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Patidar, Kavisha,Deshmukh, Aruna,Bandaru, Srinivas,Lakkaraju, Chandana,Girdhar, Amandeep,Gutlapalli, VR,Banerjee, Tushar,Nayarisseri, Anuraj,Singh, Sanjeev Kumar Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.
Munyakazi, Justin B.,Patidar, Kailash C. Korean Mathematical Society 2014 대한수학회지 Vol.51 No.4
Investigation of the numerical solution of singularly perturbed turning point problems dates back to late 1970s. However, due to the presence of layers, not many high order schemes could be developed to solve such problems. On the other hand, one could think of applying the convergence acceleration technique to improve the performance of existing numerical methods. However, that itself posed some challenges. To this end, we design and analyze a novel fitted operator finite difference method (FOFDM) to solve this type of problems. Then we develop a fitted mesh finite difference method (FMFDM). Our detailed convergence analysis shows that this FMFDM is robust with respect to the singular perturbation parameter. Then we investigate the effect of Richardson extrapolation on both of these methods. We observe that, the accuracy is improved in both cases whereas the rate of convergence depends on the particular scheme being used.
In-Situ Temperature Monitoring and Feedback Control in the Gas Tungsten Arc Welding Process
Anas Ullah Khan,Manish Patidar,Yuvraj K. Madhukar 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.12
An approach has been developed to automate the gas tungsten arc welding (GTAW) process. The process temperature was monitored in-situ and employed to implement feedback control using the infrared ratio pyrometer. The automation of the process was achieved by replacing the foot pedal of the GTAW power source with an in-house developed control system consisting of a data acquisition system and a relay. The GTAW current was made variable automatically to achieve the desired or setpoint temperature. The temperature control is demonstrated for a broad range of 400–1600 °C for both stationary and moving heat source (GTAW torch). The standard deviation from the setpoint temperature was found to be within ± 25 °C for all the cases. It was also implemented for the single-pass bead deposition by feeding a low alloy steel wire to control the bead temperature in the range of 1200–1400 °C at different deposition speeds. The bead geometrical and mechanical properties could be altered by controlling the deposition temperature. The maximum bead width increased, and height decreased with the increase of the deposition temperature at a constant deposition speed. The microhardness was found to decrease by ~ 12% with the increase in deposition temperature from 1200 to 1400 °C, while the deposition speed had a marginal effect.
Justin B. Munyakazi,Kailash C. Patidar 대한수학회 2014 대한수학회지 Vol.51 No.4
Investigation of the numerical solution of singularly perturb- ed turning point problems dates back to late 1970s. However, due to the presence of layers, not many high order schemes could be developed to solve such problems. On the other hand, one could think of applying the convergence acceleration technique to improve the performance of existing numerical methods. However, that itself posed some challenges. To this end, we design and analyze a novel fitted operator finite difference method (FOFDM) to solve this type of problems. Then we develop a fitted mesh finite difference method (FMFDM). Our detailed convergence analysis shows that this FMFDM is robust with respect to the singular perturbation parameter. Then we investigate the effect of Richardson extrapolation on both of these methods. We observe that, the accuracy is improved in both cases whereas the rate of convergence depends on the particular scheme being used.
Kim, Jin Ho,Wang, Pengbin,Park, Bum Soo,Kim, Joo-Hwan,Patidar, Shailesh Kumar,Han, Myung-Soo Elsevier 2018 HARMFUL ALGAE Vol.73 No.-
<P><B>Abstract</B></P> <P>Genetic sub-populations (clades) of cosmopolitan marine diatom <I>Pseudo-nitzschia pungens</I> might have distinct habitats, and their hybrid zone is suspected in higher latitude area of the West Pacific area, however, it is still unrevealed because of technical difficulties and lack of evidences in natural environments. The aim of this study is to investigate the habitat characteristics of each clade of <I>P. pungens</I> on geographical distribution with the habitat temperature ranges of each clade and to reveal their hybrid zone in the West Pacific area. We employed the 137 number of nucleotide sequences of <I>P. pungens</I> and its sampling data (spatial and temporal scale) originated from the West Pacific area, and used field application of qPCR assay for intra-specific level of <I>P. pungens</I>. Only two genotypes, clade I and III, were identified in the West Pacific area. Clade I was distributed from 39 to 32.3°N, and clade III were from 1.4 to 34.4°N. The estimated habitat temperature for the clade I and clade III ranges were 8.1–26.9 °C and 24.2–31.2 °C, respectively. The latitudinal distributions and temperature ranges of each clade were significantly different. The qPCR assay employed, and results suggested that the hybrid zone for clade I and III has been observed in the southern Korean coasts, and clade III might be introduced from the Southern Pacific area. The cell abundances of clade III were strongly related with the higher seawater temperature and warm current force. This study has defined distinct habitat characteristics of genetically different sub-populations of <I>P. pungens</I>, and revealed its hybrid zone in natural environment for the first time. We also provided strong evidences about dispersion of the population of clade III to higher latitude in the West Pacific area.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The habitat ranges of genetically different sub-populations of marine phytoplankton is defined. </LI> <LI> The hybrid zone of genetically different sub-populations of target species is proposed in natural environment. </LI> <LI> The evidences about dispersion for sub-population of target species are provided. </LI> </UL> </P>
Kim, Jin Ho,Kim, Joo-Hwan,Park, Bum Soo,Wang, Pengbin,Patidar, Shailesh Kumar,Han, Myung-Soo Elsevier 2017 HARMFUL ALGAE Vol.63 No.-
<P><B>Abstract</B></P> <P>Three genetic sub-populations (clade I, II and III) of <I>Pseudo-nitzschia pungens</I>, the potential toxic marine diatom, are known to have distinguishable growth characteristics under different culture conditions and distinct distributed patterns in the world. However, to date their exact eco-physiological traits are unrevealed in fields due to lack of the method to detect and/or measure abundances of each sub-populations, hence, the qPCR (quantitative real-time polymerase chain reaction) assay was developed to detect and quantify the <I>P. pungens</I> cells of each clade. Designed two specific primer sets, Pcla12F/R (for clade I and II) and Pcla3F/R (for clade III) only could amplify each target genomic DNA. The, significant linear relationships (R<SUP>2</SUP> >0.998) was established between C<SUB>t</SUB> (threshold cycle) value and the log of cell abundance for each clade. Through the melting curve analysis, comparisons for gene copy numbers among the three clades and spike test for field study, our qPCR assay was reliable to quantify the cell numbers of each clade. There was strong linear correlation (R<SUP>2</SUP> >0.990) between cell abundances as estimated by qPCR assay and direct counting via light microscope in spike test, and 0.24 (clade I), 0.25 (clade II) and 0.33 (clade III) <I>P. pungens</I> cells per mL were detected markedly upon the use of specific two-primer set. Finally, developed qPCR assay was applied on field samples successfully. Our study implicate that our qPCR assay is an accurate and sensitive technique to estimate the cell abundances of each clade of <I>P. pungens</I> in field works.</P>
Bashir A. Dar,Meena Sharma,Baldev Singh,Akshya K. Sahu,Praveen Patidar,Parduman R. Sharma,Nagaraju Mupparapu,Dushyant Vyas,Sudip Maity 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2
The present research work is intended to synthesize a series of substituted 2,3-dihydro-2-phenylquinazolin-4(1H)-ones using clay-supported heteropolyacid as a novel heterogeneous, reusable and inexpensive catalyst. This catalyst afforded excellent yields in very short reaction times that shows high selectivity without affecting other functional groups, such as carbon–carbon double bond and heterocyclic moieties. The catalyst could be recycled at least six times and reused. The synthesis involves cyclo-condensation of anthranilamide with an aldehyde at room temperature in the presence of small amount of the catalyst. No column purification is required and products can be purified by simple crystallization.
Internal carotid artery agenesis presenting with ruptured Acom aneurysm: Rare case report
Bhanu Pratap Singh Chauhan,Harkaran Singh Sahni,Jyoti Gupta,Rajan Pandya,Jayant Patidar,Anita Jagetia 대한뇌혈관외과학회 2023 Journal of Cerebrovascular and Endovascular Neuros Vol.25 No.4
Developmental anomalies of internal carotid artery (ICA), being rare entities, are mostly asymptomatic by themselves because of good collateral supply. However, when present with other associated intracranial anomalies requiring treatment, there can be catastrophic consequences, if special attention is not paid to this condition. We present a case of 36 years old male, who reported to our emergency department with complaints of headache and loss of consciousness. He was diagnosed as a case of ruptured anterior communicating aneurysm with subarachnoid hemorrhage and agenesis of left ICA with trans-cavernous anastomosis. He underwent clipping of aneurysm and was discharged uneventfully. This report highlights the importance of skillful microsurgical clipping in extremely high-risk conditions, in contemporary era of hybrid neurosurgeons.