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Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting
Patrı´cia L. Alves de Lima,Marina M. Sugui,Angela I.M. Petrı´cio,Lı´zia C. Vilela,Andre´a V.F. Pinto,Priscila R. Martins,Ramon Kaneno,Daniel A. Ribeiro,Daisy M.F. Salvadori,Lu´cia R. Ribeiro 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
This study was undertaken to understand how Lentinula edodes modulates in vivo mutagenesis induced by alkylating agents in bone marrow and peripheral blood as described in our previous article. Male Swiss mice were pretreated for 15 consecutive days with aqueous extracts prepared from L. edodes, after which, the number of circulating blood cells, normal erythroid bone marrow cell cycling, and phagocytosis of micronucleated reticulocyte (MNRET) and activation of spleen macrophages were assessed. The results indicate that the antimutagenicity seen in bone marrow and peripheral blood is exerted by distinct compounds with different actions. The antimutagenic effect in bone marrow is exerted by compounds subject to degradation at deep-freeze storage temperature of - 20 C. On the other hand, compounds responsible for antimutagenicity in peripheral blood are not subject to degradation at - 20 C. The results also indicate that the antimutagenic action in peripheral blood leading to the reduction of circulating MNRET occurs in the spleen primarily through a phagocytic activity due to higher macrophage numbers and probably not due to the enhanced activation state of individual cells.
Patrı´cia Silva de Camargo,Carla Rigo Lima,Maria Luiza de Andrade E Rezende,Adriana Teresa Silva Santos,Joa˜o Wagner Rodrigues Hernandez,Andre´ia Maria Silva 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.1
The purpose of this study was to analyze and compare intra and intergroup the immediate effect of the auricular and LR8 systemic acupuncture on the electromyographic activity of the trapezius with the trigger points. This is an experimental clinical trial; 40 people were split in 4 distinct groups (n = 10): GI mustard seed application in the auricular acupoint; GII bilateral needle application in the LR8 acupoint; GIII combination of the techniques; GIV/Control Group mustard seed application in an acupoint not linked to the muscle tension. The EMG was used to assess the muscle contraction for 5 seconds during the resting time and during the isometric contraction time. The EMG signal was first collect without the acupuncture intervention; then both techniques were applied for 5 minutes; and the EMG was collected again right after these applications. The Shapiro-Wilk test was used, the t test was paired with the Wilcoxon test to the intragroup comparison; One-way analysis of variance test for intergroup comparison. There was no statistical difference in the intragroup comparison for the groups. The same happened to the intergroup comparison before and after application. Systemic and auricular acupuncture did not promote immediate changes in the EMG activity of the trapezius muscle in individuals with MTrPs.
Antidiabetic and Antilipidemic Effects of Manilkara zapota
Sandra Maria Barbalho,Patrı´cia Cincotto dos Santos Bueno,De´bora Souza Delazari,Elen Landgraf Guiguer,,Daniel Pereira Coqueiro,Adriano Cressoni Arau´jo,Maricelma da Silva Soares de Souza,Fla´via M.V. 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.3
Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs and colds and possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, and hypocholesterolemic effects. There are no studies on metabolic profile after using the fruit, and this study aimed at evaluating the effects of the leaf and pulp of M. zapota fruit on the metabolic profile of Wistar rats. Male rats were treated for 50 days with M. zapota leaf juice or fruit juice, after which their biochemical and body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, and body mass index). Our results indicate significantly lower levels of glycemia, insulin, leptin, cholesterol, and triglycerides and augmented levels of HDL-c in animals treated with the leaves or fruit of this plant. The percentage of weight gain also declined in animals treated with M. zapota fruit pulp. The use of the M. zapota may be helpful in the prevention of obesity, diabetes, dyslipidemia, and their complications.
Annona montana Fruit and Leaves Improve the Glycemic and Lipid Profiles of Wistar Rats
Sandra Maria Barbalho,Maricelma da Silva Soares de Souza,Patrı´cia Cincotto dos Santos Bueno,Elen Landgraf Guiguer,,Fla´via Maria Vasques Farinazzi-Machado,Adriano Cressoni Arau´jo,Carla Omete Menegui 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.10
Species of the family Annonaceae has been used traditionally as a medicinal plant in tropical regions of South and North America and in Africa. Annona montana is known popularly as false graviola and originates from tropical America and can be cultivated throughout Brazil. There are no studies in the literature that associate A. montana with the metabolic profile of animals. Therefore, the purpose of this work was to assess the effects of the consumption of pulp and leaves of this plant on the metabolic profile of Wistar rats. The animals, which were treated for 40 days, were divided into two control groups—treated with water via gavage and ad libitum, respectively, and two treated groups—one treated with leaf juice and the other with pulp juice of the fruit. Glycemia, lipids, and body weight were found to decrease and high density lipoprotein-cholesterol (HDL-c) levels to increase in the animals treated with leaf juice. The group treated with pulp juice showed a reduction in lipids and augmented HDL-c. The use of A. montana may have beneficial effects in the prevention of diabetes mellitus and dyslipidemia and may thus contribute to the prevention of cardiovascular diseases.
Pereskia aculeata Miller Flour: Metabolic Effects and Composition
Sandra Maria Barbalho,Elen Landgraf Guiguer,Paulo Sergio Marinelli,Patrı´cia Cincotto do Santos Bueno,Leticia Maria Pescinini-Salzedas,Mirele Cristine Batista dos Santos,Marie Oshiiwa,Claudemir Gregor 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.9
Pereskia aculeata Miller is known in Brazil as ora-pro-nobis (OPN) and has been used commonly in the folklore medicine. The purpose of our study was to evaluate the composition and the effects of OPN flour on the metabolic profile and intestinal motility of Wistar rats. Animals were divided randomly into five groups (n = 10): G1 (control group) and G2 (treated with OPN flour). For the intestinal motility: G3 (control group), G4 (treated with senne), and G5 (treated with OPN flour). After 40 days, G1 and G2 were euthanized and metabolic profiles were analyzed (glycemia, cholesterol, triglycerides, high density lipoprotein [HDL-c], C reactive protein, AST, ALT, Lee Index, weight, and visceral fat). The flour of OPN was effective in reducing percentage of weight gain, visceral fat, levels of total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, and increased HDL-c. Significance was also found in the distance covered by the activated charcoal from the pylorus to the beginning of the cecum, which was higher in animals treated with OPN. Our results indicate that OPN flour may bring health benefits, as the improvement of the intestinal motility, and it is associated with reduction of visceral fat and lipid profile, as well as the increase of HDL-c levels. With these results, we may suggest that the incorporation of this flour in different industrial products may be a convenient and effective way for the intake of healthier products.
Antinociceptive Activity of Aqueous Extract of Bowdichia virgilioides in Mice
Juliane P. Silva,Renato S. Rodarte,Andrea S. Calheiros,Cristiane Z. Souza,Fabio C. Amendoeira,Marco A. Martins,Patrı´cia Machado R. Silva,Valber S. Frutuoso,Emiliano Barreto 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.2
Bowdichia virgilioides Kunth (Family Fabaceae) is a plant that is distributed widely in the tropical and subtropical regions of the world. In the northeast region of Brazil, where B. virgilioides is called “sucupira-preta,” the stem bark is used in folk medicine to treatment of inflammatory and painful diseases. This study aimed to evaluate the antinociceptive activity of the aqueous extract of the dried stem bark of B. virgilioides. The aqueous extract of B. virgilioides in doses of 50, 100, 200, and 400mg/kg was administered orally 1 hour prior to pain induction. Only the doses of 200 and 400mg/kg produced an inhibition by 61% and 74%, respectively, in the number of abdominal writhings induced by acetic acid. This antinociceptive effect was not reversed by pretreatment with naloxone, indicating that the effect is not associated with the activation of opioid receptors. In the formalin test, using the two highest doses, the extract had no effect in the first phase but produced an analgesic effect on the second phase with the inhibition of licking time (P<.001). In the hot plate test, no effect was seen at the dose of 400mg/㎏ p.o. Our findings show that B. virgilioides contains pharmacologically active constituents that possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions.