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        • KCI등재

          Influence of CBCT metal artifact reduction on vertical radicular fracture detection

          Oliveira,Mariana,Rodrigues,Sousa,Thiago,Oliveira,Caetano,Aline,Ferreira,de,Paiva,Rogério,Ribeiro,Valladares-Neto,José,Yamamoto-Silva,Fernanda,Paula,Silva,Maria,Alves,Garcia 대한영상치의학회 2021 Imaging Science in Dentistry Vol.51 No.1

          Purpose: This study evaluated the influence of a metal artifact reduction (MAR) tool in a cone-beam computed tomography (CBCT) device on the diagnosis of vertical root fractures (VRFs) in teeth with different root filling materials. Materials and Methods: Forty-five extracted human premolars were classified into three subgroups; 1) no filling; 2) gutta-percha; and 3) metallic post. CBCT images were acquired using an Orthopantomograph 300 unit with and without a MAR tool. Subsequently, the same teeth were fractured, and new CBCT scans were obtained with and without MAR. Two oral radiologists evaluated the images regarding the presence or absence of VRF. Receiver operating characteristic (ROC) curves and diagnostic tests were performed. Results: The overall area under the curve values were 0.695 for CBCT with MAR and 0.789 for CBCT without MAR. The MAR tool negatively influenced the overall diagnosis of VRFs in all tested subgroups, with lower accuracy (0.45- 0.72), sensitivity (0.6-0.67), and specificity (0.23-0.8) than were found for the images without MAR. In the latter group, the accuracy, sensitivity, and specificity values were 0.68-0.77, 0.67-083, and 0.53-087, respectively. However, no significant difference was found between images with and without MAR for the no filling and gutta-percha subgroups (P>0.05). In the metallic post subgroup, CBCT showed a significant difference according to MAR use (P<0.05). Conclusion: The OP 300 MAR tool negatively influenced the detection of VRFs in teeth with no root canal filling, gutta-percha, or metallic posts. Teeth with metallic posts suffered the most from the negative impact of MAR.

        • KCI등재

          Impact of Zinc Stress on Biochemical and Biophysical Parameters in Coffea Arabica Seedlings

          Jacqueline,Oliveira,dos,Santos,Cinthia,Aparecida,Andrade,Kamila,Rezende,Dázio,de,Souza,Meline,de,Oliveira,Santos,Isabel,Rodrigues,Brandão,Jose,Donizeti,Alves,Iasminy,Silva,Santos 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.3

          Zinc is an essential micronutrient for the healthy development of plants, since its insufficient and supraoptimal doses can disrupt the metabolism and biomass production. We aimed to investigate the physiological responses of coffee seedlings to Zn deficiency and excess. Six-month-old seedlings were transferred to plastic pots containing a nutrient solution. The treatments were control (0.03 ppm), zinc deficiency (0.00 ppm), and zinc excess (0.12 ppm). The evaluations were performed in leaves and roots at the beginning of the treatments and after 30 and 60 d of treatments. Zn deficiency and excess increased the production of hydrogen peroxide, antioxidant enzymes activity, ascorbate, and lipid peroxidation contents. The imbalance in zinc nutrition reduced total chlorophyll content and increased carotenoids content throughout the experimental period. Lower biomass and proline accumulation were observed only for deficient seedlings at the end of the experiment. The characteristics analyzed showed that zinc deficiency caused greater damage to the Coffea arabica plants of (Catuai cultivar) than zinc excess.

        • KCI등재

          Genipa americana (Rubiaceae) Fruit Extract Affects Mitogen-Activated Protein Kinase Cell Pathways in Human Trophoblast–Derived BeWo Cells: Implications for Placental Development

          Aline,Oliveira,da,Conceição,Maria,Helena,Rossi,Fernando,Faustino,de,Oliveira,Larissa,Takser,Julie,Lafond 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5

          Genipa americana L. (Rubiaceae) is a fruit tree and a traditional medicine used to treat anemia, icterus, asthma, and liver and spleen problems. The aim of the present study was to verify the effect of G. americana fruit ethanolic extract on the mechanism for proliferation and differentiation of trophoblast-like cells. Qualitative analysis of G. americana fruit extract was performed, and BeWo cells, a well-established placental choriocarcinoma cell line that can undergo differentiation, were used to analyze cell viability and proliferation. Methods consisted of cytotoxic and proliferation measurement, detection of release of human chorionic gonadotrophins, cell fusion observation, and evaluation of cell-signaling pathways (production of cyclic adenosine monophosphate and phosphorylation of mitogen-activated protein kinases [MAPKs]). A stock solution of the extract was diluted in Ham's F-12 medium with 10% fetal bovine serum at concentrations ranging from 50 to 1000 μg/mL. Cells treated with dimethylsulfoxide, forskoline, and MAPK inhibitors (PD98059 or SB203580) were used as a control. Forskoline was used to induce the differentiation state in BeWo cells. Phytoanalysis indicated the presence of steroids only. Results showed that the G. americana fruit extract did not cause any cytotoxicity or interference in cell differentiation. However, a significant antiproliferative state related to inhibition and reactivation of ERK1/2 and p38 MAPK in BeWo cells was seen. These results suggest that steroids from G. americana may affect placental cell regulation.

        • SCIESCOPUSKCI등재

          Corns with Different Nutritional Profiles on Growing and Finishing Pigs Feeding (30 to 90 kg)

          De,Oliveira,,Gisele,Cristina,Moreira,,Ivan,De,Souza,,Ana,Lucia,Pozzobon,Murakami,,Alice,Eiko,Parra,,Angela,Rocio,Poveda,De,Oliveira,Carvalho,,Paulo,Levi,Borile,,Maicon,Danner Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.7

          Three experiments were carried out to determine the nutritional value and to verify the pig performance in growing and finishing phases (30 to 90 kg) fed on diets containing common corn (CC), high-lysine corn (HLC) and high-oil corn (HOC). In the total digestibility trial (Exp. I) 12 barrows were used. Values of digestible energy (DE) and metabolizable energy (ME) as-fed basis for CC, HLC and HOC, were: 3,396 and 3,275 kcal/kg; 3,248 and 3,139 kcal/kg; 3,445 and 3,308 kcal/kg, respectively. In order to determine the apparent and true ileal digestibility coefficients of amino acids, as well as the values of true digestible amino acids of the CC, HLC and HOC, an ileal digestibility trial was done (Exp. II) with T-cannulated barrows ("T" simple). The treatments consisted of three diets, with one of them as the sole source of protein (CC, HLC and HOC). In the performance experiment (Exp. III), 36 crossbred pigs, allotted in a completely randomized design with three treatments and 12 replications were used. Treatments consisted of three diets: 1 - CC; 2 - HLC and 3 - HOC. It was observed no difference for performance and carcass variables among the corns with different nutritional profiles. Results of the three experiments highlighted the importance of segregating corns in their real chemical and energetic composition as well as the values of true digestible amino acids for formulating diets for growing and finishing pigs.

        • KCI등재SCOPUS

          Epizootic Infection by Trypanosoma vivax in Cattle from the State of Minas Gerais, Brazil

          Matheus,de,Oliveira,Reis,Fernanda,Rezende,Souza,Adriana,Silva,Albuquerque,Fernanda,Monteiro,Luan,Francisco,dos,Santos,Oliveira,Djeison,Lutier,Raymundo,Flademir,Wouters,Angélica,Terezinha,Barth,Wouter 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.2

          Trypanosomiasis is caused by a pathogenic protozoan of the genus Trypanosoma, being Trypanosoma vivax the most important agent for cattle. The aim of the present study was to demonstrate the expansion of T. vivax infection in different mesoregions of Minas Gerais, Brazil, and describe the clinicopathological findings of trypanosomiasis in cattle. The diagnosis was based on visualization of the parasite in blood smears and DNA detection of T. vivax in the blood of live cows and tissues of necropsied animals by the polymerase chain reaction (PCR). Thirty suspected herds were tested, of which 11 were positive for T. vivax. The most frequent clinical signs were anemia, apathy, drop in milk production, weight loss, reproductive disorders, and nervous signs. Concomitant diseases, such as malignant edema, pneumonia and increased cases of mastitis were associated with T. vivax infection. Three cows were necropsied and the most significant findings were low body condition score, pale mucous and spleen with white pulp hyperplasia. The results demonstrated the expansion of T. vivax infection in Minas Gerais, that PCR-associated blood smears are promising for diagnosis, and that other diseases often occur concomitantly to T. vivax infection in regions with trypanosomiasis in cattle.

        • KCI등재

          Does the Agaricus blazei Murill Mushroom Have Properties That Affect the Immune System? An Integrative Review

          Cristiane,Urcina,Joanna,Oliveira,Lima,Cláudio,Olavo,de,Almeida,Cordova,Otávio,de,Tolêdo,Nóbrega,Silvana,Schwerz,Funghetto,Margô,Gomes,de,Oliveira,Karnikowski 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

          There has been a significant increase in the use of mushrooms for therapeutic and medicinal purposes, in particular, use of the species Agaricus blazei Murrill, a basidiomycota of Brazilian origin. The objective of this study was to identify scientific evidence regarding the influence of A. blazei Murrill on the immune system. We undertook an integrative review of indexed publications published between 2000 and 2009, using the following question as a guideline: “What evidence can be found in the literature regarding the influence of A. blazei Murrill on the immune system?” Fourteen studies verified that there is in vitro and in vivo research demonstrating this mushroom's influence on the immune system. All research was characterized as evidence level 7 (preclinical study [animals/in vitro]). The research shows that A. blazei Murrill functions through bioactive compounds via mechanisms that are not yet entirely clear, although it has been shown that they promote action on the innate and adaptive immunological response, activation of the complement system, and synthesis of pro- and anti-inflammatory cytokines and even aid in diapedesis. Despite broad scientific evidence demonstrating relevant immunomodulatory properties of A. blazei Murrill, randomized clinical trials with human subjects are still needed in order for the mushroom to be put into clinical practice.

        • KCI등재

          Arthrospira (Spirulina) platensis Attenuates Dextran Sulfate Sodium-induced Colitis in Mice by Suppressing Key Pro-inflammatory Cytokines

          Francisca,Adilfa,de,Oliveira,Garcia,Helioswilton,Sales-Campos,Violet,G.,Yuen,Juliana,Reis,Machado,Glauce,Socorro,de,Barros,Viana,Carlo,José,Freire,Oliveira,John,H.,McNeill 대한소화기학회 2020 대한소화기학회지 Vol.76 No.3

          Background/Aims: Therapies aimed at modulating cytokines have been used to treat inflammatory illnesses, such as inflammatory bowel disease. On the other hand, patients may become intolerant, refractory, or present with several side effects. Arthrospira (Spirulina) platensis (SPI) is a blue-green microalga with bioactive molecules that have been evaluated to treat inflammatory diseases. On the other hand, few studies have examined their effects on the production of specific cytokines and the intestinal architecture in dextran sulfate sodium (DSS)-induced colitis. Therefore, this study examined the effects of a treatment using SPI in a murine model of intestinal inflammation. Methods: All mice (C57BL/6 male) were evaluated daily for their food and water intake, bodyweight variations, and clinical signs of disease. Colon inflammation was induced by exposure to DSS for 6 consecutive days. SPI was given orally at 50, 100, and 250 mg/kg/day. ELISA was performed to assess the production of cytokines. Myeloperoxidase and nitric oxide were also investigated. The level of microscopic damage was assessed by staining colon sections with hematoxylin and eosin. Results: SPI attenuated the DSS-induced inflammation, with improvements in the clinical signs and a decrease in the production of inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ. In addition, particularly at 250 mg/kg, SPI attenuated the severity of colitis by modulating the level of mucosal and submucosal cell infiltration, which preserved the epithelial barrier. Conclusions: SPI may be an alternative source of bioactive molecules with immunomodulatory properties, and has great potential to be used in the treatment of inflammatory diseases.

        • SCIESCOPUSKCI등재

          Trametes villosa Lignin Peroxidase (TvLiP): Genetic and Molecular Characterization

          Carneiro,,Rita,Terezinha,de,Oliveira,Lopes,,Maiza,Alves,Silva,,Marilia,Lordelo,Cardoso,Santos,,Veronica,da,Silva,Souza,,Volnei,Brito,de,Sousa,,Aurizangela,Oliveira,de,Pirovani,,Carlos,Priminho,Koblitz The Korean Society for Microbiology and Biotechnol 2017 Journal of microbiology and biotechnology Vol.27 No.1

          White-rot basidiomycetes are the organisms that decompose lignin most efficiently, and Trametes villosa is a promising species for ligninolytic enzyme production. There are several publications on T. villosa applications for lignin degradation regarding the expression and secretion of laccase and manganese peroxidase (MnP) but no reports on the identification and characterization of lignin peroxidase (LiP), a relevant enzyme for the efficient breakdown of lignin. The object of this study was to identify and partially characterize, for the first time, gDNA, mRNA, and the corresponding lignin peroxidase (TvLiP) protein from T. villosa strain CCMB561 from the Brazilian semiarid region. The presence of ligninolytic enzymes produced by this strain grown in inducer media was qualitatively and quantitatively analyzed by spectrophotometry, qPCR, and dye fading using Remazol Brilliant Blue R. The spectrophotometric analysis showed that LiP activity was higher than that of MnP. The greatest LiP expression as measured by qPCR occurred on the $7^{th}$ day, and the ABSA medium (agar, sugarcane bagasse, and ammonium sulfate) was the best that favored LiP expression. The amplification of the TvLiP gene median region covering approximately 50% of the T. versicolor LPGIV gene (87% identity); the presence of Trp199, Leu115, Asp193, Trp199, and Ala203 in the translated amplicon of the T. villosa mRNA; and the close phylogenetic relationship between TvLiP and T. versicolor LiP all indicate that the target enzyme is a lignin peroxidase. Therefore, T. villosa CCMB561 has great potential for use as a LiP, MnP, and Lac producer for industrial applications.

        • KCI등재

          Antidiabetic Effect of the Chrysobalanus icaco L. Aqueous Extract in Rats

          Ana,Paula,de,Oliveira,Barbosa,Gabriela,de,Oliveira,Silveira,Igor,Alexandre,Cortes,de,Menezes,Jose´,Melquiades,Rezende,Neto,Jose´,Leal,C.,Bitencurt,Charles,dos,Santos,Estavam,Amanda,do,Carmo,Bion,de,Li 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.6

          Chrysobalanus icaco L. is a medicinal plant popularly known in Brazil as ‘‘Grageru'' or ‘‘Abageru.'' It is used in African and American continents as medicinal food in the treatment of several diseases, including diabetes. This study used phytochemical screening to determine the antioxidant and α-amylase inhibitor activities of the aqueous extract (AECI) of C. icaco, and evaluated its antidiabetic potential in rodents. Phytochemical screening was performed using colorimetric tests with specific reagents. The in vitro antioxidant activity was evaluated by the scavenging activity of 2,2-diphenyl-1-picril-hydrazyl. The lethality test and behavioral screening was performed using an oral administration of 5 g/kg of AECI. The antidiabetic potential of AECI was evaluated through the oral glucose tolerance test (OGTT) and chronic hypoglycemic test at the doses of 100, 200, and 400 mg/kg (orally). Metformin was used as a reference drug in all tests. Diabetes was induced by injection of alloxan (40 mg/kg; intravenously). Phytochemical screening showed the presence of various compounds, including tannins, flavones, triterpenoids, steroids, saponins, and alkaloids. The in vitro antioxidant test demonstrated that AECI presented potent antioxidant activity. The lethality test and behavioral screening did not show lethality signs. In the OGTT test, AECI administration was not able to inhibit the elevation of glycemia. However, chronically administrated, it was able to cause a significant (P < .05) reduction of glycemia from 335 ± 27 up to 197 ± 15 mg/dL. These results demonstrate that the AECI presents a potential beneficial effect for diabetes.

        • SCIESCOPUSKCI등재

          Epizootic Infection by Trypanosoma vivax in Cattle from the State of Minas Gerais, Brazil

          Reis,,Matheus,de,Oliveira,Souza,,Fernanda,Rezende,Albuquerque,,Adriana,Silva,Monteiro,,Fernanda,Oliveira,,Luan,Francisco,dos,Santos,Raymundo,,Djeison,Lutier,Wouters,,Flademir,Wouters,,Angelica,Terezin The Korean Society for Parasitology 2019 The Korean Journal of Parasitology Vol.57 No.2

          Trypanosomiasis is caused by a pathogenic protozoan of the genus Trypanosoma, being Trypanosoma vivax the most important agent for cattle. The aim of the present study was to demonstrate the expansion of T. vivax infection in different mesoregions of Minas Gerais, Brazil, and describe the clinicopathological findings of trypanosomiasis in cattle. The diagnosis was based on visualization of the parasite in blood smears and DNA detection of T. vivax in the blood of live cows and tissues of necropsied animals by the polymerase chain reaction (PCR). Thirty suspected herds were tested, of which 11 were positive for T. vivax. The most frequent clinical signs were anemia, apathy, drop in milk production, weight loss, reproductive disorders, and nervous signs. Concomitant diseases, such as malignant edema, pneumonia and increased cases of mastitis were associated with T. vivax infection. Three cows were necropsied and the most significant findings were low body condition score, pale mucous and spleen with white pulp hyperplasia. The results demonstrated the expansion of T. vivax infection in Minas Gerais, that PCR-associated blood smears are promising for diagnosis, and that other diseases often occur concomitantly to T. vivax infection in regions with trypanosomiasis in cattle.

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