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      • KCI등재

        도시공원 입지특성에 따른 그린네트워크 활성화 연구 - 부산광역시 도심권을 대상으로 -

        김승환,이규홍,박승범,Kim, Sung-Hwan,Lee, Gyu-Hong,Park, Sung-Bum 한국조경학회 2010 韓國造景學會誌 Vol.38 No.2

        부산은 해안구릉지의 지형특성으로 인하여 공원의 입지가 이용가치가 낮은 산지 주변으로 다수의 공원이 지정되어 있으며, 지역 간의 균형적 입지 측면에서도 문제를 안고 있다. 본 연구에서는 도심생활권 내 도시공원에 대한 환경특성 분석과 더불어 주변시가지와의 상호 관계적 특성에 따라 유형을 구분하고, 그린네트워크 활성화를 위한 유형별 도시공원의 관리방안을 모색하였다. 이를 위해 내륙권역과 해안권역으로 구분하고, 녹지연계적 관점에서 결절부 녹지대에 해당하는 내륙권역의 표고 150~300m, 해안권역의 100~150m 내외의 산지 및 구릉지에 입지하는 도시공원을 분석한 결과, 시가지와 도시공원의 형태가 관입되거나, 지대(地帶)적 중첩의 영향력이 크게 나타나고 있다. 도시공원이 이루는 녹지대는 시가지의 형상과 도시기능에 의해 녹지연계의 방향성과 영향력이 결정적으로 작용하고 있다. 이러한 현황을 바탕으로 도시공원을 유형화하고, 유형별로 미조성 도시공원에 대한 이용성 증진 방안, 녹지연계를 통한 효과적인 그린네트워크 활성화방안을 검토하였다. 완사면 녹지대를 이루는 도시공원은 비교적 양호한 접근성과 뚜렷한 인식성을 지니고 있으며, 중심산지에서 연계된 녹지대가 수렴되는 도시하천과 해안지대에서의 도시기능의 활력과 개방성 확보가 그린네트워크 활성화의 중요한 요인으로 분석되었다. 또한 고지대생활권에서 녹지대에 분포하는 한정적 가용지와 배후녹지로 연계되는 주요 연결로를 중심으로 일상생활영역에서의 그린웨이를 활성화하고, 주요 도로와 도시공원의 주진입부가 교차하는 지역에 지역 커뮤니티의 거점을 형성하는 것이 그린네트워크 활성화의 주요방안으로 제시하였다. Seen topographically, Busan is a city that is coastal and hilly. In the city, most parks have been formed around mountain areas that are not so useful. They also are unbalanced in location among different regions of the city. The purpose of this study is to find how to manage urban parks towards green network promotion. For the purpose, this researcher first analyzed physical and environmental characteristics of urban parks located within the main living spheres of Busan. Then, the researcher examined interactive relations between those parks and downtown areas surrounding them to classify types of the parks. In association, the researcher classified the entire of the city into inland and coastal regions. And the researcher examined mountainous and hilly urban parks that were 150 to 300 meters above sea level in the former region and 100 to 150 meters above sea level in the latter. Findings of the study can be summarized as follows. The above examination found that parks of Busan feature physically penetrating and overlapping with downtown areas of the city. How well the green zones of Busan in form of urban park are inter-connective and influential to each other heavily depends on shapes and functions that the downtown areas of the city have. In this study, urban parks of Busan were grouped according to their types and then analyzed. Based on results of the analysis, the researcher tried to find how to increase the utility of another urban parks that are expected to be formed and how to promote so-called the green network that integrates greens. Considering findings of the study, the researcher would make the following suggestions. In case of forming an urban park in a gently sloped green zone which is easily accessible and noticeable, it's important that the park should include a stream to which another green zone is converged or, if the park is located near a costal area, contribute to promote urban functions and openness. While, in a high-altitude green zone, it's more effective to form so-called the green way that consists of some limited usable site of the zone and greens behind it and then form a hub of regional community at the intersection between the main road and main gate to the urban park, contributing to the green network promotion.

      • KCI등재

        한국 국립공원 산림생태계의 수목 탄소저장량 평가

        이상진,박홍철,박관수,김현숙,이창민,김진원,심규원,최승운,Lee, Sang-Jin,Park, Hong-Chul,Park, Gwan-Soo,Kim, Hyoun-Sook,Lee, Chang-Min,Kim, Jin-Won,Sim, Gyu-Won,Choi, Seung-Woon 한국환경복원기술학회 2022 한국환경복원기술학회지 Vol.25 No.3

        The purpose of this study is to quantitatively evaluate the amount of carbon storage for trees in forest ecosystem to support the foundation for carbon neutrality implementation in Korea National Park. It targeted 22 national parks designated and managed as national parks in Korea, and conducted research on forest trees in the terrestrial ecosystem among various natural and ecological carbon sink. The survey and analysis method followed the IPCC guidelines and the National Greenhouse Gas Inventory in Korea. The amount of tree carbon storage in the forest ecosystem of Korea National Park was confirmed to be about 218,505 thousand CO<sub>2</sub>-ton and the amount of carbon storage per unit area was 570.8 CO<sub>2</sub>-ton per hectare. Compared to 299.7 CO<sub>2</sub>-ton per hectare, the average carbon storage per unit area of the entire Korean forest, it was found that about twice as much carbon was stored when assuming the same area. In other words, it means that the tree carbon storage function of the national park is about twice as high as that of the average tree carbon storage function of entire Korean forest. It has great implications in Korea National Park not only provides biodiversity promotion and exploration services as a national protected area, but also performs excellent functions as a carbon sink.

      • KCI등재

        Effect of Body Condition Score (BCS) on In Vivo Embryo Production and Pregnancy Rate Following Superovulation in Hanwoo

        Gyu-Tae Yeom,Hae-Geum Park1,Nam-Tae Kim,Sung-Woo Kim,Hyun Kim,Yoon-Jung Do,Young-Sin Kim,Soo-Bong Park,Jae-Hwan Kim,Sang-Rae Cho,Jae-Hyeon Cho,Yeoung-Gyu Ko 韓國受精卵移植學會 2013 한국동물생명공학회지 Vol.28 No.1

        Body condition score (BCS) is a useful management tool for distinguishing differences in nutritional needs of cows in the herd. Although it is not always possible to quantify the nutrient content of the feed supplied to the donor cow, the nutritional status can be determined by the BCS. The objective of this study was to evaluate in vivo embryo production, return to estrous of donor and pregnancy rate of recipients following BCS in Hanwoo superovulation. Sixty nine Hanwoo donor cows were flushed on day 7 of estrus cycle with same FSH and artificial insemination by the same technicians. Embryos were recovered on 7 days after the third insemination by flushing the uterus with Embryo Collection Medium. The results obtained were as follows: No differences were observed in the efficiency of superovulation rates regardless of BCS (≤2.0, 2.5 to 3.0, and ≥3.5). The mean number of total embryos was each 5.20±0.86, 11.56±1.04, and 6.23±1.07. The mean number of transferable embryo from ≤2.0, 2.5 to 3.0, and ≥3.5 of BCS was 2.60±0.87, 7.94±0.89, and 4.75±1.32, respectively (p<0.05). Return to estrous regardless of donor BCS was no difference. The pregnancy rates of recipient were BCS ≤2.0 11.76%, 2.5 to 3.0 40.79%, and ≥3.5 11.11%, following transfer of fresh embryos produced in vivo, respectively. These results indicate that if the Hanwoo with BCS 2.5 to 3.3 are used for donor and recipient, the embryo production and the conception rate will be greater.

      • KCI등재

        The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2

        ( Sung Yong Han ),( Hyun Young Woo ),( Jeong Heo ),( Sang Gyu Park ),( Sung Ik Pyeon ),( Young Joo Park ),( Dong Uk Kim ),( Gwang Ha Kim ),( Hyung Hoi Kim ),( Geun Am Song ),( Mong Cho ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3

        Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sustained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment. Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treated with SOF/RBV for 16/12 weeks. Rapid virological response (RVR) was defined as non-detectable HCV RNA at 4 weeks. Results: The RVR rate was 80.7% (146/181), the end of treatment response rate was 97.8% (177/181) and the SVR12 rate was 92.8% (168/181). Of eight patients with relapse, four did not achieve RVR. Three patients had a history of hepatocellular carcinoma (HCC). Multivariable analysis showed that RVR (p = 0.015) and no previous history of HCC (p = 0.007) were associated with SVR12. Factors significantly contributing to RVR included cirrhosis, creatinine concentration, and pre-treatment HCV RNA level. SVR12 rate was significantly higher in RVR (+) than RVR (-) patients (95.2% vs. 82.9%, p = 0.011) and also significantly higher in patients without than with a history of HCC (94.1% vs. 72.7%, p = 0.008). During treatment, 80/181 patients (44.2%) experienced mild to moderate adverse events, with 32 (17.7%) requiring RBV dose reductions due to anemia. Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 patients. RVR and no previous history of HCC were positive predictors of SVR12.

      • SCISCIESCOPUS

        Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl) ethenyl]-quinazoline induces apoptosis via Fas-mediated pathway in HL-60 human leukemia cells

        Park, Eun Young,Kim, Joo-Il,Leem, Dong-Gyu,Shin, Ji-Sun,Kim, Kyung-Tack,Choi, Sang Yoon,Lee, Myung-Hee,Choi, Jung-Hye,Lee, Yong Sup,Lee, Kyung-Tae Spandidos Publications 2016 ONCOLOGY REPORTS Vol.36 No.6

        <P>Previously, we reported that (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline (8-ADEQ), a synthetic analogue of resveratrol had anti-inflammatory and G(2)/M cell cycle arrest activities, but the underlying molecular mechanism of cytotoxic effects of this compound was not determined. In this study, 8-ADEQ displayed potent cytotoxicity and triggered apoptosis in HL-60 cells as evidenced by DNA fragmentation, DNA ladder formation, and the externalization of Annexin V-targeted phosphatidylserine residues in HL-60 cells. In addition, 8-ADEQ triggered activation of caspases-8,-9,-6 and -3 and cleavage of their substrates such as poly(ADP-ribose) polymerase (PARP). Moreover, 8-ADEQ induced loss of mitochondrial membrane potential (MMP) and release of cytochrome c to the cytosol. Caspase-3 inhibitor (z-DEVD-fmk), caspase-8 inhibitor (z-IETD-fmk), caspase-9 inhibitor (z-LEHD), and broad caspase inhibitor (z-VAD-fmk) significantly suppressed the 8-ADEQ-induced DNA fragmentation. Interestingly, pretreatment with z-IETD-fmk, a caspase-8 inhibitor, completely abolished 8-ADEQ-induced caspase-3 and -9 activation, and subsequent DNA fragmentation. 8-ADEQ also increased the expression of Fas, Fas-associated death domain (FADD) and FasL, and formation of death-inducing signaling complex (DISC). Further analysis revealed that 8-ADEQ-induced apoptosis was mediated by upregulation of reactive oxidative species (ROS) generation. Taken together, our data indicated that 8-ADEQ-stimulated apoptosis in HL-60 leukemia cells is due to a Fas-mediated caspase-8-dependent pathway via ROS generation, but also, to a lesser extent cytochrome c release and caspase-9 activation.</P>

      • KCI등재

        Classification of Nasal Index in Koreans According to Sex

        Sung-Suk Bae,Hee-Jeung Jee,Min-Gyu Park,Jeong-Hyun Lee 한국치위생과학회 2023 치위생과학회지 Vol.23 No.3

        Background: The nose is located at the center of the face, and it is possible to determine race, sex, and the like. Research using the nasal index (NI) classification method to classify the shape of the nose is currently in progress. However, domestic research is required as most research is being conducted abroad. In this study, we used a 3D program to confirm the ratio of the nose shape of Koreans.Methods: One hundred patients (50 males and 50 females) in their 20s were evaluated (IRB approval no. DKUDH IRB 2020-01-007). Cone beam computed tomography was performed using the Mimics ver.22 (Materialise Co., Leuven, Belgium) 3D program to model the patient’s skull and soft tissues into three views: coronal, sagittal, and frontal. To confirm the ratio of measurement metrics, analysis was performed using the SPSS ver. 23.0 (IBM Co., Armonk, NY, USA) program. Results: Ten leptorrhine (long and narrow) type, 76 mesorrhine (moderate shape) type, and 14 platyrrhine (broad and short) type noses were observed. In addition, as a result of sex comparison, five males had the leptorrhine (long and narrow) type, 40 mesorrhine (moderate shape), and five platyrrhine (broad and short) types. For females, five patients had the leptorrhine (long and narrow) type, 36 patients had the mesorrhine (moderate shape) type, and nine patients had the platyrrhine (broad and short) type. Conclusion: This study will be helpful when performing nose-related surgeries and procedures in clinical practice and for similar studies in the future.

      • SCISCIESCOPUSKCI등재

        Effect of Low-Cycle Fatigue on the Hot Ductility of Plain Carbon Steel

        ( Sang Chul Seo ),( Hyun Jung Kim ),( Byung Ho Park ),( Kwang Suk Son ),( Sung Keun Lee ),( Sun Bae Kang ),( Dong Gyu Kim ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 METALS AND MATERIALS International Vol.12 No.3

        In a continuous casting steelmaking operation, the surface of a slab is under a condition that can be characterized as high-temperature, low-cycle fatigue in which the tensile and compressive stress is repeatedly developed. For this reason, for the evaluation of the hot ductility of a slab, considering the fatigue deformation is more feasible before a tensile or compressive test. In this study, the effects of low-cycle fatigue on the hot ductility of steels with a carbon content of 0.06-0.8 wt.% are investigated at various temperatures. For a carbon content of 0.06 %, there were no significant differences between the RA values from a simple tensile test and those from a tensile test after fatigue deformation. The tendency of ductility deterioration with fatigue deformation is evident in 0.1 %C steel, and is due to the deformation-induced ferrite film that forms around the prior austenite grain. Conversely, high carbon steel containing 0.8 %C did not show a recovery of hot ductility in a low temperature region, and the specimen on which the tensile was measured after fatigue showed a higher hot ductility in the low temperature region, which is thought to result from the pearlite refinement effects. As the results obtained in this work showed noticeable differences in the hot ductility of carbon steel through the test conditions, it is suggested that for more accurate data, fatigue deformation be adopted in which the temperature range in an unbending operation is determined in the steelmaking factory.

      • KCI등재

        Expression of the survivin-2B splice variant related to the progression of colorectal carcinoma

        Gyu-Seok Cho,Tae Sung Ahn,Dongjun Jeong,Jae-Jun Kim,Chang-Jin Kim,Hyun-Deuk Cho,Dong-Kook Park,Moo-Jun Baek 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.6

        Purpose: Recently, two alternatively spliced survivin variants, survivin-ΔEx3 and survivin-2B, were identified in a single copy of the survivin gene. It has been reported that the expressions of survivin splice variants significantly correlates with the clinical results in many types of human carcinoma. We investigated the transcription levels of survivin and its splice variants in human colorectal carcinomas, and analyzed correlations between survivin expression levels and clinicopathologic features. Methods: We used Western blot and real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) to analyze the protein and mRNA expression levels of survivin variants in 51 colorectal carcinomas. The quantitative RT-PCR was performed using primer pairs specific for survivin and each of its splice variants, then normalized for the gene that encodes glyceraldehydes-3-phosphate dehydrogenase. Results: In Western blotting, the protein levels of survivin were higher in the tumor tissue than in normal tissue. The expression of survivin, survivin-2B and survivin-ΔEx3 mRNA was present in 96%, 64.7%, and 82.4% of the samples, respectively. When the pathologic parameters were compared, colorectal cancers of advanced pT stages showed significant decrease in survivin-2B mRNA expression by the quantitative RT-PCR (P < 0.001). Conclusion: The decreased expression of survivin-2B might be related to tumor progression in colorectal cancers. This finding indicates that alternatively spliced variants of survivin may be involved in refining the functions of survivin during tumor progression.

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