山林鳥類의 繁殖經過와 育雛期의 食習性에 關한硏究 (Ⅰ)

元炳徽,金閏山,李海浜 동국대학교 농림과학연구소 1967 農林科學 論文集 Vol.1 No.-

1. This investigation has been made as a result of observation upon the breeding habits and feeding habits of nestling during nesting period with five species birds "Hypsipetes amaurotis hensoni, Garrulus glandarius brandtii, Oriolus chinensis diffusus, Accipiter soloe¨nsis, Cyanopica cyanus koreensis breeded at Kwang Nung, Kyung Kido, Expreimental forest from the begining of June to the end of July, 1965. 2. Above five Species birds are all Common forest bird and three species of this, Hypsipetes amaurotis hensoni, Garrulus glandarius brandtii, Cyanopica cyanus koreensis, are permanent resident, and the remaining two Species. Oriolus chinensis diffusus, Accipiter soloe¨nsis are common summer resident birds. 3. Hypsipetes amaurotis hensoni finish their breeding from the middle of may to the end of July and their nestling period is 15 days. The food consumed during the nesting period of nestlings, composed of : Insect adult 76.35% Insect larvae 2.7%, Araneina 1.35%, Mollusca 12.5% and the seeds of Prunus levrille and Kochee 5.12%, In view of forest protection, hexious inesct Occupied from 76.65% of all food. 4. Garrulus glandarius brandtii laid their 2∼7 eggs from the middle of may to the middle of July and the incubation would take place for 14 days. Nestling period is 16∼18days. The food during the nesting period of nestling composed of: Insect larvae 38.72%, Insect adult 32.65%, Insect pupae 2.3% Araneina 16.28%, Hyla alborea 10.12%, and Noxions insect occupied from 73.48% of all. 5. Oriolus chinensis diffusus arrive here from the middle of may and migrated to south ward from the beginining of September. Incubation period is 14 days and the number of eggs laid is 4∼6. The food during the nesting period of nestlings composed of: Iasect larvae 57.57%, Insect adult 15.15%, Aranina 13.64% and Noxions insect occupied from 72.72%, of all food. 6. Accipiter soloe¨nsis arrive here from the middle of may and migrate from the late part of september. The number of eggs laid is 3∼5. Inculation period is 21∼23 days and the nesting period of nestlings is 16∼19days. The food during the nesting period of nestling composed of: Rana n. nigromaculate 92.97% platyleura kaempferi 6.99% 7. Cyanopica cyanus koreensis laid their 4∼6 eggs from the middle of may to the late part of July and nesting period of nestling is 15∼18 days. The food during the nesting period of nestling composed of: Insect Adult 56.14%, Insect larvae 10.83%, Insect pupae 8.24%, Other animal items 23.69% and some of seeds of Oldhaml 8. Hypsipetes amaurotis hensoni "garrulus glandarius brandtii, Oriolus chinensis diffusus, "Cyanopica cyanus koreensis, feed on forest naxions insect as the principle food and we have to protect these useful birds for forest protection.

전해산성수를 이용한 새로운 내시경 소독 시스템(Cleantop WM-1??)의 소독효율

이준행,이풍렬,송재훈,이남용,임윤정,장재권,김영호,김재준,백승운,이종철,최규완 대한감염학회 2001 감염 Vol.33 No.2

Background : Electrolyzed acid water (EAW) is a new liquid chemical germicide containing a mixture of oxidizing species and prepared by mixing a small amount of salt with tap water in an electrolyzer. We attempted an in-use evaluation of the high-level disinfection capability of Cleantop WM-1□, a new endoscope reprocessing system using EAW. Methods : Forty-seven flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using Cleantop WM-1□. Parts of the endoscopes without contact to EAW were disinfected with 75% ethyl alcohol. Immediately after the disinfection procedure, samples were taken from the biopsy channel (S-1), tip of the insertion tube (S-2), the umbilical cord (S-3), and the angulation knob (S-4). Results : In EAW-disinfected parts of the endoscopes, the culture-positive rates were 4.3% (2/47) in S-1 samples and 12.8% (6/47) in S-2 samples. In ethyl alcohol-disinfected area, the culture-positive rates were 2.1% (1/47) in S-3 samples and 25.5% (12/47) in S-4 samples. The colony counts of culture-positive samples ranged from 1 to 144. Pseudomonas aerugi-nasa was recovered from the angulation knob of an endoscope, but other contaminating organisms were mostly : normal flora or opportunistic pathogens. Conclusion : Although part of the endoscopes disinfected with 75% ethyl alcohol were contaminated with more organisms than EAW-disinfected areas, Cleantop WM-1□ showed a relatively good disinfection efficacy in reprocessing patient-used endoscopes. (Korean J Infect Dis 33:133∼138, 2001)

긴볼레기말의 항고지혈증 효과에 관한 연구 : Triton WR-1339 주사에 의한 고지혈증 유발 생쥐의 간세포내 지방 축적 감소를 중심으로 Based on the Decreasing Effect of Lipid Accumulation in Hepatocyte of Murine with Hyperlipidemia induced by Triton WR-1339

박인식,안상현,정재만,강윤호,이해풍,서귀문,홍용기,김호현,김진택 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

본 연구는 긴볼레기말 추출물의 항고지혈증 효과를 조사하기 위해 ICR 생쥐에 TritonWR-1339(TX) 복강주사로 인위적인 고지혈증을 유발시킨 후 긴볼레기말 추출물(30㎎/㎏)를 복강주사하여 시간의 경과에 따른 간세포내에서의 지방 축적 변화를 조직화학적으로 관찰하였다. TX 주사후 그물구조의 세포질출 가진 간세포가 간엽 전체에서 관찰되었고, 일부 간소엽에서는 간세포 손상으로 인한 간세포판 소실이 나타났다. 또한 간세포내 지방축척도 증가하여 전체 간소엽의 간세포에서 지방의 과출현을 확인 할 수 있었고, 지방의 크기도 대조군에 비해 증가된 것으로 관찰되었다. 그러나 긴볼레기말 추출물 주사군에서는 그물구조의 세포질을 가진 간세포의 수가 TX 주사군에 비해 감소되었고, 대부분의 간소엽에서 정상적인 간세포판의 배열을 확인할 수 있었다. 간세포내의 지방 축적과 크기도 감소된 경향으로 관찰되었다. 이상의 결과로 볼 때 해조류 긴볼레기말 추출물은 고지혈증이 유발된 생쥐 간세포 내에서의 과도한 지방축적을 감소시키는 항고지혈증 효과를 하는 것으로 사료된다. Hepatic tissues of ICR mouse were intraperitoneally injeced with Colpomenia bullosa(CB) Extract after Triton WR-1339(TX) injection were observed to investigate the antihyperlipermic effect of CB extract for hyperlipidemic hepatic tissue caused by destruction of lipid metabolism. The hepatic tissues were obtained at hour-24, 48, and 72 after TX injection with CB extract treatment. And then these specimen were fixed in 10% neutral buffer solution and were cryocut. The tissue stained by H&E for general morphology and sudan black B for lipid distribution. The increase of hepatocyte having rneshlike cytoplasm were shown in all hepatic lobules after TX injection and the hepatic plates were disappeared in the region of meshlike hepatocyte aggregation, But the hepatocyte having meshlike cytoplasm were disappeared and hapatic plate were rearranged in CB extract injected mouse. The number of blue black colored lipid drop in hepatic cytoplasm of mouse injected with TX were increased and the size of lipid drop were enlarged. But the number of lipid drop in hepatic cytoplasm of mouse treated CB extract were decreased and the size of lipid drop were diminished. As results indicated that the accumulation of lipid drop caused by TX injection were mitigated by the antihyperlipidermic effect of CB extract.

連翹敗毒散加味方이 알러지성 접촉피비염에 미치는 影響 : DNCB 재노출부위의 생쥐 피부손상완화와 비만세포 분포 변화를 중심으로 Based on the mitigation of skin damage and distributive change of mast cell on DNCB re-expasure region of Mice

권오성,김진택,박인식,안상현,이해풍,김호현,강윤호 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.8 No.1

본 실험은 連翹敗毒散加味方이 알러지성 접촉피부염 유발시 발생되는 면역과민반응과 염증반응 저해에 미치는 영향을 조사하기위해 행해진 것으로 2,4-dinitrochlorobenzene(DNCB, 5% DNCB 25㎕로 감작, 7일경과 후 2.5% DNCB 5㎕로 유발) 처리로 알러지성 접촉피부염이 유발된 ICR계 암컷 생쥐에 連翹敗毒散加味方抽出物(0.51g/㎏/day)을 음용투여 한 다음 contact hypersensitivity assay, 피부의 일반적인 구조 그리고 비만세포의 분포 변화를 관찰하였다. Contact hypersensitivity assay의 결과, 連翹敗毒散加味方抽出物 투여군의 ear swelling이 DNCB군에 비해 유의성있게 감소한 것으로 나타났다. 알러지성 접촉피부염 유발 후 관찰되는 피부손상은 48시간에 제일 심한 것으로 관찰되었으나, 連翹敗毒散加味方抽出物 투여군에서는 DNCB군 비해 완화된 결과를 보였다. 連翹敗毒散加味方抽出物 투여군의 진피에서 림프구를 비롯한 염증관여세포의 이주와 혈관생성 그리고 표피내로의 림프구의 침윤 등이 감소되었고, 표피 기저층과 가시층세포에서는 세포질내 액포화와 세포사이 공간 확장도 줄어든 것으로 관찰되었다. 한편 알러지성 접촉피부염 유발 후 분포가 증가한 비만세포는 형태가 주로 세포내 함유물이 분비된 degranulated type로 나타났다. 이에 반해 連翹敗毒散加味方抽出物 투여군는 DNCB군에 비해 출현 비만세포'수가 일부 감소했고, 비만세포의 형태는 granulated t-ype였다. 또한 serotonin 면역조직화학적 염색결과로 連翹敗毒散加味方抽出物 투여군에서 se-rotonin 양성반응성이 높은 granulated type의 비만 세포가 주로 관찰되었다. 이상의 결과로 미루어 連翹敗毒散加味方抽出物은 알러지성 접촉피부염으로 유발된 피부 손상과 염증을 완화시키는 효과가 있는 것으로 사료된다. After allergic contact dermatitis elicitated by Dinitrochlorobenzene(DNCB) treatment, ICR female mice administered Yunkyopaedocksangamibang(YPGM) extract were observed to investigate the effect of YPGM on allergic contact dermatitis. This study investigated that contact hypersensitivity assay, abdominal skin morphologic changes including mast cells. At contact hypersensitivity assay, the right ear swelling in YPGM group were probability decrease than DNCB group. At obsevation of abdominal skin morphologic change, the infilteration of lymhocyte, lymphocyte insertion to epithelium, enlarged capillary, angiogenesis, and damages of epithelium as cytoplasmic vacuolation and enlarge of inter cellular space in YPGM were diminshed than DNCB group. The number of mast cell was increased both DNCB and YPGM group. The shape of mast cell in DNCB group was mainly appeared degranulated type, but granulated type in YPGM group. The number of serotonin positive cell was increased both DNCB and YPGM group. The shape of serotonin positive cell in DNCB group was mainly appeared degranuled type, but granulated type in YPGM group. As results indicated that the YPGM exrtact administration work on the mitigation of skin damages in mouse with allergic contact dermatitis.

Lipopolysaccharide 로 유발된 생쥐 무릎관절낭 염증에 관한 형태학적 연구 : 윤활관절막과 섬유관절막의 변화를 중심으로 Based on the Morphological Changes of Synovial Membrane and Fibrous Membrane

김진택,안상현,최난희,정재만,박인식,강윤호,김호현,이해풍 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

본 연구는 관절염 유발시 일어나는 관절낭의 형태학적 변화를 조사하기위해 ljpopolysaccharide(LPS)주사로 인위적 관절낭 염증을 유발시킨 후 시간경과에 따른 윤활관절막과 섬유관절막의 형태 변화를 관찰하였다. BALB/C 암컷 생쥐 오른쪽 무릎관절낭에 LPS 300㎍/㎏를 주사한 후 3, 7 그리고 14일에 무릎관절을 얻었다. 무릎관절은 4주동안 EDTA용액에 탈회한 후 통상적 방법으로 paraffin에 포매하였다. 또한 윤활관절막의 미세구조변화는 embed812로 포매한 후 관찰하였다. LPS 주사후 관절연골 인접부위의 윤활관절막에서 시작된 세포과형성(hyperplasia)은 시간 경과후 전체 윤활관절막으로 확대되었다. 윤활관절막내의 미세구조의 변화로는 윤활포식세포(type 1)가 관절강내로의 많은 돌기(filopodia)를 내었고, 잘 발달된 과립형질내세망을 가지는 type 2 윤활분비세포의 숫적 증가가 보였다. 한편 LPS 주사후 섬유관절막에서 나타나는 형태학적 변화는 collagen fiber 생성에 의한 섬유화가 증가되며, 이러한 섬유화를 주도하는 섬유모세포의 이주증가파 관찰되었다. 또한 혈관 주위에서는 백혈구의 이주 증가가 나타났으며, 탈과립형(degranulated type) 비만세포가 많이 관찰되었다. 이상의 결과로 LPS 주사로 관절낭에서 염증이 유발되어 윤활관전막과 섬유관절막에서 형태학적 변화가 나타났다. 이러한 일련의 형태학적 변화는 발병초기 류마티스성 관절염에서 나타나는 병리학적 소건과 동일한 결과로서, 앞으로 진행될 치료제 개발과 유발기전에 관한 해석을 위한 in vivo 실험의 적절한 모델로 기여한 것으로 기대된다. Synovial joint of BALB/C mice were injeced with Lipopolysaccharide(LPS) were observed to investigate the morphological changes of synovial capsule caused by rheumatoid arthritis(RA). The RA on female Balb/c mice were induced by LPS injection, as dose of 300㎍/㎏, into synovial cavity of knee joint. And then these specimen were fixed in 10% neutral buffered formalin and were decalcificated in EDTA solution for 4 weeks. The hyperplasia of synovium were appeared in synovial membrane. The filopodia of phagocytic like synoviocyte(type Ⅰ synoviocyte) projected into synovial cavity and the number of fibroblast like synoviocyte(type Ⅱ synoviocyte) with well-developed endoplasmic reticulum were increased in synovium. In fibrous membrane, the fibrosis induced by synthesis of collagen fiber were enlarged to all fibrous membrane, and the number of fibroblast were increased. A great number of inflammation component cell as Iymphocyte and neutrophil leukocyte were infiltrated around capillary and the degranulate typed mast cell were increased. As results indicated that the hyperplasia of synovium induced by LPS, subsequently to cause the fibrosis, infiltration of imflammation component cell, and increase of degranulated type mast call as same as symptoms of RA.

La nuit dans les oeuvres de Saint - Exupery

Chung, Yun Poong 한국불어불문학회 1979 佛語佛文學硏究 Vol.14 No.1

CASE REPORT : Endoscopic Findings of Enteropathy-Associated T-Cell Lymphoma Type II: A Case Series

( Yun Soo Hong ),( Young Sik Woo ),( Gaeun Park ),( Kyungho Lee ),( Soo Hoon Kang ),( Hyun Woo Lee ),( Eun Ran Kim ),( Sung Noh Hong ),( Dong Kyung Chang ),( Young Ho Kim ),( Poong Lyul Rhee ),( Jae J 대한간학회 2016 Gut and Liver Vol.10 No.1

Enteropathy-associated T-cell lymphoma (EATL) is a rare extranodal T-cell lymphoma arising from the intestine. Two types of EATL have been reported. In contrast to the classic EATL type I, EATL type II occurs sporadically, is unrelated to celiac disease, and comprises 10% to 20 % of all EATL cases. A total of five cases of EATL type II were diagnosed at our clinic from January 2009 to September 2012. Four of the five patients were diagnosed with the help of endoscopy. Among the four patients, two of the cases involved both the small and large intestines, whereas in the other two patients, EATL was limited to the small intestine. Common endoscopic findings included innumerable fine granularities (also called mosaic mucosal patterns) and diffuse thickening of the mucosa with a semicircular shallow ulceration in the lesions of the small bowel. In contrast, the endoscopic findings of the colon were nonspecific and could not distinguish EATL type II from other diseases. There are only few published reports regarding the representative endoscopic findings of EATL. Here, we present the clinical and endoscopic findings of four cases of EATL type II diagnosed by endoscopy. (Gut Liver 2016;10:147-151)

Two Distinct Types of Hypercontractile Esophagus: Classic and Spastic Jackhammer

( Yun Soo Hong ),( Yang Won Min ),( Poong-lyul Rhee ) 대한간학회 2016 Gut and Liver Vol.10 No.5

Hypercontractile esophagus (nicknamed jackhammer esophagus) is a recently defined disease within the esophageal motility disorders classification. Responses to treatments for jackhammer esophagus have been inconsistent in previous trials, possibly due to its heterogeneous manifestation. Thus, we reviewed 10 patients diagnosed with jackhammer esophagus and compared their clinical and manometric features at baseline. Additionally, manometric and symptomatic responses after treatment with known smooth muscle relaxants, including anticholinergic drugs (cimetropium bromide and scopolamine butylbromide) and a phosphodiesterase-5 inhibitor (sildenafil) were compared. We observed two distinct subgroups in the findings: one with hypercontractility and normal distal latencies ("classic jackhammer esophagus," n=7) and the other with hypercontractility and short distal latencies ("spastic jackhammer esophagus," n=3). The two types also differed in their responses to medications in that symptoms improved upon treatment with an anticholinergic agent in classic jackhammer esophagus patients, while spastic jackhammer esophagus was unresponsive to both the anticholinergic drugs and the phosphodiesterase-5 inhibitor. In conclusion, hypercontractile esophagus may be a heterogeneous disease with different underlying pathophysiologies. We introduced two novel terms, "classic jackhammer esophagus" and "spastic jackhammer esophagus," to distinguish the two types. (Gut Liver 2016;10:859-863)

Celecoxib attenuates fluorouracil-induced cell death via cell cycle arrest in colon cancer cell

( Yun Jeong Lim ),( Jong Chul Rhee ),( Young Ho Kim ),( Jun Haeng Lee ),( Hee Jung Son ),( Poong Lyul Rhee ),( Jae J. Kim ),( Seung Woon Paik ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-

<Aims> Celecoxib has been known to have a chemopreventive effect. We investigated the possibility in the use of celecoxib as a combined chemotherapeutic agent. <Methods> Various concentrations of celecoixb were added to the 5-FU treated HCT-15 and HT-29 h

The Korean Society of Gastroenterology& SLDDS 2052 : Slide Session ; K-MO-02 : GI Motility ; The Value of Multiple Rapid Swallow in Assessment of Esophageal Motor Function

( Yun Soo Hong ),( Yang Won Min ),( Poong Lyul Rhee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Multiple rapid swallow (MRS) during esophageal manometry is a simple provocative maneuver, which could predict esophageal peristaltic reserve. We aimed to assess the value of MRS in patients with ineffective esophageal motility. Methods: Between November 2013 and July 2014, a total of 36 patients showing ineffective esophageal motility (IEM) on esophageal manometry were included in the study. We analyzed contractions after MRS. If a contraction after MRS stronger than that of single swallow, MRS was considered normal. The patients were classifi ed as having normal/abnormal MRS and differences between groups were tested in terms of proportions of gastroesophageal refi ux disease (GERD), pathologic acid exposure (PAE) and pathologic bolus exposure (PBE) and total AE and BE times (%). PAE and PBE was defi ned as an intraesophageal pH of <4 for more than 4.2% and refi uxate in contact with distal impedance electrodes for more than 1.4% of the recording time, respectively. Results: After exclusion of 4 patients with unavailable MRS results, 32 were analyzed. Of them, 15 patients (46.9%) had abnormal post-MRS response. The proportion of GERD, PAE and PBE did not show statistically signifi cant differences between the two groups (abnormal MRS group vs normal MRS group, 46.7% vs 35.3%, P=0.513; 40.0% vs 8.3%, P=0.135; 60.0% vs 33.3%, P=0.391). Total AE and BE time (%) was longer in abnormal MRS group than normal MRS group although it did not reach statistical signifi cance (4.2% vs 1.6%, P=0.125 and 3.7% vs 1.4%, P=0.237, respectively). Conclusions: Our results show that ineffective esophageal motility patients with abnormal post-MRS response have a tendency to be accompanied by more prolonged acid and/or bolus refi ux than those with normal response. Further large scaled study is warranted to confi rm out results in the future.