비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Electrochemical Dechlorination of 1,2,4-Trichlorobenzene Using a Reticulated Vitreous Carbon Electrode

Paeng, Ki-Jung,Lim, Chae-Yun,Lee, Bo-Young,Myung, No-Seung,Rhee Paeng, In-Sook Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.9

Stepwise dechlorination of 1,2,4-trichlorobenzene was observed at a glassy carbon electrode in dimethylformamide containing 0.1 M tetraethylammonium perchlorate. Especially, dechlorination to dichlorobenzene and further to monochlorobenzene or benzene was successfully demonstrated with a porous reticulated vitreous carbon electrode. Electrochemical dechlorination of polychlorobenzenes employing a flow cell with a reticulated vitreous carbon working electrode is also described. Preliminary experiments with a flow cell showed that dechlorination of trichlorobenzene to dichlorobenzene was partially completed while dechlorination to benzene or monochlorobenzene was not successful, suggesting that a flow rate and electrolysis time should be further optimized for the complete electrolysis.

Kaon condensation in baryonic Fermi liquid at high density

Paeng, Won-Gi,Rho, Mannque American Physical Society 2015 PHYSICAL REVIEW C - Vol.91 No.1

Computation of the Mutual Radiation Impedance in the Acoustic Transducer Array: A Literature Survey

Paeng, Dong-Guk,Bok, Tae-Hoon,Lee, Jong-Kil The Acoustical Society of Korea 2009 韓國音響學會誌 Vol.28 No.e2

Mutual radiation impedance becomes more important in the design and analysis of acoustic transducers for higher power, better beam pattern, and wider bandwidth at low frequency sonar systems. This review paper focused on literature survey about the researches of mutual radiation impedance in the acoustic transducer arrays over 60 years. The papers of mutual radiation impedance were summarized in terms of transducer array structures on various baffle geometries such as planar, cylindrical, spherical, conformal, spheroidal, and elliptic cylindrical arrays. Then the computation schemes of solving conventional quadruple integral in the definition of mutual radiation impedance were surveyed including spatial convolution method, which reduces the quadruple integral to a double integral for efficient computation.

The Goldreich-Goldwasser-Halevi cryptosystem using polynomial representations

Paeng, Seong-Hun 建國大學校基礎科學硏究所 2003 理學論集 Vol.28 No.-

A public key cryptosystem based on the closest vector problem was suggested by Goldreich, Goldwasser and Halevi [2]. We suggest an improvement of this system by suing polynomial representations.

Feasibility and kinetic characteristics of 68Ga-NOTA-RGD PET for in vivo atherosclerosis imaging

Paeng, J. C.,Lee, Y. S.,Lee, J. S.,Jeong, J. M.,Kim, K. B.,Chung, J. K.,Lee, D. S. Springer Science + Business Media 2013 Annals of nuclear medicine Vol.27 No.9

Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions

PAENG, SUNG HWA,JUNG, WON-KYO,PARK, WON SUN,LEE, DAE-SUNG,KIM, GI-YOUNG,CHOI, YUNG HYUN,SEO, SU-KIL,JANG, WON HEE,CHOI, JUNG SIK,LEE, YOUNG-MIN,PARK, SAEGWANG,CHOI, IL-WHAN UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.5

<P>Choroidal neovascularization (CNV) can lead to progressive and severe visual loss. Vascular endothelial growth factor (VEGF) promotes the development of CNV. Caffeic acid phenethyl ester (CAPE), a biologically active component of the honeybee (Apis mellifera) propolis, has been demonstrated to have several interesting biological regulatory properties. The objective of this study was to determine whether treatment with CAPE results in the inhibition of the production of vascular endothelial growth factor (VEGF) in retinal pigment epithelial cells (RPE cells) under hypoxic conditions and to explore the possible underlying mechanisms. An in vitro experimental model of hypoxia was used to mimic an ischemic microenvironment for the RPE cells. Human RPE cells (ARPE-19) were exposed to hypoxia with or without CAPE pre-treatment. ARPE-19 cells were used to investigate the pathway involved in the regulation of VEGF production under hypoxic conditions, based on western blot analysis, enzyme-linked immunosorbent assay (ELISA) and electrophoretic mobility shift assay (EMSA). The amount of VEGF released from the hypoxia-exposed cells was significantly higher than that of the normoxic controls. Pre-treatment with CAPE suppressed the hypoxia-induced production of VEGF in the ARPE-19 cells, and this effect was inhibited through the attenuation of reactive oxygen species (ROS) production, and the inhibition of phosphoinositide 3-kinase (PI3K)/AKT and hypoxia-inducible factor-1α (HIF-1α) expression. These in vitro findings suggest that CAPE may prove to be a novel anti-angiogenic agent for the treatment of diseases associated with CNV.</P>

MANIFOLDS WITH NONNEGATIVE RICCI CURVATURE ALMOST EVERYWHERE

Paeng, Seong-Hun Korean Mathematical Society 1999 대한수학회지 Vol.36 No.1

Under the condition of RicM $\geq$ -(n-1), injM $\geq$ I0, we prove the existence of an $\varepsilon$>0 such that on the region of volume $\varepsilon$>0 the curvature condition of splitting theorem can be weakened.

Ultrasonic Visualization of Dynamic Behavior of Red Blood Cells in Flowing Blood

Paeng, D.-G.,Nam, K.-H. IOS Press 2009 JOURNAL OF VISUALIZATION Vol.12 No.4

<P>It is well known that the scatter of ultrasound by blood is mainly attributed to red blood cells (RBCs) and RBC aggregation. In the present review, researches of hemodynamic influence on RBC aggregation and ultrasound backscatter from blood were overviewed. A mock flow loop and a cylindrical chamber were employed to produce various blood flows, such as pulsatile, oscillatory, and rotational flow. The 'black hole' (BLH), a dark hole at the tube center surrounded by bright zone in the cross sectional B-mode image and 'bright collapsing ring' (BRCR) phenomena, appearance of bright ring at the periphery and collapse of it at the center during a pulsatile cycle, were observed under pulsatile flow. The combined effects of shear rate and flow acceleration on RBC aggregation were suggested as a possible mechanism for these phenomena. The stroke volume-dependence of the 'bright ring' phenomenon under oscillatory flow could also be explained by flow acceleration. The enveloped echo images from rotational flow in a compact blood chamber showed the spatial and temporal variations of RBC aggregation, which varied with the mammalian species. In the stenotic model, it was found that the echogenic variation increased locally at a distance of three tube diameters downstream from the stenosis during decelerating period, which was proposed to be mainly due to flow turbulence. The similar 'bright ring' was also observed from in vivo human carotid artery in harmonic imaging. </P>

Alternative Medical Treatment for Radioiodine-Refractory Thyroid Cancers

Paeng, Jin-Chul,Kang, Keon-Wook,Park, Do-Joon,Oh, So-Won,Chung, June-Key The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.4

Thyroid cancer is one of the most rapidly increasing cancers in many countries. Although most thyroid cancers are differentiated cancers and easily treated with radioiodine (RI), a portion of differentiated and undifferentiated cancers is refractory not only to RI therapy, but also to radiotherapy and chemotherapy. Thus, various alternative therapies have been tested in RI-refractory thyroid cancers. These alternative therapies include two major categories: redifferentiation therapy and recent molecular target therapy. Several clinical trials have investigated these therapies. They demonstrated potential effects of the therapies, although the results have been somewhat limited so far. Thus, the future strategy for undifferentiated thyroid cancers will involve individualized, lesion-specific, and combined therapy. In this review, the basic mechanism of each redifferentiation and molecular target therapy is discussed, and results of recent clinical trials using these therapeutic agents are summarized.