Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Pisha, Emily,Chai, Heesyung,Lee, Ik Soo,Changwedera, Tangai E.,Farnsworth, Norman R.,Cordell, Geoffrey A.,Beecher, Christopher W.W.,Fong, Harry H. S.,Kinghorn, A.Douglas,Brown, Daniel M.,Wani, Mansukh 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

Reproducibility of the sella turcica landmark in three dimensions using a sella turcicaspecific reference system

Pisha Pittayapat,Reinhilde Jacobs,Guillaume A. Odri,Karla de Faria Vasconcelos,Guy Willems,Raphael Olszewski 대한영상치의학회 2015 Imaging Science in Dentistry Vol.45 No.1

Purpose: This study was performed to assess the reproducibility of identifying the sella turcica landmark in a threedimensional (3D) model by using a new sella-specific landmark reference system. Materials and Methods: Thirty-two cone-beam computed tomographic scans (3D AccuitomoR 170, J. Morita, Kyoto, Japan) were retrospectively collected. The 3D data were exported into the Digital Imaging and Communications in Medicine standard and then imported into the MaxilimR software (Medicim NV, Sint-Niklaas, Belgium) to create 3D surface models. Five observers identified four osseous landmarks in order to create the reference frame and then identified two sella landmarks. The x, y, and z coordinates of each landmark were exported. The observations were repeated after four weeks. Statistical analysis was performed using the multiple paired t-test with Bonferroni correction (intraobserver precision: p.0.005, interobserver precision: p.0.0011). Results: The intraobserver mean precision of all landmarks was .1 mm. Significant differences were found when comparing the intraobserver precision of each observer (p.0.005). For the sella landmarks, the intraobserver mean precision ranged from 0.43?0.34 mm to 0.51?0.46 mm. The intraobserver reproducibility was generally good. The overall interobserver mean precision was .1 mm. Significant differences between each pair of observers for all anatomical landmarks were found (p.0.0011). The interobserver reproducibility of sella landmarks was good, with .50% precision in locating the landmark within 1 mm. Conclusion: A newly developed reference system offers high precision and reproducibility for sella turcica identificationin a 3D model without being based on two-dimensional images derived from 3D data.

Reproducibility of the sella turcica landmark in three dimensions using a sella turcica-specific reference system

Pittayapat, Pisha,Jacobs, Reinhilde,Odri, Guillaume A.,Vasconcelos, Karla De Faria,Willems, Guy,Olszewski, Raphael Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.45 No.1

Purpose: This study was performed to assess the reproducibility of identifying the sella turcica landmark in a three-dimensional (3D) model by using a new sella-specific landmark reference system. Materials and Methods: Thirty-two cone-beam computed tomographic scans (3D Accuitomo$^{(R)}$ 170, J. Morita, Kyoto, Japan) were retrospectively collected. The 3D data were exported into the Digital Imaging and Communications in Medicine standard and then imported into the Maxilim$^{(R)}$ software (Medicim NV, Sint-Niklaas, Belgium) to create 3D surface models. Five observers identified four osseous landmarks in order to create the reference frame and then identified two sella landmarks. The x, y, and z coordinates of each landmark were exported. The observations were repeated after four weeks. Statistical analysis was performed using the multiple paired t-test with Bonferroni correction (intraobserver precision: p<0.005, interobserver precision: p<0.0011). Results: The intraobserver mean precision of all landmarks was <1 mm. Significant differences were found when comparing the intraobserver precision of each observer (p<0.005). For the sella landmarks, the intraobserver mean precision ranged from $0.43{\pm}0.34mm$ to $0.51{\pm}0.46mm$. The intraobserver reproducibility was generally good. The overall interobserver mean precision was <1 mm. Significant differences between each pair of observers for all anatomical landmarks were found (p<0.0011). The interobserver reproducibility of sella landmarks was good, with >50% precision in locating the landmark within 1 mm. Conclusion: A newly developed reference system offers high precision and reproducibility for sella turcica identification in a 3D model without being based on two-dimensional images derived from 3D data.

GENERALIZED IDEAL ELEMENTS IN le-Γ-SEMIGROUPS

Hila, Kostaq,Pisha, Edmond Korean Mathematical Society 2011 대한수학회논문집 Vol.26 No.3

In this paper we introduce and give some characterizations of (m, n)-regular le-${\Gamma}$-semigroup in terms of (m, n)-ideal elements and (m, n)-quasi-ideal elements. Also, we give some characterizations of subidempotent (m, n)-ideal elements in terms of $r_{\alpha}$- and $l_{\alpha}$- closed elements.

Cephalometric landmark variability among orthodontists and dentomaxillofacial radiologists: a comparative study

Ana Paula Reis Durão,Aline Morosolli,Pisha Pittayapat,Napat Bolstad,Afonso P. Ferreira,Reinhilde Jacobs 대한영상치의학회 2015 Imaging Science in Dentistry Vol.45 No.4

Purpose: The aim this study was to compare the accuracy of orthodontists and dentomaxillofacial radiologists in identifying 17 commonly used cephalometric landmarks, and to determine the extent of variability associated with each of those landmarks. Material and Methods: Twenty digital lateral cephalometric radiographs were evaluated by two groups of dental specialists, and 17 cephalometric landmarks were identified. The x and y coordinates of each landmark were recorded. The mean value for each landmark was considered the best estimate and used as the standard. Variation in measurements of the distance between landmarks and measurements of the angles associated with certain landmarks was also assessed by a subset of two observers, and intraobserver and interobserver agreement were evaluated. Results: Intraclass correlation coefficients were excellent for intraobserver agreement, but only good for interobserver agreement. The least reliable landmark for orthodontists was the gnathion (Gn) point (standard deviation [SD], 5.92 mm), while the orbitale (Or) was the least reliable landmark (SD, 4.41 mm) for dentomaxillofacial radiologists. Furthermore, the condylion (Co)-Gn plane was the least consistent (SD, 4.43 mm). Conclusions: We established that some landmarks were not as reproducible as others, both horizontally and vertically. The most consistently identified landmark in both groups was the lower incisor border, while the least reliable points were Co, Gn, Or, and the anterior nasal spine. Overall, a lower level of reproducibility in the identification of cephalometric landmarks was observed among orthodontists.

Cephalometric landmark variability among orthodontists and dentomaxillofacial radiologists: a comparative study

Durao, Ana Paula Reis,Morosolli, Aline,Pittayapat, Pisha,Bolstad, Napat,Ferreira, Afonso P.,Jacobs, Reinhilde Korean Academy of Oral and Maxillofacial Radiology 2015 Imaging Science in Dentistry Vol.45 No.4

Purpose: The aim this study was to compare the accuracy of orthodontists and dentomaxillofacial radiologists in identifying 17 commonly used cephalometric landmarks, and to determine the extent of variability associated with each of those landmarks. Materials and Methods: Twenty digital lateral cephalometric radiographs were evaluated by two groups of dental specialists, and 17 cephalometric landmarks were identified. The x and y coordinates of each landmark were recorded. The mean value for each landmark was considered the best estimate and used as the standard. Variation in measurements of the distance between landmarks and measurements of the angles associated with certain landmarks was also assessed by a subset of two observers, and intraobserver and interobserver agreement were evaluated. Results: Intraclass correlation coefficients were excellent for intraobserver agreement, but only good for interobserver agreement. The least reliable landmark for orthodontists was the gnathion (Gn) point (standard deviation [SD], 5.92 mm), while the orbitale (Or) was the least reliable landmark (SD, 4.41 mm) for dentomaxillofacial radiologists. Furthermore, the condylion (Co)-Gn plane was the least consistent (SD, 4.43 mm). Conclusion: We established that some landmarks were not as reproducible as others, both horizontally and vertically. The most consistently identified landmark in both groups was the lower incisor border, while the least reliable points were Co, Gn, Or, and the anterior nasal spine. Overall, a lower level of reproducibility in the identification of cephalometric landmarks was observed among orthodontists.