PREDICTION OF THERMAL STRATIFICATION IN A U-BENT PIPE: A URANS VALIDATION

Pellegrini, M.,Endo, H.,Ninokata, H. Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.1

In the present study, CFD is employed to investigate phenomena occurring during a process of thermal stratification in U-bent pipes at transitional Reynolds number. URANS evaluation had been chosen for its low computational costs during transient analysis and for the evaluation of modeling performance in these conditions. Application of CFD at transitional Reynolds number and buoyancy driven flows indeed contains deeper uncertainties in relation to the range of applicability for hydrodynamic and thermal models. The methodology applied in the work points out, through validations with the basic problems constituting the complex stratified phenomenon, the applicability of the current turbulence modeling. Accurate predictions have been found in relation to transitional Reynolds number in bent pipes and region of stability induced by the gravitational field. On the other hand the defects introduced in the unstable region of the U bent pipe, are discussed in relation to the adopted modeling.

CriticalReviews in Oral Biology & Medicine: Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

Pellegrini, G.,Seol, Y.J.,Gruber, R.,Giannobile, W.V. SAGE Publications 2009 Journal of dental research Vol.88 No.12

<P>The development of new medical formulations (NMF) for reconstructive therapies has considerably improved the available treatment options for individuals requiring periodontal repair or oral implant rehabilitation. Progress in tissue engineering and regenerative medicine modalities strongly depends on validated pre-clinical research. Pre-clinical testing has contributed to the recent approval of NMF such as GEM 21 S<SUP>®</SUP> and INFUSE<SUP>®</SUP> bone grafts for periodontal and oral regenerative therapies. However, the selection of a suitable pre-clinical model for evaluation of the safety and efficacy of a NMF remains a challenge. This review is designed to serve as a primer to choose the appropriate pre-clinical models for the evaluation of NMF in situations requiring periodontal or oral reconstruction. Here, we summarize commonly used pre-clinical models and provide examples of screening and functional studies of NMF that can be translated into clinical use.</P>

PREDICTION OF THERMAL STRATIFICATION IN A U-BENT PIPE: A URANS VALIDATION

M. PELLEGRINI,H. ENDO,H. NINOKATA 한국원자력학회 2012 Nuclear Engineering and Technology Vol.44 No.1

In the present study, CFD is employed to investigate phenomena occurring during a process of thermal stratification in U-bent pipes at transitional Reynolds number. URANS evaluation had been chosen for its low computational costs during transient analysis and for the evaluation of modeling performance in these conditions. Application of CFD at transitional Reynolds number and buoyancy driven flows indeed contains deeper uncertainties in relation to the range of applicability for hydrodynamic and thermal models. The methodology applied in the work points out, through validations with the basic problems constituting the complex stratified phenomenon, the applicability of the current turbulence modeling. Accurate predictions have been found in relation to transitional Reynolds number in bent pipes and region of stability induced by the gravitational field. On the other hand the defects introduced in the unstable region of the U bent pipe, are discussed in relation to the adopted modeling.

THE NEW SOCIALLY RESPONSIBLE CONVERSATION BETWEEN COMPANIES AND CITIZENS AT WORK

Davide Pellegrini 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.11

The work analyses three key concepts frequently recalled and strictly correlated: contemporarity of dialogue, convergence of interests and collectivity of responsibilities. The continuous digital conversations between companies and customers are changing the value creation processes and leading to new positive convergence of customers and citizens at work. Convergence is driven by a renewed social sensitivity which is clearly influenced by collective responsibilities. After introducing the literature we bring logical arguments and empirical evidences to focus on the new convergence of market and society interests. Through a new Co-Value Model we measure the intensity of conversations contents: co-advertising contents show the highest level of consumer involvement, followed by co-planning, co-selling, co-use, co-post-sales, co-logistic and co-production. The metrics of the Co-Value Model are aimed to measure and reinforce the basic idea of convergence between the customer perspective- logic of money- and the citizen perspective -logic of gift-. Analyzing the continuous conversation between customer and companies within 21 international digital services, we demonstrate that a) the continuous digital conversations between companies and customers are changing definitively the value creation processes; b) the renewed social sensitivity gradually brings a new convergence between market and society interests which is evidenced by the high frequence of conversation focussed on social topics: c) the new convergence is driven by a renewed collective sense of co-responsibility. The findings show the robustness of the core concept of convergence: companies and customers maintain separate and complementary roles but their conversations are fundamentally remodelled both in content and in shape. Individuals are now called to play an economic role as prosumers, but at the same time, they have new opportunities as citizens for new forms of dialogue which reinforce their critical and social role. This is what we call convergence of interests. Market and society do not coincide, companies and customer act as counterparts and have different roles but their interests are converging. In many cases, prosumerism can generate a new loop between companies and consumers responsibility, and consumers can commit to this new social game of being customer and citizen at work. The model is applied to a large number of very recent case histories able to focus on the managerial implications of the new social game.

THE NEW SOCIALLY RESPONSIBLE CONVERSATION BETWEEN COMPANIES AND CITIZENS AT WORK

Davide Pellegrini 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

The work analyses three key concepts frequently recalled and strictly correlated: contemporarity of dialogue, convergence of interests and collectivity of responsibilities. The continuous digital conversations between companies and customers are changing the value creation processes and leading to new positive convergence of customers and citizens at work. Convergence is driven by a renewed social sensitivity which is clearly influenced by collective responsibilities. After introducing the literature we bring logical arguments and empirical evidences to focus on the new convergence of market and society interests. Through a new Co-Value Model we measure the intensity of conversations contents: co-advertising contents show the highest level of consumer involvement, followed by co-planning, co-selling, co-use, co-post-sales, co-logistic and co-production. The metrics of the Co-Value Model are aimed to measure and reinforce the basic idea of convergence between the customer perspective- logic of money- and the citizen perspective -logic of gift-. Analyzing the continuous conversation between customer and companies within 21 international digital services, we demonstrate that a) the continuous digital conversations between companies and customers are changing definitively the value creation processes; b) the renewed social sensitivity gradually brings a new convergence between market and society interests which is evidenced by the high frequence of conversation focussed on social topics: c) the new convergence is driven by a renewed collective sense of co-responsibility. The findings show the robustness of the core concept of convergence: companies and customers maintain separate and complementary roles but their conversations are fundamentally remodelled both in content and in shape. Individuals are now called to play an economic role as prosumers, but at the same time, they have new opportunities as citizens for new forms of dialogue which reinforce their critical and social role. This is what we call convergence of interests. Market and society do not coincide, companies and customer act as counterparts and have different roles but their interests are converging. In many cases, prosumerism can generate a new loop between companies and consumers responsibility, and consumers can commit to this new social game of being customer and citizen at work. The model is applied to a large number of very recent case histories able to focus on the managerial implications of the new social game.

Performance of carbon fiber added to anodes of conductive cement-graphite pastes used in electrochemical chloride extraction in concretes

M. J. Pellegrini-Cervantes,C. P. Barrios-Durstewitz,R. E. Nú,ñ,ez-Jaquez,F. J. Baldenebro-Lopez,R. Corral-Higuera,S. P. Arredondo-Rea,M. Rodriguez-Rodriguez,O. Llanes-Cardenas,R. Beltran-Chaco 한국탄소학회 2018 Carbon Letters Vol.26 No.-

Pollution of chloride ion-reinforced concrete can trigger active corrosion processes that reduce the useful life of structures. Multifunctional materials used as a counter-electrode by electrochemical techniques have been used to rehabilitate contaminated concrete. Cement-based pastes added to carbonaceous material, fibers or dust, have been used as an anode in the non-destructive Electrochemical Chloride Extraction (ECE) technique. We studied the performance of the addition of Carbon Fiber (CF) in a cement-graphite powder base paste used as an anode in ECE of concretes contaminated with chlorides from the preparation of the mixture. The experimental parameters were: 2.3% of free chlorides, 21 days of ECE application, a Carbon Fiber Volume Fraction (CFVF) of 0.1, 0.3, 0.6, 0.9%, a lithium borate alkaline electrolyte, a current density of 4.0 A / m2 and a cement/graphite ratio of 1.0 for the paste. The efficiency of the ECE in the traditional technique using metal mesh as an anode was 77.6% and for CFVF of 0.9% it was 90.4%, with a tendency to increase to higher percentages of the CFVF in the conductive cement-graphite paste, keeping the pH stable and achieving a homogeneous ECE in the mass of the concrete contaminated with chlorides.

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning

Giovanna Lattanzi,Camilla Pellegrini,Marta Columbaro,Elisa Schena,Sabino Prencipe,Davide Andrenacci,Patricia Iozzo,Maria Angela Guzzardi,Cristina Capanni,Elisabetta Mattioli,Manuela Loi,David Araujo-V 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Type-2 Familial Partial Lipodystrophy is caused by LMNA mutations. Patients gradually lose subcutaneous fat from the limbs, while they accumulate adipose tissue in the face and neck. Several studies have demonstrated that autophagy is involved in the regulation of adipocyte differentiation and the maintenance of the balance between white and brown adipose tissue. We identified deregulation of autophagy in laminopathic preadipocytes before induction of differentiation. Moreover, in differentiating white adipocyte precursors, we observed impairment of large lipid droplet formation, altered regulation of adipose tissue genes, and expression of the brown adipose tissue marker UCP1. Conversely, in lipodystrophic brown adipocyte precursors induced to differentiate, we noticed activation of autophagy, formation of enlarged lipid droplets typical of white adipocytes, and dysregulation of brown adipose tissue genes. In agreement with these in vitro results indicating conversion of FPLD2 brown preadipocytes toward the white lineage, adipose tissue from FPLD2 patient neck, an area of brown adipogenesis, showed a white phenotype reminiscent of its brown origin. Moreover, in vivo morpho-functional evaluation of fat depots in the neck area of three FPLD2 patients by PET/CT analysis with cold stimulation showed the absence of brown adipose tissue activity. These findings highlight a new pathogenetic mechanism leading to improper fat distribution in lamin A-linked lipodystrophies and show that both impaired white adipocyte turnover and failure of adipose tissue browning contribute to disease.

Diet Patterns and Risk of Squamous Cell Oesophageal Carcinoma: A Case-control Study in Uruguay

De Stefani, Eduardo,Deneo-Pellegrini, Hugo,Ronco, Alvaro L.,Boffetta, Paolo,Correa, Pelayo,Mendilaharsu, Maria,Acosta, Gisele,Quarneti, Aldo,Silva, Cecilia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: Oesophageal cancer presents high incidence rates in the so-called Brazilian-Uruguayan belt. Materials and Methods: The present study included 1,170 participants (234 cases and 936 controls) which were analyzed by unconditional multiple logistic regression in order to examine risk of oesophageal squamous cell carcinoma (OESCC) associated with several food groups. Results: Boiled red meat (OR 2.59, 95%CI 1.69-3.97), lamb meat (OR 1.64, 95%CI 1.07-2.51), processed meat (OR 1.49, 95%CI 1.01-2.21), whole milk (OR 1.78, 1.19-1.68), fresh vegetables and fruits (OR 0.42, 95%CI 0.27-0.63), mate consumption (OR 2.04, 95%CI 1.32-3.16), and black tea (OR 0.10, 95%CI 0.04-0.28) were significantly associated with risk of OESCC. Conclusions: Hot beverages (mate) and hot foods (boiled meat) appear to be important determinants in the risk of OESCC, allowing the penetration of carcinogens in tobacco and alcohol into the oesophageal mucosa.

Multidisciplinary approach to Gorlin-Goltz syndrome: from diagnosis to surgical treatment of jawbones

Francesco Spadari,Federica Pulicari,Matteo Pellegrini,Andrea Scribante,Umberto Garagiola 대한악안면성형재건외과학회 2022 Maxillofacial Plastic Reconstructive Surgery Vol.44 No.-

Background: Gorlin syndrome, also known as Gorlin-Goltz syndrome (GGS) or basal cell nevus syndrome (BCNS) or nevoid basal cell carcinoma syndrome (NBCCS), is an autosomal dominant familial cancer syndrome. It is characterized by the presence of numerous basal cell carcinomas (BCCs), along with skeletal, ophthalmic, and neurological abnormalities. It is essential to anticipate the diagnosis by identifying the pathology through the available diagnostic tests, clinical signs, and radiological manifestations, setting up an adequate treatment plan. Main body: In the first part, we searched recent databases including MEDLINE (PubMed), Embase, and the Cochrane Library by analyzing the etiopathogenesis of the disease, identifying the genetic alterations underlying them. Subsequently, we defined what are, to date, the major and minor clinical diagnostic criteria, the possible genetic tests to be performed, and the pathologies with which to perform differential diagnosis. The radiological investigations were reviewed based on the most recent literature, and in the second part, we performed a review regarding the existing jawbone protocols, treating simple enucleation, enucleation with bone curettage in association or not with topical use of cytotoxic chemicals, and “en bloc” resection followed by possible bone reconstruction, marsupialization, decompression, and cryotherapy. Conclusion: To promote the most efficient and accurate management of GGS, this article summarizes the clinical features of the disease, pathogenesis, diagnostic criteria, differential diagnosis, and surgical protocols. To arrive at an early diagnosis of the syndrome, it would be advisable to perform radiographic and clinical examinations from the young age of the patient. The management of the patient with GGS requires a multidisciplinary approach ensuring an adequate quality of life and effective treatment of symptoms.

Study of Chloride Corrosion Organic Inhibitors in Alkaline Pore Solution

( M. Cabrini ),( S. Lorenzi ),( T. Pastore ),( S. Pellegrini ) 한국부식방식학회(구 한국부식학회) 2018 Corrosion Science and Technology Vol.17 No.5

This paper compares the inhibition properties of aspartic and lactic acid salts with nitrite ions and their effect on critical chloride concentration. The tests were carried employing carbon steel specimens in saturated lime solution with varying pH in the range between13 to 13.6. The critical chloride concentration was estimated through multiple specimen potentiostatic tests at potentials in the usual range for passive rebar in the alkaline concrete of atmospheric structures. During tests, chloride salt was added every 48 h until all the specimens showed localized attacks. The cumulative distribution curves, i.e. the number of corroded specimens as a function of the chlorides concentration was obtained. Furthermore, IR spectra were recorded for the evaluation of the presence of the organic inhibitors on the passivity film. The results confirmed the inhibitory effect of 0.1M aspartate comparable with nitrite ions, at a similar concentration. Addition of calcium lactate did not result in an increase in the critical chloride concentration. However, the formation of a massive scale containing the substance that could reduce the corrosion propagation was observed.