/3); in the drug sensitivity test group, the clinical effective rate was 80.8%, the experience group response rate was 63.8%, with a significant difference in clinical effects between the ATP-based sensitivity and experience groups (${\chi}^2$=7.0153, P<0.01). Conclusion: ATP-CRA is a stable, accurate and potentially practical chemosensitivity test providing a predictor of chemotherapeutic response in patients with superficial bladder cancer.

      • KCI등재

        Factor-analysis based questionnaire categorization method for reliability improvement of evaluation of working conditions in construction enterprises

        Jeng-Wen Lin,Pu Fun Shen 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6

        This paper presents a factor-analysis based questionnaire categorization method to improve the reliability of the evaluation of working conditions without influencing the completeness of the questionnaire both in Taiwanese and Chinese construction enterprises for structural engineering applications. The proposed approach springs from the AI application and expert systems in structural engineering. Questions with a similar response pattern are grouped into or categorized as one factor. Questions that form a single factor usually have higher reliability than the entire questionnaire, especially in the case when the questionnaire is complex and inconsistent. By classifying questions based on the meanings of the words used in them and the responded scores, reliability could be increased. The principle for classification was that 90% of the questions in the same classified group must satisfy the proposed classification rule and consequently the lowest one was 92%. The results show that the question classification method could improve the reliability of the questionnaires for at least 0.7. Compared to the question deletion method using SPSS, 75% of the questions left were verified the same as the results obtained by applying the classification method.

      • Chinese Patients with Gastric Cancer Need Targeted Adjuvant Chemotherapy Schemes

        Shi, Wen-Tao,Wei, Lei,Xiang, Jin,Su, Ke,Ding, Qiong,Tang, Meng-Jie,Li, Ji-Qiang,Guo, Yi,Wang, Pu,Zhang, Jing-Wei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

        Background: Gastric cancer (GC) is one of the most common cancers in China. Adjuvant chemotherapy (AC) is a routine auxiliary treatment for GC recommended by the guidelines issued in 2011 by the Ministry of Health of the People's Republic of China, but the relevant credible consequences in China have been insufficient because of China's late start and ethical concerns. Methods: A series of databases, including Cochrane Library, MEDLINE, EMBASE, the Chinese database of the National Knowledge Infrastructure and the VIP database, were searched by 2 reviewers independently for studies investigating AC for GC through March 2012. The retrieved literature was screened according to the eligibility criteria. Results: A total of 35 randomized control trials (RCTs) were subjected to the final analysis, including 4,043 patients in treatment group and 3,884 in the control group, as well as 4 clinical-control trials (CCTs), which accessed the final analysis with 238 and 252 patients, respectively. AC reduced the risk of death as a protective treatment with statistical significance (HR=0.91, 95%CI: [0.85, 0.97], P=0.002), and it seemed more effective for Asian than non-Asian patients. The effects of AC were not influenced by the starting time (P>0.05). D2 lymphadenectomy-based chemotherapy was effective (HR=0.89, 95%CI: [0.80, 0.99], P=0.04). Oral S-1 40 mg/m2 after D2 lymphadenectomy might be a better choice for Asians with advanced GC and might result in a greater reduction of adverse events than in non-Asian patients. GRADE quality assessment determined that the strength of the evidence from foreign studies from Europe, the United States and Asian countries other than China was high, while it was moderate for Chinese studies. Conclusion: AC was effective or even curative in Chinese patients in general, although it is still necessary to optimize a targeted AC scheme for Chinese patients with GC.

      • A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling.

        Yao, Tsun-Wen,Kim, Woo-Shin,Yu, Denise M T,Sharbeen, George,McCaughan, Geoffrey W,Choi, Kang-Yell,Xia, Pu,Gorrell, Mark D American Association for Cancer Research 2011 Molecular cancer research Vol.9 No.7

        <P>Dipeptidyl peptidase IV (DPP4), DPP8, DPP9, and fibroblast activation protein (FAP), the four proteases of the DPP4 gene family, have unique peptidase and extra-enzymatic activities that have been implicated in various diseases including cancers. We report here a novel role of DPP9 in regulating cell survival and proliferation through modulating molecular signaling cascades. Akt (protein kinase B) activation was significantly inhibited by human DPP9 overexpression in human hepatoma cells (HepG2 and Huh7) and human embryonic kidney cells (HEK293T), whereas extracellular signal-regulated kinases (ERK1/2) activity was unaffected, revealing a pathway-specific effect. Interestingly, the inhibitory effect of DPP9 on Akt pathway activation was growth factor dependent. DPP9 overexpression caused apoptosis and significantly less epidermal growth factor (EGF)-mediated Akt activation in HepG2 cells. However, such inhibitory effect was not observed in cells stimulated with other growth factors, including connective tissue growth factor, hepatic growth factor, insulin or platelet-derived growth factor-BB. The effect of DPP9 on Akt did not occur when DPP9 enzyme activity was ablated by either mutagenesis or inhibition. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a major downstream effector of Ras. We found that DPP9 and DPP8, but not DPP4 or FAP, associate with H-Ras, a key signal molecule of the EGF receptor signaling pathway. These findings suggest an important signaling role of DPP9 in the regulation of survival and proliferation pathways.</P>

      • Coevolution between Human's Anticancer Activities and Functional Foods from Crop Origin Center in the World

        Zeng, Ya-Wen,Du, Juan,Pu, Xiao-Ying,Yang, Jia-Zhen,Yang, Tao,Yang, Shu-Ming,Yang, Xiao-Meng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

        Cancer is the leading cause of death around the world. Anticancer activities from many functional food sources have been reported in years, but correlation between cancer prevalence and types of food with anticancer activities from crop origin center in the world as well as food source with human migration are unclear. Hunger from food shortage is the cause of early human evolution from Africa to Asia and later into Eurasia. The richest functional foods are found in crop origin centers, housing about 70% in the world populations. Crop origin centers have lower cancer incidence and mortality in the world, especially Central Asia, Middle East, Southwest China, India and Ethiopia. Asia and Africa with the richest anticancer crops is not only the most important evolution base of humans and origin center of anticancer functional crop, but also is the lowest mortality and incidence of cancers in the world. Cancer prevention of early human migrations was associated with functional foods from crop origin centers, especially Asia with four centers and one subcenter of crop origin, accounting for 58% of the world population. These results reveal that coevolution between human's anticancer activities associated with functional foods for crop origin centers, especially in Asia and Africa.

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