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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
박병우,강길전 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1
119 amenorrheic patients were diagnosed in the department of Obstetrics and Gynecology of Chungnam National University Hospital and Hanyang University Hospital during the period of 57 months from November, 1979 to July, 1984. The retrospective study was undertaken to determine whether or not the division of patients with amenorrhea into specific categories based on physical findings and specific laboratory tests would be valid and useful for the differential diagnosis of amenorrhea. The results obtained were as follows : 1. Of 119 amenorrheic patients 38 patients (31.9%) were primary type and 81 patients (68.1%) were secondary type. 2. Of 38 primary amenorrheic patients the most common cause of the amenorrhea was hypogonadotrophic hypogonadism (9 cases). The cause of the remainder was Turner syndrome (5 cases), testicular feminization (5 cases), gonadal dysgenesis (3 cases), hypothalamic dysfunction (3 cases), hypothalamo-pituitary failure (3 cases), Rokitansky syndrome (2 cases), pituitary adenoma (2 cases;, Stein-Leventhal syndrome (2 cases), ovarian failure (2 cases), CO poisoning (1 case) and anorexia nervosa (1 case). 3. Of 81 secondary amenorrheic patients the most common cause of amenorrhea was hypothalamic dysfunction (42 cases). The cause of the remainder was functional hyperprolactinemia (11 cases), premature menopause (9 cases), Stein-Leventhal syndrome (6 cases), hypothalamopituitary failure (5 cases), pituitary adenoma (4 cases), hypothyroidism (1 case), empty sella syndrome (1 case), Sheehan's syndrome (1 case) and adrenal masculinizing tumor (1 case). 4. 119 amenorrheic patients were classified into 3 group : 1) breast development absent and uterus present (17 cases), 2) breast development present and uterus absent (7 cases), and 3) both breast development and uterus present (95 cases). 5. Patients in category 1 were diagnosed as having hypogonadotrophic hypogonadism or gonadal dysgenesis. Patients in category 2 were diagncsed as having Rokitansky syndrome or testicular feminization. Patients in category 3 were diagnosed as having ovarian failure, Stein-Leventhal syndrome, hyperprolactinemia, hypothalamc dysfunction, or hypothalamo-pituitary failure. 6. Patients in category 1 could be differentiated by measurement of serum FSH level. Patients in category 2 could be differentiated by chromosome study. Patients in category 3 could be differentiated by following method. By measurement of serum FSH levl ovarian failure was differentiated. Of the remaining patients, patients with Stein-Leventhal syndrome were identified by measurement of serum LH. The next step of measurement of serum prolactin could identify hyperprolactinemia. The remaining patients were divided into hypothalamic dysfunction or hypothalamo-pituitary failure by progesterone withdrawal test. This study demonstrated that it is possible to classify patients with primary or secondary amenorrhea into 3 useful diagnostic categories based on physical examination and minimal laboratory test.
골반내에 발생한 Proximal-type 유상피성 육종 1예
길준철,이상수,전병화,김성훈,손우석,목정은,박양순,강길현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4
유상피성 육종은 매우 드문 악성 연조직 육종으로, 전형적인 경우들은 주로 젊은 남성의 수부, 전완부와 같은 신체의 원위부에 피하 혹은 심재성 피부 종괴로 발생하며, 조직학적 소견상 적은 비정형성을 나타내는 유상피성 세포와 방추형 세포의 증식에 의한 다발성 결절 형태의 배열을 보인다. 최근에 전형적인 유상피성 육종과 조직학적 유사성을 가지나 더 공격적인 형태인 proximal-type 유상피성 육종이 보고되었으며, proximal-type은 전형적인 유상피성 육종에 비하여 현저한 유상피성 세포의 발현과 매우 심한 비정형성을 나타내며, 세포가 매우 크고, 소포성 핵과 뚜렷한 핵소체를 보이며, 자주 rhabdoid 세포의 양상을 띈다. 임상적으로는 전형적인 형태에 비하여 호발 연령이 조금 늦고, 주로 체간부에, 특히 골반, 회음부, 생식기 등과 같은 심부에 발생하고, 더욱 공격적인 양상을 나타낸다. 저자들은 13세 소녀에서 원발부위를 알 수 없는, 골반내에 발생한 proximal-type 유상피성 육종 1예를 경험하여, 문헌 고찰과 함께 보고하는 바이다. Epithelioid sarcoma is a rare malignant soft-tissue sarcoma with an unknown histiogenesis, typically presenting as a subcutaneous or deep dermal mass lesion in the distal portions of the extremities of young adults. Recently, a more aggressive, so-called 'proximal-type' epithelioid sarcoma has been reported. In contrast to conventional epithelioid sarcoma, the proximal type is characterized by a predominantly large cell epithelioid cytomorphology, marked cytologic atypia, and frequent occurrence of rhabdoid features in most patients. Proximal-type epithelioid sarcoma has a predilection for appearing in the genitalia, especially the vulva, penis, pelvis and buttocks. Also this lesion appears to be somewhat more aggressive or at least metastasizes earlier than the conventional epithelioid sarcoma. We report a 13-year-old girl who presented with a buge mass filling the pelvic cavity which was painful, hard and fixed on palpation, and was radiologically diagnosed as a malignant germ cell tumors on the CT scan. The mass was surgically excised and pathologically proved to be an proximal-type epithelioid sarcoma of unknown origin.
박재선,박두병,이길홍 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.4
The present study was to examine the relationship between psychiatric inpatients' occuputions and their anxiety level. The sampling subjects were randomly selected by 3 stage probability proportional culster extraction method among psychiatric who were admitted to the psychiatric clinics and hospitals nationwide. Four hundred and twenty eight subjects including 249 males and 179 females were undergone by questionnaire survey while measurement of anxiety was done by using Zung's self-rating anxiety scale. Collected data were processed by IBM PC AT computer using SPSS program and statistically analyzed by chi-square test and analysis of variance. 1) It was revealed that these psychiatric inpatients showed relatively higher rates of the unemployed (34.6%), single(43.2%), and divorce(5.1%). 2) Patients with higher classes of occupation such as administrative, managerial or clerical workers showed higher rate of divorce. 3) In the occupational distribution of psychiatric disorders, psychotic disorders were more prevalent among high or low occupational classes, neurotic disorders more prevalent among middle occupational classes, while psychoactive substance use disorder more prevalent among farmers and sales workers. 4) Overall the mean anxiety score of the whole subjects is 39.28 ±14.67. The mean anxiety score (39.71±14.89) of the pschiatric inpatients with job is higher than that (36.59±14.20) of the unemployed. 5) In the anxiety tendency according to occupational classification, the unemployed showed less anxiety compared with the employed. Patients with middle occupational classes such as fishing workers and sales workers showed higher levels of the cardiovascular, musculoskeletal, respiratory and skin system anxiety, while patients with higher or lower occupational classes showed lower anxiety. In the relationship between occupational classes and level of anxiety, it showed profiles of inverted V curve. 6) The lower occupational classes such as sales workers showed higher anxiety level, while the higher occupational classes such as clerical workers showed lowest one. Particularly the fishing group exposed in the higher stress situation showed the highest level of anxiety.
박병천,이성길,이용택 慶熙大學校 材料科學技術硏究所 1997 材料科學技術硏究論集 Vol.10 No.-
Epoxy resin based upon the N,N'-diglycidylaniline was modified with poly(amic acid)(PAA). Prior to aromatic amine cure, the possible reactions in the epoxy resin/PAA blends were investigated used FT-IR and inherent viscosity techniques with the addition of 4,4'-diamino-3,3'-diethyldicyclohexylmethane(3DCM) as hardener. PI-modified epoxy(GAYA) blends were prepared by IPNs method. IR, TGA, DSC, DMA, TMA and UTM are used to measured the thermal and mechanical properties. Thermal stability increasing with increasing PAA content in blends. Lowering Tgs with increasing PAA content in blends are observed except for the blend modified with thermoplastic. Improvement of the impact strengths in J/M in the range 920∼2,412 are observed for blends and the improvement of the impact strength is closely related to the content of PAA in blends. A rough surface was observed by SEM examination on the propagation surface of the impact specimen, while a smooth surface is observed on the unmodified epoxy specimen. The morphological observations suggest the PAA segment may act as a toughening agent in the epoxy networks, thus contributing to the impact improvement of the blends.
안홍길,박경우,김병기 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-
In Software development the new paradigm. Component-based Software Development is processes which assembly component that encapsulate it's structure and operation, that interact through it's interface. CBD is inducing an interest from the existing development way to the component assembly and composition, improving the software quality by supporting the verified component-based reuse. Even though well-organized component, if component composition were not efficient because of non-effective information about component, it would be a low productivity and would be made of low qualified software. Thus, in order to provide information for composition, the author introduced the relevance between component structure and composition knowledge, making efficient component composition.
소아 척수종양 24예의 임상분석(1973~1986) : Clinical Analysis of 24 Cases(1973~1986)
조병규,박인성,왕규창,최길수 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6
The authors analyzed 24 cases of intraspinal tumors in children who had been operated upon at the Seoul National University Hospital from 1973 to 1986. The ratio of male to female was 2 : 1. The pathologic diagnosis revealed neurogenic tumor in 8 cases(33%), metastasis in 3 cases(13%), glioma in 3 cases(13%), lymphoma in 3 cases(33%), metastasis in 3 cases(13%), sarcoma in 3 cases(13%), and tumor of dysembryogenesis in 2 cases(8%). The tumors were located most frequently in the thoracolumbar area(7 cases, 29%) and in the epidural space(12 cases, 50%). Two thirds of the epidural tumors were malignant. The most common initial presentation was motor weakness(9 cases, 38%). Three cases(13%) presented with mass and one case(4%) with flexion deformity. On admission 9 cases(38%) were in the paraparetic stage, 6 cases(25%) in the radiculopathic stage, and 6 cases in the Brown-Sequard syndrome stage. The mean value of the CSF protein was 1, 108 mg%. Plain spine X-rays were abnormal in 17 cases(74%) and the increased interpedicular distance(11 cases, 48%) was the most common radiological abnormality. Myelographic studies were performed in 21 cases and all of them revealed abnormal findings. Total and gross total removal was possible in 13 cases(54%). Radiation therapy was done in 8 cases(33%) and chemotherapy in 5 cases(21%). The surgical result on discharge or at the postoperative one month was recovery in 7 cases(29%), improvement in 10 cases(42%), stationary state in 4 cases(17%), and progression in 3 cases(13%). After 20.8 months of mean follow-up duration in 20 cases(84%), the result was recovery in 13 cases(65%), improvement in 2 cases(10%), stationary state in one case(5%), and progression in cases(20%). As a major complication, there was a spinal deformity in 6 cases(29%) among 21 cases who did not have spinal deformity preoperatively. Three cases(13%) were followed up to their deaths. And the authors discussed the clinical features of the pediatric intraspinal tumors reported in the literature and the results of the present study.
깁병철,박세현,이행세,김영길 亞洲大學校 1986 論文集 Vol.9 No.-
In this paper, a new focusing method, to be called the sampled delay focusing (SDF), is proposed to improve the B-scan lateral resolution. In SDF, sampling sum process can replace the conventional delay sum sampling process, and thus the analog delay lines are no longer necessary. This method offers continuous dynamic focusing on the resolution pixel basis if the maximum delay time is less than the sampling interval. Second order sampling is adopted in order to extend the sampling interval.
민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.