DBA/2J 생쥐에서 점안 안압하강제 투여 후 망막신경세포구성의 변화

박명희,이경민,권재성,문정일.Myoung-Hee Park. M.D.. Kyung-Min Lee. M.D.. Jae-Sung Kwon. Ph.D.. Jung-Il Moon. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.12

Purpose: The DBA/2J (D2) mouse is a transgenic mouse with pigmentary glaucoma. In a previous study, we found a reduction of inner retinal thickness in D2 mice. We attempted to discover the effect of eye drops on the retina of D2 mice. Methods: Ten-month-old D2 mouse eyes were treated with Timoptic XE?, Cosopt?, and Xalacom? eye drops for a 1-month period. Immunohistochemical staining was performed on the mouse eye sections for analysis. Results: In the control group, GABA and OPN immunoreactivity were markedly decreased and NOS immunoreactivity was increased. In all experimental group, GABA and OPN immunoreactivity were increased, and OPN immunoreactivity was markedly increased especially in the Cosopt?group. NOS immunoreactivity was decreased in all experimental groups. There was no difference in glycine immunoreactivity between the control and experimental groups. Conclusions: Combination anti-glaucoma eye-drops to the D2 mouse changed the retinal neuronal population and these drugs might play an important role in the mechanisms of retinal neuronal death; potential strategies for neuroprotection should therefore be evaluated.

KAL기 폭파범의 법의치과학적 개인식별 감정 예

김종열 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

A Korean Airliner, KAL 858 was exploded over Thailand on November 29, 1987. The suspect with the forged Japanese passport was dead by biting an ample of cyanide gas contained in the filter tip of a cigarette. Forensic odontological examinations including bite mark, dental age estimation and dental characteristics were performed. From these examinations, it could be assumed that (1) he had specific difference in dental treatment which suggested a North Korean by comparison of the fisherman arrested under the North Korea, (2) the filter of cigarette was positioned between the suspect's dentition, (3) he was approximately 70 years old by dental age estimation at time of death. This paper indicates that forensic odontological examination can support personal identification and the circumstances of death in international case where disguised identity plays a part.

Permeation of Ranitidine through the Intestinal Membrane : Site- , pH- and Concentration - dependency

Ok Nam Kim,Ph . D,Gordon L . Amidon 한국응용약물학회 1995 학술대회 Vol.1995 No.1

1999년도 법의부검에 대한 통계적 고찰

이원태 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

This is a statistical analysis based on the data of medicolegal autopsies so called unusual death, brought to this institute by all of law enforcement agencies in Korea during the year of 1999. This report aims to reveal the facts on various causes of unusual death in Korea. Followings are the summary of results. 1.he total numbers of autopsy made for the unusual deaths were 2,461 cases, among them 1,732 cases were males and 729 cases were females. 2.Violent deaths were 1,476 cases(60.0%), natural deaths were 842 cases(34.2%), and unknown cases were 143(5.8%). 3.For deaths due to injuries, blunt object injuries were the leading ahead, 332 cases(44.9%) and sharp object injuries were 169 cases(22.8%). 4.Asphyxial deaths were 354 cases(24.0%), and death due to fatal pressure on the neck were 175 cases showing the biggest number among the asphyxial deaths. 5.For the death due to poisoning, 185 cases(12.5%) were recorded and the biggest number among these was agrochemical poisoning(78 cases). 6.Deaths by fire or burning were 152 cases, deaths due to hypothermia were 22 cases and deaths due to heatstroke were 2 cases. 7.Deaths due to electrocution were 18 cases and all cases were male. 8.There were 3 cases for death due to starvation. 9.The natural deaths were 842 cases(34.2%) and the death due to the disease of the cardiovascular system was taking the most of the total number with 469 cases. 10.Cause of death unknown due to negative autopsy and to the severe decomposition of the body were 143 cases, 5.8 percents of the total number.

제주의대 법의부검례 분석(1998-1999)

강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

The aim of this study was to reveal the current status of forensic practice in Cheju. The range of subjects was limited to deaths autopsied in Cheju National University during the years of 1998 through 1999. All subjects were reviewed with respect to age, sex, cause of death and manner of death. The total number of deaths was 100, of these 85 cases were males and 15 were females. In age distribution, the age group of 30-39 occupied the highest proportion(25.%). According to the manner of death, the cases of violent deaths were 78, natural deaths 20, and unknown cases 2. For the violent deaths, the percentage of accidental death was 30.8 and homicide 25.6, suicide 18.0, undetermined cases 25.6. According to the cause of death, asphyxia was the most common (35%), followed by injury(31%) and disease(20%). Among 35 deaths of asphyxia, 24(68.8%) were deaths due to drowning. Medicolegal scene investigation was done in 16 cases. Two cases remained as deaths of unknown cause because of severe decomposition.

Impact of Financial Crisis on Productivity of Agriculture : Korean Case

Yu, Young-Bong 濟州大學校 社會發展硏究所 2003 社會發展硏究 Vol.18 No.-

임신중절과 관련된 법적 문제

정규원 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

In Korea, abortion is punished by criminal law. But some of them are legalized by "Health Care Act of Mother and Infant.", "Health Care Act of Mother and Infant", enacts the indications of legalized abortions. So it follows the model of "Abortion an Cause.", These indications are genetic indications, ethical indications, and medical indications. But there is not social indications in that Act. And the Act enacts that abortion must be operated by doctors until 28 weeks after pregnancy. I think that the Korean legal system that regulates abortion is not good. I think that abortion must be allowed until some period of early pregnancy. And it is also legalized after that period because of indications. We can not compel the ethical values by the criminal law.

영미 과학수사제도 고찰

표창원 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

The Fingerprint Section was first introduced to Korean Law Enforcement System in 1909, only 8 years after when the Fingerprint Branch at London Metropolitan Police had been created in 1901. Today, while the English Police are equipped with a sophisticated and highly professionalized system of scientific support to criminal investigation, the Korean counterpart is still considered to be highly depending on the field experience and individual efforts of police officers without any scientific qualification in searching for, collecting and analyzing materials and traces from scenes of crime. By reviewing the English and American systems of scientific support to criminal investigation, desirable ways to develop Korean system are being sought in this paper.

Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields

Hye Jung Park, M.D., Ph.D.,Yong Jun Choi, M.D.,Min Jae Lee, M.D.,Min Kwang Byun, M.D., Ph.D.,Sangho Park, B.S.,Jimyung Park, M.D., Ph.D.,Dongil Park, M.D., Ph.D.,Sang-Hoon Kim, M.D., Ph.D.,Young Sam K 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.1

Background: Exhaled condensates contain inflammatory biomarkers; however, theirroles in the clinical field have been under-investigated. Methods: We prospectively enrolled subjects admitted to pulmonology clinics. Wecollected exhaled breath condensates (EBC) and analysed the levels of six and 12biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results: Among the 123 subjects, healthy controls constituted the largest group (81participants; 65.9%), followed by the preserved ratio impaired spirometry group (21patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strongpositive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specificversion of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725,p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). GranzymeB showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078,p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positivecorrelation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophiland basophil counts showed positive correlations with pro-collagen I alpha 1(ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forcedexpiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significantcorrelation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin(ρ=0.4445 and p=0.0017). Conclusion: Inflammatory biomarkers in EBC might be useful to predict quality of lifeconcerning respiratory symptoms and serologic markers. Further studies are needed.

Perception of Long-Term Oxygen Therapy for Chronic Lung Diseases May Affect Poor Adherence in Korea

Hyun-Kyung Lee, M.D., Ph.D.,Hyo Jin Kim, M.D.,Hongyeul Lee, M.D.,Ji Young Yang, M.D.,Jae Ha Lee, M.D.,Seung Won Ra, M.D., Ph.D.,SungMin Hong, M.D.,Ho Young Lee, M.D.,Sung Hyun Kim, M.D.,Mi-Yeong Kim, 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.1

Background: Long-term oxygen therapy (LTOT) improves the survival of patients withhypoxemia due to chronic respiratory diseases. The clinical outcomes of LTOT arestrongly associated with patient adherence. To improve the adherence of patients,physicians have focused on the efficacy of LTOT. However, poor adherence may stemfrom patients’ perceptions of LTOT. Herein we evaluated patients’ perceptions of LTOTaffecting adherence. Methods: We conducted a cross-sectional survey study using descriptive, open, andclosed-ended questionnaire. Patients using oxygen therapy (OT) or requiring it butavoiding OT responded to the questionnaires at three university hospitals. Results: Seventy-nine patients responded to the questionnaires. The number of patientsusing home and portable OT was 69 (93%) and 37 (46.3%), respectively. Patientswith good adherence were 22 (30.1%). Among patients with good adherence, 90.9%used oxygen according to physicians’ prescriptions whereas only 37.3% of those withpoor adherence followed physicians’ prescriptions (p<0.01). The reasons for avoidingusing home OT were fear of permanent use (50%), unwanted attention (40%), and lackof symptoms (40%). They avoided portable OT because of unwanted attention (39%),heaviness (31.7%), and lack of symptoms (21.6%). Conclusion: Patients on LTOT had the perception of the misunderstanding the effectsof OT and of psychosocial barriers to initiate or use LTOT. Considering these findings,health professionals need to provide effective education on the purpose of LTOT toimprove patient adherence to OT and provide sufficient support for the management ofpsychosocial barriers in patients using LTOT.