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Facile synthesis of carbon layered TiO2 nanocomposite for high photocatalytic activity
Vijayarohini Parasuraman,Muhammad Awais Aslam,Parasuraman Perumalswamy Sekar,Van-Quyet Nguyen,Ye eun Lee,Hojae Lee,Woo Ram Lee,Seungdo Kim 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-
A green synthesis route was designed to develop a visible-light-driven thin carbon layered titanium dioxide(CLT) nanocomposite using ascorbic acid as carbon precursor. The presence of a thin layer of carbon(CLT) on the TiO2 surface was observed from HR-TEM. The thickness of CLT is directly proportional to theconcentration of carbon precursor, where this CLT acts a photosensitizer for harvesting the broad band ofvisible light spectrum. CLT nanocomposite (15.485 m2/g) showed an improved surface area of 1.4 timesthat of a commercial TiO2 (7.461 m2/g). The photocatalytic activity of CLT nanocomposite was investigatedfor the volatile organic compound destruction using p-xylene pollutant in a standard ISO photocatalyticoxidation reactor under daylight. The mechanism pathway of CLT nanocomposite was followed bythe adsorption of chemical contaminants in the pores of CLT that precisely capture the contaminants captureand destruction on its surface. The electron-hole pair recombination rate of CLT nanocomposite waslower than the pristine TiO2 was evident from photoluminescence spectra. The antibacterial activity ofCLT was also studied using E. coli as a model pathogen. This environmentally friendly photocatalyst CLToffers a novel route for good industrial utilization because of its low cost and mass production.
Parasuraman Basker,Pichai Kannan,Karumana Gounder Kolandaswamy 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.1
Objectives: To know the prevalence of leptospirosis cases reported in private clinics among fever cases in Villupuram District, Tamil Nadu, India to know its real magnitude of the problem and to diagnose Leptospirosis among fever cases from differential diagnosis. Methods: 1502 Blood serum samples collected from three urban towns namely Kallakurichi (Latitude: 11' 73' N; Longitude: 78' 97' E), Villupuram (Latitude: 11' 75' N; Longitude: 79' 92' E) and Thindivanam (Latitude: 12' 25' N; Longitude: 79' 65' E) in fifteen clinics based on case definition of leptospirosis delineated by the National Vector Borne Disease Control Programme (NVBDCP), Government of India. Samples were tested in the laboratory of the Zonal Entomological Team (ZET), Cuddalore with Macroscopic Slide Agglutination Test (MSAT) and Ig-M ELISA. Result: There were 65 positive cases detected from 1502 blood serum samples in both MSAT and Ig-M ELISA. It could be known that there was 4% cases contributed from private clinics among fever cases. From this study, further it was known that all age groups of people affected irrespective of sexes based on their living condition associated with the environment prevailed of the disease. Conclusion: From this study, it was quantified that 4% of cases reported in private clinics among fever cases and its findings ascertained both the importance of differential diagnosis as well as reports that should be included to the Government for knowing its real magnitude for planning.
Parasuraman Basker,Karumana Gounder Kolandaswamy 질병관리본부 2015 Osong Public Health and Research Persptectives Vol.6 No.3
Objectives: This study was carried out in order to understand the behavior of dengue viruses through the entomological and laboratory surveillance of outbreaks. The aim of the study was to provide additional research to support current knowledge of epidemiological, clinical, and laboratory diagnosis of dengue virus and ultimately to use this information to forecast dengue as well as to justify intervention measures. Methods: Data on the presence of Aedes larvae in human dwellings during the entomological surveillance in Cuddalore, Nagapattinam, and Tirunelveli dengue outbreaks were taken to compute indices, namely the House Index (HI), Container index (CI), and the Breteau Index (BI). Standard procedures were followed for nonstructural Protein 1 (NS1) and immunoglobulin M enzyme linked immunosorbent assay for the confirmation of dengue. Serovar confirmation was made in the Kottayam field station of the Vector Control Research Center, Puducherry. Results: Larval indices HI < 2e3% and BI < 20 contributed to halting the outbreak. Incubation of the dengue viruses in humans was detected at 15 days, NS1 was identified as a tool for the early diagnosis of dengue cases and its presence indicated the need to implement all available interventions. It was also discovered that it is helpful to search for hidden habitats of Aedes when dengue cases have not been reduced even after the sustainable management of the larval indices, HI < 5% and BI < 20. Based on the observed incidences of stopping dengue outbreaks, it was learnt that neighborhood areas of the outbreak villages, around 400 m, should have permissible larval indices < 5% HI and BI < 20. Heterogeneous serovars that led to dengue hemorrhagic fever and Dengue Shock Syndrome (DSS) were identified using reverse transcription polymerase chain reaction and reconfirmed in the field as DEN-1 and DEN-3 viruses and were circulating in Tirunelveli during the outbreak. Conclusion: The behaviors of dengue viruses experienced in experimental, clinical, epidemiological, entomological, and laboratory surveillance did not deviate from observations in the field during dengue outbreaks in the Cuddalore, Nagapattinam, and Tirunelveli districts of Tamil Nadu, India.
Pump availability prediction using response surface method in nuclear plant
Suganya Parasuraman,Swaminathan Ganapathiraman,Anoop Bhargavan 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1
The safety-related raw water system’s strong operational condition supports the radiation defense and biological shield of nuclear plant containment structures. Gaps and failures in maintaining proper working condition of main equipment like pump were among the most common causes of unavailability of safety related raw water systems. We integrated the advanced data analytics tools to evaluate the maintenance records of water systems and gave special consideration to deficiencies related to pump. We utilized maintenance data over a three-and-ahalf- year period to produce metrics like MTBF, MTTF, MTTR, and failure rate. The visual analytic platform using tableau identified the efficacy of maintenance & deficiency in the safety raw water systems. When the number of water quality violation was compared to the other O&M deficiencies, it was discovered that water quality violations account for roughly 15% of the system’s deficiencies. The pumps were substantial contributors to the deficit. Pump availability was predicted and optimized with real time data using response surface method. The prediction model was significant with r-squared value of 0.98. This prediction model can be used to predict forth coming pump failures in nuclear plant.
Inhibition of Microbial Quorum Sensing Mediated Virulence Factors by Pestalotiopsis sydowiana
Paramanantham Parasuraman,B Devadatha,V. Venkateswara Sarma,Sampathkumar Ranganathan,Dinakara Rao Ampasala,Dhanasekhar Reddy,Ranjith Kumavath,김인원,Sanjay K. S. Patel,Vipin Chandra Kalia,이정걸,Busi Siddha 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.4
Quorum sensing (QS)-mediated infections cause severe diseases in human beings. The control of infectious diseases by inhibiting QS using antipathogenic drugs is a promising approach as antibiotics are proving inefficient in treating these diseases. Marine fungal (Pestalotiopsis sydowiana PPR) extract was found to possess effective antipathogenic characteristics. The minimum inhibitory concentration (MIC) of the fungal extract against test pathogen Pseudomonas aeruginosa PAO1 was 1,000 μg/ml. Sub-MIC concentrations (250 and 500 μg/ml) of fungal extract reduced QSregulated virulence phenotypes such as the production of pyocyanin, chitinase, protease, elastase, and staphylolytic activity in P. aeruginosa PAO1 by 84.15%, 73.15%, 67.37%, 62.37%, and 33.65%, respectively. Moreover, it also reduced the production of exopolysaccharides (74.99%), rhamnolipids (68.01%), and alginate (54.98%), and inhibited the biofilm formation of the bacteria by 90.54%. In silico analysis revealed that the metabolite of P. sydowiana PPR binds to the bacterial QS receptor proteins (LasR and RhlR) similar to their respective natural signaling molecules. Cyclo(- Leu-Pro) (CLP) and 4-Hydroxyphenylacetamide (4-HPA) were identified as potent bioactive compounds among the metabolites of P. sydowiana PPR using in silico approaches. The MIC values of CLP and 4-HPA against P. aeruginosa PAO1 were determined as 250 and 125 μg/ml, respectively. All the antivirulence assays were conducted at sub-MIC concentrations of CLP (125 μg/ml) and 4-HPA (62.5 μg/ml), which resulted in marked reduction in all the investigated virulence factors. This was further supported by gene expression studies. The findings suggest that the metabolites of P. sydowiana PPR can be employed as promising QS inhibitors that target pathogenic bacteria.
Vijayarohini Parasuraman,Muhammad Awais Aslam,Seungdo Kim 한국대기환경학회 2021 한국대기환경학회 학술대회논문집 Vol.2021 No.10
Visible light driven carbon doped titanium dioxide (CA-TiO₂) nanoparticles have been developed by a single-pot green synthesis method by ascorbic acid as a carbon dopant. The physicochemical properties of as-prepared photocatalyst are characterized by various spectroscopic techniques (XRD, FT-IR, and UV-VIS). A simple post-pyrolysis step is applied to increase the photocatalytic activity of CA-TiO₂ under visible light. The interface combination between TiO₂ and the precursor carbon increases the specific surface of TiO₂, extends light response, and enhances its efficiency due to electron migration stimulated by white daylight. Titanium dioxide nanoparticles combined with carbon layer via surface carbonyl groups to facilitate high interactions among the interfaces is evidenced by XPS spectroscopy. This environment-friendly photocatalyst CA-TiO₂ offers a novel route for promising industrial uses because of its low cost and mass production.