On ϑ-quasi-Geraghty Contractive Mappings and Application to Perturbed Volterra and Hypergeometric Operators

Olalekan Taofeek Wahab 경북대학교 자연과학대학 수학과 2023 Kyungpook mathematical journal Vol.63 No.1

In this paper we suggest an enhanced Geraghty-type contractive mapping for examining the existence properties of classical nonlinear operators with or without prior degenerates. The nonlinear operators are proved to exist with the imposition of the Geraghty-type condition in a non-empty closed subset of complete metric spaces. To showcase some efficacies of the Geraghty-type condition, convergent rate and stability are deduced. The results are used to study some asymptotic properties of perturbed inte gral and hypergeometric operators. The results also extend and generalize some existing Geraghty-type conditions.

Antidiabetic potential of Chromolaena Odorata leave extract and its effect on Nrf2/keap1 antioxidant pathway in the liver of diabetic-induced Wistar Rats

Olusola Olalekan Elekofehinti,Nicholas Adeyemi Adewumi,Opeyemi Iwaloye 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.2

The incidence of liver dysfunction increases in diabetes due to insulin resistance and oxidative stress. Chromolaena odorata is a dominant medicinal plant used in traditional medicine as a remedy for many diseases, particularly diabetes mellitus but the underlying mechanism of the plants chemicals is yet to be documented. This study investigated possible mechanisms behind the folkloric use of C. odorata in the management of diabetes. The effect of this plant on genes linked with glucose metabolism and oxidative stress was investigated in the liver of diabetic rats. The rats were divided into diabetes control, normal control, C. odorata extract (200 mg/kg) and diabetic + C. odorata extract (200 gm/kg). Diabetes was induced in the rats by intraperitoneal injection of a buffered solution of STZ (65 mg/kg). Ethanolic extract of C. odorata leaves (200 mg/kg) was orally administered to the treatment groups for a period of three weeks. The mRNA expression of Glut2, glucokinase, Nrf2 and keap1 were quantified using RT-PCR. Molecular docking studies were further explored to denote compounds from C. odorata that might be responsible for its liver protective effect in diabetes. In the diabetic group, liver mRNA expressions of Glut2, glucokinase and Nrf2 were down-regulated (p < 0.05) while the expression of keap1 was upregulated (p < 0.05), relative to the control group. The treatment of diabetic rats with ethanolic extract of C. odorata leaves (200 mg/kg), however, upregulated the mRNA expression of Glut2, glucokinase and Nrf2 while repressing keap1 mRNA expression. Docking results showed that 5,7-dihydroxy-6–4-dimethoxyflavanone and luteolin as possible compounds from C. odorata potentiating this protective role. These findings suggest that C. odorata could mitigate liver dysfunction induced by diabetes.

The Use of E-journals by Health Researchers: A Case Study of the Nigerian Institute of Medical Research (NIMR)

Olayemi, Olalekan Moses,Abolarinwa, Timothy Shola,Olayemi, Kemi Jummai Korea Institute of Science and Technology Informat 2017 Journal of Information Science Theory and Practice Vol.5 No.3

This study investigated the use of e-journals by health researchers in the Nigerian Institute of Medical Research (NIMR). A descriptive survey method was adopted for the study and a questionnaire was used for data collection. The study population was comprised of fifty-four (54) respondents who are health researchers in the institute. The data collected were presented and analyzed using tables, frequency distribution, simple percentages, and charts. The result of the study revealed that all the respondents are aware of the availability of e-journals and attest to making use of them. The study revealed that electronic journals were mostly used for the purpose of conducting research work and the PDF format was preferred for downloading e-journals. However, it was observed that low Internet connectivity and intermittent electricity supply constitute a major obstacle to the use of e-journals. The study, therefore, recommended that the institute's management invest more resources on network connectivity, particularly its bandwidth, and ensure reliable power supply.

Removal of copper from industrial wastewaters by activated carbon prepared from periwinkle shells

Muslih Olalekan Adegoke Badmus,Thomas Okpo Kimble Audu,Benedict Anyata 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.2

Maximal covering location problem for nuclear medicine clinics allocation in Nigeria

Taiwo Olalekan John,Orunmuyi Akintunde T. 대한공간정보학회 2021 Spatial Information Research Vol.29 No.6

Several studies demonstrate the usefulness of nuclear medicine procedures for public health problems in developing countries. Little is known about the location and accessibility of nuclear medicine facilities, thus making the assessment of their location and allocation an integral part in strengthening nuclear medicine services in these countries. This paper employed the Maximal Covering Location Problem to identify the optimum numbers of University Teaching and Research Hospitals (UTRHs) that can be upgraded to provide Nuclear Medicine (NM) services to the largest number of Local Government Areas (LGAs) within a 200 km threshold drive time in Nigeria. It also identified developmental priority for the optimum UTRHs. Our analysis shows that about 26% of the LGAs are within 200 km distance from the two existing NM facilities and if NM services are restricted to only the UTRHs, 84% coverage of the LGAs can be achieved within a 200 km drive time of 11 UTRHs in Nigeria. Compared with others, Aminu Kano Teaching Hospital, Kano, Kano State should be prioritized because it consistently has between 90 and 110 LGAs within its 200 km distance. Our study identified the optimal locations for nuclear medicine facilities and offers additional theoretical insights into strengthening nuclear medicine services in developing countries.

Sex determination using humeral dimensions in a sample from KwaZulu-Natal: an osteometric study

Oluwatosin Olalekan Ogedengbe,Sunday Adelaja Ajayi,Omobola Aderibigbe Komolafe,Aung Khaing Zaw,Edwin Coleridge Stephen Naidu,Onyemaechi Okpara Azu 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.3

The morphological characteristics of the humeral bone has been investigated in recent times with studies showing varying degrees of sexual dimorphism. Osteologists and forensic scientists have shown that sex determination methods based on skeletal measurements are population specific, and these population-specific variations are present in many body dimensions. The present study aims to establish sex identification using osteometric standards for the humerus in a contemporary KwaZulu-Natal population. A total of 11 parameters were measured in a sample of n=211 humeri (males, 113; females, 98) from the osteological collection in the Discipline of Clinical Anatomy, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. The difference in means for nearly all variables were found to be significantly higher in males compared to females (P<0.01) with the most effective single parameter for predicting sex being the vertical head diameter having an accuracy of 82.5%. Stepwise discriminant analysis increased the overall accuracy rate to 87.7% when all measurements were jointly applied. We conclude that the humerus is an important bone which can be reliably used for sex determination based on standard metric methods despite minor tribal or ancestral differences amongst an otherwise homogenous population.

Well-Being and Jesus` Healing Ministry in Relation to Healing in African Religion

( Afolorunso Olalekan Dairo ) 삼육대학교 선교와사회문제연구소 2012 Asia-Africa Journal of Mission and Ministry(AAMM) Vol.6 No.-

This paper is premised on the dictum that ``health is wealth``. The issue of well-being is an important matter to all in any society. In the ancient world, health was a highly prized possession, and it is one of the most important considerations occupying our modern society. The study examines the processes of well-being in the ministry of Jesus and in African traditional religion visa-vis the advancement of medicine in modern civilization. The study discovered various religious views of illness and explored how Africans utilize healing systems and religious practices to address matters of disease and affliction. Moreover, the element of secrecy in African religion and its healing practices is an issue that cannot be under-estimated. The paper discusses Jesus` healing ministry exhaustively, and its relation to healing in African Religion. The necessity of the healing ministry to Jesus was highlighted. A multi-dimensional approach is recommended in healing all manners of diseases and enhancing wellbeing for all.

Inflation-poverty causal nexus in sub-Saharan African countries: an asymmetric panel causality approach

Clement Olalekan Olaniyi,Nicholas M Odhiambo 경희대학교 글로벌 통상·금융연구원 2024 International Trade, Politics and Development Vol.8 No.1

Abstract Purpose – This study examines the roles of cross-sectional dependence, asymmetric structure and country-to- country policy variations in the inflation-poverty reduction causal nexus in selected sub-Saharan African (SSA) countries from 1981 to 2019. Design/methodology/approach – To account for cross-sectional dependence, heterogeneity and policy variations across countries in the inflation-poverty reduction causal nexus, this study uses robust Hatemi-J data decomposition procedures and a battery of second-generation techniques. These techniques include cross- sectional dependency tests, panel unit root tests, slope homogeneity tests and the Dumitrescu-Hurlin panel Granger non-causality approach. Findings – Unlike existing studies, the panel and country-specific findings exhibit several dimensions of asymmetric causality in the inflation-poverty nexus. Positive inflationary shocks Granger-causes poverty reduction through investment and employment opportunities that benefit the impoverished in SSA. These findings align with country-specific analyses of Botswana, Cameroon, Gabon, Mauritania, South Africa and Togo. Also, a decline in poverty causes inflation to increase in the Congo Republic, Madagascar, Nigeria, Senegal and Togo. All panel and country-specific analyses reveal at least one dimension of asymmetric causality or another. Practical implications – All stakeholders and policymakers must pay adequate attention to issues of asymmetric structures, nonlinearities and country-to-country policy variations to address country-specific issues and the socioeconomic problems in the probable causal nexus between the high incidence of extreme poverty and double-digit inflation rates in most SSA countries. Originality/value – Studies on the inflation-poverty nexus are not uncommon in economic literature. Most existing studies focus on inflation’s effect on poverty. Existing studies that examine the inflation-poverty causal relationship covertly assume no asymmetric structure and nonlinearity. Also, the issues of cross- sectional dependence and heterogeneity are unexplored in the causal link in existing studies. All panel studies covertly impose homogeneous policies on countries in the causality. This study relaxes this supposition by

Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats

Ahmed Olalekan Bakare,Bamidele Victor Owoyele 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.1

Background: The continuous search for a novel neuropathic pain drug with few or no side effects has been a main focus of researchers for decades. This study investigated the antinociceptive and neuroprotective effects of bromelain in sciatic nerve ligation-induced neuropathic pain in Wistar rats. Methods: Forty-eight Wistar rats randomly divided into eight groups comprised of six animals each were used for this study. Peripheral neuropathy was induced via chronic constriction of the common sciatic nerve. Thermal hyperalgesic and mechanical allodynia were assessed using a hotplate and von Frey filaments, respectively. The functional recovery and structural architecture of the ligated sciatic nerve were evaluated using the sciatic functional index test and a histological examination of the transverse section of the sciatic nerve. The neuroprotective effects of bromelain were investigated in the proximal sciatic nerve tissue after 21 days of treatment. Results: Bromelain significantly (P < 0.05) attenuated both the thermal hyperalgesia and mechanical allodynic indices of neuropathic pain. There were improvements in sciatic function and structural integrity in rats treated with bromelain. These rats showed significant (P < 0.05) increases in sciatic nerve nuclear transcription factors (nuclear factor erythroid-derived-2-related factors-1 [NrF-1] and NrF-2), antioxidant enzymes (superoxide dismutase and glutathione), and reduced membranelipid peroxidation compared with the ligated control group. Conclusions: This study suggest that bromelain mitigated neuropathic pain by enhancing the activities of nuclear transcription factors (NrF-1 and NrF-2) which increases the antioxidant defense system that abolish neuronal stress and structural disorganization.

Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe2+ and sodium nitroprusside in rat brain synaptosome P2 fraction

Olusola Olalekan Elekofehinti,Jean Paul Kamdem,Daiane Francine Meinerz,Ige Joseph Kade,Isaac Gbadura Adanlawo,Joa˜o Batista Teixeira Rocha 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9

Solanum anguivi fruit saponin has antidiabeticproperty via interference with cellular energy metabolismand inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidantrole of S. anguivi saponin was investigated in the P2synaptosomal fraction of rat brain. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reductionassay, S. anguivi saponin concentration- dependently(10–200 lg/ml) reversed Fe2? and sodium nitroprussideinduceddecrease in mitochondrial activity via inhibition ofROS production, ROS-induced oxidation of protein andnon-protein thiol-containing molecules and lipid peroxidationas measured by thiobarbituric acid reactive substanceslevels. Conclusively, S. anguivi fruit saponin represents a class of natural compounds with the ability toreverse synaptosomal disruption, loss of mitochondrialintegrity and function often associated with the progressionof Huntington’s disease, Alzheimer disease, Parkinsondisease and amyotrophic lateral sclerosis diseases.