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Francisco J. Ortega,Francisco J. Navarro,Moisés García-Morales,Tony McNally 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-
Polymer modified bitumens (PMBs) have largely been utilized as a construction material. However, lackof affinity between bitumen and polymer leads to phase separation, and eventually, performancedepletion. In this paper, alternative formulations of bitumen with an organically-modified montmorillonite(OMMT) Cloisite 20A1 and polymeric methylene diphenyl diisocyanate (MDI) were prepared bymelt blending. Their comprehensive rheological characterisation evidenced improved linear viscoelasticproperties when OMMT is added, revealing a noticeable structural reinforcement and thermal stability. Rheological data also showed that MDI-involved reactions control the composite end properties, beinggreatly influenced by the shear conditions applied
Norberto Chavarría-Hernández,Eduardo Ortega-Morales,Apolonio Vargas-Torres,Juan-Carlos Chavarría-Hernández,Adriana-Inés Rodríguez-Hernández 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.4
This study is the first to describe the evolution of both hydrodynamic and oxygen transfer conditions during the submerged culture of the entomopathogenic nematode,Steinernema carpocapsae CABA01 (an indigenous strain isolated within the State of Hidalgo, Mexico), and its symbiotic bacterium, Xenorhabdus nematophila, using an internal-loop mechanically agitated bioreactor of 4.5 L of liquid volume. Concentrations up to 217,306 viable nematodes per mL, with 94% in infective juvenile (IJ) stage (i.e.,204,444 IJ/mL), were achieved in 16 days of bioprocess. The Reynolds number (Re) was used as an index of the actual hydrodynamic conditions, and it varied within the interval 5,150 < Re (dimensionless) < 9,440, involving apparent culture broth viscosity changes from 3 to 5.4 mPa s during the processing. The aeration efficiency was expressed on the basis of the volumetric oxygen transfer coefficient, kLa, which varied within the range 0.026 to 0.170 s−1.
Alida Ospina-Orejarena,Ricardo Vera-Graziano,Maria Monica Castillo-Ortega,Juan Paulo Hinestroza,Mabel Rodriguez-Gonzalez,Laura Palomares-Aguilera,Marissa Morales-Moctezuma,Alfredo Maciel-Cerda 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.4
Increasing bioactivity and mechanical properties of polymers to produce more suitable scaffold for tissue engineering is a recurrent goal in the development of new biomedical materials. In this study, collagen-functionalized poly (lactic acid), PLA, was obtained by means of a simple grafting route, and electrospun scaffolds were produced to grow cells in vitro; their bioactivity was compared with scaffolds made of physical blends of PLA and collagen. Grafting was verified via nuclear magnetic resonance, attenuated total reflection-Fourier transform infrared and X-ray photoelectron spectroscopy. The cell adhesion performance of the scaffolds was studied using macrophages. Elastic modulus (74.7 megapascals) and tensile strength (3.0 megapascals) of the scaffold made from PLA grafted with collagen were substantially higher than the scaffolds made from physical blends of collagen and PLA: 32 and 2.16 megapascals, respectively, implying a more resistant material because of the chemical bond of the polypeptide to PLA. Besides, the fibers had more uniform diameter without defects. Scaffolds made from PLA grafted with collagen presented four-fold increase in cell adhesion than those of PLA blended with collagen. Furthermore, cell spreading within the scaffolds occurred only when collagen-functionalized poly (lactic acid) was used. These results open a new option for the easy tailoring of nanofiber-based scaffolds in three dimensions for tissue engineering.
David Moro-Valdezate,Salvador Peiró,Elvira Buch-Villa,Antonio Caballero-Gárate,M. Dolores Morales-Monsalve,Ángel Martínez-Agulló,Félix Checa-Ayet,Joaquín Ortega-Serrano 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1
Purpose: The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. Methods: Observational, multicenter and prospective study of a cohort of breast cancer patients, assessing HRQOL at 1, 6, and 12 months after surgery using three questionnaires: EuroQol-5D-3L, EORTC QLQ-C30, and EORTC QLQ-BR23. Results: A total of 364 women participated in the study. Visual Analogue Scale (VAS) scores from the EuroQol improved (1 month vs. 1 year: 70 vs. 80; p<0.0001); however, the EuroQol score showed no significant change (0.81 vs. 0.83; p=0.1323). In contrast, Global Health Status on the EORTC QLQ-C30 improved (66.67 vs. 100.00; p<0.0001), as did all of this instrument´s scales and most of its independent items. The EORTC QLQ-BR23 dimensions showed improvement, except for sexual functioning (100.00 vs. 86.67; p=0.0030) and future perspective (33.33 vs. 66.67; p<0.0001). Patients with good HRQOL outcomes at 1 month showed improved levels of HRQOL at 1 year; HRQOL measured at 1 month was predictive of HRQOL at 1 year. Conclusion: HRQOL improved during the follow-up period. Likewise, HRQOL measurement instruments can predict early HRQOL.