Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

Kang, Kwi Young,Kim, Hyun-Ok,Kwok, Seung-Ki,Ju, Ji Hyeon,Park, Kyung-Su,Sun, Dong-Il,Jhun, Joo Yeon,Oh, Hye Jwa,Park, Sung-Hwan,Kim, Ho-Youn BioMed Central 2011 ARTHRITIS RESEARCH AND THERAPY Vol.13 No.5

<P><B>Introduction</B></P><P>Interleukin (IL)-21 is a cytokine that controls the functional activity of effector T helper cells and the differentiation of Th17 cells, and promotes B-cell differentiation. To test whether IL-21 participates in the pathogenesis of primary Sjögren's syndrome (SS), serum IL-21 level was measured and IL-21 expression in the labial salivary glands (LSG) was examined.</P><P><B>Methods</B></P><P>Serum IL-21 levels in 40 primary SS, 40 rheumatoid arthritis (RA), and 38 systemic lupus erythematosus (SLE) patients and 20 healthy controls were measured. Serum IL-21 levels of SS patients were assessed for correlations with laboratory data, including anti-nuclear antibody, anti-Ro/La antibodies, globulin, immunoglobulin (Ig) class, and IgG subclass. LSGs from 16 primary SS and 4 controls with sicca symptoms were evaluated for IL-21 and IL-21 receptor (IL-21R) expression by immunohistochemistry. Confocal microscopy was performed to further characterize the IL-21 positive cells.</P><P><B>Results</B></P><P>Primary SS patients had significantly higher serum IL-21 levels than controls, and these increments correlated positively with levels of IgG, IgG1. Serum IgG1 levels correlated with anti-Ro antibody titers. Immunohistochemical analyses showed that lymphocytic foci and the periductal area of the LSGs from SS patients expressed high levels of IL-21 and lower levels of IL-21R, whereas the control LSGs showed minimal expression of both antigens. The more the lymphocyte infiltrated, IL-21expression in LSGs showed a tendency to increase. Confocal microscopic analyses revealed that IL-21 expressing infiltrating lymphocytes in the LSGs of SS patients also expressed CXCR5.</P><P><B>Conclusions</B></P><P>Primary SS is associated with high serum IL-21 levels that correlate positively with serum IgG, especially IgG1, levels. The expression of IL-21 is increased as more lymphocytes infiltrated in LSGs. These observations suggest that IL-21 may play an important role in primary SS pathogenesis.</P>

Positive and negative roles of interleukin-6 in bone metabolism , inflammation and cell differentiation : application in oriental medical research

Lee, Dong Kyu,Kang, Dong Hwi,Kim, Dong Il,Lee, Tae Kyun,Park, Young Guk,Kim, Cheorl Ho 대한한의학회 부인과학회 2000 大韓韓方婦人科學會誌 Vol.13 No.2

Interleukin 6 (IL-6)은 여러종류의 세포에서 분화 및 주화인자로 작용하는 사이토카인이다. 사람 IL-6의 분자구조는 21에서 28 kDa의 분자량을 갖는 하나의 폴리펩타이드 단백질로서 N-형과 O-형당부가반응과 세린잔기에 인산화를 수반하여 수식되어 있다. 이 사이토카인은 수성의 28-아미노산 자기로 구성된 시그날배열을 가진 212 아미노산의 전구체 단백질로서 생합성된다. IL-6와 가장 밀접한 분자구조를 갖는 물질로는 granulocyte colony-stimulating factor (G-CSF)가 있으며 사람 IL-6의 유전자는 염색체 7p21에 암호화되어 있다. IL-6는 IL-6수용체 (80 kDa subunit, IL-6Ra)의 a-사슬의 세포의 영역과 상호작용을 거쳐 세포표면에 결합하게 되며 이렇게 생성된 결합체는 gp130수용체와 상호작용하며, 이때 gp130 subunit는 JAK/STAT signaling cascade의 계속적인 활성화능력을 보유하도록 리간드-의존적인 2량화 형성이 유도된다. IL-6Ra의 세포내 영역도메인은 신호전달반응에 아무런 역할을 하지 않으며 IL-6Ra의 세포막통과와 세포질도메인이 결여된 수용성 IL-6수용체도 마찬가지로 IL-6와 반웅하며 상승제로서 가능을 하게 된다. 이러한 광범위한 발현과 효과 때문에 IL-6생성의 생체내에서의 부적절한 발현과 조절은 중요한 생리적인 변화를 야기시킨다. 본 총설에서는 생리적이고 병태생리적인 조건에서의 IL-6의 역할과 기능을 검토하였으며 한의학에서의 면역, 천식, 골대사, 당뇨, 암, 순환기계질환, 신경계질환의 약물개발과 기전해석의 수단으로서 검토하였다. Interleukin 6 (IL-6) is a cytokine that functions as a trophic and differentiating factor in cells of many types. Human IL-6 is a single-chain protein with a molecular mass ranging from 21 to 28 kDa. IL-6 is modified by N- and O-glycosylations, as well as by phosphorylation on serine residues. The cytokine is synthesized as a precursor protein of 212 amino acids with a hydrophobic 28-residue signal sequence. Its closest homolog is granulocyte colony-stimulating factor (G-CSF). The gene for human IL-6 is located on chromosome 7p21. IL-6 binds to the cell surface via an interaction with the extracellular region of the a-chain of the IL-6 receptor (80 kDa subunit, IL-6Ra). This complex then associates with the gp130 receptor. The gpl30 subunit undergoes ligand-dependent dimerization with subsequent activation of the JAK/STAT signaling cascade. The intracellular domain of IL-6Ra does not play a role in signal transduction. The soluble IL-6 receptor, which lacks the transmembrane and cytoplasmic domain of IL-6Ra, is also responsive to IL-6 and acts as an agonist. Because of its wide-ranging expression and effects, the inappropriate expression and modulation of IL-6 production has important physiological consequences. Presently, it was examined that role of IL-6 under physiological and pathophysiological conditions, and its feasibility as a drug discovery target are meaningful in fields of oriental medical research.

위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성

이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1

Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)

Inflammatory Endotypes of Chronic Rhinosinusitis in the Korean Population: Distinct Expression of Type 3 Inflammation

Min Jin-Young,Kim Jin Youp,성충만,Kim Seon Tae,조현진,문수진,Cho Sung-Woo,Hong Sang Duk,Ryu Gwanghui,Cho Kyoung Rai,Kim Young Hyo,Park Soo-Kyoung,Kim Dong-Kyu,Lee Dong Hoon,Heo Sung Jae,Lee Ki-Il,Kim Su Jin,Le 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.4

Purpose: Cluster analyses on inflammatory markers of chronic rhinosinusitis (CRS) in Asians from multicenter data are lacking. This multicenter study aimed to identify the endotypes of CRS in Koreans and to evaluate the relationship between the endotypes and clinical parameters. Methods: Nasal tissues were obtained from patients with CRS and controls who underwent surgery. The endotypes of CRS were investigated by measuring interleukin (IL)-5, interferon (IFN)-γ, IL-17A, IL-22, IL-1β, IL-6, IL-8, matrix metalloproteinase-9, eotaxin-3, eosinophil cationic protein, myeloperoxidase (MPO), human neutrophil elastase (HNE), periostin, transforming growth factor-β1, total immunoglobulin E (IgE), and staphylococcal enterotoxin (SE)-specific IgE. We performed hierarchical cluster analysis and evaluated the phenotype, comorbidities, and Lund-Mackay computed tomography (LM CT) score in each cluster. Results: Five clusters and 3 endotypes were extracted from 244 CRS patients: cluster 1 had no upregulated mediators compared to the other clusters (mild mixed inflammatory CRS); clusters 2, 3, and 4 had higher concentrations of neutrophil-associated mediators including HNE, IL-8, IL-17A, and MPO (T3 CRS); and cluster 5 had higher levels of eosinophil-associated mediators (T2 CRS). SE-specific IgE was undetectable in T3 CRS and had low detectable levels (6.2%) even in T2 CRS. The CRS with nasal polyps (CRSwNP) phenotype and LM CT scores showed no significant differences between T2 and T3 CRS, while the incidence of comorbid asthma was higher in T2 CRS than T3 CRS. In T3 clusters, higher levels of neutrophilic markers were associated with disease severity and CRSwNP phenotype. Conclusions: In Koreans, there is a distinct T3 CRS endotype showing a high proportion of CRSwNP and severe disease extent, along with T2 CRS.

Improvement of interlaminar properties of carbon fiber‑reinforced epoxy composites using aluminum trihydroxide

Dong‑Jun Kwon,Sung‑Min Park,Il‑Jun Kwon,Joung‑Man Park,Euigyung Jeong 한국탄소학회 2019 Carbon Letters Vol.29 No.2

This study provides an economical and effective method to improve the interlaminar properties of carbon fiber-reinforced polymers (CFRPs) using aluminum trihydroxide (ATH) microparticles. ATH microparticles are cheap and are expected to show good affinity to epoxies in the matrix and sizing agents of the carbon fibers owing to the presence of three hydroxyl groups. In addition, ATH particles are reported to improve the mechanical properties of polymers when used as the reinforcement. In this study, ATH microparticles of various sizes, 1.5, 10, and 20 μm, were used to improve the interlaminar properties of the CFRPs. ATH particles with a size of 1.5 μm improved the tensile properties of the ATH/epoxy resin and did not significantly alter the curing behavior. The interfacial adhesion between the carbon fiber and the epoxy resin was also improved, and the impregnation of the resin mixture remained similar to that of the neat resin, resulting in no significant void and defect formation. Considering the above results, the resulting 1.5 μm ATH-reinforced CFRP showed improved interlaminar properties compared to CFRP without ATH. However, 10 and 20 μm ATH-reinforced CFRPs showed deteriorated interlaminar properties due to the diminished tensile properties of the resin itself and resin impregnation, which resulted in more voids and defects, despite the interfacial adhesion between the fiber and the matrix resin.

Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line

Park, Kwang Il,Kim, Dong Gun,Lee, Bo Hyoung,Ma, Jin Yeul Hindawi Publishing Corporation 2016 MEDIATORS OF INFLAMMATION Vol.2016 No.-

<P>Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis (UC). IBD increases the risk of colorectal cancer (CRC), depending on the extent and duration of intestinal inflammation. Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ). KIOM-MA is a specific agent for allergic diseases and cancer, and it is composed of several plants; these herbs have been used in traditional oriental medicine. We fermented KIOM-MA, the product of KIOM-MA128, using probiotics to improve the therapeutic efficacy via the absorption and bioavailability of the active ingredients. In this study, we demonstrated that KIOM-MA/MA128 exhibited anticolitis effects via the modulation of TJ protein. Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 <I>µ</I>g/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction. Furthermore, protein and mRNA TJ levels remained stable after pretreatment with 400 <I>µ</I>g/ml KIOM-MA/MA128. Moreover, KIOM-MA/MA128 suppressed the expression of PLC<I>γ</I>1 and PKC. Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction.</P>

捻轉法이 竝行된 鍼刺戟 및 電鍼刺戟이 鎭痛效果에 미치는 影響

Park, Dong-Seok,Kim, Ji-Hoon,Min, Byung-Il,Oh, Soo-Myung 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Dong-Seok Park¹, Ji-Hoon Kim¹ and Byung-Il Min, Soo-Myung Oh,³¹Department of Acupuncture and Moxibustion, College of Medicine, ²Department of Physiology, College of Medicine, And ³East-West Medical Research Institute, Kyung Hee University,Seoul, Korea. Analgesic Effect of Manual Acupuncture and Electroacupuncture combined with Twirling Method. Proceeding of International Symposium on East-West Medicine Seoul. 187-200, 1999.-Twirling the needle (TN) is one of several needing methods frequently used for acupuncture in the oriental medicine. The present study was conducted to see if TN enhanced the antinociceptive effect produced by plain-or electroacupuncture in the rat tail flick test. Rats (Sprague-Dawley, 200-300g)lightly anesthetized with thiopental sodium(40mg/kg, i.p.) were used in the tail-flick test. The basal reaction time for tail-flick was 2 sec. For "plain" acupuncture(PA), a needle was inserted for 20 min into a Chock-samni (ST36) acupuncture point which (is located at the anterior tibial muscle and about 10mm below the knee joint). For electroacupuncture(EA), train-pulses(3 Hz,0.3-ms pulse width, 0.2-0.3mA) were applied to the inserted needle for the period of insertion. For combining TN with either PA or EA, TN was performed during the each acupuncture period. Two methods for TN were used; twirling 3 times for 1 second persisted for 1 min in every 5 mins(long-duration and long-interval;LDLI) and twirling 3 times for 1 second persisted for 10 sec in every 1 min(short-duration and short-interval;SDSI). PA and EA produced an increase in tail flick latency (TFL); peak increases were 21.3±5.1% and 42.1±17.3% of the pre-acupunture control, respectively, and occurred immediately after cessation of 20min-acupuncture. Performing TN combined with PA increased TFL more than PA itself by showing a greater peak increase in TFL when performed with a SDSI-TN than with a LDLI-TN(60.6±12.5% and 42.7±22.7% of the pre-acupuncture control, respectively). Performing TN combined with EA also increased TFL more than EA itself and a greater peak increase in TFL was observed with a SDSI-TN as compared to a LDLI-TN(77.5±13.8% and 67.3±14.0% of the pre-acupuncture control, respectively). These results indicate that TN enhances both PA-and EA-produced antinociception where an greater enhanced antinociception than a LDLI-TN. It is suggested that performing a SDSI-TN combined with EA seems to be one of the most effective ways to produce analgesia.

新聞에 揭載된 韓國人 自殺記事 內容 分析

박동철,이영식,박두병,곽동일,이길홍 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.4

To analyze the suicide patterns of Koreans, a research study was conducted from the suicide cases taken from the Dong-A Newspaper from 1981 to 1990. Four hundred and eleven cases were obtained from the collected data, which were composed of 275 cases of males and 136 cases of fe-males. The age groups were classified into 6 groups for convenience, 10's, 20's, 30's, 40's, 50's, and 60's. The group differences were then compared for analysis. The characteristics in relation to the socio-demographics and family environment were conpared for analysis. Suicide types compared and analyzed by gender and age group in terms of frequency, type, time, place, method, motivation, location and size of articles, and risk factors for suicide. Sta-tistical analysis used SPSS/PC^+ for cross-tabulation analysis. 1. In relation to the rate of Koreans' suicide, male suicide rate was at least double that of fe-male(2.02 : 1). The age group of the 20's(118 cases) and 30's(96 cases) accounted for a pre-dominant rate of 52.6% of the sample. 2. The distribution of occupation of suicides showed that most were students(22.5%), followed by the unemployed(17.8%) and housewives(12.7%), retrospectively. In relation to the residency of those that had committed suicide, residents who lived in large cities accounted for the greatest number as 70.3%, Especially, females and cases in their 40's were more likely to live in large cities. In the marital status, singles were in the lead(144 cases, 33.0%). With respect to marital status by age group, cases in their 40's(17.4%) tended to have an unstable status such as divorce, separation, co-habitation, remarriage, or widowed, In birth order, the first child were the highest ones as 22.1%. 3. In relationship to the family structure, data revealed that nuclear families were the most(163 cases). Especially, males and cases in their 40's were likely to be form a nuclear familiy, while those in their 60's were from and extended family. In relation to parental survival, data showed that both parents dead were at the highest frequency as 264 cases. In case of female, loss of both parents were more frequent. 4. With respect to the frequency of recurrent suicide, data presented that 6.3% of the cases ex-perienced recurrent suicide. In case of the recurrent suicide of male(8.0%), the rate was about 2.3 times higher than of female(2.9%) 5. For the relationships of homicide and suicide, data showed that 128cases(31.2%) hurt others and attempted suicide. Among them, 96 cases(23.4%) attempted co-suicide and 32 cases(7.8%) attempted homicide others. Analyzed by the characteristics of gender and age group, 10's males were more likely to commit solo-suicide, women in their 30's or 40's commit co-suicide, and 50's commit suicide after homicide. Among the victims of homicide, family members were the most(42 cases). Analysis by age difference between the suicide partners, the cases of 30's or 40's were with family members, 20's with lovers, and 10's with their peers. 6. In relation to the annual distribution of frequency of suicide, data revealed that most cases of suicide were reported in 1990(95 cases), 70 case in 1981, 45 cases in 1982, 44 in 1983, 30 in 1986, 1987, 1989, each, the fewest cases were in 1985(14 cases). In terms of the trend of sui-cide, recently the rate of male and old cohorts over 50's has been increasing. A great number of suicide were in 1981∼1982 and 1989∼1990, the period of a treat political-economical up-heaval. On the other hand, the number of suicide was low during the period of political-economical stability of 1985 and of political thawing in 1988. These fact demonstrated that there were some relationships between political-economical change and the rate of suicide. 7. For the month of suicide, data showed that the highest frequency of cases were in May and June(21.7%), followed by 44(10.7%) in September. For the season of suicide, the fewest cases were in winter(78 cases). The cases of 10's or 20's were more likely to suicide in May and June, and those of older aged group above 50's in fall, weekend, between 1 : 00∼6 : 00 A.M. 8. With respect to the place of suicide, data presented that in most cases suicide was attempted at home(210 cases). Compared by gender, the rate of femal's suicide at home(71.3%) was remarkably higher than that of male's(41.4%). On the other hand, the rate of male's suicide in indoors was much higher(36.4%) than that of female's(15.4%). Analyzed by age groups over 50's were more likely to attempt suicide at home, 30's in indoors, 20's in the office or outdoors. 9. For the methods of suicide, 31.9% resort to intoxication followed hanging(21.9%), jumping(13.1%), burning(10.2%), CO poisoning(6.1%), gunshot(3.9%) or drowning(2.9%), Compared by gender, while females were more likely to take such passive methods as intoxication or CO poisoning, males were more likely to take rather fatal methods such as hanging, burning, gunshot. 10. In relation to the general motives of suicide, data showed that economic poverty was the lead(20.9%), followed by emotional conflict(19.2%), marital conflict(16.1%), demonstration(8.5%), health problem (6.3%), school problems(5.8%), and job problems(5.6%). Analyzed by age group, in case of 10's adolescent conflicts such as school problems, scolding of parents of teachers, mockery, and frustration were the major motivations of their suicide, in the cases of 20's hetero-sexual problems, job and demonstration were their motivators. In case of 30's marital and legal problems were the motivators, economic problems in the age of 40's, loss of objects in 50's and health problems in 60's were their major motivations of suicide. 11. Analyzed by subtypes of suicide in the socio-psychological perspective, data showed that fatalistic suicide was the most frequent(30.2%), followed by anomic suicide(29.4%), egoistic suicide(21.7%), altruistic suicide(11.2%). Whereas in case of males altruistic and egoistic suicide were relatively more frequent, in case of females fatalistic and egoistic suicide were relatively more frequent. Analyzed by age group, fatalistic suicide in the 60's, anomic suicide in the 40's, egoistic suicide in the 10's adolescents and altruistic suicide in the 20's were more frequent. 12. For the psychodynamic factors of suicide, data revealed that most cases were escape from despair and loneliness(28.5%), followed by revenge toward the objects that hurt him or her(14.8%), inferiority(12.7%), escape from a conflict situation(11.4%), altruistic(7.8%), self-punishment for guilt(6.8%), pessimism(3.9%), reunion fantasy(1.0%), and other(13.1%). Whereas the psychodynamic factors of males were altruistic and inferiority, those of females were despair and revenge. Analyzed by age group, incase of old age groups over 50's despair and loneliness were the major fcators, revenge in the 30's and 40's, altruistic in the 20's inferiority and escape from a conflict situation in the 10's were more frequent psychodynamic factors. 13. With respect to the suicide risk rescue factors, data showed that as the helpers at the time of trying suicide, family members were the most(111 cases). Family members as helpers were more frequent in the case of females and in those of 10's or 60's. While passerbys were more frequent in the case of males and in those of 50's. For the suicide notes, 17.3% left the notes behind and those in their 60's males were more likely to have a relatively higher rate of leaving motes behind. 14. In relation to the experience rate of the suicide risk factors, data demonstrated that 16.8% had a history of depression which comprised the highest rate, followed by an alcoholism history(10.0%), unemployment and retirement(7.1%), recent death of intimates and separation(4.6%), health change(3.2%). Analyzed by gender and age groups, males were more likely to have an alcoholism or depression history, those in their 40's were more likely to have an alcoholism history than those of any other age group cohorts.

判別分析法을 利用한 脂肪肝의 高危險群 豫測

朴鏞萬,金埈淵,金東一,李常柱,朴耕一,金源述,鄭甲烈 동아대학교 부설 산업의학연구소 1995 산업의학연구소 논총 Vol.- No.2

This study was carried out on 484 persons who visited Dong-A University Hospital Human Dock Center from March to August 1992. The objective of this study is prediction of high risk group of fatty liver from obesity, liver function test, and serum lipid levels using method of discriminant analysis, in general screening of health check, especially abdominal ultrasonography was not done. Result of discriminant analysis were 328 cases in control group, 267 were predicted correctly to be members of control group(81.4%), while 61 were assinged incorrectly to fatty liver group. Similarly, 95 out of 70(73.7%) of the fatty liver group were identified correctly, and 25(26.3%) were misclassified. The overall percentage of cases classified correctly was 79.67%.

산악형 국립공원의 구조활동 현황과 개선방안 -설악산 국립공원을 중심으로-

조태동 ( Tae Dong Jo ),김일수 ( Il Su Kim ),박진홍 ( Jin Hong Park ) 한국녹지환경디자인학회 2005 녹지환경학회지 Vol.1 No.1

This study examines current situation of rescue activities in mountainous national parks and suggests various measures to improve the pending problems, with a special focus on Soraksan National Park. Its method includes theoretical consideration, field survey and interviews with visitors. The results are as follows; We need; First, supplement of specialized rescue workers. Second, information and education against possible safety accidents for visitors. Third, region-specific education and improvement of working environment for 119 rescue workers. Forth, active rescue activities by establishing policies for private rescue units.