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A Possible Pathogenic Linkage Among Headache, Migraine, and Nocturnal Enuresis in Children
Pietro Ferrara,Livia Dell’Aquila,Giacomo Perrone,Giulia Spina,Francesco Miconi,Valentina Rapaccini,Ester Del Vescovo,Vincenzo Di Lazzaro,Alberto Verrotti 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.4
Purpose: This study aims to evaluate the prevalence of headaches and migraine in children with nocturnal enuresis (NE) and to improve knowledge on these conditions. In particular, for this purpose, a possible pathogenic relationship linking both conditions and the impact of headaches and migraine on NE persistence was evaluated. Methods: Researchers enrolled 123 children with NE, aged between 5 and 15 years, referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome between January 2014 and January 2015. Parents of all children enrolled in the study were invited to complete a self-reported questionnaire. The study protocol was approved by the Human Research Ethics Committee of Campus-Bio-Medico University. The NE group data was compared with the data of a control group (107 children). Results: Of the eligible patients, 7.8% suffer from headaches/migraine (mean age, 9.63 years; interquartile range [IQR], 3.5 years) and 47.1% have a family history of headaches (mean age, 8.46 years; IQR, 3.75 years). Of the 8 patients with headaches, all are male, 3 have tension-type headaches (2 of them have maternal family history) and 5 have migraine (3 of them have maternal family history). Of the 35.3% with a migraine family history (mean age, 8.36 years; IQR, 3.5 years), 22 are male, and 14 are female. Three of these patients have migraine. A total of 92.2% suffer from NE but not from headaches (mean age, 8.43 years; IQR, 3 years). Of these patients, 33 are female (35.1%), and 61 are male (64.9%). In the control group, 4.7% (5 out of 107) of the children suffer from headaches, and of these, 4 are affected by nonmigraine headaches and 1 by migraine. Conclusions: In conclusion, according to the hypothesis, NE and headaches/migraine could be linked by several similarities.
Pietro Carrieri,Maria Petracca,Silvana Montella,Giovanni Cerullo,Ilaria Cerillo,Gianfranco Cimmino 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.3
Sporadic Porphyria Cutanea Tarda in a Patient with Multiple Sclerosis Treated with Interferon Beta 1-a Therapy: A Case Report
Melatonin’s Effect on the Efficacy of Desmopressin in the Treatment of Enuresis
Pietro Ferrara,Annamaria Sbordone,Costanza Cutrona,Francesca Ianniello,Chiara Guadagno,Giacomo Perrone,Antonio Chiaretti,Alberto Verrotti,Vincenzo Di Lazzaro 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3
Purpose: This study aims to evaluate and compare the efficacy of exogenous melatonin associated with desmopressin (dDAVP) and dietary recommendations. Methods: A total of 189 patients were enrolled from the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to June 2015. Of the 189 original patients, 153 children, aged between 5 and 14 years (mean age, 8.7 years) were included in the study. After clinical evaluation and a 3-month period of observation without treatment, children were assigned to receive treatment in one of 3 groups: group 1, dDAVP at a dose of 120 mcg a day (Minirin); group 2, dDAVP at a dose of 120 mcg and dietary recommendations; or group 3, dDAVP at a dose of 120 mcg, dietary recommendations, and melatonin at a dose of 1 mg a day (Melamil plus). Each patient was treated for 3 months. Results: After the 3 months of therapy, a desiderable response was achieved in 30 of 51 patients (58.82%) treated with dDAVP, 35 of 53 patients (66.04%) treated with dDAVP and dietary recommendations, and 35 of 49 patients (71.43%) treated with dDAVP, dietary recommendations, and melatonin. Conclusions: Although not statistically significant, the results show that the association between dDAVP treatment with dietary recommendations and melatonin could be considered a safe and effective treatment of NE. Considering that the statistically insignificant results might be due to the small sample size, the study will be continued to increase the number of subjects.
Pietro Matricardi,Giovanna Pitarresi,Fabio Salvatore Palumbo,Chiara Di Meo,Antonella Albanese,Tommasina Coviello,Claudia Cencetti,Calogero Fiorica,Gaetano Giammona 한국고분자학회 2011 Macromolecular Research Vol.19 No.12
The mechanical properties of hydrogel scaffolds based on hyaluronic acid (HA) that were chemically crosslinked with α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PHEA-EDA) were investigated. Variation of these properties as a function of three different PHEA-EDA amounts used to crosslink HA has been related to the reaction efficiency evaluated using a colorimetric assay. Moreover, the amount of unreacted amino groups that was still present in the hydrogels was related to the attachment behavior of human dermal fibroblasts to the hydrogel surface. The mechanical data and biological results suggest the suitability of the investigated hydrogels as scaffolds for the regeneration of soft tissues such as skin.
ON PERTURBED TRAPEZOIDAL AND MIDPOINT RULES
Pietro Cerone 한국전산응용수학회 2002 Journal of applied mathematics & informatics Vol.9 No.2
Explicit bounds are obtained for the perturbed, or corrected, trapezoidal and midpoint rules in terms of the Lebesque norms of the second derivative of the function. It is demonstrated that the bounds obtained are the same for both rules although the perturbation or the correction term is different. Explicit bounds are obtained for the perturbed, or corrected, trapezoidal and midpoint rules in terms of the Lebesque norms of the second derivative of the function. It is demonstrated that the bounds obtained are the same for both rules although the perturbation or the correction term is different.
Pietro Giovanni di Summa,Gianluca Sapino,Olivier Bauquis 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.3
Total reconstruction of the penis (TPR) represents a challenge for urologists and plastic surgeons, especially when urethral length is severely reduced.We here describe, for the first time in an oncologic scenario, a double flap phalloplasty using a pedicled anterolateral thigh (ALT) flap for penile reconstruction and a radial forearm free flap (RFFF) for complete neourethra and glans reconstruction following penile amputation. A 48-year-old patient came to our department following a total penectomy with inferior urethral derivation. The indication for a double flap phalloplasty was posed as only way to fully reconstruct the urethra on its length avoiding possible complications of single flap reconstruction using tube-into-tube technique. Both flaps healed uneventfully with no neourethral strictures or fistulas described. At 18 months follow-up, the patient was extremely satisfied with the aesthetic result and was able to void in standing position. We think that a double free tissue transfer for TPR should be considered, particularly when a urethral length>14 cm needs to be reconstructed. While the pedicled ALT can be used to reconstruct a proper penile shaft with an easily concealed scar, the RFFF can provide adequate neourethra length with satisfactory sensory recovery at the neoglans.