Variation in the <i>RPTN</i> gene may facilitate straight hair formation in Europeans and East Asians

Poś,piech, Ewelina Elsevier 2018 JOURNAL OF DERMATOLOGICAL SCIENCE Vol.91 No.3

Allometric analysis of tylosin tartrate pharmacokinetics in growing male turkeys

Błażej Poźniak,Marta Tikhomirov,Karolina Motykiewicz-Pers,Kamila Bobrek,Marcin Świtała 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.3

Background: Despite common use of tylosin in turkeys, the pharmacokinetic (PK) data for this drug in turkeys is limited. Within a few months of growth, PK of drugs in turkeys undergoes changes that may decrease their efficacy due to variable internal exposure. Objectives: The objective of this study was to investigate the influence of age on the PK of a single intravenous (i.v.) and oral administration of tylosin to turkeys at a dose of 10 and 50 mg/kg, respectively. Methods: Plasma drug concentrations were measured using high-performance liquid chromatography with UV detection. The PK parameters were assessed by means of non-compartmental approach and were subjected to allometric analysis. Results: During a 2.5-month-long period of growth from 1.4 to 14.7 kg, the median value for area under the concentration-time curve after i.v. administration increased from 2.61 to 7.15 mg × h/L and the body clearance decreased from a median of 3.81 to 1.42 L/h/kg. Over the same time, the median elimination half-life increased from 1.03 to 2.96 h. For the oral administration a similar trend was noted but the differences were less pronounced. Bioavailability was variable (5.76%–21.59%) and age-independent. For both routes, the plasma concentration of the major tylosin metabolite, tylosin D, was minimal. Protein binding was age-independent and did not exceed 50%. Allometric analysis indicated a relatively poor predictivity of clearance, volume of distribution and elimination half-life for tylosin in turkeys. Conclusions: Age has a significant impact on tylosin PK in turkeys and dosage adjustment may be needed, particularly in young individuals.

흉부손상후 전신마취중 발생한 지연성 기흉

이근상,강포순,조재군,김정성,이규청 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.6

A 62-year-old female patient was scheduled for emergent explo-laparotomy under general anesthesia because of traffic accident. Preoperative checked chest x-ray showed multiple fractures of the ribs but didn't show the sign of pneumothorax or hemothorax. she had no dyspnea. Compared with previous value(PaO2; 210.5 mmHg), Arterial PO2 value(PaO2; 143.0 mmHg) was reduced significantly two hours after starting general anesthesia. Chest x-ray was taken in the operating room, which showed pneumothorax in the right side lung. The patient was treated with immediate closed thoracostomy. She recovered uneventfully three days later with complete resorption of the pneumothorax. (Korean J Anesthesiol 1997; 32: 1028∼1030)

RFID 금속태그용 평면 모노폴 안테나의 설계

박정용(Jung-Y ong POαk),우종명(Jong-Myung Woo) 한국통신학회 2007 한국통신학회 학술대회논문집 Vol.2007 No.7

Effect of Temperature on the Killing of Opisthorchis viverrini Eggs In Vitro

Parichart Boueroy,Kunyarat Duenngai,Chatanun Eamudomkarn,Panupan Sripan,Thidarut Boonmars,Benjamabhorn Pumhirunroj,Atchara Artchayasawat,Jiraporn Songsri,Kanpicha Chomphumee,Panaratana Rattanasuwan,Po 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.1

Contaminated liver fluke egg in the environment has led to the high prevalence of human opisthorchiasis asso- ciated with cholangiocarcinoma in Southeast Asia. To find the effective lessening methods of Opisthorchis viverrini eggs in the contaminated environment, we investigated the temperature conditions for killing of these trematode eggs in vitro. Numerous O. viverrini eggs were obtained in the proximal part of uteri of adult worms from experimental hamsters. Ma- ture eggs with miracidium were allocated by experimental groups (2 control: positive and negative and 4 treatment: 50, 60, 70, and 80°C) with 0.85% saline, and treated by the experimental plan. Eggs in each experimental groups were ob- served under the confocal microscope after stain with Propidium Iodide (PI) to evaluate the effect of temperatures. Eggs in 70 and 80°C groups were all killed after over 10 min heated. Majority of eggs in 60°C (10, 15, and 30 min heated), 70 and 80°C (5 min heated) groups were inactivated. However in 50°C group, below half of eggs were to be killed in all time lapse (10, 15 and 30 min). In order to prevent O. viverrini infection and cholangiocarcinoma, direct treatment of sewage by heating at 70 or 80°C at least 10 min is essential. Therefore, treatment of O. viverrini eggs at a high temperature is a po- tential method for controlling egg contamination in sewage.

『樂學軌範』 60調圖의 構成原理와 五音略譜의 意味

이보형 한국음악사학회 2002 한국음악사학보 Vol.29 No.-

Although modal theory is one of the complicated subject in the field of Korean musicology, it is of great significance in understanding the essence of Korean traditional music. 'Mode' is referred to in Sino-Korean as cho or jo 調 (t'iao in Chinese). The theory for sixty modes in the Akhak kwebo˘m 『樂學軌範』(1493) was explained by ou˘m yakpo 五音略譜, one of notational systems invented during the reign of King Sejo 世祖 (1455-1468) in the early Choso˘n 朝鮮 period. The purpose of this paper is to investigate the meaning of ou˘myakpo and structural principle of the sixty modes known as yuksipcho 六十調. This paper is based on not only Korean literary sources including Sejong sillok 『世宗實錄』 and Akhak kwebo˘m, but also such Chinese sources as Lu¨lu¨ hsin-shu 『律呂新書』 by Ts'ai Yu¨n-ting 蔡元定, Lu¨-lu¨ ching-i 『律呂精義』 by Chu Tsau-yu¨ 朱載堉, and so on. This paper deals with 1. Introduction, 2. Structural Method of Modal Diagram (Chodo 調圖), 3. The Meaning and Structural Principle of Modal Diagram, 4 Conclusion. In viewing of an intensive investigation, it is concluded that the theory for sixty modes of Akhak kwebo˘m is based on the that of Lu¨-lu¨ hsin-shu by Ts'ai Yu¨n-ting. Since a tonal center (kung 宮) of the sixty modal theory in Akhak kwebo˘m means to indicate a king (kun 君), the tonal center was notated as kung in the ou˘m yakpo, literally meaning 'five-tone simplified notation,' but actually a scale-degree notation in which a tonal center (kung) is specified and other notes are described in terms of their distance up or down from the tonal center.

中國의 類書考

金抱玉 全北大學校 1984 論文集 Vol.26 No.-

The Purpose of this study is to study the development of Chinese and Korean Encyclopedias, Ryu-Seo (類書), analyzing its form and content. Ryu-Seo is an ancient book which is similar to the encyclopedia of these days. Especially, it is the book involved with all of the knowledge about oriential studies. In China, the Ryu-Seo encyclopedia originated from the King Mun-Je(文帝) of the Wi(魏)-Dynasty. The Development of the encyclopedia Rhy-Seo is as follows; 'Hwa-Chon-Pyeon-Pyag'(華村遍略) was created during the Je(齊)-and the Yang(梁)-dynasty, and 'Su-Mun-Jeon-O-Ram'(修文殿御覽) was formulated during the Dang(唐)-and Song(宋)-dynasty. Ryu-Seo blossmed the Cheong(淸)-dynasty, in which 'Tae-Pyeong-O-Ram'(太平御覽) was made. Ryu-Seo can be catagorized into three periods by the development of its form and content: Firstly, it is concerned with the ancient customs and events. The next period consists mainly of words and letters. Then, the third period was concerned with both historical events and phrasology rather than individual words. 'Um-Bu-Gun-Ok'(韻府群玉) is the oldest Ryu-Seo of all that was inherited in China. Imitating the form and system of the 'Um-Bu-Gun-Ok the Korean people created the 'Dae-Dong-Um-Bu-Gun-Ok'(大東韻府群玉) which was admitted as the first completed encyclopedia in Korea.

판소리 公演文化의 變動이 판소리에 끼친 影響

李輔亨 고려대학교 한국학연구소 1995 한국학연구 Vol.7 No.-

척추주위근을 침범한 신경통양 근위축증(Neuralgic Amyotrophy) 2례

전포성,정상욱,김기찬,정호중 高神大學 醫學部 1998 高神大學醫學部 論文集 Vol.13 No.1-2

전북지역 도서관 사서직의 직무현황 분석 및 문제점 : 공공도서관을 중심으로

김포옥 全北大學校 人文科學大學 圖書館學科 文獻情報學會 1989 全北文獻情報 Vol.3 No.-

A Library is the fundamental character of culture in a country and it is also barometer of culture in its community. Every cultural reality, however, can hardly come to fruition in a short time and so, it will be effected through a long time and tradition. This study aims at catching up how the above-mentioned public libraries have an influence on culture of its community people. For this purpose, the actual conditions of the public libraries have been investigated and analyzed and as a result of it, the problems have been reilluminated from the nation-wide point of view. And in the new changes, developing improvement measures have been tried th find. How to study was on the bais of the actual materials of the on-the-spot survey, the interviews with the working officials and the response by way of questionnaire. Summing up the investigated and analyzed contents are as followings. In the above mentioned province, therefore, number of the public libraries are very limited compared with number of the people. and so, it is very essential to increase the public libraries in the province. In terms of the actual conditions, the public livraries lags far behind the other provinces in Korea from this library field. The present chronic conditions are the budgetary deficit, the collections insufficient to the legal minimal standards, the lack of professional librarians ignorance of the people and library managements by unprofessionals, etc. The hinders the progress of the public libraries and to circulated them from the people. The improvements and the solutions to the above-mentioned problems are as follows. 1. To recruit the personnal sufficient to the legal standards and to reorganize the offices and to turn upward the highest class of librarian's position above the 4th class. 2. To secure collections sufficient to the legal standards and to streghten the extension services. 3. To organze th ecouncil composed of the chief librarians of the public libraries including the working chiefs in the province and to develop the works-in-hand of the libraries from the level of decision-making. 4. To organize the librarian training group and to study the working problems and to seek the qualified improvement of librarians. 5. The management of the public libraries in the province are, at present, under the Ministry of Education and the local government takes the financial power. So both should be shortly unified. 6. To do regularly the course of how to use library materials for the community people and to seek the inducement measures for the people through the various cultural events. 7. The public libraries organize the mutual cooperation networks and to seek the system automatized plans of free use of library materials and every library works. 8. To enlarge book mobile system actively and to infiltrated into the daily living of people deeply. Finally, What the present writer would like to speak to the chief liberarians of the public libraries the human aspects of librarians should not be ignored no mater how excellent a library organization may be. In addition to this, the present writer is sure that the farreached future of our library organization will depend the librarians.