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      • KCI등재

        Wear-Induced Attenuation on Transmission Lines and Their Causes

        Philipp Lenz,Philipp Baron,Armin Wittmann,Georg Fischer 한국전기전자재료학회 2023 Transactions on Electrical and Electronic Material Vol.24 No.1

        In this paper, the radio frequency (RF) behavior of mechanically stressed coaxial and for the first time also twisted-pair transmission lines is investigated over their service life. The main goal is to enable predictive maintenance for cables in moving applications and avoid preventive replacement. This also reduces the use of high-cost resources. For this purpose, stranded and solid-core variants of coaxial and twisted-pair type cables are mechanically loaded on the two-pulley apparatus according to EN 50396. Their RF transmission (S21) behavior is measured using a vector network analyzer and presented over bending cycles. For the first time, the phase response of mechanically loaded transmission lines is evaluated with respect to their service life. Two significant causes for the increasing attenuation and altered phase response are identified: breakage in foil screen and increasing surface roughness on the copper conductors. The identified causes are supported with literature evidence. Through measurements and theoretical calculations, it is proven that the phase is much more suitable for an assessment of the remaining service life than the amplitude. The findings can be used to implement a cable monitoring system in industrial environments which monitors the lines in-situ and reminds the user to replace them, whenever a certain wear-level is reached.

      • Poster Session : PS 0441 ; Infectious Disease ; Severe Infection in Elderly Patients Treated for Multiple Myeloma: Analysis of the Intergroupe Francophone Du Myelome (IFM) 2009 01 Protocol

        ( Philippe Rodon ),( Brigitte Pegourie ),( Laurent Garderet ),( Philippe Casassus ),( Olivier Decaux ),( Murielle Roussel ),( Carine Chaleteix ),( Bruno Royer ),( Mourad Tiab ),( Xavier Leleu ),( Clai 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Although infection is a major complication of multiple myeloma (MM), there are few data on its incidence, presentation and outcome. We reviewed severe infections occurring in the IFM 2009 01 protocol. Methods: The IFM 2009 01 protocol evaluated a combination of bendamustine, bortezomib and dexamethasone (BVD) in the treatment of elderly patients (65 years or more) with a relapsed or refractory (RR) MM (Rodon P. et al, Blood 2013;122:1971A). Patients did not receive any prophylactic antibiotics. All adverse events were collected and graded prospectively. We report here an analysis of the episodes of severe infection (grade 3 or more). Results: Seventy-three patients were included. The median age was 75.8 years (range 66-86). Twenty episodes of grade 3 or more infection occurred in 17 patients (23.2%): lung and respiratory tract infection 13 episodes, bloodstream infection 6 episodes and pyelonephritis 1 episode, respectively. Fourteen episodes were diagnosed in the early phase of therapy (within the 4 fi rst BVD cycles). Only 1 severe infection underwent during a chemotherapy-induced neutropenic phase (absolute neutrophil count < 1000/mm3). fifteen episodes occurred among 34 patients older than 75 years versus 5 episodes in 39 younger patients (p=0.0028). Sepsis was responsible of death in 4 of these 17 patients (23.5%), all occurring in the early phase. Conclusions: Infection was a major severe adverse event in elderly patients treated for RRMM in the IFM 2009 01 protocol, occurring in approximately one quarter of the patients. Its incidence was signifi cantly higher in patients older than 75 years. Severe episodes of infection mainly occurred in the early phase of treatment. Mortality rate was high. These fi ndings suggest that a systematic prophylactic use of antibiotics may be needed in this population of patients.

      • KCI등재

        Polish of interface areas between zirconia, silicate-ceramic, and composite with diamond-containing systems

        Philipp-Cornelius Pott,Johannes Philipp Hoffmann,Meike Stiesch,Michael Eisenburger 대한치과보철학회 2018 The Journal of Advanced Prosthodontics Vol.10 No.4

        PURPOSE. Fractures, occlusal adjustments, or marginal corrections after removing excess composite cements result in rough surfaces of all-ceramic FPDs. These have to be polished to prevent damage of the surrounding tissues. The aim of this study was to evaluate the roughness of zirconia, silicate-ceramic, and composite after polish with different systems for intraoral use. MATERIALS AND METHODS. Each set of 50 plates was made of zirconia, silicate-ceramic, and composite. All plates were ground automatically and were divided into 15 groups according to the treatment. Groups Zgrit, Sgrit, and Cgrit received no further treatment. Groups Zlab and Slab received glaze-baking, and group Clab was polished with a polishing device. In the experimental groups Zv, Sv, Cv, Zk, Sk, Ck, Zb, Sb, and Cb, the specimens were polished with ceramic-polishing systems “v”, “k”, and “b” for intraoral use. Roughness was measured using profilometry. Statistical analysis was performed with ANOVA and Scheffé-procedure with the level of significance set at P=.05. RESULTS. All systems reduced the roughness of zirconia, but the differences from the controls Zgrit and Zlab were not statistically significant (P>.907). Roughness of silicate ceramic was reduced only in group Sv, but it did not differ significantly from both controls (P>.580). Groups Cv, Ck, and Cb had a significantly rougher surface than that of group Clab (P<.003). CONCLUSION. Ceramic materials can be polished with the tested systems. Polishing of interface areas between ceramic and composite material should be performed with polishing systems for zirconia first, followed by systems for veneering materials and for composite materials.

      • KCI등재후보

        Event date model: a robust Bayesian tool for chronology building

        Philippe, Lanos,Anne, Philippe The Korean Statistical Society 2018 Communications for statistical applications and me Vol.25 No.2

        We propose a robust event date model to estimate the date of a target event by a combination of individual dates obtained from archaeological artifacts assumed to be contemporaneous. These dates are affected by errors of different types: laboratory and calibration curve errors, irreducible errors related to contaminations, and taphonomic disturbances, hence the possible presence of outliers. Modeling based on a hierarchical Bayesian statistical approach provides a simple way to automatically penalize outlying data without having to remove them from the dataset. Prior information on individual irreducible errors is introduced using a uniform shrinkage density with minimal assumptions about Bayesian parameters. We show that the event date model is more robust than models implemented in BCal or OxCal, although it generally yields less precise credibility intervals. The model is extended in the case of stratigraphic sequences that involve several events with temporal order constraints (relative dating), or with duration, hiatus constraints. Calculations are based on Markov chain Monte Carlo (MCMC) numerical techniques and can be performed using ChronoModel software which is freeware, open source and cross-platform. Features of the software are presented in Vibet et al. (ChronoModel v1.5 user's manual, 2016). We finally compare our prior on event dates implemented in the ChronoModel with the prior in BCal and OxCal which involves supplementary parameters defined as boundaries to phases or sequences.

      • Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases

        Jurmeister, Philipp,Bockmayr, Michael,Seegerer, Philipp,Bockmayr, Teresa,Treue, Denise,Montavon, Gré,goire,Vollbrecht, Claudia,Arnold, Alexander,Teichmann, Daniel,Bressem, Keno,Schu¨ller, Ulrich American Association for the Advancement of Scienc 2019 Science translational medicine Vol.11 No.509

        <P>Head and neck squamous cell carcinoma (HNSC) patients are at risk of suffering from both pulmonary metastases or a second squamous cell carcinoma of the lung (LUSC). Differentiating pulmonary metastases from primary lung cancers is of high clinical importance, but not possible in most cases with current diagnostics. To address this, we performed DNA methylation profiling of primary tumors and trained three different machine learning methods to distinguish metastatic HNSC from primary LUSC. We developed an artificial neural network that correctly classified 96.4% of the cases in a validation cohort of 279 patients with HNSC and LUSC as well as normal lung controls, outperforming support vector machines (95.7%) and random forests (87.8%). Prediction accuracies of more than 99% were achieved for 92.1% (neural network), 90% (support vector machine), and 43% (random forest) of these cases by applying thresholds to the resulting probability scores and excluding samples with low confidence. As independent clinical validation of the approach, we analyzed a series of 51 patients with a history of HNSC and a second lung tumor, demonstrating the correct classifications based on clinicopathological properties. In summary, our approach may facilitate the reliable diagnostic differentiation of pulmonary metastases of HNSC from primary LUSC to guide therapeutic decisions.</P>

      • SCOPUSKCI등재

        Design of an Antidumping Rule with Incomplete Information about Material Injury

        ( Philippe Kohler ),( Michael O. Moore ) 세종대학교 경제통합연구소 (구 세종대학교 국제경제연구소) 1998 Journal of Economic Integration Vol.13 No.1

        This paper deals with the inability of an administering authority to directly observe the level of material injury in antidumping petitions. We focus on the use, by the domestic firm, of private information about injury in order to obtain higher protection. By using an incentive framework, we show that asymmetric information about the level of injury can be resolved by using a mix of lump-sum compensation, domestic unit taxes and antidumping duties rather than just import duties. Surprisingly, the lump-sum transfer decreases and the domestic unit tax increases with the level of material injury. This efficient antidumping rule will induce the domestic firm to tell the truth about the level of material injury. (JEL Classification: F13, L50)

      • KCI등재

        Machinability Study of Single-Crystal Sapphire in a Ball- End Milling Process

        Philipp Maas,민상기,Yuta Mizumoto,Yasuhiro Kakinuma 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.1

        Sapphire has received increasing attention as an engineering material even though its machinability is still an issue. In this study, the influence of the milling process parameters on the surface quality of single-crystal sapphire is investigated. Due to the hardness and brittleness of the sapphire substrate, crack initiation becomes the main concern with respect to up- and down-milling, feed rate, tool inclination angle and tool wear. With an inclined ball-end mill cutter in feed direction various cutting tests were performed to find optimal parameters for machining microchannel. It was observed that the feed rate and depth of cut are dominant factors for the surface quality. The tool inclination angle shows a parabolic relation to the quality of the machined surface. After tool wear events, such as peeling-off of the tool coating, an increased surface roughness is observed.

      • KCI등재

        Influence of the material for preformed moulds on the polymerization temperature of resin materials for temporary FPDs

        Philipp-Cornelius Pott,Hans Schmitz-Wätjen,Meike Stiesch,Michael Eisenburger 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.4

        PURPOSE. Temperature increase of 5.5 °C can cause damage or necrosis of the pulp. Increasing temperature can be caused not only by mechanical factors, e.g. grinding, but also by exothermic polymerization reactions of resin materials. The aim of this study was to evaluate influences of the form material on the intrapulpal temperature during the polymerization of different self-curing resin materials for temporary restorations. MATERIALS AND METHODS. 30 provisonal bridges were made of 5 resin materials: Prevision Temp (Pre), Protemp 4 (Pro), Luxatemp Star (Lux), Structure 3 (Str) and an experimental material (Exp). Moulds made of alginate (A) and of silicone (S) and vacuum formed moulds (V) were used to build 10 bridges each on a special experimental setup. The intrapulpal temperatures of three abutment teeth (a canine, a premolar, and a molar,) were measured during the polymerization every second under isothermal conditions. Comparisons of the maximum temperature (TMax) and the time until the maximum temperature (tTMax) were performed using ANOVA and Tukey Test. RESULTS. Using alginate as the mould material resulted in a cooling effect for every resin material. Using the vacuum formed mould, TMax increased significantly compared to alginate (P<.001) and silicone (P<.001). In groups Lux, Pro, and Pre, tTMax increased when the vacuum formed moulds were used. In groups Exp and Str, there was no influence of the mould material on tTMax. CONCLUSION. All of the mould materials are suitable for clinical use if the intraoral application time does not exceed the manufacturer’s instructions for the resin materials.

      • KCI등재후보

        OPTIMAL CURRENCY AREA THEORY AND MONETARY INTEGATION IN THE ANDEAN AND CARIBBEAN REGIONS

        Philippe De Lombaerde 연세대학교 동서문제연구원 2004 Global economic review Vol.33 No.2

        In this article, the author analyses the prospects for monetary integration in the Andean and Caribbean regions and stresses the regional specificities that should be taken into account. He points to the necessity to combine economic, political economy and institutional approaches to assess scenarios for monetary integration. The author also argues that the application of optimum currency area theory to regions with specific characteristics (in many respects different from the EU) might produce positive feed-back effects for the development of OCA theory itself, highlighting specific aspects and implications of the same theory and stimulating theoretical research.

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