Pd 촉매 하에서 terminal alkynes, aryl, alkenyl 혹은 alkynyl iodine 화합물의 수용성 조건에서 cross-coupling에 관한 연구

강석구,이홍우,장수범,호필수 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

The ligand-free Pd(OAc)_2-catalyzed coupling reaction of aryl-, alkenyl-, and alkynyliodonium tetrafluoroborate and iodanes with terminal alkynes proceeds readily in the presence of NaHCO_3 in aqueous medium to afford the substituted alkynes in high yields under mild conditions.

貸株去來가 株價에 미치는 影響에 관한 硏究

林錫弼 단국대학교 산업연구소 1991 산업연구 Vol.14 No.-

주요 우울증을 동반한 신경성 식욕과항진증 1례

신석호,권용실,김보연,이정태,이성필 한국의학사 1992 診斷과治療 Vol.12 No.7

通貨衡擊이 外換市場에 미치는 影響에 관한 硏究

林錫弼 단국대학교 산업연구소 1996 산업연구 Vol.19 No.-

통화 공급량 공표의 정보 효과

임석필 단국대학교 1998 論文集 Vol.32 No.-

The effect of unanticipated changes in the weekly money supply on the Treasury-Bill market is examined. A hypothesis for the bid - ask spread in the T-Bill market is introduced to access the information content of the Federal Reserve's money supply announcement. In almost all cases, the bid - ask spread of spot bills declined after announcements but none of them are statistically significant. Two interpretations are possible. First, the Fed's release of new monetary information does not contribute the resolution of uncertainty. but at least it is not a nuisance to the market. Another possible interpretation is that the market expectations for the weekly money supply is so efficient the Fed's announcement does not contain valuable information for the future interest rate movement.

非母數統計法을 이용한 通貨衝擊과 換率과의 관계에 대한 연구

임석필 단국대학교 1999 論文集 Vol.34 No.-

The effect of unanticipated changes in the money supply on the foreign exchange market is examined under very general framework of interest rate parity. By examining jointly the spot and the forward exchange markets of different maturities, we can identify testable restrictions which should be held in equilibrium. Based on the forward premiums increase occurs simultaneously after unanticipated increase in money supply, we provide convincing evidence that the complete chain of equilibrium process in the foreign exchange market is consistent with the hypothesis suggested by the interest rate parity theory and the real interest rate theory of money supply announcemant effect. The evidence obtained in the paper is also consistent with the usual linear regression study, which depends on particular model and distribution assumption. Investors in the foreign exchange market do not show any asymmetric response to the unexpected increase and decrease in the money supply. We also find that the Fed's stated monetary policy significantly affects the market participants' reactions to the unanticipated money supply changes.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

구리촉매를 이용한 유기주석화합물 및 유기붕소화합물과 다가 요오드 화합물과의 Cross-Coupling과 Carbonylative Cross-Coupling에 관한 연구

강석구,야마구치토쿠타로,김태현,호필수 성균관대학교 기초과학연구소 1996 論文集 Vol.47 No.2

The copper-catalyzed cross-coupling and carbonylative cross-coupling of organostannanes(aryl-, alkenyl-, alkynyl-, allylstannanes) and anoboranes(aryl-, alkenylboranes)with hypervalent aryl- and alkenyliodonium tetrafluoroborates were achieved at mild conditions.

정크채권이 미국 기업구조에 미친 영향

林錫弼 단국대학교 1994 論文集 Vol.28 No.-

In the 1980's, so called "the age of merger mania", many corporations around the world experienced massive restructuring. Corporate restructuring is a rational response to the social and economic changes. Corporate restructuring is a reallocation of resources to the more profitable business units, also it is a way to enhance the competitiveness of the economy. "The Junk Bonds Revolution" in the 1980's played an important role for the corporate restructuring in the States. However, there has been two opposing views about the role of junk bonds with respect to the corporate restructuring in the 1980's. The paper is intended to bring about the facts together, and by doing so, we can see the true picture of the financial innovation in the 1980's Ex post financial performance of junk bonds shows that junk bonds are over-compensated for the risk. This proves that, as the word "junk" implies, the assessment for the riskiness of the junk bonds are biased. Also we find that junk bonds has positive impact on the corporate performance across a wide range of performance measures. Firms issuing junk bonds for corporate restructuring evidence a greater capacity than the U. S. industry in general to create new jobs and retain old ones. Also, the distribution of junk bonds parallells the distribution of restructuring activity. These findings about the industrial performance are consistent with the findings about the financial performance of the junk bonds issuing firms as well.

한국상장기업의 所有構造와 資本調達政策에 관한 연구

임석필,송영열 단국대학교 산업연구소 1997 산업연구 Vol.20 No.-