원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

고양이 감각 및 운동겉질에서 calbindin D-28k와 parvalbumin에 대한 면역세포화학적연구

김종중,장인엽,정윤영,윤상필,문정석 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.2

DEM을 이용한 3차원 GIS 구현

정종필 朝鮮大學校 統計硏究所 2007 統計硏究所論文誌 Vol.9 No.1

최근 지리정보시스템은 기존의 2차원적인 표현에서 3차원적인 표현으로의 연구개발이 활발하게 진행되고 있으나, 방대한 양의 지리정보를 빠르고 효율적으로 처리하는데 많은 시간과 비용이 소요되는 문제를 내포하고 하고 있다. 더욱이 대용량의 지형자료는 3차원 지형가시화에 큰 문제가 되고 있고, 지속적인 연구가 진행되고 있으나 여전히 대용량의 데이터를 효율적으로 처리하는 데는 많은 문제점을 가지고 있다. 본 논문에서는 위성이나 항공으로부터 획득한 DEM 데이터를 이용하여 VRML로 변환하고, 변환된 VRML을 보다 사실적으로 가상 공간상에 디지털 콘텐츠를 생성하기 위해서 실제공간의 x, y, z 축 방향의 좌표 값을 가진 실물과 같은 데이터를 입력하고, 가상의 공간 상에 하나씩 그려 나가게 된다. 이렇게 외형이 만들어진 후 사실감 있는 질감과 재질을 표현하기 위하여 실물에 가까운 텍스처 맵핑 작업을 하고, 텍스처 맵핑된 정보를 이용하여 웹 기반의 3차원 GIS를 구현하고자 한다.

陸軍의 企劃制度가 韓國行政發展에 미친 影響

姜棕泌 동국대학교 행정대학원 1973 행정논집 Vol.4 No.-

터널과 도로 및 교량에 대한 VE/LCC 분석에 관한 연구

안종필,박경호,임재춘 朝鮮大學校 建設技術硏究所 2006 建設技術硏究 Vol.26 No.1

It is actual state in our country that the number of tunnels on the road increases consistently but there is no study or computer program on life cycle cost Ihereinafter "LCC") of tunnel. This research is for the purpose of calculating the LCC for tunnel on the road and applying it to the systematic maintenance & management and analysis of economical efficiency. Further the developed computer program calculating the LCC for tunnel on the road increases the efficiency in tunnel design and in decision of investment considering the maintenance & management and the economical efficiency and it will be a useful tool with relation to VE/LCC technique. VE analysis is constituted of performance represented by P. life cycle cost represented by C and value represented by V. P is calculated under considering weight and degree of estimation which explain the importance of each facilities to the estimation item. C is determined from getting sum of the present prices of initial construction cost, maintenance & management cost during service life, break-up & disposal cost. V is obtained from dividing the P by C, that is V=P/C. The estimation list of the maintenance & management on tunnel has been set up as items whose maintenance & management cost was appeared to be relatively larger than the others and there were decision of the variables of effect such as frequency of maintenance & repair, unit cost, repairing rate, etc.. And also, all the cost were converted into present prices considering the economic variables for example discount rate, etc. Excel base LCC analysis system of tunnel on road was developed and tested on a sample tunnel.

모래가 섞인 실트지반의 측방유동에 관한 연구

안종필,박주원,김대해 朝鮮大學校 建設技術硏究所 2003 建設技術硏究 Vol.23 No.1

This study analysed general behaviors of the lateral flow when unsymmetrical surcharge is worked on silt soils mixed with sand through model tests, and then investigated comparing with the existing suggestions. The critical surcharge, the point of time when lateral flow begins to occur was q_(cr),=0.40C_(u)-0.01 and the ultimate surcharge was q_(ult)=1.73C_(u)-0.10. The maximum lateral flow pressure was slightly lower theoretical value than that of the experiment value when the ultimate surcharge works, which indicates excessive consideration of safety rate. The formula of maximum lateral flow pressure of the silt soils mixed with sand was P_(max)=-5.27q_(ult)²+5.0q_(ult)+4 19. It occurred at 0.25H∼0.4H, which indicates that its occurrence depth was vertically distributed at 0.3H. The quadrilateral distribution where P_(0)=P_(max)/3 as the lateral flow pressure was applied bore a great resemblance to the distribution according to actual measurement. As the displacement obtained in the model tests was applied to the control diagram {Sv-(Ym/Sv)} presented by Matsuo·Kawamura, the result was that ; the destructive surcharge according to the standard of Matsuo·Kawamura showed a slightly lower value than the ultimate surcharge and the formula of settlement of the ultimate surcharge obtained in the three model tests was Sv=0.95exp{3.62(Ym/Sv)}.

스포츠센터 직원의 직무와 조직관련 요인이 조직헌신도에 미치는 영향

김종달,이병익,이한경,김종필,이남수 龍仁大學校 2001 용인대학교 논문집 Vol.19 No.-

This study is to determine and analyze the effect of work-and organization-related factors of Sports Center employees on their devotion to the organization. In so doing, this study involved 348 people who are currently working for Sports Centers around Kyonggi Province. The survey used in the study was Survey on the effect of work- and organization-related factors of Sports Center employees on their devotion to the organization. And t-test, One-way ANOVA, correlation analysis, recurrent analysis were introduced to analyze the data resulting from the survey. Based on the analysis, following conclusion was drawn : First, Sports Center employees work-related factor based on their personal background variables showed a statistically significant distinction according to their age, level of education, monthly salary, position and the length of their service. In addition, organization-related factor suggested a statistically significant distinction according to the employees age, monthly salary, position and the length of their service. Secondly, Sports Center employees degree of devotion to the organization indicated a statistically significant difference according to their gender, age, monthly salary, position and the length of service. However, no difference was shown in the level of education. Thirdly, the study suggested that both work-related factor(β= .463) and organization-related factor(β= .368) had an influence on the degree of devotion to the organization.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

半夏瀉心湯과 Cimetidine의 병용투여가 흰쥐의 위궤양에 미치는 영향

林鍾弼,卜鎭尤 又石大學校 1988 論文集 Vol.10 No.-

Banhasasim-tang, chinese medicine, has been used for the treatment of the gastric ulcer and cimetidine, H_2-receptor blocker, has been also used as the gastric ulcer remedy. Therefore the concurrent administration of these two drugs may increase antiulcer activities more than administrating one by one. In order to investigate antiulcer activities, some experiments were conducted. The results obtained were as follows; 1.The concurrent administration of Banhasasim-tang and cimetidine given intraperitoneally (cimetidine 50㎎/㎏+extract 300㎎/㎏ and 50㎎/㎏+500㎎/㎏), significantly inhibited Shay ulceration in rats (12 hr ligation). 2.Aspirin ulcers induced by the administration of aspirin 200㎎/㎏(p.o) to pylorus-ligated rats were inhibited by the concurrent administration of Banhassasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏, 50㎎/㎏+300㎎/㎏ and 50㎎/㎏+500㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 3.Indomethacin ulcers induced by intraperitoneal injection of indomethacin 20㎎/㎏ were inhibited by the concurrent administration of Banhasasim-tang and cimetidine. The combination of these two drugs (cimetidine 50㎎/㎏+extract 100㎎/㎏. 50㎎/㎏+300㎎/㎏ and 50㎎/㎏) resulted in a potentiated effect on the inhibition of the ulceration. 4.The antiulcer actions by the concurrent administration of Banhansasim-tang and cimetidine against Indomethacin ulcers were more effective than those against Aspirin ulcers or shay ulcers.

Phosfon-D 및 CCC의 處理가 夏播양배추 育苗時의苗徒長抑制效果 및 收量에 미치는 影響

李鍾弼,韓相政 대구 효성가톨릭대학교 1968 연구논문집 Vol.1968 No.3

This experiment was carried out in order to study the effect of Phosfon-D and CCC on suppresive growth young cabbage seedlings sown in summer and on the yield after the transplantation in the field. The summer sown cabbage seedlings often cause unnecessary stem growth and this reduces the yield and produces an unsatisfactory marketable quality. Therefore, the availability of these chemicals in summer cultivated cabbages were investigated.