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Pediatric Liver Transplantation: Caregivers' Quality of Life
Tavares, Ana Paula Bastos,Seixas, Lucas Belem Pessoa de Melo Guerra,Jayme, Caren Lopes Wanderlei,Porta, Gilda,Seixas, Renata Belem Pessoa de Melo,Carvalho, Elisa de The Korean Society of Pediatric Gastroenterology 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.6
Purpose: The survival rate of pediatric patients undergoing liver transplantation has increased considerably. Despite this, the period after transplantation is still complex and poses several challenges to the recipient's family, which is responsible for care management. Recently, more attention has been paid to the impact of this complex procedure on the quality of life of caregivers. Hence, this study is aimed at assessing the quality of life of caregivers of patients who have undergone liver transplantation and the aspects that influence it. Methods: This was an observational and cross-sectional study. From November 2020 to January 2021, short-form-36 questionnaires and additional questions were given to the main caregivers of children and adolescents who underwent pediatric liver transplantation. Results: Thirty-eight questionnaires were completed and the results revealed a lower quality of life in comparison to Brazilian standards, primarily in the mental domains (41.8±14.1 vs. 51.1±2.8; p<0.001). It did not show a significant association with socioeconomic or transplant-related factors, but it did show a negative impact on parents' perception of the child's health. Parents who reported worse health status for their children had a lower mental quality of life (44.1±13.8 vs. 33.3±12.6; p<0.05). Conclusion: The caregivers of transplanted children have a lower quality of life than those of the local population. Psychological assistance should be routinely provided to parents for long-term follow-up to mitigate potential negative effects on the transplanted child's care.
Cezinande Meira,Valsair Matos Pessoa,Jo? Carlos Pinheiro Ferreira,Gustavo Henrique M. Araujo,Marilu M. Gioso,Sony Dimas Bicudo,Eunice Oba,Cassia Orlandi 대한수의학회 2006 Journal of Veterinary Science Vol.7 No.4
The present study was conducted in order to verify the efficacy of lower doses and alternative routes of a prostaglandin F2α analogue, luprostiol (PGF), for the induction of luteolysis and the precipitation of estrus in nonlactating Nelore cows (Bos taurus indicus). A conventional dose (15 mg) of PGF was compared to doses lower than the conventional dose, which ranges from 10 to 50%, that were administered intramuscularly (IM), intravulvosubmucosally (IVSM), or in the Bai-hui acupuncture site located within the lumbosacral area. The cows were administered PGF 8 day after estrus in the presence of a corpus luteum, and randomly assigned to the following groups: G1 (positive control), 15 mg, IM (n = 23); G2, 7.5 mg, IM (n = 23); G3, 3.75 mg, IM (n = 24); G4, 7.5 mg, IVSM (n = 25); G5, 3.75 mg, Bai-hui acupoint (n = 24); and G6, 1.5 mg, Bai-hui acupoint (n = 25). The results indicated that 50% of a conventional dose of PGF (7.5 mg) resulted in a complete luteal regression (plasma progesterone <1 ng/ml) at Hour 48, and hastened estrus, regardless of whether or not PGF was administered IM or IVSM. Comparatively, 10 or 25% of the conventional dose, even when administered to the Bai-hui acupoint, resulted in an initial reduction in the concentration of progesterone at Hour 24, followed by an increase observed at Hour 48. In conclusion, 25% of a conventional PGF dose administered via the Bai-hui acupoint proved inadequate to induce a complete luteal regression, whereas 50% of a conventional dose administered IM or IVSM was found to be the minimal dose required to induce effectively a complete luteal regression, and to precipitate the onset of estrus in nonlactating Nelore cows.
Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Izabela G. Barbosa,Gabriela Neves Vaz,Natalia Pessoa Rocha,Rodrigo Machado-Vieira,Marcio Rogerio Diniz Ventura,Rodrigo B. Huguet,Moises E. Bauer,MIchael Berk,Antônio L. Teixeira 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
Daniela Sánchez Aldana,Cristobal Noé Aguilar,Juan Carlos Contreras-Esquivel,Marthyna Pessoa Souza,Maria das Graças Carneiro-da-Cunha,Guadalupe Virginia Nevárez-Moorillón 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.5
This work aimed to develop an edible coating based on Mexican lime ( Citrus aurantifolia Swingle) pectic extract and essentialoil on Haden mango ( Mangifera indica L.) to extend its shelf life. Mango cubes were coated by immersion in a lime pecticextract (1% pectin w/v), lime essential oil (0.05% v/v), and glycerol (0.7% v/v) solution for 2, 5, and 10 min. Subsequently,coated and uncoated (control) test samples were stored for 21 days, and physical–chemical and microbiological analyseswere performed every 3 days. The results showed no signifi cant diff erences for total soluble solids, pH, and fi rmness. On thesixth day, bacterial growth was signifi cantly lower in coated mangos than in the control (log 6.08 ± 0.49 and 7.63 ± 0.20 UFCg −1 , respectively). The application of the edible coating extended the shelf life of minimally processed mangos by 3 days,delaying physical and chemical changes as well as bacterial growth.
Marcos R da S Vieira,Luiz G M Pessoa,Walter S E Junior,Ygor H Leal,Luzia F da Silva,Rafael C Silva,Eduardo S dos Santos,Thialla L Amorim,Damina C de Medeiros 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.2
This study aimed to assess changes in peroxidase activity and total protein content of cut flowers of Strelitzia reginae that were treated with the chemical preservatives 8-hydroxyquinoline citrate (8-HQC) or chlorine during cold storage. The bases of the cut flowers were immersed in 1.5 L of tap water with 48 h pulsing treatments (a control with no chemical preservatives (0 mg·L-1, 100 mg·L-1 chlorine, 250 mg·L-1 8-HQC or 500 mg·L-1 8-HQC) during cold storage at 10.5°C and 90% relative humidity. The solutions were then replaced with tap water and the cut flowers remained in cold storage for 12 days. For biochemical characterization of peroxidase activity and total protein content, tissue samples (sepals, petals, stems, and bracts) were collected and analyzed at 0, 4, 8, and 12 days after treatment. There was an increase in peroxidase activity in petals, stems, and bracts and a decrease in total protein content, regardless of the treatment used. In this experiment, therefore, differences in peroxidase activity and total protein content due to treatments with 8-HQC or chlorine were not identified.
Noureddine Baaka,Manel Ben Ticha,Wafa Haddar,Maria Teresa Pessoa Amorim,Mohamed Farouk Mhenni 한국섬유공학회 2018 Fibers and polymers Vol.19 No.2
The desire to offer clothes protective properties against the harmful UV rays continues to attract the interest of researchers. Several works have been elaborated in this topic and have proved that the clothes do not protect sufficiently against the solar ultraviolet radiation. Their protectiveness depends on the fiber type, the fabric composition, the fabric construction and the dyeing method. This research presents a novel approach which target the improvement of the textile protective properties against UV rays by their dyeing with grape pomace aqueous extract. These properties were tested in combination with several fabrics (natural and synthetic) and mordants (potassium alum and ferrous sulphate). Through this study, it has been shown that the UV-protective properties of the several dyed fibers were upgraded after dyeing with the grape pomace extract, and is intensely relying on the types of fibers and mordants.
Draulio C. Silva,Ana L.P. Freitas,Carla D.S. Pessoa,Regina C.M. Paula,Jacilane X. Mesquita,Luzia K.A.M. Leal,Gerly A.C. Brito,Danilo O. Gonc¸alves,Glauce S.B. Viana 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. This study evaluated the effects of pectin from P. edulis on rats with alloxan-induced diabetes, on myeloperoxidase release from human neutrophils, and on carrageenan-induced paw edema. In the experiments on carrageenan-induced paw edema, paws were dissected for hematoxylin–eosin staining and immunohistochemistry determinations of tumor necrosis factor-α and inducible nitric oxide synthase. Male Wistar rats were divided into the following groups: diabetic controls and diabetic treated with pectin daily for 5 days (0.5–25 mg/kg orally). Glibenclamide and metformin were used as reference drugs. Forty-eight hours after alloxan administration, blood measures were determined (before treatment) and again 5 days later (after treatment). Pectin decreased blood glucose and triglyceride levels in diabetic rats. Pectin also decreased edema volume and release of myeloperoxidase (0.1–100 μg/mL). It also significantly decreased neutrophil infiltration and partially decreased immunostaining for tumor necrosis factor-α and inducible nitric oxide synthase. In conclusion, these data indicated that pectin, a bioactive compound present in P. edulis, has potential as a useful alternative treatment for type 2 diabetes. Its anti-inflammatory properties are probably involved in its antidiabetic action.
Clinical Predictors of Excessive Daytime Sleepiness in Patients with Parkinson’s Disease
Bruno Terra Junho,Arthur Kummer,Francisco Cardoso,Antonio Lucio Teixeira,Natalia Pessoa Rocha 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.4
Background and Purpose Excessive daytime sleepiness (EDS) is a common complaint among patients with Parkinson’s disease (PD). Several factors have been associated with EDS in PD, especially neuropsychiatric symptoms. This study aimed to determine the relationships between neuropsychiatric symptoms, sociodemographic and clinical parameters, and EDS in PD. Methods This cross-sectional study analyzed 85 patients with PD. All patients underwent socioeconomic and clinical data evaluations followed by a psychiatric interview and a neurological examination, including the assessment of sleep features. Patients were divided into two groups according to the presence or absence of EDS, which was defined as a score higher than 10 on the Epworth Sleepiness Scale. Binary logistic regression was performed in order to describe the predictors of EDS. Results We found that EDS affects 40% of PD patients and is associated with older age, restless legs syndrome, depressive and anxious symptoms, and worse sleep quality. In the multivariate analysis, older age, levodopa use, and worse sleep quality remained as significant predictors of EDS in PD. Conclusions Nighttime sleep problems, older age, and levodopa use are significantly associated with EDS in PD. A careful assessment and the management of sleep problems in PD patients might help to improve their quality of life.
( Santos Ebinuma valeria Carvalho ),( Maria Francisca Simas Teixeira ),( Adalberto Pessoa Jr ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.6
This work aims at investigating the production of yellow, orange, and red natural colorants in a submerged culture of Penicillium purpurogenum DPUA 1275. For this purpose, different experimental conditions evaluating the effect of incubation time, type and size of in℃ulum, and different carbon and nitrogen sources were performed. Furthermore, the growth kinetics were obtained in the conditions of 108 spores/ml and 5 mycelia agar discs during 360 h. These experiments showed that 5 mycelia agar discs and 336 h promoted the highest yellow (3.08 UA400nm), orange (1.44 UA470nm), and red (2.27 UA490nm) colorants production. Moreover, sucrose and yeast extract were the most suitable carbon and nitrogen sources for natural colorants production. Thus, the present study shows a new source of natural colorants, which can be used as an alternative to others available in the market after toxicological studies.
Optimization of Cellulose Extraction from Jute Fiber by Box-behnken Design
Lizandro Manzato,Mitsuo Lopes Takeno,Wanison André Gil Pessoa-Junior,Luis André Morais Mariuba,John Simonsen 한국섬유공학회 2018 Fibers and polymers Vol.19 No.2
Cellulose was isolated from plant material for the first time in 1839 by the French chemist Anselme Payen. In recent years, due to the need in reduce the world’s environmental problems, there has been an increase in studies related to the physical and chemical factors of cellulose. It is important to emphasize that experiments and studies with a cellulose occur individually, because of the variation in the amount of cellulose and the extraction method that differs from plant to plant. In the present study, we determined the optimal conditions for cellulose extraction of jute fiber, using the response surface method. The Box-Behnken Design (BBD) was used statistically evaluate the ratio effects of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO), temperature and extraction time in the process used. The analysis of the results showed a significant variable in the linear and quadratic terms of the temperature and also a significant level of interaction in the effect between the variables of temperature and time. Besides this, the BBD used for the analysis of the extraction yield, resulted in a polynomial regression of second order, in complete agreement with experimental results, with R2=0.9627 (p<0.05). The optimal condition was obtained in a ratio of 1.3 at 45 oC for 2 h. Under the best possible conditions, the obtained experimental value is in accordance with the value predicted by the model, thus indicating a model combination and success to optimize the extraction conditions of the jute fiber pulp in the response surface methodology.