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Treatment-failure tularemia in children
Karli, Arzu,Sensoy, Gulnar,Paksu, Sule,Korkmaz, Muhammet Furkan,Ertugrul, Omer,Karli, Rifat The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.2
Purpose: Tularemia is an infection caused by Francisella tularensis. Its diagnosis and treatment may be difficult in many cases. The aim of this study was to evaluate treatment modalities for pediatric tularemia patients who do not respond to medical treatment. Methods: A single-center, retrospective study was performed. A total of 19 children with oropharyngeal tularemia were included. Results: Before diagnosis, the duration of symptoms in patients was $32.15{\pm}17.8days$. The most common lymph node localization was the cervical chain. All patients received medical treatment (e.g., streptomycin, gentamicin, ciprofloxacin, and doxycycline). Patients who had been given streptomycin, gentamicin, or doxycycline as initial therapy for 10-14 days showed no response to treatment, and recovery was only achieved after administration of oral ciprofloxacin. Response to treatment was delayed in 5 patients who had been given ciprofloxacin as initial therapy. Surgical incision and drainage were performed in 9 patients (47.5%) who were unresponsive to medical treatment and were experiencing abcess formation and suppuration. Five patients (26.3%) underwent total mass excision, and 2 patients (10.5%) underwent fine-needle aspiration to reach a conclusive differential diagnosis and inform treatment. Conclusion: The causes of treatment failure in tularemia include delay in effective treatment and the development of suppurating lymph nodes.
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Treatment-failure tularemia in children
Arzu Karlı,Gülnar Sensoy,Sule Paksu,Muhammet Furkan Korkmaz,Ömer Ertugrul,Rıfat Karlı 대한소아청소년과학회 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.2
Purpose: Tularemia is an infection caused by Francisella tularensis. Its diagnosis and treatment may be difficult in many cases. The aim of this study was to evaluate treatment modalities for pediatric tularemia patients who do not respond to medical treatment. Methods: A single-center, retrospective study was performed. A total of 19 children with oropharyngeal tularemia were included. Results: Before diagnosis, the duration of symptoms in patients was 32.15±17.8 days. The most common lymph node localization was the cervical chain. All patients received medical treatment (e.g., streptomycin, gentamicin, ciprofloxacin, and doxycycline). Patients who had been given streptomycin, gentamicin, or doxycycline as initial therapy for 10–14 days showed no response to treatment, and recovery was only achieved after administration of oral ciprofloxacin. Response to treatment was delayed in 5 patients who had been given ciprofloxacin as initial therapy. Surgical incision and drainage were performed in 9 patients (47.5%) who were unresponsive to medical treatment and were experiencing abcess formation and suppuration. Five patients (26.3%) underwent total mass excision, and 2 patients (10.5%) underwent fine-needle aspiration to reach a conclusive differential diagnosis and inform treatment. Conclusion: The causes of treatment failure in tularemia include delay in effective treatment and the development of suppurating lymph nodes.
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Gorkem Gedik,Aysun Aksit,Birol Engin,Ufuk Paksu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12
The main aim of this study was to produce PVC coated textile based antibacterial textile material and to investigate the antibacterial mechanism with detailed analyzes. Metal oxide (calcium oxide, zinc oxide, magnesium oxide) powders were used to provide antibacterial functionality to coated materials. Metal oxide concentrations were varied between 5-35 %. Antibacterial tests were performed according to ISO 22196-2011 standard. Antibacterial efficiency of the samples was tested for each metal oxide type and concentration with L. innocua species. The antibacterial mechanism was investigated with ESR technique, fluorescent microscobe and microplate reader using DCFH-DA probe, UV-vis spectrometer using fluorescein probe. The results indicated that the antibacterial effect of used metal oxides was strongly arisen from radical oxygen species. The morphology of coatings was investigated with SEM and the distribution of metal oxide particles on the surface was examined with EDX analysis and EDX mapping. The changes on the molecular basis of the coating due to the metal oxide addition was analyzed with FT-IR spectroscopy. High antibacterial efficiencies (up to 100 %) were detected. It is suggested that the non-toxic metal oxides can be used as an effective and economically feasible alternative to conventional antibacterial additives for industrial applications such as conveyor belts.
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