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Prabhakaran Vasantha-Srinivasan,Muthiah Chellappandian,Muthiah Chellappandian,Sengottayan Senthil-Nathan,Athirstam Ponsankar,Annamalai Thanigaivel,Sengodan Karthi,Edward-Sam Edwin,Selvaraj Selin-Rani 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.4
Fresh leaves of Piper betle Linn. (Piperales: Piperaceae) and Sphaeranthus indicus Linn. (Asterales: Asteraceae), commonly known as betel leaves and East Indian globe thistle, respectively, were harvested and steam distilled for the extraction of P. betle and S. indicus crude volatile oils (Pb-CVO and Si-CVO, respectively). LC 50 calculated on 3 rd instar larvae of dengue mosquito Aedes aegypti Linn. (Diptera: Culicidae) was 42.17 ppm for PbSi-CVO (i.e., herbal formulation based on the EOs of P. betle and S. indicus). The larval and pupal duration were significantly longer post-treatment with 100 ppm of PbSi-CVO, if compared to control. We observed that PbSi-CVO significantly altered the detoxifying enzymes GST and CYP450 compared to the expression of control. Sub-lethal concentrations of PbSi-CVO showed strong repellent properties against dengue mosquitoes, without adverse reactions on the volunteers experiencing the repellent assays. Lastly, the adulticidal activity of PbSi-CVO was studied. Overall, our study outlined that this herbal product represents a promising candidate for the development of botanical based adulticidal agents.
Macromolecular Docking Simulation to Identify Binding Site of FGB1 for Antifungal Compounds
Prabhakaran Soundararajan,정병룡,Iyyakkannu Sivanesan,Sugunadevi Sakkiah,이근우 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.10
Fusarium oxysporum, an important pathogen that mainly causes vascular or fusarium wilt disease which leads to economic loss. Disruption of gene encoding a heterotrimeric G-protein-β-subunit (FGB1), led to decreased intracellular cAMP levels, reduced pathogenicity, colony morphology, and germination. The plant defense protein, Nicotiana alata defensin (NaD1) displays potent antifungal activity against a variety of agronomically important filamentous fungi. In this paper, we performed a molecular modeling and docking studies to find vital amino acids which can interact with various antifungal compounds using Discovery Studio v2.5 and GRAMMX,respectively. The docking results from FGB1-NaD1 and FGB1-antifungal complexes, revealed the vital amino acids such as His64, Trp65, Ser194, Leu195, Gln237, Phe238, Val324 and Asn326, and suggested that the anidulafungin is a the good antifungal compound.The predicted interaction can greatly assist in understanding structural insights for studying the pathogen and host-component interactions.
Prabhakaran Soundararajan,Abinaya Manivannan,고정호,박지은,Byoung Ryong Jeong 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.2
Addressing the deterioration eff ects due to chlorine salt use as an anti-freezing agent to prevent the deposition of ice onroads during heavy snowfall is a serious issue to protect the ecosystem. Therefore, the present study was conducted to determinethe eff ects caused by deicing agents on three diff erent creeper plant species that commonly grow on roadsides, suchas Trachelospermum asiaticum , Euonymus fortunei , and Gelsemium sempervirens . The two chlorine salts calcium chloride(CaCl 2 ) and magnesium chloride (MgCl 2 ) were applied to plants either as a splash or spray in diff erent concentrations atdiff erent intervals. After 6 days of treatments, the results suggested that application of both CaCl 2 and MgCl 2 aff ected thechlorophyll content and physiological processes of the creepers in a dose-dependent manner. Further analysis of oxidativestress related parameters such as lipid peroxidation, superoxide, and hydrogen peroxide content showed that both CaCl 2 andMgCl 2 aff ected redox homeostasis. While the application of deicing agents induced the activities of antioxidant enzymes,they also decreased the content of ascorbate and proline, which are effi cient osmolytes, in the dose-dependent manner. Nevertheless,comparatively oxidative stress induced by CaCl 2 is higher than the MgCl 2 in all three creeper-type plants includedin our analysis; still the frequent application and higher concentration of both deicing agents interrupt the growth of roadsidevegetation. Despite the relative toxicity of the deicers, T. asiaticum was aff ected lesser than E. fortunei and G. sempervirens .