http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Paranjpe, Avina (검색결과 1 건)
-
Mechanisms and prevention of material toxicities in dentistry
Paranjpe, Avina University of California, Los Angeles 2007 해외박사(DDOD)
The use of resin based materials/methacrylates and bleaching gels in dentistry are becoming increasingly common because of their excellent bonding properties & also their esthetic appearance. However, not all patients and dental personnel are aware of the cytotoxic effects these materials have on the dental pulp and other tissues in the body. There is direct evidence that released components of dental resins do kill cells in vitro. We observed that methacrylates like 2-hydroxyethyl methacrylate (HEMA) and bleaching gels cause apoptosis in different cell types which include human & murine cells. Apoptosis in this case stress induced & is mediated via the intrinsic pathway through the mitochondria and by modulating various transcription factors like nuclear factor kappa B (NFkappaB) and c-Jun. However, apoptosis could be effectively prevented with the use of an established antioxidant like N acetyl-cysteine (NAC). Our results show that NAC stabilizes the mitochondrial membrane potential & also decreases the activation of the downstream caspases. In addition, NAC downregulates c-Jun-N-terminal kinase and upregulates NFkappaB which also contributes to the survival of cells. Hence the main of this study was to target the different pathways through which these methacryaltes cause apoptosis in addition to finding different agents that would neutralize this toxicity thereby making these dental materials more biocompatible. We present NAC as one such agent. We believe that using NAC along with these dental materials will make them potentially less harmful to the human body thereby making these materials more biocompatible.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
