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Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation
( Young Sook Park ),( Soo Hyung Kim ),( Jong Won Park ),( Younglim Kho ),( Pu Rum Seok ),( Jae-ho Shin ),( Yoon Ji Choi ),( Jin-hyun Jun ),( Hee Chan Jung ),( Eun Kyung Kim ) 대한장연구학회 2020 Intestinal Research Vol.18 No.3
Background/Aims: Stress is closely related to the deterioration of digestive disease. Melatonin has potent anti-inflammatory properties. The objective of this study was to determine the effect of water stress (WS) and sleep deprivation (SD) on intestinal microbiota and roles of melatonin in stressful condition. Methods: We used C57BL/6 mice and specially designed water bath for stress and SD for 10 days. We measured melatonin concentrations in serum, feces, and colon tissues by high-performance liquid chromatography. Genomic DNA was extracted from feces and amplified using primers targeting V3 to V4 regions of bacterial 16S ribosomal RNA genes. Results: Compared to the control, melatonin concentration was lower in the WS and SD. Fecal concentration was 0.132 pg/mL in control, 0.062 pg/mL in WS, and 0.068 pg/mL in SD. In colon tissue, it was 0.45 pg/mL in control, 0.007 pg/mL in WS, and 0.03 pg/mL in SD. After melatonin treatment, melatonin concentrations in feces and colon tissue were recovered to the level of control. Metagenomic analysis of microbiota showed abundance in colitogenic microbiota in WS and SD. Melatonin injection attenuated this harmful effect. WS and SD showed decreased Lactobacillales and increased Erysipelotrichales and Enterobacteriales. Melatonin treatment increased Akkermansia muciniphila and Lactobacillus and decreased Bacteroides massiliensis and Erysipelotrichaceae. Conclusions: This study showed that stress and SD could affect intestinal dysbiosis and increase colitogenic microbiota, which could contribute to the aggravating digestive disease. Melatonin concentrations in feces and colon tissue decreased under WS and SD. Melatonin treatment brought recovery of melatonin concentration in colon tissue and modulating dysbiosis of intestinal microbiota. (Intest Res 2020;18:325-336)
대학 기숙사 거주 대학생의 코로나19 감염예방행위 수행에 미치는 영향요인
이현주(Hyun-Ju Lee),박진희(Jin-Hee Park),김지혜(Ji-Hye Kim),강푸름(Pu-Rum Kang),송혜영(Hye-Young Song) 한국보건복지학회 2022 보건과 복지 Vol.24 No.2
본 연구는 기숙사 거주 대학생의 코로나19 감염예방행위 수행에 미치는 영향요인을 파악하고자 하는 서술적 조사연구이다. 연구 대상자는 J도 소재 일개 대학 기숙사에서 생활하고 있는 대학생이며, 153명에게 자료수집을 하였다. 수집된 자료는 SPSS 24.0을 이용하여 기술통계, t-test, pearson’s 상관관계 분석, 다중회귀분석을 실시하였다. 연구결과, 연구대상자의 코로나19 관련 감염예방행위 수행은 평균 4.38점이었으며, 코로나19에 대한 위험인식(β=.25, p =.001), 정보이해력(β=.32, p <.001)이 코로나19 감염예방행위 수행에 영향을 미치는 요인으로 나타났다. 그러므로 기숙사에 거주하는 대학생의 감염예방행위 수행도를 높이기 위해서는 대학생의 전염병에 대한 정보이해력 증진과 위험인식 고취를 위한 접근이 요구된다. 본 연구에서는 다중시설에 속하는 기숙사 거주 대학생의 코로나19 관련 감염예방행위 수행에 미치는 영향요인을 확인하였다는 의의가 있으며, 기숙사 거주 대학생 집단을 위한 감염병 예방관리지침 개발의 기초자료로 사용될 것을 기대한다. This study is a descriptive survey aiming to identify the predictors of coronavirus disease 2019 (COVID-19) prevention behaviors compliance among university students living in a dormitory. Data was collected from 153 university students living in the dormitory of one university in J Province. Using SPSS 24.0, the collected data were analyzed with descriptive statistics, t-test, pearson’s correlation, and multiple regression. The mean COVID-19 prevention behavior compliance score of the subjects was 4.38, and Health Literacy (β=.32, p <.001) and risk perception (β=.25, p=.001) were identified as the predictors of COVID-19 prevention behavior compliance. Thus, approaches targeting to improve Health Literacy regarding infectious diseases and increase awareness of the risks of infectious diseases need to be taken to promote COVID-19 prevention behavior among university students living in a dormitory.
Ovum Pick-Up derived Embryo Production and Its Application
Il-Keun Kong,Jong-In Jin,NasserGhanem,Byung-Hyun Choi,Hyun-Tae Jo,Seong-Su Kim,Jae-Il Bang,A-Na Ha,Md Fakruzzaman,Han-Seul Park,Yu-Gon Kim,Pu-Rum Park,Suk-Hwan Song,Kyu-Woan Cho,Jung-Gyu Lee 한국동물생명공학회(구 한국동물번식학회) 2013 발생공학 국제심포지엄 및 학술대회 Vol.2013 No.1